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Article ; Online: Melatonin at repeated doses alleviates hyperglycemia-exacerbated cerebral ischemia-reperfusion injury at 72 h via anti-inflammation and anti-apoptosis.

Xu, Qian / Cheung, Raymond Tak Fai

IBRO neuroscience reports

2024 Volume 16, Page(s) 418–427

Abstract: Objective: We aimed to investigate how hyperglycemia would exacerbate cerebral ischemia-reperfusion injury (CIRI) in a rat model of type 1 diabetes mellitus (T1DM) and explore the beneficial effects of multiple doses of melatonin in T1DM induced CIRI.!## ...

Abstract	Objective: We aimed to investigate how hyperglycemia would exacerbate cerebral ischemia-reperfusion injury (CIRI) in a rat model of type 1 diabetes mellitus (T1DM) and explore the beneficial effects of multiple doses of melatonin in T1DM induced CIRI. Method: The T1DM rat model was induced with streptozocin, and melatonin (10 mg/kg) was injected at 0.5 h before ischemia as well as at 24 and 48 h after reperfusion. Results: When compared to normoglycemic (NG) rats, T1DM rats had hyperglycemia with weight loss before CIRI. Despite comparable degrees of ischemia and initial reperfusion, T1DM rats tended to have greater weight loss and had worse neurological deficits and larger infarct volume than NG rats up to 72 h after CIRI. Persistent activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway but not of apoptosis or calpains was a crucial factor in T1DM-mediated exacerbation of CIRI at 72 h. Despite lacking effects on baseline hyperglycemia, ischemia and initial reperfusion, melatonin at multiple doses lessened post-CIRI weight loss, neurological deficits and infarct volume in T1DM rats at 72 h. when compared to vehicle-treated T1DM rats with CIRI. Beneficial effects of melatonin treatment included decreased activation of NF-κB pathway, apoptosis and calpains, leading to reduced expression of inducible nitric oxide synthase and enhanced neuronal density. Conclusion: Melatonin at multiple doses can alleviate T1DM-mediated exacerbation of CIRI at 72 h through anti-inflammation and anti-apoptosis.
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ISSN	2667-2421
ISSN (online)	2667-2421
DOI	10.1016/j.ibneur.2024.03.003
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Article ; Online: A Cascade of Strain-Driven Events Converting Benzynes to Alkynylbenzocyclobutenes to 1,3-Dien-5-ynes to Cyclic Allenes to Benzocyclohexadienones.

Xu, Qian / Hoye, Thomas R

Journal of the American Chemical Society

2024 Volume 146, Issue 10, Page(s) 6438–6443

Abstract: Here, we report a strain-promoted cascade reaction that proceeds via multiple strained intermediates, ultimately driven by the high potential energy inherent in alkyne triple bonds (C≡C). More specifically, four alkynes (three from an HDDA benzyne ... ...

Abstract	Here, we report a strain-promoted cascade reaction that proceeds via multiple strained intermediates, ultimately driven by the high potential energy inherent in alkyne triple bonds (C≡C). More specifically, four alkynes (three from an HDDA benzyne precursor and the fourth from a conjugated enyne reaction partner) are transformed into eight of the skeletal carbons in the benzocyclohexadienone products. The reaction pathway proceeds sequentially via strained benzyne, benzocyclobutene, and cyclic allene intermediates. DFT computations suggest that the slowest step following benzyne generation is the 4π-electrocyclic ring-opening of the alkynylbenzocyclobutene to a 1,3-dien-5-yne (an alkynylxylylene) intermediate. The activation energy for the subsequent 6π-electrocyclic ring-closure is lower than that for related acyclic dienynes because of the aromaticity that is being regained in the transition structure. Finally, the isolation of the benzocyclohexadienone products rather than their phenolic tautomers is notable.
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c10225
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Article ; Online: Tissue pressure and YAP during organogenesis.

Xu, Qian / Diekwisch, Thomas G H

Nature cell biology

2024 Volume 26, Issue 4, Page(s) 510–511

MeSH term(s)	Organogenesis ; Adaptor Proteins, Signal Transducing/metabolism
Chemical Substances	Adaptor Proteins, Signal Transducing
Language	English
Publishing date	2024-04-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-024-01392-0
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Article: Editorial: The role of non-coding RNA in the diagnosis and treatment of infection induced gastrointestinal cancers.

