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Article ; Online: Assessment of Ship-Overtaking Situation Based on Swarm Intelligence Improved KDE.

Xue, Han

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 7219661

Abstract: This paper proposes a data-driven risk assessment model for ship overtaking based on the particle swarm optimization (PSO) improved kernel density estimation (KDE). By minimizing the mean square error between the real probability distribution of the ship ...

Abstract	This paper proposes a data-driven risk assessment model for ship overtaking based on the particle swarm optimization (PSO) improved kernel density estimation (KDE). By minimizing the mean square error between the real probability distribution of the ship overtaking point and the kernel density estimation probability distribution calculated by the current kernel density bandwidth, the longitude and latitude of the ship overtaking point are displayed by the color corresponding to the probability as the cost objective function of the search bandwidth of the algorithm. This can better show the distribution of the overtaking points of channel propagation traffic flow. A probability-based ship-overtaking risk evaluation model is developed through the bandwidth and density analysis optimized by an intelligent algorithm. In order to speed up searching the optimal variable width of the kernel density estimator for ship encountering positions, an improved adaptive variable-width kernel density estimator is proposed. The latter reduces the risk of too smooth probability density estimation phenomenon. Its convergence is proved. Finally, the model can efficiently evaluate the risk status of ship overtaking and provide navigational auxiliary decision support for pilots.
MeSH term(s)	Algorithms ; Intelligence ; Probability ; Ships ; Spatial Analysis
Language	English
Publishing date	2022-06-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/7219661
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Article ; Online: Disulfidptosis features and prognosis in head and neck squamous cell carcinoma patients: unveiling and validating the prognostic signature across cohorts.

Xue, Hao / Sun, Qianyu / Zhang, Heqing / Huang, Hanxiao / Xue, Haowei

Journal of cancer research and clinical oncology

2024 Volume 150, Issue 3, Page(s) 156

Abstract: Background: Head and neck squamous cell carcinoma (HNSCC) is a significant health concern with a variable global incidence and is linked to regional lifestyle factors and HPV infections. Despite treatment advances, patient prognosis remains variable, ... ...

Abstract	Background: Head and neck squamous cell carcinoma (HNSCC) is a significant health concern with a variable global incidence and is linked to regional lifestyle factors and HPV infections. Despite treatment advances, patient prognosis remains variable, necessitating an understanding of its molecular mechanisms and the identification of reliable prognostic biomarkers. Methods: We analyzed 959 HNSCC samples and employed batch correction to obtain consistent transcriptomic data across cohorts. We examined 79 disulfidptosis-related genes to determine consensus clusters and utilized high-throughput sequencing to identify genetic heterogeneity within tumors. We established a disulfidptosis prognostic signature (DSPS) using least absolute shrinkage and selection operator (LASSO) regression and developed a prognostic nomogram integrating the DSPS with clinical factors. Personalized chemotherapy prediction was performed using the "pRRophetic" R package. Results: Batch corrections were used to harmonize gene expression data, revealing two distinct disulfidptosis subtypes, C1 and C2, with differential gene expression and survival outcomes. Subtype C1, characterized by increased expression of the MYH family genes ACTB, ACTN2, and FLNC, had a mortality rate of 48.4%, while subtype C2 had a mortality rate of 38.7% (HR = 0.77, 95% CI: 0.633-0.934, P = 0.008). LASSO regression identified 15 genes that composed the DSPS prognostic model, which independently predicted survival (HR = 2.055, 95% CI: 1.420-2.975, P < 0.001). The prognostic nomogram, which included the DSPS, age, and tumor stage, predicted survival with AUC values of 0.686, 0.704, and 0.789 at 3, 5, and 8 years, respectively, indicating strong predictive capability. In the external validation cohort (cohort B), the DSPS successfully identified patients at greater risk, with worse overall survival outcomes in the high-DSPS subgroup (HR = 1.54, 95% CI: 1.17-2.023, P = 0.002) and AUC values of 0.601, 0.644, 0.636, and 0.748 at 3, 5, 8, and 10 years, respectively, confirming the model's robustness. Conclusion: The DSPS provides a robust prognostic tool for HNSCC, underscoring the complexity of this disease and the potential for tailored treatment strategies. This study highlights the importance of molecular signatures in oncology, offering a step toward personalized medicine and improved patient outcomes in HNSCC management.
MeSH term(s)	Humans ; Prognosis ; Squamous Cell Carcinoma of Head and Neck/genetics ; Nomograms ; Gene Expression Profiling ; Head and Neck Neoplasms/genetics
Language	English
Publishing date	2024-03-25
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-024-05691-9
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Article ; Online: Gastrointestinal: Pancreatic NETs with GCGR heterozygous mutation: Mahvash disease.

