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Book ; Online: Medicinal Plants for Cardiovascular and Neurodegenerative Aging-related Diseases: From Bench to Bedside

Liu, Yue / Echeverria Moran, Valentina / Xu, Youhua

2020

Keywords	Science: general issues ; Pharmacology ; medicinal plants ; aging ; age-related diseases ; cardiovascular disease ; neurodegenerative diseases
Size	1 electronic resource (294 pages)
Publisher	Frontiers Media SA
Document type	Book ; Online
Note	English ; Open Access
HBZ-ID	HT021230427
ISBN	9782889661602 ; 2889661601
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Animal Models of Type 2 Diabetes Complications: A Review.

Sun, Zhongyan / Liu, Yadi / Zhao, Yonghua / Xu, Youhua

Endocrine research

2024 Volume 49, Issue 1, Page(s) 46–58

Abstract: Diabetes mellitus is a multifactorial metabolic disease, of which type 2 diabetes (T2D) is one of the most common. The complications of diabetes are far more harmful than diabetes itself. Type 2 diabetes complications include diabetic nephropathy (DN), ... ...

Abstract	Diabetes mellitus is a multifactorial metabolic disease, of which type 2 diabetes (T2D) is one of the most common. The complications of diabetes are far more harmful than diabetes itself. Type 2 diabetes complications include diabetic nephropathy (DN), diabetic heart disease, diabetic foot ulcers (DFU), diabetic peripheral neuropathy (DPN), and diabetic retinopathy (DR)
MeSH term(s)	Animals ; Diabetes Mellitus, Type 2/complications ; Diabetic Foot/complications ; Diabetic Nephropathies/etiology ; Diabetic Nephropathies/metabolism ; Diabetic Neuropathies/etiology ; Diabetic Neuropathies/metabolism ; Diabetic Neuropathies/pathology ; Models, Animal ; Risk Factors
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	605823-1
ISSN	1532-4206 ; 0743-5800
ISSN (online)	1532-4206
ISSN	0743-5800
DOI	10.1080/07435800.2023.2278049
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1273: Show issues

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Article ; Online: Glomerular cell cross talk in diabetic kidney diseases.

Dong, Ruixue / Xu, Youhua

Journal of diabetes

2022 Volume 14, Issue 8, Page(s) 514–523

Abstract: Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus. It is the leading inducement of end-stage renal disease (ESRD), and its global incidence has been increasing at an alarming rate. The strict control of blood ... ...

Abstract	Diabetic kidney disease (DKD) is a severe microvascular complication of diabetes mellitus. It is the leading inducement of end-stage renal disease (ESRD), and its global incidence has been increasing at an alarming rate. The strict control of blood pressure and blood glucose can delay the progression of DKD, but intensive treatment is challenging to maintain. Studies to date have failed to find a complete cure. The glomerulus's alterations and injuries play a pivotal role in the initiation and development of DKD. A wealth of data indicates that the interdependent relationship between resident cells in the glomerulus will provide clues to the mechanism of DKD and new ways for therapeutic intervention. This review summarizes the significant findings of glomerular cell cross talk in DKD, focusing on cellular signaling pathways, regulators, and potential novel avenues for treating progressive DKD.
MeSH term(s)	Blood Glucose ; Blood Pressure ; Diabetes Mellitus ; Diabetic Nephropathies/metabolism ; Humans ; Kidney/metabolism ; Kidney Failure, Chronic ; Kidney Glomerulus/metabolism
Chemical Substances	Blood Glucose
Language	English
Publishing date	2022-08-23
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	2503337-2
ISSN	1753-0407 ; 1753-0393
ISSN (online)	1753-0407
ISSN	1753-0393
DOI	10.1111/1753-0407.13304
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 6791: Show issues

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Article: Combination of

An, Xiaoning / Xu, Youhua / Gui, Dingkun

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 2945234

Abstract: Objective: This meta-analysis evaluated the curative effect of the compatibility of : Methods: We used various Chinese and English databases, including the Cochrane Library, PubMed, Embase, Web of Science, the China National Knowledge Infrastructure ( ...

