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  1. Article: [Textual research on classical famous prescription Dajianzhong Decoction].

    Liu, Ming-Xi / Zhang, Ning / Gao, Qi / Xu, Zi-Hang / Wang, Bing / Zhu, Guo-Qin / Zou, Chun-Pu

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2022  Volume 47, Issue 15, Page(s) 4025–4032

    Abstract: The classical famous prescription Dajianzhong Decoction is recorded in Synopsis of the Golden Chamber written by Zhang Zhongjing in the Eastern Han Dynasty. It has a long history and definite clinical effects, while this prescription has not been ... ...

    Abstract The classical famous prescription Dajianzhong Decoction is recorded in Synopsis of the Golden Chamber written by Zhang Zhongjing in the Eastern Han Dynasty. It has a long history and definite clinical effects, while this prescription has not been manufactured into Chinese patent medicine preparation. We collected many ancient books of traditional Chinese medicine(TCM) by using the method of bibliometrics and got 211 valid data terms which involved 67 ancient books. The history, main treated syndromes, formulation principle, origins and processiong of medicinal materials, and decoction method of Dajianzhong Decoction were analyzed. Despite the different views of various generations of medical experts toward the composition of this prescription, the compatibility ratio of Ginseng Radix et Rhizoma to Zingiberis Rhizoma Recens is constant. Furthermore, we explored the origins of synonyms of Dajianzhong Decoction. On the basis of this study, we hope to gain an insight into the research and development of the compound preparations of Dajianzhong Decoction and provide reference for the heritage and innovation of other classical prescriptions.
    MeSH term(s) Drugs, Chinese Herbal ; Medicine, Chinese Traditional ; Prescriptions ; Rhizome
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2022-08-21
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20210804.301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
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  2. Article ; Online: The Tian-Men-Dong decoction suppresses the tumour-infiltrating G-MDSCs via IL-1β-mediated signalling in lung cancer.

    Su, Lin / Zhang, Fei / Liu, Ming-Xi / Li, Hong / Li, Qiang / Zhu, Yang-Zhuangzhuang / Hou, Yi-Fei / Chen, Xiao / Wang, Xiao-Yu / Qian, Chun-Mei / Yao, Chao / Wang, Li-Xin / Jiao, Xiao-Ning / Zhu, Xian-Dan / Xu, Zi-Hang / Zou, Chun-Pu

    Journal of ethnopharmacology

    2023  Volume 313, Page(s) 116491

    Abstract: Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting ... ...

    Abstract Ethnopharmacological relevance: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting nourishment of yin and reducing dryness, clearing the lung and removing toxins. Pharmacological studies show that TD contains active antitumour ingredients, but its underlying mechanism remains unknown.
    Aim of the study: This study aims at exploring potential mechanisms of TD in the treatment of lung cancer by regulating granulocytic-myeloid-derived suppressor cells (G-MDSCs).
    Materials and methods: An orthotopic lung cancer mouse model was generated by intrapulmonary injection with LLC-luciferase cells in immunocompetent C57BL/6 mice or immunodeficient nude mice. TD/saline was orally administered once to the model mice daily for 4 weeks. Live imaging was conducted to monitor tumour growth. Immune profiles were detected by flow cytometry. H&E and ELISA were applied to test the cytotoxicity of the TD treatment. RT-qPCR and western blotting were performed to detect apoptosis-related proteins in G-MDSCs. A neutralizing antibody (anti-Ly6G) was utilized to exhaust the G-MDSCs via intraperitoneal injection. G-MDSCs were adoptively transferred from wild-type tumour-bearing mice. Immunofluorescence, TUNEL and Annexin V/PI staining were conducted to analyse apoptosis-related markers. A coculture assay of purified MDSCs and T cells labelled with CFSE was performed to test the immunosuppressive activity of MDSCs. The presence of TD/IL-1β/TD + IL-1β in purified G-MDSCs cocultured with the LLC system was used for ex vivo experiments to detect IL-1β-mediated apoptosis of G-MDSCs.
    Results: TD prolonged the survival of immune competent C57BL/6 mice in an orthotopic lung cancer model, but did not have the same effect in immunodeficient nude mice, indicating that its antitumour properties of TD are exerted by regulating immunity. TD induced G-MDSC apoptosis via the IL-1β-mediated NF-κB signalling cascade leading to effectively weaken the immunosuppressive activity of G-MDSCs and promote CD8
    Conclusion: This study reveals for the first time that TD, a classic TCM prescription, is able to regulate G-MDSC activity and trigger its apoptosis via the IL-1β-mediated NF-κB signalling pathway, reshaping the tumour microenvironment and demonstrating antitumour effects. These findings provide a scientific foundation the clinical treatment of lung cancer with TD.
    MeSH term(s) Mice ; Animals ; Myeloid-Derived Suppressor Cells ; Mice, Nude ; NF-kappa B/metabolism ; Quality of Life ; Mice, Inbred C57BL ; Lung Neoplasms/metabolism ; Immunosuppressive Agents/pharmacology ; Tumor Microenvironment
    Chemical Substances NF-kappa B ; Immunosuppressive Agents
    Language English
    Publishing date 2023-04-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
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  3. Article ; Online: The Tian-Men-Dong decoction suppresses the tumour-infiltrating G-MDSCs via IL-1β-mediated signalling in lung cancer