Xu, Qian / Liu, Jianping

Frontiers in medicine

2023 Volume 10, Page(s) 1153906

Language	English
Publishing date	2023-02-17
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2023.1153906
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Article: An Online Measurement and Calibration Method for a Radio Telescope Sub-Reflector Support Structure Using Fiber Bragg Grating.

Xu, Qian / Bao, Hong

Micromachines

2023 Volume 14, Issue 5

Abstract: The position and altitude of a sub-reflector have an important influence on the pointing accuracy of a radio telescope. With the increase of the antenna aperture, the stiffness of the support structure for the sub-reflector decreases. This causes ... ...

Abstract	The position and altitude of a sub-reflector have an important influence on the pointing accuracy of a radio telescope. With the increase of the antenna aperture, the stiffness of the support structure for the sub-reflector decreases. This causes deformation of the support structure when environmental loads, such as gravity, temperature, and wind load, are applied to the sub-reflector, which will seriously influence antenna pointing accuracy. This paper proposes an online measurement and calibration method for assessing the deformation of the sub-reflector support structure based on the Fiber Bragg Grating (FBG) sensors. Firstly, a reconstruction model between the strain measurements and the deformation displacements of a sub-reflector support structure is established based on the inverse finite element method (iFEM). In addition, a temperature-compensating device with an FBG sensor is designed to eliminate the effects of temperature variations on strain measurements. Considering the lack of the trained original correction, a non-uniform rational B spline (NURBS) curve is built to extend the sample data set. Next, a self-structuring fuzzy network (SSFN) is designed for calibrating the reconstruction model, which can further improve the displacement reconstruction accuracy of the support structure. Finally, a full-day experiment was carried out using a sub-reflector support model to verify the effectiveness of the proposed method.
Language	English
Publishing date	2023-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14051093
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Article ; Online: Analyzing the dynamics of social media texts using coherency network analysis: a case study of the tweets with the co-hashtags of #BlackLivesMatter and #StopAsianHate.

Jiang, Ke / Xu, Qian

Frontiers in research metrics and analytics

2023 Volume 8, Page(s) 1239726

Abstract: Introduction: This study examines the associations between time series, termed "coherency," using spectral analysis. Coherence squared, analogous to the squared correlation coefficient, serves as a metric to quantify the degree of interdependence and co- ...

Abstract	Introduction: This study examines the associations between time series, termed "coherency," using spectral analysis. Coherence squared, analogous to the squared correlation coefficient, serves as a metric to quantify the degree of interdependence and co-evolution of individual nodes. Methods: We utilized spectral analysis to compute coherence squared, unveiling relationships and co-evolution patterns among individual nodes. The resultant matrix of these relationships was subjected to network analysis. Results: By conducting a case study analyzing tweets associated with the co-hashtags #StopAsianHate and #BlackLivesMatter, we present a novel approach utilizing coherency network analysis to investigate the dynamics of social media text. Frequency domain analysis aided in calculating coherence squared, effectively illustrating the relationships and co-evolution of individual nodes. Furthermore, an analysis of the phase spectrum's slope facilitated the determination of time lag and potential causality direction between highly co-evolved node pairs. Discussion: Our findings underline the potential of coherency network analysis in comprehending the intricate dynamics of social media text. This approach offers valuable insights into how topics, sentiments, or movements manifest and evolve within the digital realm. Future research should explore diverse datasets and domains to broaden our understanding of this novel analytical technique.
Language	English
Publishing date	2023-10-18
Publishing country	Switzerland
Document type	Journal Article
ISSN	2504-0537
ISSN (online)	2504-0537
DOI	10.3389/frma.2023.1239726
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Article ; Online: Melatonin mitigates type 1 diabetes-aggravated cerebral ischemia-reperfusion injury through anti-inflammatory and anti-apoptotic effects.

Xu, Qian / Cheung, Raymond Tak Fai

Brain and behavior

2023 Volume 13, Issue 9, Page(s) e3118

Abstract: Introduction: Cerebral ischemia and diabetes mellitus (DM) are common diseases that often coexist and interact with each other. DM doubles the risk of ischemic stroke, and cerebral ischemia causes stress-induced hyperglycemia. Most experimental stroke ... ...

