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Article: Optimizing the fuel economy of hydrostatic power-split system in continuously variable tractor transmission.

Wang, Guangming / Zhao, Yehui / Song, Yue / Xue, Lijun / Chen, Xiaohan

2023 Volume 9, Issue 5, Page(s) e15915

Abstract: The aim of this study is to enhance the fuel economy of a continuously variable tractor transmission by analyzing its energy and fuel consumption. First, we present the principle of a self-developed tractor transmission based on power splitting and ... ...

Abstract	The aim of this study is to enhance the fuel economy of a continuously variable tractor transmission by analyzing its energy and fuel consumption. First, we present the principle of a self-developed tractor transmission based on power splitting and examine its parasitic power characteristics. Next, we construct a mathematical model of the hydraulic system, mechanical system, and entire transmission, calibrating the model to ensure the accuracy of subsequent results. We then perform a systematic analysis of the energy and fuel consumption of the tractor transmission. Finally, we optimize the transmission through design and power matching, investigating the impact of changes in parameters and control strategies on the fuel economy of the transmission. The results indicate that fuel consumption can be reduced by 2%-14% through parameter optimization and by an additional 0%-20% through appropriate power matching.
Language	English
Publishing date	2023-05-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15915
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Article ; Online: Application of Geophysical Technology in Engineering Investigation

Zhao Chuanting / Ran Jiantao / Xue Lijun / Wang Kaifei / Cui Yangang

E3S Web of Conferences, Vol 338, p

2022 Volume 01003

Abstract: With the development of science and technology and the progress of society, various high and new technologies have increasingly shown their respective advantages. Among them, geophysical prospecting technology is a typical representative. Because it can ... ...

Abstract	With the development of science and technology and the progress of society, various high and new technologies have increasingly shown their respective advantages. Among them, geophysical prospecting technology is a typical representative. Because it can greatly improve the speed and efficiency of engineering, and at the same time, it also plays an important role in engineering safety and prevention. Therefore, it is widely promoted and applied, especially in engineering survey work. This article studies the importance of geophysical prospecting in engineering exploration, the methods of geophysical prospecting technology, the application of geophysical prospecting technology, and the development trend of geophysical prospecting technology. How to better understand the application of geophysical prospecting technology and rationally choose working methods and methods, so as to serve the geological exploration work to the utmost extent, is an important topic that needs to be solved and studied urgently.
Keywords	Environmental sciences ; GE1-350
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
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Article ; Online: Optimizing the fuel economy of hydrostatic power-split system in continuously variable tractor transmission

Wang, Guangming / Zhao, Yehui / Song, Yue / Xue, Lijun / Chen, Xiaohan

Heliyon. 2023 May, v. 9, no. 5 p.e15915-

2023

Abstract	The aim of this study is to enhance the fuel economy of a continuously variable tractor transmission by analyzing its energy and fuel consumption. First, we present the principle of a self-developed tractor transmission based on power splitting and examine its parasitic power characteristics. Next, we construct a mathematical model of the hydraulic system, mechanical system, and entire transmission, calibrating the model to ensure the accuracy of subsequent results. We then perform a systematic analysis of the energy and fuel consumption of the tractor transmission. Finally, we optimize the transmission through design and power matching, investigating the impact of changes in parameters and control strategies on the fuel economy of the transmission. The results indicate that fuel consumption can be reduced by 2%-14% through parameter optimization and by an additional 0%-20% through appropriate power matching.
Keywords	energy ; energy use and consumption ; fuels ; mathematical models ; tractors ; Tractor ; Continuously variable transmission ; Power split ; Energy consumption ; Fuel economy
Language	English
Dates of publication	2023-05
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e15915
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Article ; Online: Bovine pulmonary surfactant alleviates inflammation and epithelial cell apoptosis in the early phase of lipopolysaccharide-induced acute lung injury in rats.

Chen, Xinxin / Dumbuya, John Sieh / Du, Jiang / Xue, Lijun / Zeng, Qiyi

Biotechnology & genetic engineering reviews

2023 , Page(s) 1–19

Abstract: We investigate the impact of bovine pulmonary surfactant (PS) on LPS-induced ALI in vitro and in vivo to improve recognition and prevent mortality in sepsis-induced ALI. Primary alveolar type II (AT2) cells were treated with LPS alone or in combination ... ...

