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  1. AU="Xu, Yi-Ming"
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  1. Article ; Online: PAHs removal by soil washing with thiacalix[4]arene tetrasulfonate.

    Xing, Le-Yao / Meng, Guan-Han / Yang, Ji-Xian / Xu, Ming-Han / Xu, Yi-Ming / Xie, Hai-Xiao / Wang, Ai-Jie / Sun, Yi-Lu

    Environmental science and ecotechnology

    2024  Volume 21, Page(s) 100422

    Abstract: Remediating soil contaminated with polycyclic aromatic hydrocarbons (PAHs) presents a significant environmental challenge due to their toxic and carcinogenic properties. Traditional PAHs remediation methods-chemical, thermal, and bioremediation-along ... ...

    Abstract Remediating soil contaminated with polycyclic aromatic hydrocarbons (PAHs) presents a significant environmental challenge due to their toxic and carcinogenic properties. Traditional PAHs remediation methods-chemical, thermal, and bioremediation-along with conventional soil-washing agents like surfactants and cyclodextrins face challenges of cost, ecological harm, and inefficiency. Here we show an effective and environmentally friendly calixarene derivative for PAHs removal through soil washing. Thiacalix[4]arene tetrasulfonate (TCAS) has a unique molecular structure of a sulfonate group and a sulfur atom, which enhances its solubility and facilitates selective binding with PAHs. It forms host-guest complexes with PAHs through π-π stacking, OH-π interactions, hydrogen bonding, van der Waals forces, and electrostatic interactions. These interactions enable partial encapsulation of PAH molecules, aiding their desorption from the soil matrix. Our results show that a 0.7% solution of TCAS can extract approximately 50% of PAHs from contaminated soil while preserving soil nutrients and minimizing adverse environmental effects. This research unveils the pioneering application of TCAS in removing PAHs from contaminated soil, marking a transformative advancement in resource-efficient and sustainable soil remediation strategies.
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2666-4984
    ISSN (online) 2666-4984
    DOI 10.1016/j.ese.2024.100422
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  2. Article ; Online: Accelerated Discovery of Targeted Environmentally Friendly A(II)B(I)X

    Xu, Yi-Ming / Li, Kai / Jian, Zhi-Bin / Bie, Jie / Wei, Meng / Chen, Shuang

    ACS applied materials & interfaces

    2023  

    Abstract: The engineered hybrid organic-inorganic perovskites (HOIPs) with outstanding multifunctionalities have realized overarching targeted-driven applications and thus aroused intense research interest. The emergence of three-dimensional (3D) A(II)B(I) ... ...

    Abstract The engineered hybrid organic-inorganic perovskites (HOIPs) with outstanding multifunctionalities have realized overarching targeted-driven applications and thus aroused intense research interest. The emergence of three-dimensional (3D) A(II)B(I)X
    Language English
    Publishing date 2023-11-03
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c13439
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  3. Article ; Online: Par3L, a polarity protein, promotes M1 macrophage polarization and aggravates atherosclerosis in mice via p65 and ERK activation.

    Huang, Yi-Min / Wu, Yu-Sen / Dang, Yuan-Ye / Xu, Yi-Ming / Ma, Kong-Yang / Dai, Xiao-Yan

    Acta pharmacologica Sinica

    2023  Volume 45, Issue 1, Page(s) 112–124

    Abstract: Proinflammatory M1 macrophages are critical for the progression of atherosclerosis. The Par3-like protein (Par3L) is a homolog of the Par3 family involved in cell polarity establishment. Par3L has been shown to maintain the stemness of mammary stem cells ...