Abstract	Objective: This meta-analysis evaluated the curative effect of the compatibility of Methods: We used various Chinese and English databases, including the Cochrane Library, PubMed, Embase, Web of Science, the China National Knowledge Infrastructure (CNKI), China Biology Medicine Disc (SinoMed), VIP, and Wanfang, to search for randomized controlled trials on the compatibility of Result: A total of 17 studies involving 1342 patients with diabetic nephropathy were included. Compared with the control group, ARPN can significantly improve the clinical effective rate of diabetic nephropathy (OR 5.12, 95% CI 3.42 to 7.66, Conclusions: The compatibility of Radix Astragali and Radix notoginseng as the main components can effectively improve the renal function of patients with diabetic nephropathy and delay the progress of diabetic nephropathy. However, the results of this study need further research to be confirmed because of the uncertainty of the evidence and the suboptimal risk bias.
Language	English
Publishing date	2023-04-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/2945234
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Article: Evaluation on the Efficacy and Safety of Panax Notoginseng Saponins in the Treatment of Stroke among Elderly People: A Systematic Review and Meta-Analysis of 206 Randomized Controlled Trials.

Guan, Peiyu / Gui, Dingkun / Xu, Youhua

Evidence-based complementary and alternative medicine : eCAM

2023 Volume 2023, Page(s) 4312489

Abstract: Background: Evidence regarding the effect of Panax notoginseng saponins (PNS) on treating elderly stroke patients is scare and inconsistent. This study investigated the efficacy and safety of PNS by means of meta-analysis so as to provide an evidence- ... ...

Abstract	Background: Evidence regarding the effect of Panax notoginseng saponins (PNS) on treating elderly stroke patients is scare and inconsistent. This study investigated the efficacy and safety of PNS by means of meta-analysis so as to provide an evidence-based reference for the treatment of elderly patients with stroke. Methods: We searched the PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wanfang, and China Biomedical Database to identify the eligible randomized controlled trials (RCTs) concerning using PNS to treat elderly people with stroke from their inception to first, May 2022. Meta-analysis was used for pool analysis of the included studies, whose quality was assessed via Cochrane Collaboration's RCT risk of bias tool. Results: Altogether 206 studies published between 1999 and 2022 with a low risk of bias were included, covering 21,759 participants. The results showed that the improved neurological status shown in the intervention group with PNS alone was statistically significant (SMD = -0.826, 95% CI: -0.946 to -0.707) in contrast to the control group. The total clinical efficacy (Relative risk (RR) = 1.197, 95% Confidence interval (CI): 1.165 to 1.229) and daily living activities (SMD = 1.675, 95% C: 1.218 to 2.133) of elderly stroke patients were significantly improved as well. In addition, the invention group using PNS combined with WM/TAU displayed significant improvement in neurological status (SMD = -1.142, 95% CI: -1.295 to -0.990) and the total clinical efficacy (RR = 1.191, 95% CI: 1.165 to 1.217) compared with the control group. Conclusion: Single PNS intervention or PNS combined with WM/TAU significantly improves the neurological status, the overall clinical efficacy and daily living activities of elderly stroke patients. However, more multicenter RCT research with high quality is required in the future to verify the results in this study. The trial registration number: Inplasy protocol 202330042. doi:10.37766/inplasy2023.3.0042.
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2023/4312489
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Article: Salvianolic acids and its potential for cardio-protection against myocardial ischemic reperfusion injury in diabetes.

Jiang, Yuxin / Cai, Yin / Han, Ronghui / Xu, Youhua / Xia, Zhengyuan / Xia, Weiyi

Frontiers in endocrinology

2024 Volume 14, Page(s) 1322474

Abstract: The incidence of diabetes and related mortality rate increase yearly in modern cities. Additionally, elevated glucose levels can result in an increase of reactive oxygen species (ROS), ferroptosis, and the disruption of protective pathways in the heart. ... ...

Abstract	The incidence of diabetes and related mortality rate increase yearly in modern cities. Additionally, elevated glucose levels can result in an increase of reactive oxygen species (ROS), ferroptosis, and the disruption of protective pathways in the heart. These factors collectively heighten the vulnerability of diabetic individuals to myocardial ischemia. Reperfusion therapies have been effectively used in clinical practice. There are limitations to the current clinical methods used to treat myocardial ischemia-reperfusion injury. As a result, reducing post-treatment ischemia/reperfusion injury remains a challenge. Therefore, efforts are underway to provide more efficient therapy. Salvia miltiorrhiza Bunge (Danshen) has been used for centuries in ancient China to treat cardiovascular diseases (CVD) with rare side effects. Salvianolic acid is a water-soluble phenolic compound with potent antioxidant properties and has the greatest hydrophilic property in Danshen. It has recently been discovered that salvianolic acids A (SAA) and B (SAB) are capable of inhibiting apoptosis by targeting the JNK/Akt pathway and the NF-κB pathway, respectively. This review delves into the most recent discoveries regarding the therapeutic and cardioprotective benefits of salvianolic acid for individuals with diabetes. Salvianolic acid shows great potential in myocardial protection in diabetes mellitus. A thorough understanding of the protective mechanism of salvianolic acid could expand its potential uses in developing medicines for treating diabetes mellitus related myocardial ischemia-reperfusion.
MeSH term(s)	Humans ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/prevention & control ; Myocardial Reperfusion Injury/metabolism ; Heart ; Myocardium/metabolism ; Diabetes Mellitus/metabolism ; Alkenes ; Polyphenols
Chemical Substances	salvianolic acid ; Alkenes ; Polyphenols
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1322474
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Colon cancer exosome-derived biomimetic nanoplatform for curcumin-mediated sonodynamic therapy and calcium overload.