Abstract	We investigate the impact of bovine pulmonary surfactant (PS) on LPS-induced ALI in vitro and in vivo to improve recognition and prevent mortality in sepsis-induced ALI. Primary alveolar type II (AT2) cells were treated with LPS alone or in combination with PS. Cell morphology observation, CCK-8 proliferation assay, flow cytometry apoptosis assay, and ELISA for inflammatory cytokine levels were performed at different time points after treatment. An LPS-induced ALI rat model was established and treated with vehicle or PS. Lung wet/dry weight ratio, histopathological changes, lung function parameters, and serum inflammatory cytokine levels were examined 6 h after PS treatment. Survival analysis by Kaplan-Meier method. RNA sequencing was conducted to identify LPS-induced differentially expressed genes in rat lungs. Proapoptotic gene expression in rat lungs was determined by Western blot. LPS significantly inhibited cell proliferation while promoting apoptosis of AT2 cells starting 2 h after treatment, accompanied by a significant increase in inflammatory cytokine production; PS reversed these effects. PS decreased the lung wet/dry ratio in septic rats, histological abnormalities, alterations in lung function parameters, and inflammatory cytokines production; while improving the overall survival of rats. LPS-induced differentially expressed genes were closely associated with apoptosis. PS attenuated LPS-induced upregulation of proapoptotic gene expression starting 2 h after treatment in AT2 cells while restoring lung ATPase activity in vivo. Bovine PS alleviates LPS-induced ALI in the early phase, possibly by suppressing inflammation and AT2 cell apoptosis, as a preemptive therapeutic agent for managing sepsis-induced ALI.
Language	English
Publishing date	2023-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	49457-4
ISSN	2046-5556 ; 0264-8725
ISSN (online)	2046-5556
ISSN	0264-8725
DOI	10.1080/02648725.2023.2210452
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Article ; Online: PTOV1-AS1 desensitizes colorectal cancer cells to 5-FU through depressing miR-149-5p to activate the positive feedback loop with Wnt/β-catenin pathway.

Chen, Yanan / Mao, Xiaobei / Xu, Yichen / Li, Lin / Geng, Jian / Dai, Tingting / Wang, Qian / Xue, Lijun / Tao, Leilei / Liu, Xiaobei

Phytotherapy research : PTR

2024 Volume 38, Issue 3, Page(s) 1313–1328

Abstract: 5-Fluorouracil is a commonly used chemotherapy drug for colorectal cancer. Resistance to 5-Fluorouracil remains a challenge. This research aimed to explore the mechanism of 5-Fluorouracil resistance in colorectal cancer. RT-qPCR and Western blot were ... ...

Abstract	5-Fluorouracil is a commonly used chemotherapy drug for colorectal cancer. Resistance to 5-Fluorouracil remains a challenge. This research aimed to explore the mechanism of 5-Fluorouracil resistance in colorectal cancer. RT-qPCR and Western blot were used to determine the RNA and protein expression in both cells and exosome. Assays in vitro and in vivo were performed to measure the role of miR-149-5p in colorectal cancer cells. RIP, luciferase activity report, and RNA pulldown assay were applied to detect the association of PTOV1-AS1, SUV39H1, miR-149-5p, and FOXM1. MiR-149-5p was down-expressed in 5-Fluorouracil-resistant cells. MiR-149-5p enhanced the effectiveness of 5-Fluorouracil both in vitro and in vivo. Sensitive colorectal cancer cells released exosomal miR-149-5p to sensitize resistant cells to chemotherapy. Mechanistically, miR-149-5p targeted the FOXM1 to inactivate Wnt/β-catenin pathway, and PTOV1-AS1 recruited SUV39H1 to suppress miR-149-5p transcription, in turn activating Wnt/β-catenin pathway, and forming a positive feedback loop with FOXM1. PTOV1-AS1 inhibits miR-149-5p by a positive feedback loop with FOXM1-mediated Wnt/β-catenin pathway, which provides insights into a potential novel target for enhancing the effectiveness of chemotherapy in colorectal cancer patients.
MeSH term(s)	Humans ; MicroRNAs/genetics ; beta Catenin/metabolism ; Cell Line, Tumor ; Feedback ; Cell Proliferation ; Wnt Signaling Pathway ; Fluorouracil ; Colorectal Neoplasms/genetics ; Gene Expression Regulation, Neoplastic ; RNA, Long Noncoding/genetics ; Neoplasm Proteins/metabolism ; Biomarkers, Tumor/therapeutic use
Chemical Substances	MicroRNAs ; beta Catenin ; Fluorouracil (U3P01618RT) ; RNA, Long Noncoding ; PTOV1 protein, human ; Neoplasm Proteins ; Biomarkers, Tumor ; MIRN149 microRNA, human
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.8095
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Article ; Online: Micromechanical model for the ferromagnetic shape memory alloy-epoxy resin composite considering variant reorientation and magneto-mechanical coupling.

