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Article ; Online: Role of Tamm-Horsfall protein in acute kidney injury

XU Yi-wen, LI Qing-chu

Jichu yixue yu linchuang, Vol 42, Iss 11, Pp 1795-

2022 Volume 1798

Abstract: The Tamm-Horsfall protein (THP), also known as uromodulin (UMOD), is a kidney-derived protein released bidirectionally in the blood and urine. Blood and urinary THP may be markers of early predictive diagnosis of acute kidney injury(AKI) and possibly as ... ...

Abstract	The Tamm-Horsfall protein (THP), also known as uromodulin (UMOD), is a kidney-derived protein released bidirectionally in the blood and urine. Blood and urinary THP may be markers of early predictive diagnosis of acute kidney injury(AKI) and possibly as one of the indicators of AKI severity. At the same time, THP plays a role in protecting kidney function in AKI through inhibiting reactive oxygen species accumulation, anti-inflammatory response and regulating macrophages. So it is a potential target in the clinical treatment of AKI.
Keywords	tamm-horsfall protein\|uromodulin\|acute kidney injury ; Medicine ; R
Language	Chinese
Publishing date	2022-11-01T00:00:00Z
Publisher	Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Increased Expression Levels of Thermophilic Serine Protease TTHA0724 through Signal Peptide Screening in

Xu, Yiwen / Xuan, Xiaoran / Gao, Renjun / Xie, Guiqiu

International journal of molecular sciences

2023 Volume 24, Issue 21

Abstract: The thermostable protease TTHA0724 derived ... ...

Abstract	The thermostable protease TTHA0724 derived from
MeSH term(s)	Bacillus subtilis/metabolism ; Serine Proteases/metabolism ; Protein Sorting Signals ; Escherichia coli/metabolism ; Serine Endopeptidases/metabolism
Chemical Substances	Serine Proteases (EC 3.4.-) ; Protein Sorting Signals ; Serine Endopeptidases (EC 3.4.21.-)
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242115950
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Why mobile social media-related fear of missing out promotes depressive symptoms? the roles of phubbing and social exclusion.

Gao, Bin / Shen, Quanwei / Luo, Gui / Xu, Yiwen

BMC psychology

2023 Volume 11, Issue 1, Page(s) 189

Abstract: Background: With the popularity of mobile socialization, people have become more closely connected with their phones. While people enjoy the convenience that phones bring (e.g., accessing information and socializing), they also feel anxious about ... ...

Abstract	Background: With the popularity of mobile socialization, people have become more closely connected with their phones. While people enjoy the convenience that phones bring (e.g., accessing information and socializing), they also feel anxious about missing out on certain information. Previous researches have shown that fear of missing out (FoMO) can trigger depressive symptoms, however, the underlying psychological mechanisms are not yet clear. In addition, limited research has explored this issue in the context of mobile social media. Methods: To address this research gap, we surveyed 486 Chinese college students (278 males and 208 females, mean age = 19.95 years, SD = 1.14) and all participants completed a self-report questionnaire including mobile social media-related FoMO scale, phubbing scale, social exclusion scale, and the patient health questionnaire-9. The data were analyzed by SPSS24.0 and the Process macro and developed a mediating and moderating model incorporating phubbing and social exclusion. Results: The results showed that (1) mobile social media-related FoMO (MSM-related FoMO) can significantly and positively predict depressive symptoms among college students; (2) phubbing partially mediates the relationship between MSM-related FoMO and depressive symptoms; (3) the direct predictive effect of MSM-related FoMO on depressive symptoms is moderated by social exclusion. Conclusion: These findings are not only valuable for understanding the underlying mechanisms linking MSM-related FoMO and depressive symptoms, but also contribute to the development of psychological intervention programs (e.g., interventions based on social exclusion or phubbing) aiming at reducing college students' depressive symptoms.
MeSH term(s)	Female ; Humans ; Male ; Young Adult ; Depression ; Fear ; Social Isolation ; Social Media
Language	English
Publishing date	2023-06-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2705921-2
ISSN	2050-7283 ; 2050-7283
ISSN (online)	2050-7283
ISSN	2050-7283
DOI	10.1186/s40359-023-01231-1
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Article ; Online: Development and validation of a nomogram for predicting in-hospital mortality of patients with cervical spine fractures without spinal cord injury.

