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Article ; Online: Information and Data Analysis Based on Big Data and Blockchain Technology in Promoting the Development of Cultural Tourism Industry

Xuan Qin

Security and Communication Networks, Vol

2022 Volume 2022

Abstract: With the introduction of the reform and opening-up policy, the Chinese tourism industry has made considerable progress, but the current development is facing new development shortcomings and limitations. With the rapid development of technology and ... ...

Abstract	With the introduction of the reform and opening-up policy, the Chinese tourism industry has made considerable progress, but the current development is facing new development shortcomings and limitations. With the rapid development of technology and informatization, big data and blockchain technology provide new ideas and directions for the development of information and data analysis in the cultural and tourism industry. Under big data and blockchain technology, an in-depth research is conducted on the statistical system and GDP accounting data of the two industries of culture and tourism using coupling coordination model, model setting, and proxy re-encryption technology. It coordinates the statistical system of cultural and tourism industries, forming a unified cultural and tourism statistical report and value-added accounting report. It uses blockchain technology to calculate and analyze that the total output value of the tourism industry and cultural integration development in the past two years has increased by 1,4677.5 billion yuan, with a growth rate of 42.79%. Under the integrated development of culture and tourism in various regions, the overall income has shown an upward trend, with the highest growth rate of nearly 50%. The deep integration and development of cultural and tourism industry will become the top priority of Chinese cultural and tourism work in the future. With the addition of big data and blockchain technology, the great development of cultural and tourism integration has been realized.
Keywords	Technology (General) ; T1-995 ; Science (General) ; Q1-390
Subject code	910
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Preparation and Properties of Impact Resistant Polyurea Coating for Fluorochemical Pipeline

Gang Wu / Zhou Fang / Xuan Qin / Junjie Fu

Processes, Vol 10, Iss 193, p

2022 Volume 193

Abstract: A new type of high elastic polyurea protective coating reinforced by nano silica is prepared by filler composite in order to avoid both the leakage of fluorine chemical pipelines containing highly toxic and dangerous media as well as the damage to ... ...

Abstract	A new type of high elastic polyurea protective coating reinforced by nano silica is prepared by filler composite in order to avoid both the leakage of fluorine chemical pipelines containing highly toxic and dangerous media as well as the damage to fluorine chemical pipelines under impact loads. The aim is to improve the intrinsic safety of fluorine chemical pipelines and ensure the safety of the ecological environment, life and property. The effects of different processes and process parameters on the properties of polyurea coating were studied. The polyurea coating was blended and strengthened with nano silica modified by silane coupling agent KH-550. The suitable stirring speed, material addition sequence and nano silica concentration of the new polyurea material were put forward to prepare a new polyurea coating with excellent properties. The properties of the polyurea coating were characterized, including curing time, tensile strength, elongation at break and impact resistance. Then, by using the numerical simulation method, the protection law of polyurea coating on fluorochemical pipelines with or without polyurea coating under the impact of small balls with different speeds was studied, and the equivalent stress mitigation and energy absorption mechanism of polyurea coating were analyzed from the perspective of macro and micro mechanisms. The results show that silane coupling agent KH-550 has successfully modified nano silica, and the optimal filling concentration of modified nano silica is 4 wt%. At this time, the tensile strength of filled reinforced polyurea coating is increased to 15.7 MPa, the elongation at break is 472%, the hardness is 61 HA, and the impact resistance of the matrix material is increased by 9.7 kJ/m 2 . This shows that the polyurea reinforced by nano silica has excellent mechanical properties and impact resistance. The simulation results show that the polyurea coating can slow down the impact caused by the equivalent stress of small balls at different speeds. When the ball speed is 5 ...
Keywords	polyurea ; fluorochemical pipeline ; impact resistant ; numerical simulation ; Chemical technology ; TP1-1185 ; Chemistry ; QD1-999
Subject code	620
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Flavonoids from the Aerial Parts of Sophora tonkinensis and Their Potential Anti-inflammatory Activities.

Yang, Qing-Qing / Yang, Yan-Fei / Chen, Xuan-Qin / Li, Rong-Tao / Zhang, Zhi-Jun

Chemistry & biodiversity

2024 , Page(s) e202400399

Abstract: Four undescribed prenylated flavonoids, sophoratones A-D (1-4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR ... ...