Li, Yang / Huang, Chunyu / Xu, Youhua

Frontiers in bioengineering and biotechnology

2022 Volume 10, Page(s) 1069676

Abstract: Sonodynamic therapy (SDT) possesses unique properties such as being minimally invasive, exhibiting low toxicity, as well as ability to impart the treatment in the deep tissues, and hence has been extensively used. However, inherent defects such as low ... ...

Abstract	Sonodynamic therapy (SDT) possesses unique properties such as being minimally invasive, exhibiting low toxicity, as well as ability to impart the treatment in the deep tissues, and hence has been extensively used. However, inherent defects such as low water-soluble sonosensitizers can limit the clinical application of SDT, and tumor microenvironment (TME) can further compromise the effect of a single SDT. To overcome these challenges, we have designed a bionic nano-system (ECaC) by coating mesoporous calcium carbonate nanoparticles (CaCO
Language	English
Publishing date	2022-11-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2022.1069676
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Article ; Online: Notoginsenoside Fc, a novel renoprotective agent, ameliorates glomerular endothelial cells pyroptosis and mitochondrial dysfunction in diabetic nephropathy through regulating HMGCS2 pathway.

Shen, Yilan / Chen, Wei / Lin, Kanghong / Zhang, Haiying / Guo, Xieyi / An, Xiaoning / Yang, Liu / Wang, Niansong / Xu, Youhua / Gui, Dingkun

Phytomedicine : international journal of phytotherapy and phytopharmacology

2024 Volume 126, Page(s) 155445

Abstract: Background: Diabetic nephropathy (DN) is the primary cause of end-stage renal disease (ESRD), and the therapeutic strategies for DN are limited. Notoginsenoside Fc (Fc), a novel saponin isolated from Panax Notoginseng (PNG), has been reported to ... ...

Abstract	Background: Diabetic nephropathy (DN) is the primary cause of end-stage renal disease (ESRD), and the therapeutic strategies for DN are limited. Notoginsenoside Fc (Fc), a novel saponin isolated from Panax Notoginseng (PNG), has been reported to alleviate vascular injury in diabetic rats. However, the protective effects of Fc on DN remain unclear. Purpose: To investigate the beneficial effects and mechanisms of Fc on DN. Methods: Db/db mice were treated with 2.5, 5 and 10 mg·kg Results: Our data found that Fc ameliorated urinary microalbumin level, kidney dysfunction and histopathological damage in diabetic mice. Moreover, Fc alleviated the accumulation of oxidative stress, the collapse of mitochondrial membrane potential and the expression of mitochondrial fission proteins, such as Drp-1 and Fis1, while increased the expression of mitochondrial fusion protein Mfn2. Fc also decreased pyroptosis-related proteins levels, such as TXNIP, NLRP3, cleaved caspase-1, and GSDMD-NT, indicating that Fc ameliorated GECs pyroptosis. In addition, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2) expression was increased in diabetic group, which was partially abrogated by Fc. Our data further proved that knockdown of HMGCS2 could restrain HG-induced GECs mitochondrial dysfunction and pyroptosis. These results indicated that the inhibitory effects of Fc on mitochondrial damage and pyroptosis were associated with the suppression of HMGCS2. Conclusion: Taken together, this study clearly demonstrated that Fc ameliorated GECs pyroptosis and mitochondrial dysfunction partly through regulating HMGCS2 pathway, which might provide a novel drug candidate for DN.
MeSH term(s)	Rats ; Mice ; Animals ; Diabetic Nephropathies/metabolism ; Endothelial Cells ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/metabolism ; Pyroptosis ; Mitochondrial Diseases/metabolism ; Hydroxymethylglutaryl-CoA Synthase/metabolism ; Cell Cycle Proteins/metabolism ; Ginsenosides
Chemical Substances	notoginsenoside Fc ; HMGCS2 protein, mouse (EC 2.3.3.10) ; Hydroxymethylglutaryl-CoA Synthase (EC 2.3.3.10) ; TXNIP protein, rat ; Cell Cycle Proteins ; Ginsenosides
Language	English
Publishing date	2024-02-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2024.155445
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Article ; Online: Exosomal ncRNAs: Multifunctional contributors to the immunosuppressive tumor microenvironment of hepatocellular carcinoma.