Xing, Zhibin / Cai, Lingli / Wu, Yuxuan / Shen, Pengfei / Fu, Xiaochen / Xu, Yiwen / Wang, Jing

European journal of medical research

2024 Volume 29, Issue 1, Page(s) 80

Abstract: Background: The incidence of cervical spine fractures is increasing every day, causing a huge burden on society. This study aimed to develop and verify a nomogram to predict the in-hospital mortality of patients with cervical spine fractures without ... ...

Abstract	Background: The incidence of cervical spine fractures is increasing every day, causing a huge burden on society. This study aimed to develop and verify a nomogram to predict the in-hospital mortality of patients with cervical spine fractures without spinal cord injury. This could help clinicians understand the clinical outcome of such patients at an early stage and make appropriate decisions to improve their prognosis. Methods: This study included 394 patients with cervical spine fractures from the Medical Information Mart for Intensive Care III database, and 40 clinical indicators of each patient on the first day of admission to the intensive care unit were collected. The independent risk factors were screened using the Least Absolute Shrinkage and Selection Operator regression analysis method, a multi-factor logistic regression model was established, nomograms were developed, and internal validation was performed. A receiver operating characteristic (ROC) curve was drawn, and the area under the ROC curve (AUC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were calculated to evaluate the discrimination of the model. Moreover, the consistency between the actual probability and predicted probability was reflected using the calibration curve and Hosmer-Lemeshow (HL) test. A decision curve analysis (DCA) was performed, and the nomogram was compared with the scoring system commonly used in clinical practice to evaluate the clinical net benefit. Results: The nomogram indicators included the systolic blood pressure, oxygen saturation, respiratory rate, bicarbonate, and simplified acute physiology score (SAPS) II. The results showed that our model had satisfactory predictive ability, with an AUC of 0.907 (95% confidence interval [CI] = 0.853-0.961) and 0.856 (95% CI = 0.746-0.967) in the training set and validation set, respectively. Compared with the SAPS-II system, the NRI values of the training and validation sets of our model were 0.543 (95% CI = 0.147-0.940) and 0.784 (95% CI = 0.282-1.286), respectively. The IDI values of the training and validation sets were 0.064 (95% CI = 0.004-0.123; P = 0.037) and 0.103 (95% CI = 0.002-0.203; P = 0.046), respectively. The calibration plot and HL test results confirmed that our model prediction results showed good agreement with the actual results, where the HL test values of the training and validation sets were P = 0.8 and P = 0.95, respectively. The DCA curve revealed that our model had better clinical net benefit than the SAPS-II system. Conclusion: We explored the in-hospital mortality of patients with cervical spine fractures without spinal cord injury and constructed a nomogram to predict their prognosis. This could help doctors assess the patient's status and implement interventions to improve prognosis accordingly.
MeSH term(s)	Humans ; Nomograms ; Hospital Mortality ; Fractures, Bone ; Cervical Vertebrae ; Spinal Cord Injuries ; Retrospective Studies
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1329381-3
ISSN	2047-783X ; 0949-2321
ISSN (online)	2047-783X
ISSN	0949-2321
DOI	10.1186/s40001-024-01655-4
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Article: Timing dependent neuronal migration is regulated by Cdk5-mediated phosphorylation of JIP1.

Fei, Qinglin / Im, Doo Soon / Xu, Yiwen / Huang, Tianwen / Qu, Dianbo

Frontiers in cell and developmental biology

2024 Volume 12, Page(s) 1371568

Abstract: The mammalian brain, especially the cerebral cortex, has evolved to increase in size and complexity. The proper development of the cerebral cortex requires the coordination of several events, such as differentiation and migration, that are essential for ... ...

Abstract	The mammalian brain, especially the cerebral cortex, has evolved to increase in size and complexity. The proper development of the cerebral cortex requires the coordination of several events, such as differentiation and migration, that are essential for forming a precise six-layered structure. We have previously reported that Cdk5-mediated phosphorylation of JIP1 at T205 modulates axonal out-growth. However, the spatiotemporal expression patterns and functions of these three genes (Cdk5, Cdk5r1 or p35, and Mapk8ip1 or JIP1) in distinct cell types during cortical development remain unclear. In this study, we analyzed single-cell RNA-sequencing data of mouse embryonic cortex and discovered that Cdk5, p35, and JIP1 are dynamically expressed in intermediate progenitors (IPs). Pseudotime analysis revealed that the expression of these three genes was concomitantly upregulated in IPs during neuronal migration and differentiation. By manipulating the expression of JIP1 and phospho-mimetic JIP1 using
Language	English
Publishing date	2024-03-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2024.1371568
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Article ; Online: Effect of short-term moderate intake of ice wine on hepatic glycolipid metabolism in C57BL/6J mice.