    Abstract Proinflammatory M1 macrophages are critical for the progression of atherosclerosis. The Par3-like protein (Par3L) is a homolog of the Par3 family involved in cell polarity establishment. Par3L has been shown to maintain the stemness of mammary stem cells and promote the survival of colorectal cancer cells. In this study, we investigated the roles of the polar protein Par3L in M1 macrophage polarization and atherosclerosis. To induce atherosclerosis, Apoe
    MeSH term(s) Mice ; Humans ; Animals ; Plaque, Atherosclerotic/metabolism ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Atherosclerosis/metabolism ; Macrophages/metabolism ; Apolipoproteins E/metabolism ; Macrophage Activation ; Mice, Inbred C57BL
    Chemical Substances Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Apolipoproteins E
    Language English
    Publishing date 2023-09-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/s41401-023-01161-z
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  4. Article: UiO-66-NH2 incorporated dual-layer hollow fibers made by immiscibility induced phase separation (I2PS) process for ethanol dehydration via pervaporation

    Xu, Yi Ming / Chung, Tai-Shung / Japip, Susilo

    Journal of membrane science. 2019 Oct. 13,

    2019  

    Abstract: High performance dual-layer hollow fiber membranes have been developed for ethanol dehydration by incorporating a tiny amount (i.e., less than 0.3 wt%) of UiO-66-NH2 particles into cellulose triacetate (CTA)/Ultem® hollow fibers fabricated by the ... ...

    Abstract High performance dual-layer hollow fiber membranes have been developed for ethanol dehydration by incorporating a tiny amount (i.e., less than 0.3 wt%) of UiO-66-NH2 particles into cellulose triacetate (CTA)/Ultem® hollow fibers fabricated by the immiscibility induced phase separation (I2PS) process. Effects of particle loading, air gap, feed temperature, feed composition and heat treatment on membrane performance for ethanol dehydration were systematically studied. Positron annihilation spectroscopy (PAS) analyses were conducted to disclose the mechanisms of performance enhancement. Adding UiO-66-NH2 particles improves the permeation flux due to the reduced transport resistance and the enhanced affinity between water and the membrane. The hollow fiber (O-0.2-1.5) consisting of 0.2 wt% UiO-66-NH2 particles in the outer layer possesses the most outstanding separation performance among the newly developed hollow fibers. It has an ultra-high flux of 2667g/m2h (i.e., water permeance of 20.05 mol/m2h kPa) and its permeate comprises 95.00 wt% water, equivalent to a mole-based selectivity of 152 at 50 °C with a feed comprising 85 wt% water and 15 wt% ethanol. After annealing at 120 °C for 2h, the flux drops to 1977 g/m2h but the water concentration in permeate jumps to 98.07 wt%. A comparison with literature data verifies the excellent performance of the newly developed I2PS membrane. The membrane also shows impressively stable performance throughout the 200h monitored period for ethanol dehydration. The newly developed membrane may have great potential for pervaporation dehydration of ethanol for industrial applications.
    Keywords air ; annealing ; artificial membranes ; cellulose ; electrons ; ethanol ; feed composition ; heat treatment ; industrial applications ; permeability ; pervaporation ; separation ; spectroscopy ; temperature
    Language English
    Dates of publication 2019-1013
    Publishing place Elsevier B.V.
    Document type Article
    Note Pre-press version
    ZDB-ID 194516-6
    ISSN 0376-7388
    ISSN 0376-7388
    DOI 10.1016/j.memsci.2019.117571
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  5. Article ; Online: Progress of antibiotic-loaded bone cement in joint arthroplasty.

    Xu, Yi-Ming / Peng, Hui-Ming / Feng, Bin / Weng, Xi-Sheng

    Chinese medical journal

    2020  Volume 133, Issue 20, Page(s) 2486–2494

    Abstract: Bone cement, consisting of polymethyl methacrylate, is a bioinert material used for prothesis fixation in joint arthroplasty. To treat orthopedic infections, such as periprosthetic joint infection, antibiotic-loaded bone cement (ALBC) was introduced into ...

