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  1. Article: The role of targeting protein for Xklp2 in tumorigenesis of hepatocellular carcinoma.

    Li, Ting / Zhu, Lu-Jian / Huang, An-Min / Wei, Yi-Feng / Xu, Jun / Xu, Ye-Jin

    Hepatobiliary & pancreatic diseases international : HBPD INT

    2022  Volume 22, Issue 4, Page(s) 418–422

    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/pathology ; Cell Transformation, Neoplastic/genetics ; Cell Cycle Proteins/metabolism ; Carcinogenesis/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic
    Chemical Substances Cell Cycle Proteins
    Language English
    Publishing date 2022-11-02
    Publishing country Singapore
    Document type Letter
    ZDB-ID 2241386-8
    ISSN 1499-3872
    ISSN 1499-3872
    DOI 10.1016/j.hbpd.2022.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6313: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article: The Emerging Role of Ferroptosis in Various Chronic Liver Diseases: Opportunity or Challenge.

    Zhu, Lujian / Luo, Shengnan / Zhu, Yin / Tang, Shiyue / Li, Chenge / Jin, Xiaozhi / Wu, Faling / Jiang, Huimian / Wu, Lina / Xu, Yejin

    Journal of inflammation research

    2023  Volume 16, Page(s) 381–389

    Abstract: Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by ... ...

    Abstract Ferroptosis is a recently identified iron-dependent form of intracellular lipid peroxide accumulation-mediated cell death. Different from other types of cell death mechanisms, it exhibits distinct biological and morphological features characterized by the loss of lipid peroxidase repair activity caused by glutathione peroxidase 4, the presence of redox-active iron, and the oxidation of phospholipids-containing polyunsaturated fatty acids. In recent years, studies have shown that ferroptosis plays a key role in various liver diseases such as alcoholic liver injury, non-alcoholic steatohepatitis, liver cirrhosis, and liver cancer. However, the mechanism of ferroptosis and its regulation on chronic liver disease are controversial among different types of cells in the liver. Herein, we summarize the current studies on mechanism of ferroptosis in chronic liver disease, aiming to outline the blueprint of ferroptosis as an effective option for chronic liver disease therapy.
    Language English
    Publishing date 2023-01-31
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2494878-0
    ISSN 1178-7031
    ISSN 1178-7031
    DOI 10.2147/JIR.S385977
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Metagenomic Next-Generation Sequencing for Accurate Diagnosis of Acute HIV Infection with Aseptic Meningitis: A Case Report.

    Zhou, Jing / Fu, Miao / Zhang, Dehe / Xu, Yejin / Lian, Jiangshan / Xu, Hanglu / Zhang, Yang / Chen, Haijun

    Infection and drug resistance

    2022  Volume 15, Page(s) 2529–2536

    Abstract: Background: Although individuals infected with HIV for the first time manifest a series of acute syndromes, most patients show mild or no symptoms, which complicates the initial clinical diagnosis. Early diagnosis is important for effective prevention ... ...

    Abstract Background: Although individuals infected with HIV for the first time manifest a series of acute syndromes, most patients show mild or no symptoms, which complicates the initial clinical diagnosis. Early diagnosis is important for effective prevention and management of patients. Metagenomic next-generation sequencing technology (mNGS) can rapidly detect a wide range of pathogenic microorganisms, even in atypical cases. However, to date, few studies have reported the application of mNGS to diagnose acute HIV infection with aseptic meningitis.
    Case presentation: A 38-year-old man was admitted to the Department of Infectious Diseases due to repeated fever, headache, and scattered rashes on his limbs. Routine blood analysis revealed elevated absolute lymphocytes and monocytes. Moreover, monocytes were found to be significantly increased following a lumbar puncture and cerebrospinal fluid detection. mNGS results revealed the presence of the human immunodeficiency virus (HIV-1), with HIV RNA of 910 copies/mL in his cerebrospinal fluid. The HIV antigen/antibody test was negative. According to a study by Fie Big et al, a clear diagnosis of acute HIV infection at Fiebig stage I. The patient's condition improved after treatment, and he was prescribed antiretroviral therapy (ART) after discharge.
    Conclusion: Aseptic meningitis is easily misdiagnosed during the initial stages of acute HIV infection. mNGS can be used to identify the pathogen early, rapidly, and accurately, thereby improving the treatment of acute HIV infections.
    Language English
    Publishing date 2022-05-16
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S361049
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Roles of multidisciplinary team in diagnosis and treatment of suspected cases of COVID-19].

    Ding, Shubo / Yu, Shi'an / Chen, Haijun / Zhang, Dehe / Xu, Yejin / Zhu, Dan / Cheng, Kun

    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

    2020  Volume 49, Issue 2, Page(s) 209–214

    Abstract: Objective: To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19).: Methods: The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Municipal ... ...

    Abstract Objective: To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19).
    Methods: The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Municipal Central Hospital from January 21, 2020 to March 20, 2020 were retrospectively analyzed.
    Results: In the 48 suspected cases, 18 were diagnosed with COVID-19, and 30 were excluded. Each of the confirmed cases were discussed among MDT for 2 to 12 times with an average of (4.7±3.2) times; while for non-COVID-19 patients were discussed for 2 to 4 times with an average of (2.3±0.6) times. With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. Except one transferred patient, all 17 confirmed COVID-19 patients were cured and discharged. There was no cross-infection occurred in suspected patients during the hospitalization. There were no deaths and no medical staff infections.
    Conclusions: The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved with MDT, particularly for complicated cases.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; China ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Humans ; Interdisciplinary Communication ; Pandemics ; Patient Care Team/standards ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome
    Keywords covid19
    Language Chinese
    Publishing date 2020-05-01
    Publishing country China
    Document type Journal Article
    ISSN 1008-9292
    ISSN 1008-9292
    DOI 10.3785/j.issn.1008-9292.2020.03.15
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interleukin 10 Gene-Modified Bone Marrow-Derived Dendritic Cells Attenuate Liver Fibrosis in Mice by Inducing Regulatory T Cells and Inhibiting the TGF-