    Su, Lin / Zhang, Fei / Liu, Ming-xi / Li, Hong / Li, Qiang / Zhu, Yang-zhuangzhuang / Hou, Yi-fei / Chen, Xiao / Wang, Xiao-yu / Qian, Chun-mei / Yao, Chao / Wang, Li-xin / Jiao, Xiao-ning / Zhu, Xian-dan / Xu, Zi-hang / Zou, Chun-pu

    Journal of Ethnopharmacology. 2023 Apr. 16, p.116491-

    2023  , Page(s) 116491–

    Abstract: The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting nourishment of yin and reducing ... ...

    Abstract The traditional Chinese medicine (TCM) Tian-Men-Dong decoction (TD) has been able to effectively treat lung cancer in China for thousands of years. TD improves the quality of life in lung cancer patients by promoting nourishment of yin and reducing dryness, clearing the lung and removing toxins. Pharmacological studies show that TD contains active antitumour ingredients, but its underlying mechanism remains unknown. This study aims at exploring potential mechanisms of TD in the treatment of lung cancer by regulating granulocytic-myeloid-derived suppressor cells (G-MDSCs). An orthotopic lung cancer mouse model was generated by intrapulmonary injection with LLC-luciferase cells in immunocompetent C57BL/6 mice or immunodeficient nude mice. TD/saline was orally administered once to the model mice daily for 4 weeks. Live imaging was conducted to monitor tumour growth. Immune profiles were detected by flow cytometry. H&E and ELISA were applied to test the cytotoxicity of the TD treatment. RT–qPCR and western blotting were performed to detect apoptosis-related proteins in G-MDSCs. A neutralizing antibody (anti-Ly6G) was utilized to exhaust the G-MDSCs via intraperitoneal injection. G-MDSCs were adoptively transferred from wild-type tumour-bearing mice. Immunofluorescence, TUNEL and Annexin V/PI staining were conducted to analyse apoptosis-related markers. A coculture assay of purified MDSCs and T cells labelled with CFSE was performed to test the immunosuppressive activity of MDSCs. The presence of TD/IL-1β/TD + IL-1β in purified G-MDSCs cocultured with the LLC system was used for ex vivo experiments to detect IL-1β-mediated apoptosis of G-MDSCs. TD prolonged the survival of immune competent C57BL/6 mice in an orthotopic lung cancer model, but did not have the same effect in immunodeficient nude mice, indicating that its antitumour properties of TD are exerted by regulating immunity. TD induced G-MDSC apoptosis via the IL-1β-mediated NF-κB signalling cascade leading to effectively weaken the immunosuppressive activity of G-MDSCs and promote CD8⁺ T-cell infiltration, which was supported by both the depletion and adoptive transfer of G-MDSCs assays. In addition, TD also showed minimal cytotoxicity both in vivo and in vitro. This study reveals for the first time that TD, a classic TCM prescription, is able to regulate G-MDSC activity and trigger its apoptosis via the IL-1β-mediated NF-κB signalling pathway, reshaping the tumour microenvironment and demonstrating antitumour effects. These findings provide a scientific foundation the clinical treatment of lung cancer with TD.
    Keywords Oriental traditional medicine ; T-lymphocytes ; antibodies ; apoptosis ; coculture ; cytotoxicity ; flow cytometry ; fluorescent antibody technique ; immunosuppression ; intraperitoneal injection ; lung neoplasms ; lungs ; mice ; models ; quality of life ; China ; Traditional Chinese medicine ; Tian-Men-Dong decoction ; G-MDSCs ; CD8+ T cells ; IL-1β
    Language English
    Dates of publication 2023-0416
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116491
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 90/710: Show issues