Deng, W / He, M / Wang, W / Xue, H

Journal of gastroenterology and hepatology

2023 Volume 38, Issue 8, Page(s) 1243

MeSH term(s)	Humans ; Glucagon ; Mutation ; Pancreatic Neoplasms
Chemical Substances	Glucagon (9007-92-5)
Language	English
Publishing date	2023-01-25
Publishing country	Australia
Document type	Journal Article ; Review
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16104
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Zs.A 2180: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Liu, H H / Xue, H / Chen, R S

Zhonghua yi shi za zhi (Beijing, China : 1980)

2023 Volume 53, Issue 2, Page(s) 107–110

Abstract: The unique manuscript, ...

Abstract	The unique manuscript,
MeSH term(s)	Humans ; Schools, Medical ; Books ; Medicine ; Medicine, Chinese Traditional ; Physicians ; China
Language	Chinese
Publishing date	2023-05-15
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20220809-00111
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Article: [Miao Zunyi - his life, writings and students].

Li, Y / Xue, H / Chen, R S

Zhonghua yi shi za zhi (Beijing, China : 1980)

2023 Volume 53, Issue 1, Page(s) 22–27

Abstract: Miao Zunyi was an influential physician in the mid-Qing Dynasty. He was self-taught as he read a great amount of prescription books of traditional Chinese medicine. He was proficient in medical theories but flexible in treatment. It was recorded ... ...

Abstract	Miao Zunyi was an influential physician in the mid-Qing Dynasty. He was self-taught as he read a great amount of prescription books of traditional Chinese medicine. He was proficient in medical theories but flexible in treatment. It was recorded in
MeSH term(s)	Humans ; Medicine, Chinese Traditional ; Books ; Physicians ; Students ; Writing ; China
Language	Chinese
Publishing date	2023-03-14
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20220331-00039
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Article: [The Ding medical family in Jiangpu in the Ming and the Qing Dynasties].

Xue, H / Chen, R S

Zhonghua yi shi za zhi (Beijing, China : 1980)

2021 Volume 51, Issue 4, Page(s) 220–223

Abstract: The Jiangpu Ding family was a Gentry Family with many scholars in Nanjing, running through the Ming and the Qing Dynasties. Successful in both medicine and the imperial examination, talents in various fields emerged in large numbers over more than ten ... ...

Abstract	The Jiangpu Ding family was a Gentry Family with many scholars in Nanjing, running through the Ming and the Qing Dynasties. Successful in both medicine and the imperial examination, talents in various fields emerged in large numbers over more than ten generations. Their practice of medicine began with Ding Zhongbao from the original generation, and the second generation of Ding Yi was promoted from a doctor to a local medical officer. From the fifth generation, Ding Feng, became a famous doctor.However, only Ding Yi and Ding Feng were professional doctors in the whole family lineage. The Ding's were still a Gentry Family in essence. The feature of the family was that the Ding's kept their medical background and interests although there existed no professional doctors after Ding Feng in the middle of the Ming Dynasty. This is because the Ding family expected their heirs to acquire medical skills. The Ding's had a number of medical books handed down, such as
MeSH term(s)	Books ; China ; Humans ; Medicine, Chinese Traditional ; Physicians ; Prescriptions
Language	Chinese
Publishing date	2021-10-11
Publishing country	China
Document type	Journal Article
ZDB-ID	1052411-3
ISSN	0255-7053
ISSN	0255-7053
DOI	10.3760/cma.j.cn112155-20200509-00067
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Article ; Online: Notch signaling regulates Th17 cells differentiation through PI3K/AKT/mTORC1 pathway and involves in the thyroid injury of autoimmune thyroiditis.

He, C / Li, Y / Gan, L / Lin, Y / Zhang, B / Ma, L / Xue, H

Journal of endocrinological investigation

2024

Abstract: Purpose: Autoimmune Thyroiditis (AIT) is the most common thyroid disease; however, there were no measures to prevent the progression of the disease. The present study attempts to identify that Notch signaling regulates the differentiation of T helper 17 ...