    Abstract Bone cement, consisting of polymethyl methacrylate, is a bioinert material used for prothesis fixation in joint arthroplasty. To treat orthopedic infections, such as periprosthetic joint infection, antibiotic-loaded bone cement (ALBC) was introduced into clinical practice. Recent studies have revealed the limitations of the antibacterial effect of ALBC. Moreover, with the increase in high infection risk patients and highly resistant microbes, more researches and modification of ALBC are required. This paper reviewed latest findings about ALBC for most popular and destructive pathogens, summarized the influence of antibiotic kind, drug dosage, application method, and environment towards characteristic of ALBC. Subsequently, new cement additives and clinical applications of ALBC in joint arthroplasty were also discussed.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Arthroplasty, Replacement, Knee ; Bone Cements ; Humans ; Polymethyl Methacrylate ; Prosthesis-Related Infections/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Bone Cements ; Polymethyl Methacrylate (9011-14-7)
    Language English
    Publishing date 2020-10-23
    Publishing country China
    Document type Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001093
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  6. Article: Mixed matrix membranes with nano-sized functional UiO-66-type MOFs embedded in 6FDA-HAB/DABA polyimide for dehydration of C1-C3 alcohols via pervaporation

    Xu, Yi Ming / Susilo Japip / Tai-Shung Chung

    Journal of membrane science. 2018 Mar. 01, v. 549

    2018  

    Abstract: This study demonstrated an effective method to enhance both the normalized flux and separation factor by molecularly designing mixed matrix membranes (MMMs) consisting of porous UiO-66-NH2 nanoparticles and 6FDA-HAB/DABA polyimide. To investigate the ... ...

    Abstract This study demonstrated an effective method to enhance both the normalized flux and separation factor by molecularly designing mixed matrix membranes (MMMs) consisting of porous UiO-66-NH2 nanoparticles and 6FDA-HAB/DABA polyimide. To investigate the effects of functional groups on UiO-66 particles on alcohol dehydration, MMMs containing (1) UiO-66-NH2 nanoparticles with a particle size of 80–90nm, (2) UiO-66 with a particle size of 90–110nm and (3) UiO-66-F4 with a particle size of 90–130nm were fabricated and compared for alcohol dehydration. Three alcohol dehydration systems; namely, methanol/water, ethanol/water and isopropanol/water were studied. Results showed that UiO-66-NH2 based MMMs have superior separation performance among these three MMMs because the hydrophilic amino-functional groups can facilitate water transport. Incorporation of UiO-66-NH2 nanoparticles can greatly improve both the normalized flux and separation factor simultaneously if the particle loading is within the range of 0–20wt%. Due to the good compatibility between UiO-66-NH2 particles and the 6FDA-HAB/DABA polyimide resulting from the intermolecular bonding among the amine and imide groups, the UiO-66-NH2 based MMMs exhibited stable isopropanol dehydration performance in uninterrupted 200-h tests. The excellent alcohol dehydration performance of UiO-66-NH2 based MMMs opens up their potential for alcohol dehydration via pervaporation.
    Keywords artificial membranes ; ethanol ; hydrophilicity ; isopropyl alcohol ; methanol ; moieties ; nanoparticles ; particle size ; pervaporation
    Language English
    Dates of publication 2018-0301
    Size p. 217-226.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 194516-6
    ISSN 0376-7388
    ISSN 0376-7388
    DOI 10.1016/j.memsci.2017.12.001
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  7. Article ; Online: Systemic Delivery of Clopidogrel Inhibits Neointimal Formation in a Mouse Vein Graft Model.

    Shi, LinSheng / Chen, XiaoLi / Wang, HuiMin / Xu, YiMing / Din, ShengGuang / Liu, Jun / Zhang, Qing / Zhang, Li

    Journal of cardiovascular pharmacology

    2022  Volume 80, Issue 6, Page(s) 832–841

    Abstract: Abstract: Clopidogrel inhibits platelet aggregation and has beneficial effects on patients undergoing coronary artery bypass grafting surgery, but it is unknown whether clopidogrel inhibits the neointima formation of grafted veins. In this study, we ... ...