Ma, Xinyuan / Liu, Yang / Han, Fuliang / Cheng, Tiantian / Wang, Kaixian / Xu, Yiwen

Food & function

2024 Volume 15, Issue 9, Page(s) 5063–5072

Abstract: As the correlation between high fructose intake and metabolism-related diseases ( ...

Abstract	As the correlation between high fructose intake and metabolism-related diseases (
MeSH term(s)	Animals ; Mice, Inbred C57BL ; Male ; Liver/metabolism ; Wine/analysis ; Mice ; Glycolipids/metabolism ; Insulin Resistance ; Fructose ; Lipid Metabolism/drug effects
Chemical Substances	Glycolipids ; Fructose (30237-26-4)
Language	English
Publishing date	2024-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d3fo05665a
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Article ; Online: Study on the Spatial Damage Characteristics of Working Fluid in a Sandstone Reservoir and an Unplugged Fluid System.

Xin, Xiaozhi / Zhao, Jinming / Xu, Yiwen / Jin, Chenghong / Luo, Zhifeng / Wang, Yiming / Fu, Haoran

ACS omega

2024 Volume 9, Issue 16, Page(s) 18400–18411

Abstract: Due to its good physical properties and low pressure coefficient, the K75 reservoir is prone to leakage and intrusion of drilling and completion fluids during well construction, resulting in plugging of the borehole throat, which will inevitably affect ... ...

Abstract	Due to its good physical properties and low pressure coefficient, the K75 reservoir is prone to leakage and intrusion of drilling and completion fluids during well construction, resulting in plugging of the borehole throat, which will inevitably affect the injection and recovery capacity of the gas well. In order to ensure the strong injection and production capacity of the K75 reservoir, this paper clarifies the reservoir space damage characteristics under different pressure differences and different entry fluids by establishing physical simulation of the damage, selecting the optimal system of the decongestant, and conducting dynamic flow decongestion experiments, as well as combining with the characterization means of the continuous scanning system of the core and the permeability test of the gas measurement. The test results show that the degree of damage of the same working fluid increases with the increase of differential pressure of repulsion, and the degree of damage of sequential working fluids (drilling fluid, completion fluid, and perforating fluid) is greater than that of drilling fluid damage under the same differential pressure of repulsion. In order to relieve the damage of wellbore working fluids, a set of multifunctional, low-corrosion composite acid system formulas was selected through rock powder, mud cake dissolution experiments, and dynamic flow unblocking experiments; the permeability recovery rate of this acid system after unblocking was more than 90%, which is widely applicable, and it is useful for the acidizing and unblocking practice in similar reservoirs.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.4c00252
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Article ; Online: Exploring additives beyond phthalates: Release from plastic mulching films, biodegradation and occurrence in agricultural soils.

Xu, Yiwen / Xiong, Boya / Huang, Yu-Ming M / Xu, Jianming / He, Yan / Lu, Zhijiang

The Science of the total environment

2024 Volume 918, Page(s) 170763

Abstract: It is widely recognized that applications of plastic films result in plastic pollution in agroecosystems. However, there is limited knowledge on the release and occurrence of additives beyond phthalates in agricultural soil. In this study, the rates of ... ...

Abstract	It is widely recognized that applications of plastic films result in plastic pollution in agroecosystems. However, there is limited knowledge on the release and occurrence of additives beyond phthalates in agricultural soil. In this study, the rates of release and biodegradation of various additives, including phthalates, bisphenols, organophosphate esters, phenolic antioxidants, and ultraviolet absorbents from mulching films in soil were quantified by laboratory incubation. The rates of release and biodegradation ranged from 0.069 d
MeSH term(s)	Soil ; Ecosystem ; Plastics ; Soil Pollutants/analysis ; Agriculture ; China ; Phthalic Acids
Chemical Substances	Soil ; Plastics ; Soil Pollutants ; phthalic acid (6O7F7IX66E) ; Phthalic Acids
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2024.170763
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Article ; Online: A fully haplotype-resolved and nearly gap-free genome assembly of wheat stripe rust fungus.

