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  1. Article: Extraction, purification, characterization, anticoagulant activity, and anticoagulant mechanism of polysaccharides from the heads of Hypomesus olidus

    Liu, Xue-Jun

    Food Science & Nutrition, 8(2):849-861

    2019  

    Abstract: The aim of this work was to extract, isolate, and purify polysaccharides from the heads of Hypomesus olidus and to evaluate their anticoagulant activities and anticoagulant mechanisms. Response surface methodology was used to optimize the extraction ... ...

    Abstract The aim of this work was to extract, isolate, and purify polysaccharides from the heads of Hypomesus olidus and to evaluate their anticoagulant activities and anticoagulant mechanisms. Response surface methodology was used to optimize the extraction conditions for ultrasonic-assisted extraction of polysaccharides from the heads of Hypomesus olidus. The optimal extraction conditions consisted of ultrasonic power of 275 W, ultrasonic time of 50 min, and solid–liquid ratio of 5 ml/g, giving the yield of crude polysaccharides (GYT) of 7.73 ± 0.042%. Three polysaccharide fractions, GYT-1, GYT-2, and GYT-3 were purified from GYT by using DEAE-cellulose-52 column and Sephadex G-100 column for anticoagulant activities. The results showed that two doses (2 and 4 mg/ml) of GYT-1 and GYT-3 could significantly prolong (p < .01) in partial thromboplastin time (APTT) (2.19 and 2.37 times, 2.22 and 2.44 times, respectively) and thrombin time (TT) (2.39 and 2.46 times, 2.44 and 2.80 times, respectively) compared with normal control. In particular, GYT-3 had stronger anticoagulant activity than GYT-1, and it was composed of arabinose, fructose, glucose, and lactose with molar ratios of 0.595:1: 2.026:0.273. However, GYT-2 had no anticoagulant activity (p > .05). In addition, anticoagulation mechanism of polysaccharides from the heads of Hypomesus olidus (GYT-3) was evaluated. The results showed that the anticoagulant activity of GYT-3 was based on their binding with antithrombin AT-III. And the inhibitory effects of GYT-3 on factor IIa and Xa were related to the concentration of AT-III in plasma. This study may provide a new and promising anticoagulant drug.
    Keywords Hypomesus olidus head polysaccharides ; anticoagulant activity ; anticoagulant mechanism ; extraction and purification
    Language English
    Document type Article
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  2. Article: Antioxidant activity of vine tea (Ampelopsis grossedentata) extract on lipid and protein oxidation in cooked mixed pork patties during refrigerated storage

    Liu, Xue-Jun

    Food Science & Nutrition, 7(5):1735-1745

    2019  

    Abstract: To prevent oxidation and maintain the quality of meat products, it is essential to add antioxidants. The aim of this work was to investigate the antioxidant activity of vine tea (Ampelopsis grossedentata) extract (VTE) and evaluate the effects of VTE on ... ...

    Abstract To prevent oxidation and maintain the quality of meat products, it is essential to add antioxidants. The aim of this work was to investigate the antioxidant activity of vine tea (Ampelopsis grossedentata) extract (VTE) and evaluate the effects of VTE on the quality characteristics and lipid and protein oxidation of cooked mixed pork patties during refrigerated storage. VTE had a significant DPPH radical scavenging activity, and its IC50 was 15.35 µg/ml. VTE‐treated mixed pork patties had a better texture than that of the control group (p < 0.05). VTE could significantly inhibit an increase in the TBARS value and the formation of carbonyl compounds (p < 0.05), and the inhibition was stronger than that of the butylated hydroxytoluene (BHT) group (p < 0.05), while the amount of sulfhydryl groups significantly decreased (p < 0.05). The color of VTE itself made the mixed pork patties darker (p < 0.05), but this did not affect the sensory scores and overall acceptability of the VTE‐treated patties, indicating the VTE can be incorporated into mixed pork patties. The scanning electron microscopy (SEM) results showed that the VTE inhibited the oxidation of the cooked mixed pork patties during refrigerated storage. These findings may be significant to helping extend the shelf life of meat products.
    Keywords Ampelopsis grossedentata ; cooked mixed pork patties ; antioxidant activity ; lipid and protein oxidation ; vine tea extract
    Language English
    Document type Article
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  3. Article: Diabetic Neuropathic Pain: Directions for Exploring Treatments.

    Chen, Yuchen / Song, Xue-Jun

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: Diabetic neuropathic pain (DNP) is one of the common and severe late-stage complications of diabetes mellitus, which could greatly influence the patients' quality of life. Patients with DNP often experience spontaneous pain and evoked pain such as ... ...