Abstract	Four undescribed prenylated flavonoids, sophoratones A-D (1-4), and 17 known flavonoids, were obtained from the aerial parts of Sophora tonkinensis. Their structures with absolute configurations were elucidated by detailed interpretation of NMR spectroscopy, mass spectrometry, and ECD calculations. Meanwhile, the ability of these compounds to inhibit the release of nitric oxide (NO) by a lipopolysaccharide induced mouse in RAW 264.7 cells was assayed. The results indicated that some compounds exhibited clear inhibitory effects, with IC50 ranging from 19.91 ± 1.08 to 35.72 ± 2.92 µM. These results suggest that prenylated flavonoids from the aerial parts of S. tonkinensis could potentially be used as a latent source of anti-inflammatory agents.
Language	English
Publishing date	2024-04-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2139001-0
ISSN	1612-1880 ; 1612-1872
ISSN (online)	1612-1880
ISSN	1612-1872
DOI	10.1002/cbdv.202400399
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bioinformatics Analysis of Exercise-Related Biomarkers in Diabetes.

Bao, Xiaoju / Qiu, Jingyue / Xuan, Qin / Ye, Xinming

Genetics research

2022 Volume 2022, Page(s) 1273153

Abstract: Background: Exercise is a regular behavioral activity that not only helps to lose weight but also reduces the risk of cardiovascular and cerebrovascular diseases. Diabetes is a common disease that plagues human health. It is shown that regular exercise ... ...

Abstract	Background: Exercise is a regular behavioral activity that not only helps to lose weight but also reduces the risk of cardiovascular and cerebrovascular diseases. Diabetes is a common disease that plagues human health. It is shown that regular exercise can improve the insulin sensitivity of diabetic patients and have an important function in adjuvant therapy. Methods: We downloaded the GSE101931 dataset from the Gene Expression Omnibus (GEO) database, 10 samples were obtained from the GSE101931 dataset, including 5 before exercise and 5 postexercise samples, and GEO2R was used to screen the differentially expressed genes (DEGs) exhibited by a heat map. Then, the enrichment analysis of DEGs in Gene Ontology (GO) function was analyzed by Metascape, and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway of DEGs was also analyzed by gene set enrichment analysis (GSEA). Next, the protein-protein interaction (PPI) network maps were drawn, and the hub genes were identified through Metascape. Finally, the expressions of the hub genes in the dataset were analyzed. Results: Totally, 116 upregulated DEGs and 1017 downregulated DEGs were identified from these data. These DEGs were mainly enriched in the platelet-derived growth factor receptor signaling pathway and mRNA processing. Then, the GSEA analysis showed that 6 KEGG pathways were associated with postexercise prediabetic samples, namely, ABC transporters, focal adhesion, MAPK signaling pathway, prion diseases, melanogenesis, and gap junction. Afterward, three hub genes (HSPA8, STIP1, and HSPH1) were highly expressed after exercise through the box plot analysis. Conclusion: A myriad of research results confirms that there is a certain connection between exercise and diabetes, which provides a favorable basis for emerging exercise into the treatment of diabetic patients.
MeSH term(s)	Biomarkers ; Computational Biology/methods ; Diabetes Mellitus/genetics ; Exercise ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Humans ; Transcriptome/genetics
Chemical Substances	Biomarkers
Language	English
Publishing date	2022-06-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2412681-0
ISSN	1469-5073 ; 0016-6723
ISSN (online)	1469-5073
ISSN	0016-6723
DOI	10.1155/2022/1273153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Spatio-temporal evolution laws of storage coefficient of coal mine underground reservoir and contact network of crushed rock.

Xuan Qin / Zhiguo Cao / Lichang Wei / Huan Yang / Hao Sun / Shenggui Zhou

PLoS ONE, Vol 18, Iss 10, p e

2023 Volume 0293611

Abstract: Spatio-temporal evolution laws of storage coefficient and contact network of crushed rock are of great significance for the construction and utilization of underground reservoirs in coal mines. Based on discrete element method and irregular rigid block ... ...