    Abstract Abstract: Clopidogrel inhibits platelet aggregation and has beneficial effects on patients undergoing coronary artery bypass grafting surgery, but it is unknown whether clopidogrel inhibits the neointima formation of grafted veins. In this study, we used a murine vein graft model to study the effect of clopidogrel on intima hyperplasia of the vein graft. Vein grafting was performed among C57BL/6J mice, immediately after surgery; 1 mg/kg clopidogrel and vehicle control were used to inject mice peritoneally daily for 2 weeks. As compared with the vehicle, clopidogrel significantly inhibited the neointima formation of vein grafts at 4 weeks after surgeries. The immunohistochemistry study showed that as compared with the vehicle, clopidogrel significantly decreased the rate of proliferating cell nuclear antigen-positive cells in the wall of vein grafts and significantly increased the expression of vascular smooth muscle cell (VSMC) contractile protein markers (α-smooth muscle actin, calponin, and SM22) within the neointima area of vein grafts. Clopidogrel significantly decreased the plasma interleukin 6 (IL-6) level at 1 week after surgery as compared with the vehicle. We isolated VSMCs from mouse aortic arteries. As compared with the vehicle, clopidogrel significantly inhibited thrombin-induced VSMC proliferation and migration, significantly decreased IL-6 mRNA expression and protein secretion, and increased intracellular cyclic adenosine monophosphate generation in a dose-dependent manner. In conclusion, systemic delivery of clopidogrel inhibits neointima formation of the mouse vein graft, the mechanisms of which are associated with its inhibitory effects on VSMC proliferation, migration, and the tendency to synthetic phenotype after vein graft surgery, reducing the expression of IL-6 and increasing the intracellular cyclic adenosine monophosphate level.
    MeSH term(s) Mice ; Animals ; Clopidogrel ; Mice, Inbred C57BL ; Interleukin-6 ; Protein Transport ; Adenosine Monophosphate
    Chemical Substances Clopidogrel (A74586SNO7) ; Interleukin-6 ; Adenosine Monophosphate (415SHH325A)
    Language English
    Publishing date 2022-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391970-5
    ISSN 1533-4023 ; 0160-2446
    ISSN (online) 1533-4023
    ISSN 0160-2446
    DOI 10.1097/FJC.0000000000001361
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  8. Article ; Online: Decreasing mitochondrial fission ameliorates HIF-1α-dependent pathological retinal angiogenesis.

    Huang, Shu-Qi / Cao, Kai-Xiang / Wang, Cai-Ling / Chen, Pei-Ling / Chen, Yi-Xin / Zhang, Yu-Ting / Yu, Shi-Hui / Bai, Zai-Xia / Guo, Shuai / Liao, Mu-Xi / Li, Qiao-Wen / Zhang, Guo-Qi / He, Jun / Xu, Yi-Ming

    Acta pharmacologica Sinica

    2024  

    Abstract: Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such as retinopathy of prematurity. Endothelial mitochondria are dynamic organelles that undergo constant fusion and fission and are ... ...

    Abstract Angiogenesis plays a critical role in many pathological processes, including irreversible blindness in eye diseases such as retinopathy of prematurity. Endothelial mitochondria are dynamic organelles that undergo constant fusion and fission and are critical signalling hubs that modulate angiogenesis by coordinating reactive oxygen species (ROS) production and calcium signalling and metabolism. In this study, we investigated the role of mitochondrial dynamics in pathological retinal angiogenesis. We showed that treatment with vascular endothelial growth factor (VEGF; 20 ng/ml) induced mitochondrial fission in HUVECs by promoting the phosphorylation of dynamin-related protein 1 (DRP1). DRP1 knockdown or pretreatment with the DRP1 inhibitor Mdivi-1 (5 μM) blocked VEGF-induced cell migration, proliferation, and tube formation in HUVECs. We demonstrated that VEGF treatment increased mitochondrial ROS production in HUVECs, which was necessary for HIF-1α-dependent glycolysis, as well as proliferation, migration, and tube formation, and the inhibition of mitochondrial fission prevented VEGF-induced mitochondrial ROS production. In an oxygen-induced retinopathy (OIR) mouse model, we found that active DRP1 was highly expressed in endothelial cells in neovascular tufts. The administration of Mdivi-1 (10 mg·kg
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/s41401-024-01262-3
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  9. Article: High-performance UiO-66/polyimide mixed matrix membranes for ethanol, isopropanol and n-butanol dehydration via pervaporation