    Abstract Diabetic neuropathic pain (DNP) is one of the common and severe late-stage complications of diabetes mellitus, which could greatly influence the patients' quality of life. Patients with DNP often experience spontaneous pain and evoked pain such as mechanical allodynia and thermal hyperalgesia, meaning that their physical and psychological health are severely impaired. Unfortunately, the mechanisms of DNP remain highly elusive, so substantial breakthrough in effective DNP targeted treatments is still clinically challenging. This article will hence summarise the main mechanisms currently known to underlie DNP pathogenesis, along with describing some of the current and potential treatment methods against diabetic neuropathic pain.
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030589
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  4. Article: [Efficacy of Urapidil in treating lower urinary tract symptoms in patients with benign prostatic hyperplasia: A systematic review and meta-analysis].

    Cui, Yan-Kang / Shang, Xue-Jun

    Zhonghua nan ke xue = National journal of andrology

    2024  Volume 29, Issue 6, Page(s) 538–542

    Abstract: Objective: To investigate the potential application of α-1 blocker (urapidil) in the treatment of lower urinary tract symptoms (LUTS) in male patients with benign prostatic hypertrophy (BPH), we conducted a comprehensive meta-analysis.: Methods: Our ... ...

    Abstract Objective: To investigate the potential application of α-1 blocker (urapidil) in the treatment of lower urinary tract symptoms (LUTS) in male patients with benign prostatic hypertrophy (BPH), we conducted a comprehensive meta-analysis.
    Methods: Our study involved identifying and collecting randomized controlled trials (RCT) and clinical observational studies from databases including PubMed、MEDLINE、Web of science、CNKI and Wanfang database. We performed meta-analysis using RevMan 5.2.0 software for both fixed effects model and random effects model.
    Results: Our analysis included 3 short-term (within 1 month) observational studies and 1 RCT involving 142 patients. We found that urapidil significantly improved the International Prostate Symptom Score (IPSS, MD=－5.57, 95%CI: －7.98～－3.16，P<0.00001), nocturia（MD=－0.7, 95%CI: －1.16～－0.24，P=0.003）, residual urine rate（MD=－6.97；95%CI: －12.57～－1.37，P=0.01）, average flow rate（MD=2.04；95%CI: 0.52～3.56，P=0.008）, and maximum flow rate （MD=4.29；95%CI: 0.58～8.01，P=0.02）of patients. However, there was no significant difference in the residual urine volume（MD=－35.93；95%CI: －78.62～6.76，P=0.10）between pre-treatment and post-treatment groups.
    Conclusion: Urapidil is an effective medication for relieving LUTS in BPH patients. However, due to the limited quantity and quality of current RCT studies, high-quality and large-scale RCT studies are still needed to further confirm this conclusion.
    MeSH term(s) Male ; Humans ; Prostatic Hyperplasia/complications ; Prostatic Hyperplasia/drug therapy ; Lower Urinary Tract Symptoms/drug therapy ; Lower Urinary Tract Symptoms/etiology ; Piperazines ; Randomized Controlled Trials as Topic ; Observational Studies as Topic
    Chemical Substances urapidil (A78GF17HJS) ; Piperazines
    Language Chinese
    Publishing date 2024-04-11
    Publishing country China
    Document type Meta-Analysis ; Systematic Review ; English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
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  5. Article ; Online: Neurobiological basis of emergence from anesthesia.

    Song, Xue-Jun / Hu, Jiang-Jian

    Trends in neurosciences

    2024  

    Abstract: The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, ... ...

    Abstract The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, disrupting neural activity and the integrity and function of neural circuits responsible for signal transmission and conscious perception/subjective experience. Emergence from anesthesia was generally thought to depend on the elimination of the anesthetic from the body. Recently, studies have suggested that emergence from anesthesia is a dynamic and active process that can be partially controlled and is independent of the specific molecular targets of anesthetics. This article summarizes the fundamentals of anesthetics' actions in the brain and the mechanisms of emergence from anesthesia that have been recently revealed in animal studies.
    Language English
    Publishing date 2024-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 282488-7
    ISSN 1878-108X ; 0378-5912 ; 0166-2236
    ISSN (online) 1878-108X
    ISSN 0378-5912 ; 0166-2236
    DOI 10.1016/j.tins.2024.02.006
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1442: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article: Non-cell autonomous role of astrocytes in axonal degeneration of cortical projection neurons in hereditary spastic paraplegias.

    Li, Xue-Jun

    Neural regeneration research

    2021  Volume 17, Issue 6, Page(s) 1265–1266

    Language English
    Publishing date 2021-11-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.327342
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  7. Article: Crystal structure and Hirshfeld analysis of diethyl (2

    Zhang, Xue-Jun

    Acta crystallographica. Section E, Crystallographic communications

    2021  Volume 77, Issue Pt 9, Page(s) 895–898

    Abstract: The mol-ecule of title compound, ... ...