Abstract	Spatio-temporal evolution laws of storage coefficient and contact network of crushed rock are of great significance for the construction and utilization of underground reservoirs in coal mines. Based on discrete element method and irregular rigid block model, spatio-temporal evolution laws of storage coefficient and contact network of crushed rock under different overburden stresses are investigated and the following main conclusions are obtained: (1) The average storage coefficient and the storage coefficient at different vertical heights of the crushed rock packing system decrease exponentially as the overburden stress increases. When the overburden stress ranges from 0 to 20 MPa, the average storage coefficient decreases by 48.947%. (2) The average void radius and throat radius of water storage space decrease exponentially as the overburden stress increases. The increase in overburden stress leads to the transformation of large voids into smaller voids, causing a gradual decrease in void connectivity and a tendency towards irregular void shapes. (3) With the increase of overburden stress, the number of strong contacts in the packing system of crushed rock increases and gradually expands from the top to the bottom. The average contact force of crushed rock increases exponentially, while the coordination number increases linearly. (4) As the overburden stress increases, the majority of contact directions are concentrated within the ±30° range in the loading direction. This increase results in an enhancement of the anisotropy of the packing system structure of crushed rock.
Keywords	Medicine ; R ; Science ; Q
Subject code	612
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Spatio-temporal evolution laws of storage coefficient of coal mine underground reservoir and contact network of crushed rock

Xuan Qin / Zhiguo Cao / Lichang Wei / Huan Yang / Hao Sun / Shenggui Zhou

PLoS ONE, Vol 18, Iss

2023 Volume 10

Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Braking performance oriented multi-objective optimal design of electro-mechanical brake parameters.

Tong Wu / Jing Li / Xuan Qin

PLoS ONE, Vol 16, Iss 5, p e

2021 Volume 0251714

Abstract: Excellent braking performance is the premise of safe driving, and improve the braking performance by upgrading structures and optimizing parameters of braking systems has become the pursuit of engineers. With the development of autonomous driving and ... ...

Abstract	Excellent braking performance is the premise of safe driving, and improve the braking performance by upgrading structures and optimizing parameters of braking systems has become the pursuit of engineers. With the development of autonomous driving and intelligent connected vehicle, new structural schemes such as electro-mechanical brakes (EMBs) have become the future of vehicle braking systems. Meanwhile, many scholars have dedicated to the research on the parameters optimization of braking systems. While, most of the studies focus on reducing the brake size and weight, improving the brake responses by optimizing the parameters, almost not involving the braking performance, and the optimization variables are relatively single. On these foundations, a multi-objective optimal design of EMB parameters is proposed to enhance the vehicle's braking performance. Its objectives and constraints were defined based on relevant standards and regulations. Subsequently, the decision variables were set, and optimal math model was established. Furthermore, the co-simulation platform was constructed, and the optimal design and simulation analyses factoring in the crucial structural and control parameters were performed. The results confirmed that the maximum braking pressure response time of the EMB is decreased by approximately 0.3 s, the stopping distance (SD) of 90 km/h-0 is shortened by about 3.44 m. Moreover, the mean fully developed deceleration (MFDD) is increased by 0.002 g, and the lateral displacement of the body (LD) is reduced by about 0.037 m. Hence, the vehicle braking performance is improved.
Keywords	Medicine ; R ; Science ; Q
Subject code	600
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Novel Metric to Quantify the Effect of Pathway Enrichment Evaluation With Respect to Biomedical Text-Mined Terms

Xuan Qin / Xinzhi Yao / Jingbo Xia

JMIR Medical Informatics, Vol 9, Iss 6, p e

Development and Feasibility Study

2021 Volume 28247

Abstract: BackgroundNatural language processing has long been applied in various applications for biomedical knowledge inference and discovery. Enrichment analysis based on named entity recognition is a classic application for inferring enriched associations in ... ...

