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  1. Article ; Online: Learning Rates of Deep Nets for Geometrically Strongly Mixing Sequence.

    Men, Yueyang / Li, Liang / Hu, Ziqing / Xu, Yongli

    IEEE transactions on neural networks and learning systems

    2024  Volume PP

    Abstract: The great success of deep learning poses an urgent challenge to establish the theoretical basis for its working mechanism. Recently, research on the convergence of deep neural networks (DNNs) has made great progress. However, the existing studies are ... ...

    Abstract The great success of deep learning poses an urgent challenge to establish the theoretical basis for its working mechanism. Recently, research on the convergence of deep neural networks (DNNs) has made great progress. However, the existing studies are based on the assumption that the samples are independent, which is too strong to be applied to many real-world scenarios. In this brief, we establish a fast learning rate for the empirical risk minimization (ERM) on DNN regression with dependent samples, and the dependence is expressed in terms of geometrically strongly mixing sequence. To the best of our knowledge, this is the first convergence result of DNN methods based on mixing sequences. This result is a natural generalization of the independent sample case.
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ISSN 2162-2388
    ISSN (online) 2162-2388
    DOI 10.1109/TNNLS.2024.3371025
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Metabonomics Study of the Hematopoietic Effect of Medicinal Wine Maoji Jiu on a Blood Deficiency Rat Model by Ultra-High-Performance Liquid Chromatography Coupled to Quadrupole Time-of-Flight Mass Spectrometry and a Pattern Recognition Approach.

    Zeng, Fanqiang / Xu, Yongli / Li, Yilian / Yan, Zhigang / Li, Li

    Molecules (Basel, Switzerland)

    2022  Volume 27, Issue 12

    Abstract: Maoji Jiu (MJ) is a kind of medicinal wine that has been widely used by Chinese people for many years to nourish and promote blood circulation. The purpose of this study was to investigate the hematopoietic effect of MJ on the metabolism of blood ... ...

    Abstract Maoji Jiu (MJ) is a kind of medicinal wine that has been widely used by Chinese people for many years to nourish and promote blood circulation. The purpose of this study was to investigate the hematopoietic effect of MJ on the metabolism of blood deficient rats and to explore the underlying hematopoietic regulation mechanisms. Blood deficiency model rats were induced by subcutaneous injection of N-acetylphenylhydrazine (APH) and intraperitoneal injection of cyclophosphamide (CTX). The plasma metabolic fingerprints of blood deficiency model rats with and without MJ treatment were obtained by using metabonomics based on ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS). Orthogonal partial least squares-discriminant analysis (OPLS-DA) was used to evaluate the hematopoietic effect of MJ and identify potential biomarkers in the plasma of blood deficiency model rats. The levels of white blood cells (WBC), red blood cells (RBC) and hemoglobin (HGB) and the activity of antioxidant capacity showed a recovery trend to the control group after MJ treatment, while the dose of 10 mL/kg showed the best effect. In this study, thirteen potential biomarkers were identified, which were mainly related to seven metabolic pathways, including linoleic acid metabolism, d-glutamine and d-glutamate metabolism, alanine, aspartate and glutamate metabolism, tryptophan metabolism, pyrimidine metabolism, porphyrin and chlorophyll metabolism and arginine biosynthesis. Metabolomics was applied frequently to reflect the physiological and metabolic state of organisms comprehensively, indicating that the rapid plasma metabonomics may be a potentially powerful tool to reveal the efficacy and enriching blood mechanism of MJ.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/chemistry ; Humans ; Mass Spectrometry/methods ; Metabolomics/methods ; Rats ; Wine
    Chemical Substances Biomarkers ; Drugs, Chinese Herbal
    Language English
    Publishing date 2022-06-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules27123791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nano-Nd

    Xu, Yongli / Zhu, Liyao / Vukanti, Raja / Wang, Jichen / Shen, Congcong / Ge, Yuan

    Environmental science and pollution research international

    2023  Volume 30, Issue 32, Page(s) 78332–78338

    Abstract: Nanoparticulate- ... ...

    Abstract Nanoparticulate-Nd
    MeSH term(s) Soil ; Soil Microbiology ; Agriculture ; Bacteria ; Chloroflexi
    Chemical Substances Soil
    Language English
    Publishing date 2023-06-03
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-023-27979-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Arbuscular mycorrhiza fungi increase soil denitrifier abundance relating to vegetation community

    Wang, Jichen / Wang, Jiang / He, Ji-Zheng / Jing, Zhongwang / Xu, Yongli / Ge, Yuan

    Applied soil ecology. 2022 Mar., v. 171

    2022  

    Abstract: Denitrification by microorganisms in soil regulates ecosystem nitrogen availability and cycling. Although arbuscular mycorrhiza fungi (AMF) are best known as the key connectors between plant and microorganisms in below-ground soil, however, less ... ...