Abstract	Introduction: Cerebral ischemia and diabetes mellitus (DM) are common diseases that often coexist and interact with each other. DM doubles the risk of ischemic stroke, and cerebral ischemia causes stress-induced hyperglycemia. Most experimental stroke studies used healthy animals. Melatonin is neuroprotective against cerebral ischemia-reperfusion injury (CIRI) in non-DM, normoglycemic animals through anti-oxidant effect, anti-inflammation, and anti-apoptosis. Previous studies have also reported a negative correlation between hyperglycemia and urinary melatonin metabolite. Objectives: The present study investigated the effects of type 1 DM (T1DM) on CIRI in rats and the role of melatonin against CIRI in T1DM animals. Results: Our results revealed that T1DM aggravated CIRI, leading to greater weight loss, increased infarct volume, and worse neurological deficit. T1DM aggravated the post-CIRI activation of nuclear factor kappa B (NF-κB) pathway and increase in pro-apoptotic markers. A single intraperitoneal injection of melatonin at 10 mg/kg given 30 min before ischemia onset attenuated CIRI in T1DM rats, resulting in less weight loss, decreased infarct volume, and milder neurological deficit when compared with the vehicle group. Melatonin treatment achieved anti-inflammatory and anti-apoptotic effects with reduced NF-κB pathway activation, reduced mitochondrial cytochrome C release, decreased calpain-mediated spectrin breakdown product (SBDP), and decreased caspase-3-mediated SBDP. The treatment also led to fewer iNOS+ cells, milder CD-68+ macrophage/microglia infiltration, decreased TUNEL+ apoptotic cells, and better neuronal survival. Conclusions: T1DM aggravates CIRI. Melatonin treatment is neuroprotective against CIRI in T1DM rats via anti-inflammatory and anti-apoptotic effects.
MeSH term(s)	Rats ; Animals ; Melatonin/pharmacology ; Melatonin/therapeutic use ; Rats, Sprague-Dawley ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; NF-kappa B/metabolism ; Brain Ischemia/complications ; Cerebral Infarction/complications ; Reperfusion Injury/drug therapy ; Reperfusion Injury/metabolism ; Hyperglycemia ; Neuroprotective Agents/pharmacology ; Neuroprotective Agents/therapeutic use ; Infarction, Middle Cerebral Artery/metabolism
Chemical Substances	Melatonin (JL5DK93RCL) ; NF-kappa B ; dicesium N-succinimidyl 3-(undecahydrododecaboranyldithio)propionate (85070-11-7) ; Neuroprotective Agents
Language	English
Publishing date	2023-06-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2623587-0
ISSN	2162-3279 ; 2162-3279
ISSN (online)	2162-3279
ISSN	2162-3279
DOI	10.1002/brb3.3118
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Article ; Online: A Distinct Mode of Strain-Driven Cyclic Allene Reactivity: Group Migration to the Central Allene Carbon Atom.

Xu, Qian / Hoye, Thomas R

Journal of the American Chemical Society

2023 Volume 145, Issue 17, Page(s) 9867–9875

Abstract: Strained cyclic allenes are reactive species that can be trapped in a variety of complementary fashions that capitalize on their inherent high potential energy. 1,2,4-Cyclohexatrienes represent a subclass of allenes that, notably, can be conveniently ... ...

Abstract	Strained cyclic allenes are reactive species that can be trapped in a variety of complementary fashions that capitalize on their inherent high potential energy. 1,2,4-Cyclohexatrienes represent a subclass of allenes that, notably, can be conveniently generated by a net [4 + 2] cycloaddition within a 1,3-enyne bearing a tethered alkyne via a tetradehydro-Diels-Alder reaction. A limitation to the use of this type of thermally generated cyclic allene as a construct for the introduction of molecular complexity is their propensity to isomerize to benzenoids via a simple net 1,5-hydrogen atom migration. We have discovered that when the enyne component of the substrate is modified as an enol silyl ether (or an enol ester), migration of the silyl (or acyl) group can become the predominant event. Specifically, an appropriately electrophilic group can migrate from the O atom to the central allene carbon adjacent to the 1-siloxy(acyloxy) substituent. This process leads to highly substituted phenolic products (e.g.,
Language	English
Publishing date	2023-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c02469
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Article: Application of zone classification in multiple intracranial aneurysmal subarachnoid hemorrhage treatment strategies.

Liu, Haonan / Xu, Qian / Yang, Hua

Heliyon

2024 Volume 10, Issue 5, Page(s) e26857

Abstract: Background: The options of surgical approach and treatment stage are two challenging treatment strategy issues with multiple intracranial aneurysmal subarachnoid hemorrhage (MIA-SAH).: Methods: We retrospectively analyzed data from patients with MIA- ... ...