Abstract	BackgroundNatural language processing has long been applied in various applications for biomedical knowledge inference and discovery. Enrichment analysis based on named entity recognition is a classic application for inferring enriched associations in terms of specific biomedical entities such as gene, chemical, and mutation. ObjectiveThe aim of this study was to investigate the effect of pathway enrichment evaluation with respect to biomedical text-mining results and to develop a novel metric to quantify the effect. MethodsFour biomedical text mining methods were selected to represent natural language processing methods on drug-related gene mining. Subsequently, a pathway enrichment experiment was performed by using the mined genes, and a series of inverse pathway frequency (IPF) metrics was proposed accordingly to evaluate the effect of pathway enrichment. Thereafter, 7 IPF metrics and traditional P value metrics were compared in simulation experiments to test the robustness of the proposed metrics. ResultsIPF metrics were evaluated in a case study of rapamycin-related gene set. By applying the best IPF metrics in a pathway enrichment simulation test, a novel discovery of drug efficacy of rapamycin for breast cancer was replicated from the data chosen prior to the year 2000. Our findings show the effectiveness of the best IPF metric in support of knowledge discovery in new drug use. Further, the mechanism underlying the drug-disease association was visualized by Cytoscape. ConclusionsThe results of this study suggest the effectiveness of the proposed IPF metrics in pathway enrichment evaluation as well as its application in drug use discovery.
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	006
Language	English
Publishing date	2021-06-01T00:00:00Z
Publisher	JMIR Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tailored Dynamic Viscoelasticity of Polyurethanes Based on Different Diols

Jiadong Wang / Min Wang / Chenxin Xu / Yang Han / Xuan Qin / Liqun Zhang

Polymers, Vol 15, Iss 2623, p

2023 Volume 2623

Abstract: The development of damping and tire materials has led to a growing need to customize the dynamic viscoelasticity of polymers. In the case of polyurethane (PU), which possesses a designable molecular structure, the desired dynamic viscoelasticity can be ... ...

Abstract	The development of damping and tire materials has led to a growing need to customize the dynamic viscoelasticity of polymers. In the case of polyurethane (PU), which possesses a designable molecular structure, the desired dynamic viscoelasticity can be achieved by carefully selecting flexible soft segments and employing chain extenders with diverse chemical structures. This process involves fine-tuning the molecular structure and optimizing the degree of micro-phase separation. It is worth noting that the temperature at which the loss peak occurs increases as the soft segment structure becomes more rigid. By incorporating soft segments with varying degrees of flexibility, the loss peak temperature can be adjusted within a broad range, from −50 °C to 14 °C. Furthermore, when the molecular structure of the chain extender becomes more regular, it enhances interaction between the soft and hard segments, leading to a higher degree of micro-phase separation. This phenomenon is evident from the increased percentage of hydrogen-bonding carbonyl, a lower loss peak temperature, and a higher modulus. By modifying the molecular weight of the chain extender, we can achieve precise control over the loss peak temperature, allowing us to regulate it within the range of −1 °C and 13 °C. To summarize, our research presents a novel approach for tailoring the dynamic viscoelasticity of PU materials and thus offers a new avenue for further exploration in this field.
Keywords	micro-phase separation ; polyurethane ; dynamic viscoelasticity ; diols ; Organic chemistry ; QD241-441
Subject code	620
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Two new iridoid glycosides from Hedyotis diffusa

Wu, Juan / Ye, Zhu-Jun / Yu, Li-Juan / Chen, Xuan-Qin

Journal of Asian Natural Products Research. 2023 Jan. 2, v. 25, no. 1 p.27-35

2023

Abstract: Two new iridoid glycosides, named productasperulosidic acid butyl ester (1) and E-6-O-3-hydroxy-p-methoxycinnamoyl scandoside methyl ester (2), along with nine known ones (3–11), were isolated from Hedyotis diffusa Willd. The structures of them were ... ...

Abstract	Two new iridoid glycosides, named productasperulosidic acid butyl ester (1) and E-6-O-3-hydroxy-p-methoxycinnamoyl scandoside methyl ester (2), along with nine known ones (3–11), were isolated from Hedyotis diffusa Willd. The structures of them were elucidated by extensive 1D, 2D NMR and HR-ESI-MS spectral data. Compounds 1–11 showed no significant cytotoxic activity against HeLa cells.
Keywords	Oldenlandia diffusa ; cytotoxicity ; iridoid glycosides ; research ; spectral analysis ; Rubiaceae ; Hedyotis diffusa ; iridoid glycoside ; asperulosidic acid butyl ester ; E-6-O-3-hydroxy-p-methoxycinnamoyl scandoside methyl ester ; cytotoxic activity
Language	English
Dates of publication	2023-0102
Size	p. 27-35.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	2077926-4
ISSN	1477-2213 ; 1028-6020
ISSN (online)	1477-2213
ISSN	1028-6020
DOI	10.1080/10286020.2022.2047946
Database	NAL-Catalogue (AGRICOLA)

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