Huang, Qi / Zhong, Xin / Li, Jing / Hu, Rui / Yi, Jinyu / Sun, Jialing / Xu, Youhua / Zhou, Xiaozhou

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 173, Page(s) 116409

Abstract: Hepatocellular carcinoma (HCC) is a malignant liver cancer characterized by aggressive progression, unfavorable prognosis, and an increasing global health burden. Therapies that precisely target immunological checkpoints and immune cells have gained ... ...

Abstract	Hepatocellular carcinoma (HCC) is a malignant liver cancer characterized by aggressive progression, unfavorable prognosis, and an increasing global health burden. Therapies that precisely target immunological checkpoints and immune cells have gained significant attention as possible therapeutics in recent years. In truth, the efficacy of immunotherapy is heavily contingent upon the tumor microenvironment (TME). Recent studies have indicated that exosomes serve as a sophisticated means of communication among biomolecules, executing an essential part in the TME of immune suppression. Exosomal non-coding RNAs (ncRNAs) can induce the activation of tumor cells and immunosuppressive immune cells that suppress the immune system, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), tumor-associated neutrophils (TANs), CD
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/therapy ; Carcinoma, Hepatocellular/drug therapy ; Liver Neoplasms/pathology ; Tumor Microenvironment ; RNA, Untranslated/genetics ; Exosomes/genetics ; Exosomes/pathology
Chemical Substances	RNA, Untranslated
Language	English
Publishing date	2024-03-08
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116409
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Article ; Online: MAT1A Suppression by the CTBP1/HDAC1/HDAC2 Transcriptional Complex Induces Immune Escape and Reduces Ferroptosis in Hepatocellular Carcinoma.

Li, Yaqin / Hu, Guoxin / Huang, Furong / Chen, Mingtai / Chen, Yihua / Xu, Youhua / Tong, Guangdong

Laboratory investigation; a journal of technical methods and pathology

2023 Volume 103, Issue 8, Page(s) 100180

Abstract: Hepatocellular carcinoma (HCC) remains a significant health burden globally due to its high prevalence and morbidity. C-terminal-binding protein 1 (CTBP1) is a transcriptional corepressor that modulates gene transcription by interacting with ... ...

Abstract	Hepatocellular carcinoma (HCC) remains a significant health burden globally due to its high prevalence and morbidity. C-terminal-binding protein 1 (CTBP1) is a transcriptional corepressor that modulates gene transcription by interacting with transcription factors or chromatin-modifying enzymes. High CTBP1 expression has been associated with the progression of various human cancers. In this study, bioinformatics analysis suggested the existence of a CTBP1/histone deacetylase 1 (HDAC1)/HDAC2 transcriptional complex that regulates the expression of methionine adenosyltransferase 1A (MAT1A), whose loss has been associated with ferroptosis suppression and HCC development. Thus, this study aims to investigate the interactions between the CTBP1/HDAC1/HDAC2 complex and MAT1A and their roles in HCC progression. First, high expression of CTBP1 was observed in HCC tissues and cells, where it promoted HCC cell proliferation and mobility while inhibiting cell apoptosis. CTBP1 interacted with HDAC1 and HDAC2 to suppress the MAT1A transcription, and silencing of either HDAC1 or HDAC2 or overexpression of MAT1A led to the inhibition of cancer cell malignancy. In addition, MAT1A overexpression resulted in increased S-adenosylmethionine levels, which promoted ferroptosis of HCC cells directly or indirectly by increasing CD8
MeSH term(s)	Humans ; Mice ; Animals ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/pathology ; Liver Neoplasms/genetics ; Liver Neoplasms/pathology ; Histone Deacetylase 1/genetics ; Histone Deacetylase 1/metabolism ; Ferroptosis ; Transcription Factors ; Methionine Adenosyltransferase/genetics ; Methionine Adenosyltransferase/metabolism ; Histone Deacetylase 2/metabolism
Chemical Substances	Histone Deacetylase 1 (EC 3.5.1.98) ; Transcription Factors ; HDAC1 protein, human (EC 3.5.1.98) ; MAT1A protein, human (EC 2.5.1.6) ; Methionine Adenosyltransferase (EC 2.5.1.6) ; HDAC2 protein, human (EC 3.5.1.98) ; Histone Deacetylase 2 (EC 3.5.1.98)
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80178-1
ISSN	1530-0307 ; 0023-6837
ISSN (online)	1530-0307
ISSN	0023-6837
DOI	10.1016/j.labinv.2023.100180
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