Xue, Lijun / Mu, Haozhi / Sun, Yanfang

Journal of the mechanical behavior of biomedical materials

2021 Volume 117, Page(s) 104396

Abstract: The mechanical and magnetic properties of Ferromagnetic Shape Memory Alloy-Epoxy Resin (FSMA-ER) composite which is a new kind of functional composite material are investigated in this work. Based on the Mori-Tanaka method and equivalent inclusion theory ...

Abstract	The mechanical and magnetic properties of Ferromagnetic Shape Memory Alloy-Epoxy Resin (FSMA-ER) composite which is a new kind of functional composite material are investigated in this work. Based on the Mori-Tanaka method and equivalent inclusion theory of the micromechanics, a micromechanical constitutive model in the form of tensor for this new composite is established, which considers the interaction between different variants in FSMA, as well as the interaction between FSMA and epoxy resin. The mechanical and magnetic behavior of the FSMA-ER composite under complex loads can be well described by this model. Numerical results show that the FSMA-ER composite exhibits a good pseudoelastic property due to the reorientation of different variants in FSMA. Several other particular features of this new composite are also observed through the numerical results, which can content many special requirements in the actual applications. This research not only displays the particular mechanical and magnetic behavior of the FSMA-ER composite but also provides a base for the design of this kind of material.
MeSH term(s)	Composite Resins ; Epoxy Resins ; Shape Memory Alloys
Chemical Substances	Composite Resins ; Epoxy Resins ; Shape Memory Alloys
Language	English
Publishing date	2021-02-19
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2378381-3
ISSN	1878-0180 ; 1751-6161
ISSN (online)	1878-0180
ISSN	1751-6161
DOI	10.1016/j.jmbbm.2021.104396
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Article: Fault diagnosis of wet clutch control system of tractor hydrostatic power split continuously variable transmission

Xue, Lijun / Jiang, Honghua / Zhao, Yehui / Wang, Jiabo / Wang, Guangming / Xiao, Maohua

Computers and electronics in agriculture. 2022 Mar., v. 194

2022

Abstract: A hydrostatic power split continuously variable transmission (CVT) for a tractor often has multiple ranges to improve transmission efficiency. However, a failure of the wet-clutch control system will lead to interruption of tractor power and even ... ...

Abstract	A hydrostatic power split continuously variable transmission (CVT) for a tractor often has multiple ranges to improve transmission efficiency. However, a failure of the wet-clutch control system will lead to interruption of tractor power and even endanger driving safety. To improve the reliability of CVT tractors, methods for diagnosing faults in the wet-clutch control system were studied. A test bench was built and the clutch engagement pressure was measured under different fault modes. For these time series data, statistics such as the mean, variance, kurtosis etc. were selected as features in the analysis. An improved Gaussian naive Bayes algorithm based on a time window as well as principal component analysis were used to classify the different fault modes of the clutch control system. Finally, the performance of the algorithm was analyzed. A test with multiple faults was run, as was a comparison with traditional algorithms. By optimizing the time window for data interception, the classification accuracy of the Gaussian naive Bayes algorithm for normal operation reached 97% and reached 100% for the fault modes. The average accuracy and recall rate of fault diagnosis were 98.2% and 89.4%, respectively, which are better than the results for a support vector machine, the k-nearest neighbors algorithm, or the decision tree algorithm. Importantly, the results show that the clutch pressure fluctuations during the shift by a tractor CVT can be used for the fault diagnosis of a clutch control system.
Keywords	agriculture ; decision support systems ; electronics ; principal component analysis ; support vector machines ; time series analysis ; tractors ; variance
Language	English
Dates of publication	2022-03
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	395514-x
ISSN	0168-1699
ISSN	0168-1699
DOI	10.1016/j.compag.2022.106778
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Kaempferol Suppresses Proliferation and Induces Cell Cycle Arrest, Apoptosis, and DNA Damage in Breast Cancer Cells.