Abstract	Purpose: Autoimmune Thyroiditis (AIT) is the most common thyroid disease; however, there were no measures to prevent the progression of the disease. The present study attempts to identify that Notch signaling regulates the differentiation of T helper 17 (Th17) cells by activating downstream Phosphatidylinositol-3 kinase/protein kinase/mechanistic target of rapamycin complex 1 (PI3K/AKT/mTORC1) pathway participating in the thyroid injury of the experimental autoimmune thyroiditis (EAT). Methods: In vivo experiments, mice were randomly divided into 4 groups: a control group, an EAT group, and two groups with LY294002 treatment (pTg plus 25 mg/kg or 50 mg/kg LY294002, respectively). The degrees of thyroiditis were evaluated, and the percentage of Th17 cells, expression of interleukin-17A (IL-17A), and the main components of the Notch-PI3K signaling pathway were detected in different groups. In vitro experiments, two different dosages of LY294002 (25 and 50 μM) were used to intervene splenic mononuclear cells (SMCs) from EAT mice to further evaluate the regulatory effect of Notch-PI3K pathway on Th17 cells. Results: Our data demonstrate that the infiltration of Th17 cells and the expressions of IL-17A, Notch, hairy and split 1 (Hes1), p‑AKT (Ser473), p‑AKT (Thr308), p‑mTOR (Ser2448), S6K1, and S6K2 increased remarkably in EAT mice. After PI3K pathway was blocked, the degrees of thyroiditis were significantly alleviated, and the proportion of Th17 cells, the expression of IL-17A, and the above Notch-PI3K pathway-related molecules decreased in a dose-dependent manner. Additionally, the proportion of Th17 cells was positively correlated with the concentration of serum thyroglobulin antibody (TgAb), IL-17A, and Notch-PI3K pathway-related molecules mRNA levels. Conclusions: Notch signal promotes the secretion of IL-17A from Th17 cells by regulating the downstream PI3K/AKT/mTORC1 pathway through Hes-Phosphatase and tensin homolog (PTEN) and participates in thyroid autoimmune damage, and the PI3K pathway inhibitor may play important effects on AIT by affecting Th17 cells differentiation.
Language	English
Publishing date	2024-01-29
Publishing country	Italy
Document type	Journal Article
ZDB-ID	432272-1
ISSN	1720-8386 ; 0391-4097 ; 1121-1369
ISSN (online)	1720-8386
ISSN	0391-4097 ; 1121-1369
DOI	10.1007/s40618-023-02293-z
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Article ; Online: The impact of long-term care insurance system on family care: Evidence from China.

Cao, Siyuan / Xue, Huiyuan

The International journal of health planning and management

2023 Volume 38, Issue 5, Page(s) 1435–1452

Abstract: Aims: The inconsistent findings on the impact of the long-term care insurance (LTCI) system on family care require us to extend our study horizon to more countries with LTCI system designs or market practices. China has explored the LTCI system through ... ...

Abstract	Aims: The inconsistent findings on the impact of the long-term care insurance (LTCI) system on family care require us to extend our study horizon to more countries with LTCI system designs or market practices. China has explored the LTCI system through pilot programs, which provide a quasi-natural experimental environment. This paper aims to examine how the LTCI system affects family care in China. Methods: We primarily employ the time-varying difference-in-differences method to perform regression analyses based on the panel data from the China Health and Retirement Longitudinal Study. Results: We discover a 7.2% rise in family care under the LTCI system. Specifically, the LTCI system is more likely to promote family care as the relatively primary care for disabled women, disabled people aged 60-74, and those who cannot fully take care of themselves. In addition, the formal care support policy of LTCI will crowd in both formal care and family care, and the crowding-in-effect on formal care may even obscure the crowding-in-effect on family care. The family care support policy of LTCI may encourage the policy-covered groups to take family care as their relatively primary care. It may also lengthen family care for those groups. Conclusions: The LTCI system has a crowding-in effect on family care. It can increase family care through cash payments or linking formal and informal care resources by providing formal community and home care.
MeSH term(s)	Humans ; Female ; Insurance, Long-Term Care ; Longitudinal Studies ; Home Care Services ; Long-Term Care ; China
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	632786-2
ISSN	1099-1751 ; 0749-6753
ISSN (online)	1099-1751
ISSN	0749-6753
DOI	10.1002/hpm.3672
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Article ; Online: Changes in Heparin-Binding Protein, Procalcitonin, and C-Reactive Protein Within the First 72 Hours Predict 28-Day Mortality in Patients Admitted to the Intensive Care Unit with Septic Shock.