Abstract	Background: The options of surgical approach and treatment stage are two challenging treatment strategy issues with multiple intracranial aneurysmal subarachnoid hemorrhage (MIA-SAH). Methods: We retrospectively analyzed data from patients with MIA-SAH who underwent surgery in our center between January 1, 2014 and September 1, 2022. To define "zone classification", the cranial cavity was divided into four zones by the planes of cerebral falx and tentorium cerebelli. Aneurysms isolated to one zone were defined as zone classification I; those crossing two zones were defined as zone classification II; those crossing three zones were defined as zone classification III; and those crossing four zones were defined as zone classification IV. General and aneurysmal-related characteristics of patients with different zone classifications were collected and compared between two surgical approaches. Multivariate logistic regression analysis was used to identify factors independently associated with multistage treatment options. Results: A total of 226 patients with 523 aneurysms were included. The proportion of patients undergoing endovascular treatment increased with higher zone classification (I: 85.4%; II: 94.0%; III: 100.0%; IV: 100.0%). The proportion of patients receiving one-stage treatment decreased with higher zone classification (I: 60.2%; II: 33.6%; III: 0.0%; IV: 0.0%). Compared with patients undergoing microsurgical clipping, more patients undergoing endovascular treatment had zone classification II-IV (56.9% Conclusions: Zone classification provides a new idea in MIA-SAH treatment strategies, especially regarding surgical approach and treatment stage options.
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e26857
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Article: Association between serum estradiol levels and cognitive function in older women: a cross-sectional analysis.

Xu, Qian / Ji, Meng / Huang, Shicai / Guo, Weifeng

Frontiers in aging neuroscience

2024 Volume 16, Page(s) 1356791

Abstract: Introduction: Estradiol is a sex steroid hormone, which has been implicated in the pathogenesis of Alzheimer's disease and cognitive impairment. This cross-sectional study aimed to examine the relationship between serum estradiol levels and cognitive ... ...

Abstract	Introduction: Estradiol is a sex steroid hormone, which has been implicated in the pathogenesis of Alzheimer's disease and cognitive impairment. This cross-sectional study aimed to examine the relationship between serum estradiol levels and cognitive performance in older American women. Methods: Data were obtained from the National Health and Nutrition Examination Survey 2013-2014. A total of 731 women aged ≥60 years who met the inclusion criteria were included in this study. Serum estradiol levels were measured using the isotope dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) method developed by the Centers for Disease Control and Prevention for routine analysis. All measured serum levels were further divided into three parts: T1, <3.68 pg./mL; T2, 3.68-7.49 pg./mL; T3, >7.49 pg./mL, and analyzed. Participants' cognitive abilities were tested using the Vocabulary Learning Subtest (CERAD), Animal Fluency Test (AFS), and digital symbol substitution test (DSST). Scores for each test were calculated based on the sample mean and standard deviation (SD). To examine the relationship between serum estradiol level tertiles and cognitive scores, multiple linear regression models were developed, controlling for race/ethnicity, education level, hypertension, diabetes, and insomnia. Results: The mean age of the participants was 69.57 ± 6.68 years. The non-Hispanic whites were 78.95%, and those who had completed at least some college-level education were 60.62%. The mean BMI of the participants was 29.30 ± 6.79, and 10.85% had a history of smoking. Further, 73.41% did not have a history of alcohol consumption, and 63.03% had hypertension (63.03%). In addition, 81.81 and 88.3% did not have a history of diabetes mellitus and did not have sleep disorders, respectively. The mean serum estradiol level was 8.48 ± 0.77 pg./mL. Multivariate linear regression of the reference group consisting of participants in tertiles of serum estradiol levels revealed that one unit increase in serum estradiol levels increased DSST scores by 0.61 (0.87, 6.34) in the T3 group. However, no significant correlation was found in the CERAD and AFS tests. Conclusion: Participants with higher estradiol levels had higher DSST scores and better processing speed, sustained attention, and working memory, suggesting that serum estradiol may serve as a biomarker for cognitive decline in older women.
Language	English
Publishing date	2024-02-21
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2558898-9
ISSN	1663-4365
ISSN	1663-4365
DOI	10.3389/fnagi.2024.1356791
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