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  4. Article ; Online: 2023: A year of accomplishments for the 13 Science Citation Index Expanded- and Emerging Sources Citation Index-indexed

    Wang, Jin-Lei / Yan, Jia-Ping / Fan, Jia-Ru / Li, Xiang / Guo, Xu / Li, Jia-Wei / Wu, Yun-Xiaojian / Wang, Jing-Jie / Chen, Yu-Lu / Li, Li / Lin, Cong / Qu, Xin-Liang / Liu, Ji-Hong / Zhang, Yan-Liang / Yuan, Ying-Yi / Yu, Hua-Ge / Chen, Yu-Xi / Cai, Yi-Xuan / Zhang, Xiang-Di /
    Zhao, Si / Xu, Zi-Hang / Ma, Li / Ma, Na / Guo, Diao-Mei / Ma, Lian-Sheng

    World journal of gastroenterology

    2024  Volume 30, Issue 1, Page(s) 9–16

    Abstract: In 2023, Baishideng Publishing Group ( ...

    Abstract In 2023, Baishideng Publishing Group (
    MeSH term(s) Humans ; Publishing ; Periodicals as Topic ; Language
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Editorial
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v30.i1.9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6039: Show issues Location:
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  5. Article ; Online: Ze-Qi-Tang Formula Induces Granulocytic Myeloid-Derived Suppressor Cell Apoptosis via STAT3/S100A9/Bcl-2/Caspase-3 Signaling to Prolong the Survival of Mice with Orthotopic Lung Cancer.

    Xu, Zi-Hang / Zhu, Yang-Zhuangzhuang / Su, Lin / Tang, Xue-Yang / Yao, Chao / Jiao, Xiao-Ning / Hou, Yi-Fei / Chen, Xiao / Wei, Lu-Yao / Wang, Wan-Tao / Wang, Jie / Gong, Chen-Yuan / Zhu, Xian-Dan / Zhang, Fei / Zhu, Shi-Guo / Zou, Chun-Pu

    Mediators of inflammation

    2021  Volume 2021, Page(s) 8856326

    Abstract: Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in ... ...

    Abstract Non-small-cell lung cancer (NSCLC) remains the most common malignancy with the highest morbidity and mortality worldwide. In our previous study, we found that a classic traditional Chinese medicine (TCM) formula Ze-Qi-Tang (ZQT), which has been used in the treatment of respiratory diseases for thousands of years, could directly inhibit the growth of human NSCLC cells via the p53 signaling pathway. In this study, we explored the immunomodulatory functions of ZQT. We found that ZQT significantly prolonged the survival of orthotopic lung cancer model mice by modulating the tumor microenvironment (TME). ZQT remarkably reduced the number of MDSCs (especially G-MDSCs) and inhibited their immunosuppressive activity by inducing apoptosis in these cells via the STAT3/S100A9/Bcl-2/caspase-3 signaling pathway. When G-MDSCs were depleted, the survival promotion effect of ZQT and its inhibitory effect on lung luminescence signal disappeared in tumor-bearing mice. This is the first study to illustrate the immunomodulatory effect of ZQT in NSCLC and the underlying molecular mechanism.
    MeSH term(s) Animals ; Apoptosis/drug effects ; Calgranulin B/physiology ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Caspase 3/physiology ; Cell Line, Tumor ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Granulocytes/drug effects ; Granulocytes/pathology ; Lung Neoplasms/drug therapy ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Medicine, Chinese Traditional ; Mice ; Mice, Inbred C57BL ; Myeloid-Derived Suppressor Cells/drug effects ; Myeloid-Derived Suppressor Cells/pathology ; Proto-Oncogene Proteins c-bcl-2/physiology ; STAT3 Transcription Factor/physiology ; Signal Transduction/drug effects ; Tumor Microenvironment
    Chemical Substances Calgranulin B ; Drugs, Chinese Herbal ; Proto-Oncogene Proteins c-bcl-2 ; S100A9 protein, mouse ; STAT3 Transcription Factor ; Stat3 protein, mouse ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2021-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2021/8856326
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3575: Show issues Location:
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