    Abstract Denitrification by microorganisms in soil regulates ecosystem nitrogen availability and cycling. Although arbuscular mycorrhiza fungi (AMF) are best known as the key connectors between plant and microorganisms in below-ground soil, however, less knowledge is available about the interactive effects of AMF and vegetation community traits on soil denitrifiers. In this study, we manipulated experimental pots with or without AMF inoculation (AMF+ and AMF− treatments) under three plant richness levels and 27 different plant community compositions. Our results provided evidence that inoculation of AMF significantly increased the abundances of nirS-, nirK- and nosZ-type denitrifiers as revealed by quantitative PCR (qPCR), which inferred a positive role of AMF in N-cycling microorganisms. Plant community traits, including richness, community composition, biomass and species, were less important in influencing the abundances of soil denitrifiers, and no significant interactive effect was detected between AMF inoculation and plant richness or plant community compositions, indicating a weak direct relationship between plants and soil denitrifiers. Our study provided comprehensive insights into the roles of AMF-plant associate bio-system in driving the variation of soil denitrifiers.
    Keywords biomass ; community structure ; denitrification ; denitrifying microorganisms ; ecosystems ; nitrogen ; nitrogen cycle ; plant communities ; quantitative polymerase chain reaction ; soil ; soil ecology ; vesicular arbuscular mycorrhizae
    Language English
    Dates of publication 2022-03
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 1196758-4
    ISSN 0929-1393
    ISSN 0929-1393
    DOI 10.1016/j.apsoil.2021.104325
    Database NAL-Catalogue (AGRICOLA)

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  5. Article: Compared With Girls, Boys' Psychological Symptoms Are More Likely to Be Influenced by Lifestyle in Chinese Middle School Students.

    Lu, Jinkui / Tan, Chun / Zhou, Jianfeng / Sha, Mian / Xu, Yongli / Qiu, Jianhua / Liu, Ningling

    Frontiers in psychology

    2022  Volume 13, Page(s) 899273

    Abstract: Purpose: To explore the relationship between Chinese middle school students' lifestyles and psychological symptoms and compare the differences between genders.: Method: Using the method of stratified cluster sampling, 14,356 students aged 13-18 years ...

    Abstract Purpose: To explore the relationship between Chinese middle school students' lifestyles and psychological symptoms and compare the differences between genders.
    Method: Using the method of stratified cluster sampling, 14,356 students aged 13-18 years from 8 cities in China were selected as participants. The Multidimensional Sub-health Questionnaire of Adolescents was used to estimate psychological symptoms. Chi-square test and Logistic regression analysis were used to analyze the relationship between lifestyle and psychological symptoms.
    Results: The psychological symptom detection rate of Chinese middle school students was 21.37%. The detection rate of psychological symptoms for boys was 22.1%, which was significantly higher than for girls (20.64%, χ
    Conclusions: There was a positive correlation between unhealthy lifestyle and the occurrence of psychological symptoms, and boys are more easily influenced by lifestyles than girls.
    Language English
    Publishing date 2022-07-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.899273
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Preparation, Characterization, and Performance Evaluation of Petroleum Asphalt Modified with Bio-Asphalt Containing Furfural Residue and Waste Cooking Oil.

    Lai, Shuo-Rong / Li, Shu-Jun / Xu, Yong-Li / Xu, Wen-Yuan / Zhang, Xian-Quan

    Polymers

    2022  Volume 14, Issue 9

    Abstract: The study aims to analyze the feasibility of proposing waste cooking oil and industrial waste furfural residue as raw materials to prepare bio-asphalt as partial substitutes for petroleum asphalt, so as to reduce the cost of pavement construction and ... ...

    Abstract The study aims to analyze the feasibility of proposing waste cooking oil and industrial waste furfural residue as raw materials to prepare bio-asphalt as partial substitutes for petroleum asphalt, so as to reduce the cost of pavement construction and decrease the consumption of non-renewable resources. In this study, 90# petroleum asphalt was partially substituted with the bio-asphalt in different proportions to prepare biomass-modified petroleum asphalt, the performance of which was first evaluated based on three indices: penetration, softening point, and ductility. Comparison of the crystal structures of the bio-asphalt and furfural residue were enabled by X-ray diffraction, and the blending mechanism and microscopic morphologies of the biomass-substituted asphalt mixtures were characterized by Fourier transform infrared spectroscopy and scanning electron microscopy. The results showed that the bio-asphalt was hydrophobic and exhibited excellent compatibility with 90# petroleum asphalt. The partial substitution of petroleum asphalt with bio-asphalt improved the low-temperature crack resistance of the asphalt by adversely affecting the high-temperature stability of the asphalt; however, when the bio-asphalt content was 8 wt.%, the performance parameters of the biomass-modified asphalt met the requirements of the 90# petroleum asphalt standard.
    Language English
    Publishing date 2022-04-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym14091683
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: SMRT sequencing of the full-length transcriptome of Gekko gecko.