    Xu, Yejin / Tang, Xinyue / Yang, Min / Zhang, Shengguo / Li, Shanshan / Chen, Yukai / Liu, Minhui / Guo, Yuxiang / Lu, Mingqin

    Mediators of inflammation

    2019  Volume 2019, Page(s) 4652596

    Abstract: Aim: To explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells (DC-IL10) on liver fibrosis.: Methods: In vitro, BMDCs were transfected with lentiviral-interleukin 10-GFP (LV-IL10-GFP) at the ...

    Abstract Aim: To explore the therapeutic effects and mechanisms of interleukin 10 gene-modified bone marrow-derived dendritic cells (DC-IL10) on liver fibrosis.
    Methods: In vitro, BMDCs were transfected with lentiviral-interleukin 10-GFP (LV-IL10-GFP) at the MOI of 1 : 40. Then, the phenotype (MHCII, CD80, and CD86) and allo-stimulatory ability of DC-IL10 were identified by flow cytometry, and the levels of IL-10 and IL-12 (p70) secreted into the culture supernatants were quantified by ELISA. In vivo, DC-IL10 was injected into mice with CCl4-induced liver fibrosis through the tail vein. Lymphocytes were isolated to investigate the differentiation of T cells, and serum and liver tissue were collected for biochemical, cytokine, histopathologic, immune-histochemical, and Western blot analyzes.
    Results: In vitro, the expressions of MHCII, CD80, and CD86 in DC-IL10 were significantly suppressed, allogeneic CD4
    Conclusion: IL-10 genetic modification of BMDCs may maintain DC in the state of tolerance and allow DC to induce T cell hyporesponsiveness or tolerance. DC-IL10 suppressed liver fibrosis by inducing Treg production and inhibiting the TGF-
    MeSH term(s) Animals ; Bone Marrow Cells/cytology ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Dendritic Cells/metabolism ; Dendritic Cells/physiology ; Interleukin-10/metabolism ; Liver Cirrhosis/metabolism ; Liver Cirrhosis/therapy ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Smad Proteins/metabolism ; T-Lymphocytes, Regulatory/metabolism ; Transforming Growth Factor beta/metabolism
    Chemical Substances Smad Proteins ; Transforming Growth Factor beta ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2019-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2019/4652596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3575: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: [Roles of multidisciplinary team (MDT) in diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19)]

    Ding, Shubo / Yu, Shi039 / an, / Chen, Haijun / Zhang, Dehe / Xu, Yejin / Zhu, Dan / Cheng, Kun

    Zhejiang Da Xue Xue Bao Yi Xue Ban

    Abstract: OBJECTIVE: To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19). METHODS: The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Central ... ...

    Abstract OBJECTIVE: To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of corona virus disease 2019 (COVID-19). METHODS: The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Central Hospital from January 21, 2020 to March 20, 2020 were retrospectively analyzed. RESULTS: Of the 48 suspected cases, 18 were diagnosed with COVID-19, and 30 were excluded. Each of the confirmed cases were discussed among MDT for 2 to 12 times with an average of (4.7±3.2) times; while for non-COVID-19 patients were discussed for 2 to 4 times with an average of (2.3±0.6) times per case. With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. Except one transferred patient, all 17 confirmed COVID-19 patients were cured and discharged; there was no cross-infection occurred in suspected patients during the hospitalization; there were no deaths and no medical staff infections. CONCLUSIONS: The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved under MDT mode, particularly for complicated and refractory cases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32275128
    Database COVID19

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  7. Article: [Roles of multidisciplinary team in diagnosis and treatment of suspected cases of COVID-19]

    Ding, Shubo / Yu, Shi039 / an, / Chen, Haijun / Zhang, Dehe / Xu, Yejin / Zhu, Dan / Cheng, Kun

    Zhejiang Da Xue Xue Bao Yi Xue Ban

    Abstract: OBJECTIVE: To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19). METHODS: The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Municipal ... ...

    Abstract OBJECTIVE: To analyze the roles of multidisciplinary team (MDT) in the diagnosis and treatment of suspected cases of coronavirus disease 2019 (COVID-19). METHODS: The clinical data of 48 patients with suspected COVID-19 admitted in Jinhua Municipal Central Hospital from January 21, 2020 to March 20, 2020 were retrospectively analyzed. RESULTS: In the 48 suspected cases, 18 were diagnosed with COVID-19, and 30 were excluded. Each of the confirmed cases were discussed among MDT for 2 to 12 times with an average of (4.7±3.2) times; while for non-COVID-19 patients were discussed for 2 to 4 times with an average of (2.3±0.6) times. With the guidance of MDT, one COVID-19 patient was transferred to designated provincial hospital after effective treatment; one patient complicated with acute cholecystitis underwent gallbladder puncture and drainage; and COVID-19 was excluded in a highly suspected patient after alveolar lavage fluid examination. Except one transferred patient, all 17 confirmed COVID-19 patients were cured and discharged. There was no cross-infection occurred in suspected patients during the hospitalization. There were no deaths and no medical staff infections. CONCLUSIONS: The efficiency of diagnosis and treatment for suspected COVID-19 patients can be improved with MDT, particularly for complicated cases.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32391666
    Database COVID19

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