Xue, Hui / Yu, Feng

Medical science monitor : international medical journal of experimental and clinical research

2023 Volume 29, Page(s) e938538

Abstract: BACKGROUND This study aimed to evaluate the possible associations of heparin-binding protein (HBP), procalcitonin (PCT), and C-reactive protein (CRP) levels with 28-day mortality in septic shock patients admitted to Intensive Care Units (ICUs). MATERIAL ... ...

Abstract	BACKGROUND This study aimed to evaluate the possible associations of heparin-binding protein (HBP), procalcitonin (PCT), and C-reactive protein (CRP) levels with 28-day mortality in septic shock patients admitted to Intensive Care Units (ICUs). MATERIAL AND METHODS Blood samples were taken at ICU admission and measured again 72 h later to calculate changes in HBP (ΔHBP), changes in PCT (ΔPCT), changes in CRP (ΔCRP), and changes in Sequential Organ Failure Assessment (DSOFA) relative to baseline. RESULTS Variables included in the univariable logistic regression model for survival were age, Acute Physiology and Chronic Health Evaluation (APACHE) II scores, decreasing ΔSOFA, decreasing DHBP, decreasing ΔPCT, and decreasing ΔCRP. Survival was directly related to decreasing ΔHBP with odds ratio (OR)=9.95 (95% confidence interval [CI] 4.63 to 21.35; P<0.001), decreasing ΔPCT with OR=7.85 (3.74 to 16.49; P<0.001), decreasing ΔCRP with OR=5.83 (2.84 to 11.97; P<0.001), decreasing ΔSOFA with OR=1.93 (1.00 to 3.75; P=0.051) and APACHE II score with OR=1.93 (1.14 to 1.68; P=0.001). In a multivariable logistic regression model for survival, only decreasing DHBP with OR=7.18 (2.91 to 17.69; P<0.001), decreasing ΔPCT with OR=5.17 (2.12 to 12.56; P<0.001), and decreasing ΔCRP with OR=4.33 (1.77 to 10.61; P=0.001) remained significant. CONCLUSIONS Measuring changes in HBP, PCT, and CRP within 72 h of admission may aid in predicting 28-day mortality for patients with septic shock in ICUs.
MeSH term(s)	Humans ; Shock, Septic ; Procalcitonin ; C-Reactive Protein/metabolism ; Intensive Care Units ; Prognosis ; Sepsis/metabolism ; Retrospective Studies ; ROC Curve
Chemical Substances	Procalcitonin ; C-Reactive Protein (9007-41-4) ; AZU1 protein, human
Language	English
Publishing date	2023-01-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.938538
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Article: Effects of carbetocin combined with ergometrine maleate on blood loss and coagulation function of puerperae with postpartum haemorrhage.

Xue, Hui / Wang, Weijing

American journal of translational research

2023 Volume 15, Issue 1, Page(s) 556–562

Abstract: Objective: To determine the effects of carbetocin combined with ergometrine maleate on blood loss and coagulation function of puerperae with postpartum haemorrhage (PH).: Methods: In this retrospective study, the clinical data of 102 puerperae with ... ...

Abstract	Objective: To determine the effects of carbetocin combined with ergometrine maleate on blood loss and coagulation function of puerperae with postpartum haemorrhage (PH). Methods: In this retrospective study, the clinical data of 102 puerperae with PH treated in Harbin Red Cross Central Hospital from March 2019 to February 2022 were analyzed. Among them, 45 puerperae treated with carbetocin alone were assigned to the control group, and the other 57 treated with carbetocin combined ergometrine maleate were assigned to the observation group. After treatment, the blood loss, hemostasis time, changes of coagulation function and hemodynamic indexes, efficacy and incidence of adverse reactions were compared between the two groups. Results: The blood loss within 2 h and 24 h after treatment and hemostasis time of the observation group were greatly lower than those of the control group ( Conclusion: Ergometrine maleate combined with carbetocin can deliver favorable efficacy on PH, because it can effectively reduce the amount and duration of PH, improve the coagulation state of the body, and maintain the stability of hemodynamics, without increasing adverse reactions. Therefore, it is of high application value.
Language	English
Publishing date	2023-01-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
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