    Jiang, Jianping / Huo, Juan / Zhang, Yueyun / Xu, Yongli / Zhao, Chengjian / Miao, Jianhua

    PloS one

    2022  Volume 17, Issue 2, Page(s) e0264499

    Abstract: Tokay Gecko (Gekko gecko) is a rare and endangered medicinal animal in China. Its dry body has been used as an anti-asthmatic agent for two thousand years. To date, the genome and transcriptome of this species remain poorly understood. Here, we adopted ... ...

    Abstract Tokay Gecko (Gekko gecko) is a rare and endangered medicinal animal in China. Its dry body has been used as an anti-asthmatic agent for two thousand years. To date, the genome and transcriptome of this species remain poorly understood. Here, we adopted single molecule real-time (SMRT) sequencing to obtain full-length transcriptome data and characterized the transcriptome structure. We identified 882,273 circular consensus (CCS) reads, including 746,317 full-length nonchimeric (FLNC) reads. The transcript cluster analysis revealed 212,964 consensus sequences, including 203,994 high-quality isoforms. In total, 111,372 of 117,888 transcripts were successfully annotated against eight databases (Nr, eggNOG, Swiss-Prot, GO, COG, KOG, Pfam and KEGG). Furthermore, 23,877 alternative splicing events, 169,128 simple sequence repeats (SSRs), 10,437 lncRNAs and 7,932 transcription factors were predicted across all transcripts. To our knowledge, this report is the first to document the G. gecko transcriptome using SMRT sequencing. The full-length transcript data might accelerate transcriptome research and lay the foundation for further research on G. gecko.
    MeSH term(s) Alternative Splicing/genetics ; Animals ; Genome ; High-Throughput Nucleotide Sequencing/methods ; Lizards/genetics ; Microsatellite Repeats/genetics ; Protein Isoforms/chemistry ; Protein Isoforms/genetics ; RNA/chemistry ; RNA/isolation & purification ; RNA/metabolism ; RNA, Long Noncoding/chemistry ; RNA, Long Noncoding/genetics ; Sequence Analysis, RNA ; Transcription Factors/genetics ; Transcriptome
    Chemical Substances Protein Isoforms ; RNA, Long Noncoding ; Transcription Factors ; RNA (63231-63-0)
    Language English
    Publishing date 2022-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0264499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: CUBN gene mutations may cause focal segmental glomerulosclerosis (FSGS) in children.

    Yang, Jing / Xu, Yongli / Deng, Linxia / Zhou, Luowen / Qiu, Liru / Zhang, Yu / Zhou, Jianhua

    BMC nephrology

    2022  Volume 23, Issue 1, Page(s) 15

    Abstract: Background: Imerslund-Gräsbeck Syndrome (IGS) is mainly caused by CUBN gene biallelic mutations. Proteinuria accompanies IGS specific symptoms in about half of the patients, isolated proteinuria is rarely reported. Here we present 3 patients with ... ...

    Abstract Background: Imerslund-Gräsbeck Syndrome (IGS) is mainly caused by CUBN gene biallelic mutations. Proteinuria accompanies IGS specific symptoms in about half of the patients, isolated proteinuria is rarely reported. Here we present 3 patients with isolated proteinuria and focal segmental glomerulosclerosis (FSGS) caused by CUBN gene biallelic pathogenic variants.
    Method: Whole exome sequencing was performed on three children with isolated proteinuria. CUBN gene biallelic pathogenic variants were found and then verified by sanger sequencing. Their clinical, pathological and molecular genetic characteristics were analyzed and correlated accordingly.
    Results: All three children presented with isolated proteinuria, no megaloblastic anemia. Their urine levels of β2 microglobulin were normal or slightly higher. Renal biopsies showed focal segmental glomerulosclerosis with mild glomerular mesangial hypercellularity, partial effacement of foot processes and podocyte microvillation. Two of them were found to carry compound heterozygous mutations and one homozygous mutation of CUBN gene. Totally four CUBN gene biallelic pathogenic variants were identified, including c.9287 T > C (p.L3096P), c.122 + 1G > A, c.7906C > T (p.R2636*), c.10233G > A (p.W3411*). Except for intron splice-site mutation, all other variants are located in highly conserved sites of CUB domain for binding to albumin.
    Conclusion: The results demonstrate that CUBN gene mutations may cause isolated proteinuria pathologically presented as FSGS. Our cases extend the spectrum of renal manifestation and genotype of CUBN gene mutations.
    MeSH term(s) Child ; Female ; Glomerulosclerosis, Focal Segmental/genetics ; Glomerulosclerosis, Focal Segmental/pathology ; Glomerulosclerosis, Focal Segmental/urine ; Heterozygote ; Homozygote ; Humans ; Male ; Mutation ; Proteinuria/genetics ; Receptors, Cell Surface/genetics ; Whole Genome Sequencing ; beta 2-Microglobulin/urine
    Chemical Substances Receptors, Cell Surface ; beta 2-Microglobulin ; intrinsic factor-cobalamin receptor
    Language English
    Publishing date 2022-01-03
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-021-02654-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Hematopoietic Function of Medicinal Wine Maoji Jiu Revealed in Blood Deficiency Model Rats.