    Xu, Yi Ming / Tai-Shung Chung

    Journal of membrane science. 2017 June 01, v. 531

    2017  

    Abstract: We have designed novel mixed matrix membranes (MMMs) consisting of UiO-66 nanoparticles and 6FDA-HAB/DABA polyimide for the dehydration of ethanol, isopropanol and n-butanol via pervaporation. The UiO-66 nanoparticles have a particle size of around 100nm. ...

    Abstract We have designed novel mixed matrix membranes (MMMs) consisting of UiO-66 nanoparticles and 6FDA-HAB/DABA polyimide for the dehydration of ethanol, isopropanol and n-butanol via pervaporation. The UiO-66 nanoparticles have a particle size of around 100nm. They can be evenly dispersed in the 6FDA-HAB/DABA polyimide matrix without visible agglomeration even at the highest 30wt% loading. The incorporation of UiO-66 into the 6FDA-HAB/DABA polyimide not only significantly enhances both free-volume radius and fractional free volume as confirmed by positron annihilation lifetime spectroscopy but also remarkably improves the normalized flux of MMMs for the dehydration of ethanol/water, isopropanol/water and n-butanol/water systems. The MMMs show excellent separation efficiency for the dehydration of isopropanol and n-butanol. At the highest UiO-66 loading of 30wt%, the MMMs have the water permeability of 0.329 and 0.292mgm−1h−1kPa−1 and mole-based selectivity of 2209 and 14214 respectively for isopropanol/water and n-butanol/water systems, outperforming most literature data. These experimental results strongly suggest the newly developed UiO-66/polyimide MMMs have great potential for isopropanol and n-butanol dehydration via pervaporation.
    Keywords artificial membranes ; butanol ; electrons ; ethanol ; isopropyl alcohol ; nanoparticles ; particle size ; permeability ; pervaporation ; spectroscopy
    Language English
    Dates of publication 2017-0601
    Size p. 16-26.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 194516-6
    ISSN 0376-7388
    ISSN 0376-7388
    DOI 10.1016/j.memsci.2017.02.041
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  10. Article ; Online: Antiatherosclerotic effect of dehydrocorydaline on ApoE

    Wen, Bin / Dang, Yuan-Ye / Wu, Su-Hua / Huang, Yi-Min / Ma, Kong-Yang / Xu, Yi-Ming / Zheng, Xi-Long / Dai, Xiao-Yan

    Acta pharmacologica Sinica

    2021  Volume 43, Issue 6, Page(s) 1408–1418

    Abstract: Despite improvements in cardiovascular disease (CVD) outcomes by cholesterol-lowering statin therapy, the high rate of CVD is still a great concern worldwide. Dehydrocorydaline (DHC) is an alkaloidal compound isolated from the traditional Chinese herb ... ...

    Abstract Despite improvements in cardiovascular disease (CVD) outcomes by cholesterol-lowering statin therapy, the high rate of CVD is still a great concern worldwide. Dehydrocorydaline (DHC) is an alkaloidal compound isolated from the traditional Chinese herb Corydalis yanhusuo. Emerging evidence shows that DHC has anti-inflammatory and antithrombotic benefits, but whether DHC exerts any antiatherosclerotic effects remains unclear. Our study revealed that intraperitoneal (i.p.) injection of DHC in apolipoprotein E-deficient (ApoE
    MeSH term(s) Alkaloids ; Animals ; Apolipoproteins E ; Atherosclerosis/metabolism ; Inflammation/metabolism ; Interleukin-18/metabolism ; Lipopolysaccharides ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
    Chemical Substances Alkaloids ; Apolipoproteins E ; Interleukin-18 ; Lipopolysaccharides ; dehydrocorydalin (30045-16-0)
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/s41401-021-00769-3
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