Wang, Jierong / Xu, Yiwen / Peng, Yuxi / Wang, Yiping / Kang, Zhensheng / Zhao, Jing

Scientific data

2024 Volume 11, Issue 1, Page(s) 508

Abstract: Stripe rust fungus Puccinia striiformis f. sp. tritici (Pst) is a destructive pathogen of wheat worldwide. Pst has a macrocyclic-heteroecious lifecycle, in which one-celled urediniospores are dikaryotic, each nucleus containing one haploid genome. We ... ...

Abstract	Stripe rust fungus Puccinia striiformis f. sp. tritici (Pst) is a destructive pathogen of wheat worldwide. Pst has a macrocyclic-heteroecious lifecycle, in which one-celled urediniospores are dikaryotic, each nucleus containing one haploid genome. We successfully generated the first fully haplotype-resolved and nearly gap-free chromosome-scale genome assembly of Pst by combining PacBio HiFi sequencing and trio-binning strategy. The genome size of the two haploid assemblies was 75.59 Mb and 75.91 Mb with contig N50 of 4.17 Mb and 4.60 Mb, and both had 18 pseudochromosomes. The high consensus quality values of 55.57 and 59.02 for both haplotypes confirmed the correctness of the assembly. Of the total 18 chromosomes, 15 and 16 were gapless while there were only five and two gaps for the remaining chromosomes of the two haplotypes, respectively. In total, 15,046 and 15,050 protein-coding genes were predicted for the two haplotypes, and the complete BUSCO scores achieved 97.7% and 97.9%, respectively. The genome will lay the foundation for further research on genetic variations and the evolution of rust fungi.
MeSH term(s)	Haplotypes ; Genome, Fungal ; Triticum/microbiology ; Triticum/genetics ; Puccinia/genetics ; Plant Diseases/microbiology ; Basidiomycota/genetics ; Chromosomes, Fungal/genetics
Language	English
Publishing date	2024-05-16
Publishing country	England
Document type	Journal Article ; Dataset
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-03361-6
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Article: Evaluation of mineral dust aerosol optical depth and related components from the CHIMERE-DUST model using satellite remote sensing and ground-based observations

Xu, Yiwen

Atmospheric environment. 2018 Oct., v. 191

2018

Abstract: Dust aerosol optical depth (AOD) simulated by the CHIMERE-DUST model over North Africa during 2006–2008 was evaluated by the SeaWiFS Deep Blue satellite data and AERONET ground based remote sensing measurements. The simulations were conducted using two ... ...

Abstract	Dust aerosol optical depth (AOD) simulated by the CHIMERE-DUST model over North Africa during 2006–2008 was evaluated by the SeaWiFS Deep Blue satellite data and AERONET ground based remote sensing measurements. The simulations were conducted using two meteorological inputs, ECMWF and CFSR forecast data, downscaled by the WRF model. The two simulations generated similar AODs and PM10 surface concentrations, which are highly correlated to dust emissions. The comparison of the simulated daily value of AOD with the satellite data showed good correlations (0.6–0.8) between them. A slightly better correlation was achieved using WRF-CFSR data. The regression coefficients fluctuated around 1.0 in cold months and decreased in summer, with minimums in August. The biases had similar seasonal cycles. This is consistent with the comparison against AERONET hourly AOD data that the model underestimated AODs in warm months at most stations. The comparison of PM10 surface concentration and dry deposition also showed negative biases in warm months at stations in the Sahel. The significant underestimation of wet deposition was found in monsoon season due to the unrealistic simulation of mesoscale convective system. It indicates that the low dust emission in August is partly associated with cold pools generated by the convective precipitation. Frequent overestimations of AOD were found in the northwest mostly because of the high dust emission produced by the overestimated winds near the Atlas Mountains. The dust emissions resulted from the two simulations were similar in terms of intra annual variations but differed in terms of annul dust emission. The estimated annual emission using WRF-CFSR data could be about 200 Tg more than the estimation using WRF-ECMWF data.
Keywords	aerosols ; atmospheric chemistry ; dry deposition ; dust ; dust emissions ; governmental programs and projects ; models ; monsoon season ; mountains ; particulates ; regression analysis ; remote sensing ; Sahel ; satellites ; seasonal variation ; summer ; wet deposition ; wind ; Northern Africa
Language	English
Dates of publication	2018-10
Size	p. 395-413.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	216368-8
ISSN	0004-6981 ; 1352-2310
ISSN	0004-6981 ; 1352-2310
DOI	10.1016/j.atmosenv.2018.03.061
Database	NAL-Catalogue (AGRICOLA)

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