    Xu, Yongli / Zeng, Fanqiang / Jiang, Jianping / Huo, Juan / Zhao, Chengjian / Yan, Zhigang / Li, Li

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 1025504

    Abstract: Maoji Jiu (MJ), a medicinal wine, has been used commonly by the Chinese to enrich and nourish the blood. In this study, the aim is to examine the hematopoietic function of MJ and investigate its hematopoietic regulation mechanism. Thirty-six female ... ...

    Abstract Maoji Jiu (MJ), a medicinal wine, has been used commonly by the Chinese to enrich and nourish the blood. In this study, the aim is to examine the hematopoietic function of MJ and investigate its hematopoietic regulation mechanism. Thirty-six female Sprague-Dawley rats (200 ± 20 g) were randomly divided into six groups with six rats in each group. The blood deficiency model was induced by injecting hypodermically with N-acetylphenylhydrazine (APH) and injecting intraperitoneally with cyclophosphamide (CTX), and treatment drugs were given by oral gavage twice a day for continuous 10 days from the start of the experiments. The administration of MJ improved the levels of white blood cells (WBCs), red blood cells (RBCs), hemoglobin (HGB), and hematocrit (HCT) in the blood deficiency model rats. Hematopoietic effect involves regulating the antioxidant activity in the liver and the levels of Bcl-2, Bax, erythropoietin (EPO), transforming growth factor-beta-1 (TGF-
    Language English
    Publishing date 2022-07-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/1025504
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinical, histological and molecular characteristics of Alport syndrome in Chinese children.

    Zhou, Lanqi / Xi, Bijun / Xu, Yongli / Han, Yanxinli / Yang, Yuan / Yang, Jing / Wang, Yi / Qiu, Liru / Zhang, Yu / Zhou, Jianhua

    Journal of nephrology

    2023  Volume 36, Issue 5, Page(s) 1415–1423

    Abstract: Background: Alport syndrome is caused by COL4A3, COL4A4, or COL4A5 gene mutations. The present study aims to compare the clinicopathological features, gene mutations, and outcome of Chinese children with different forms of Alport syndrome.: Methods: ... ...

    Abstract Background: Alport syndrome is caused by COL4A3, COL4A4, or COL4A5 gene mutations. The present study aims to compare the clinicopathological features, gene mutations, and outcome of Chinese children with different forms of Alport syndrome.
    Methods: One hundred twenty-eight children from 126 families diagnosed with Alport syndrome through pathological and genetic examination between 2003 and 2021 were included in this single-center retrospective study. The laboratory and clinicopathological features of the patients with different inheritance patterns were analyzed. The patients were followed-up for disease progression and phenotype-genotype correlation.
    Results: Of the 126 Alport syndrome families, X-linked forms accounted for 77.0%, autosomal recessive for 11.9%, autosomal dominant for 7.1%, and digenic for 4.0%. Among the patients, 59.4% were males and 40.6% were females. Altogether, 114 different mutations were identified in 101 patients from 99 families by whole-exome sequencing, of which 68 have not been previously reported. The most prevalent type of mutation was glycine substitution, which was identified in 52.1%, 36.7%, and 60% of the patients with X-linked Alport syndrome, autosomal recessive and autosomal dominant Alport syndrome, respectively. At the end of a median follow up of 3.3 (1.8-6.3) years, Kaplan-Meier curves showed kidney survival was significantly lower in autosomal recessive compared to X-linked Alport syndrome (P = 0.004). Pediatric patients with Alport syndrome seldom presented extrarenal involvement.
    Conclusions: X-linked Alport syndrome is the most frequent form found in this cohort. Progression was more rapid in autosmal recessive than in X-linked Alport syndrome.
    MeSH term(s) Humans ; Male ; Female ; Nephritis, Hereditary/diagnosis ; Nephritis, Hereditary/genetics ; Retrospective Studies ; East Asian People ; Collagen Type IV/genetics ; Pedigree ; Mutation ; Autoantigens/genetics
    Chemical Substances Collagen Type IV ; Autoantigens
    Language English
    Publishing date 2023-04-25
    Publishing country Italy
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01570-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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