Zhu, Li / Xue, Lijun

Oncology research

2018 Volume 27, Issue 6, Page(s) 629–634

Abstract: Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus we ... ...

Abstract	Kaempferol is a flavonoid that has been extensively investigated owing to its antitumor effects. Nevertheless, little is known about its underlying mechanisms of action. We aimed to explore the role of kaempferol in breast cancer (BC), and thus we investigated how kaempferol suppresses the growth of BC cells. The cells were treated with kaempferol, and the effects on multiple cancer-associated pathways were evaluated. The MTS assay was used to study the cell growth inhibition induced by kaempferol. The cell cycle was analyzed by flow cytometry. Western blotting was used to analyze cellular apoptosis and DNA damage. We found that the proliferation of the triple-negative BC (TNBC) MDA-MB-231 cells was suppressed effectively by kaempferol. Interestingly, the suppressive effect of kaempferol on cell proliferation was stronger in MDA-MB-231 cells than in the estrogen receptor-positive BT474 cell line. Furthermore, after the treatment with kaempferol for 48 h, the population of cells in the G
MeSH term(s)	Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Breast Neoplasms/genetics ; Breast Neoplasms/metabolism ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; DNA Damage/drug effects ; Dose-Response Relationship, Drug ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Kaempferols/chemistry ; Kaempferols/pharmacology ; Triple Negative Breast Neoplasms/genetics ; Triple Negative Breast Neoplasms/metabolism
Chemical Substances	Antineoplastic Agents, Phytogenic ; Apoptosis Regulatory Proteins ; Kaempferols ; kaempferol (731P2LE49E)
Language	English
Publishing date	2018-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	1114699-0
ISSN	1555-3906 ; 0965-0407
ISSN (online)	1555-3906
ISSN	0965-0407
DOI	10.3727/096504018X15228018559434
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Article ; Online: N-Alkyl Linkers for DNA-Encoded Chemical Libraries.

Sun, Zhao-Mei / Yang, Shao-Guang / Xue, Li-Jun / Zhang, Jie / Yang, Kexin / Hu, Yun-Jin

Chemistry, an Asian journal

2022 Volume 17, Issue 7, Page(s) e202200016

Abstract: A series of novel N-alkyl linkers that connect small-molecule library members with their encoding DNA oligonucleotides has been developed. In comparison with the standard amide linker (usually constructed with oligo-AOP- ... ...

Abstract	A series of novel N-alkyl linkers that connect small-molecule library members with their encoding DNA oligonucleotides has been developed. In comparison with the standard amide linker (usually constructed with oligo-AOP-NH
MeSH term(s)	DNA/chemistry ; Drug Discovery/methods ; Gene Library ; Small Molecule Libraries/chemistry
Chemical Substances	Small Molecule Libraries ; DNA (9007-49-2)
Language	English
Publishing date	2022-03-07
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202200016
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Article ; Online: Constructive on-DNA Thiol Aerial Oxidization for DNA-Encoded Library Synthesis.

Xue, Lijun / Ma, Hangke / Liu, Weijie / Duchemin, Nicolas / Zeng, Fanming / Zhang, Jie / Zhang, Huanqing / Yang, Kexin / Hu, Yun Jin

ACS omega

2023 Volume 8, Issue 26, Page(s) 24072–24077

Abstract: A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs. ...

Abstract	A novel on-DNA oxidative disulfide formation method has been developed. Under ambient conditions, the methodology showcased wide applicability and swift implementation in routine DNA-encoded library synthesis to access pharmaceutically relevant motifs.
Language	English
Publishing date	2023-06-19
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c03160
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