    Abstract The mol-ecule of title compound, C
    Language English
    Publishing date 2021-08-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041947-8
    ISSN 2056-9890 ; 1600-5368
    ISSN 2056-9890 ; 1600-5368
    DOI 10.1107/S2056989021007829
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  8. Article ; Online: Crystal structure and Hirshfeld analysis of diethyl (2E,2′E)-3,3′-[1-(8-phenylisoquinolin-1-yl)-1H-indole-2,7-diyl]diacrylate

    Xue-Jun Zhang

    Acta Crystallographica Section E: Crystallographic Communications, Vol 77, Iss 9, Pp 895-

    2021  Volume 898

    Abstract: The molecule of title compound, C33H28N2O4, comprises an indole unit (A), an isoquinoline moiety (B) and a benzene ring (C). The dihedral angles between these groups are A/B = 57.47 (1), A/C = 18.48 (1) and B/C = 57.97 (1) °. The ethyl acrylate group at ... ...

    Abstract The molecule of title compound, C33H28N2O4, comprises an indole unit (A), an isoquinoline moiety (B) and a benzene ring (C). The dihedral angles between these groups are A/B = 57.47 (1), A/C = 18.48 (1) and B/C = 57.97 (1) °. The ethyl acrylate group at the 2-position is nearly co-planar with the indole unit [3.81 (2)°], while that at the 7-position is distinctly non-coplanar [52.64 (1)°]. Intramolecular π–π interactions between the indole unit and benzene ring help to establish the clip-shaped conformation of the molecule. In the crystal, the molecules are assembled into two-dimensional layers via C—H.O hydrogen bonds, π–π and C—H.π interactions. Hirshfeld surface analysis illustrates that the greatest contributions are from H.H (63.2%), C.H/H.C (15.4%) and O.H/H.O (14.8%) contacts. The terminal C2H5 group of one of the ethyl acrylate side chains is disordered over two positions of equal occupancy.
    Keywords crystal structure ; indole ; isoquinolin ; weak interactions ; hirshfeld analysis ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher International Union of Crystallography
    Document type Article ; Online
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  9. Article: [Possible roles of certain special pathogens in male chronic prostatitis / chronic pelvic pain syndrome].

    Li, Yu / Shang, Xue-Jun

    Zhonghua nan ke xue = National journal of andrology

    2023  Volume 28, Issue 2, Page(s) 162–166

    Abstract: The etiology and pathogenesis of chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS) have not been fully understood so far. It is indicated that pathogen infection may play a significant role in the development of this disease. In addition to ... ...

    Abstract The etiology and pathogenesis of chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS) have not been fully understood so far. It is indicated that pathogen infection may play a significant role in the development of this disease. In addition to typical pathogens such as Escherichia coli and Staphylococcus aureus, many special pathogens are difficult to be identified and isolated by conventional methods and are easily ignored in clinical practice. This review summarizes the possible roles of potential pathogens in CP/CPPS, in order to arouse the attention of clinicians and help solve related clinical problems. Clinicians are advised to attend better to the screening and study of abacterial prostatitis with dominant clinical characteristics of chronic inflammation, recurrence or aggravation, especially the cases receiving long-term broad-spectrum antibiotics, suggesting prostatic infection caused by special pathogens.
    MeSH term(s) Male ; Humans ; Chronic Disease ; Prostatitis/complications ; Prostatitis/diagnosis ; Inflammation ; Pelvic Pain/etiology ; Pelvic Pain/diagnosis ; Staphylococcal Infections/complications ; Escherichia coli ; Chronic Pain/diagnosis
    Language Chinese
    Publishing date 2023-07-18
    Publishing country China
    Document type Review ; English Abstract ; Journal Article
    ZDB-ID 2267480-9
    ISSN 1009-3591
    ISSN 1009-3591
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  10. Article ; Online: [Retracted] MicroRNA‑628‑5p inhibits cell proliferation and induces apoptosis in colorectal cancer through downregulating CCND1 expression levels.

    Guo, Fei / Xue, Jun

    Molecular medicine reports

    2023  Volume 28, Issue 3

    Abstract: Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the data shown for the flow cytometric assay experiments in Figs. 2E and 5E were strikingly similar to data appearing in different form ... ...

    Abstract Following the publication of this paper, it was drawn to the Editors' attention by a concerned reader that certain of the data shown for the flow cytometric assay experiments in Figs. 2E and 5E were strikingly similar to data appearing in different form in other articles by different authors. Owing to the fact that the contentious data in the above article had already been published elsewhere, or were already under consideration for publication, prior to its submission to
    Language English
    Publishing date 2023-07-07
    Publishing country Greece
    Document type Retraction of Publication
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2023.13045
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