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Article: Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: Markers predicting immune-checkpoint inhibitor efficacy and immune-related adverse events.

Jiang, Qiu-Yu / Xue, Ru-Yi

World journal of gastrointestinal oncology

2024 Volume 16, Issue 3, Page(s) 577–582

Abstract: We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor (ICI) and the occurrence of immune-related adverse events (irAEs). The predictive potential of neutrophil-to-lymphocyte ratio (NLR) ...

Abstract	We conducted a comprehensive review of existing prediction models pertaining to the efficacy of immune-checkpoint inhibitor (ICI) and the occurrence of immune-related adverse events (irAEs). The predictive potential of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in determining ICI effectiveness has been extensively investigated, while limited research has been conducted on predicting irAEs. Furthermore, the combined model incorporating NLR and PLR, either with each other or in conjunction with additional markers such as carcinoembryonic antigen, exhibits superior predictive capabilities compared to individual markers alone. NLR and PLR are promising markers for clinical applications. Forthcoming models ought to incorporate established efficacious models and newly identified ones, thereby constituting a multifactor composite model. Furthermore, efforts should be made to explore effective clinical application approaches that enhance the predictive accuracy and efficiency.
Language	English
Publishing date	2024-04-03
Publishing country	China
Document type	Editorial
ZDB-ID	2573696-6
ISSN	1948-5204
ISSN	1948-5204
DOI	10.4251/wjgo.v16.i3.577
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Article ; Online: Medical Image Encryption using Biometric Image Texture Fusion.

Liu, Zhaoyang / Xue, Ru

Journal of medical systems

2023 Volume 47, Issue 1, Page(s) 112

Abstract: In conjunction with pandemics, medical image data are growing exponentially. In some countries, hospitals collect biometric data from patients, such as fingerprints, iris, or faces. This data can be used for things like identity verification and security ...

Abstract	In conjunction with pandemics, medical image data are growing exponentially. In some countries, hospitals collect biometric data from patients, such as fingerprints, iris, or faces. This data can be used for things like identity verification and security management. However, this medical data can be easily compromised by hackers. In order to prevent illegal tampering with medical images and invasion of privacy, a new texture fusion medical image encryption (TFMIE) algorithm derived from biometric images is proposed, which can encrypt the image using biometric information for storage or transmission. First, the medical image is decomposed into n-bit-planes by bit-plane decomposition. Secondly, a fusion image is generated by a biometric image with a circular local binary pattern and pixel-weighted average method. The fused image is further decomposed into n bit-planes through bit-plane decomposition and performs XOR operation with the original medical image in reverse order. Following the execution of the XOR operation, a new scrambling and diffusion algorithm based on a one-dimensional fractional trigonometric function (1DFTF) chaotic map is employed to form the cipher image. The experimental results show that compared with the existing methods, the average information entropy value of TFMIE is 7.99, and the average values of NPCR and UACI reach 0.9958 and 0.3346, respectively, which have strong key sensitivity, good robustness, and anti-attack ability. The method is lossless and has high transmission efficiency, which can meet the needs of medical big data encryption.
MeSH term(s)	Humans ; Biometry ; Algorithms ; Entropy ; Hospitals ; Iris
Language	English
Publishing date	2023-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	423488-1
ISSN	1573-689X ; 0148-5598
ISSN (online)	1573-689X
ISSN	0148-5598
DOI	10.1007/s10916-023-02003-5
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Zs.A 1426: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article: [Experimental research progress in traditional Chinese medicine prevention and treatment of diabetic peripheral neuropathy based on autophagy].

Huang, Su-Su / Wang, Xue-Ru / Yuan, Jiu-Shu / DU, Lian

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2024 Volume 48, Issue 23, Page(s) 6315–6323

Abstract: Diabetic peripheral neuropathy(DPN) is a chronic complication resulted from peripheral nerve injury in the late stage of diabetes. It involves a variety of pathological changes such as oxidative stress, endoplasmic reticulum stress, neuroinflammation, ... ...

Abstract	Diabetic peripheral neuropathy(DPN) is a chronic complication resulted from peripheral nerve injury in the late stage of diabetes. It involves a variety of pathological changes such as oxidative stress, endoplasmic reticulum stress, neuroinflammation, and apoptosis of Schwann cells(SCs). DPN is the main factor leading to lower limb disability or amputation in diabetic patients, with high incidence, long disease course, and poor prognosis. The modern medicine treatment of DPN mainly focuses on controlling blood glucose and improving microcirculation and nerve nutrition, which can only mitigate the clinical symptoms and not fundamentally reverse the pathological changes of peripheral nerves. Autophagy is a self-clearing mechanism that maintains cellular homeostasis by removing excess metabolites. Traditional Chinese medicine(TCM), featuring the holistic concept and syndrome differentiation, can treat chronic diseases in a multi-target, multi-pathway, and wide-range manner. Modern studies have shown that the occurrence and development of DPN are related to a variety of pathological changes, and autophagy is a key mechanism associated with DPN. The environment with persistent high glucose can lead to the inhibition or over-activation of peripheral nerve cells, which causes irreversible damage of nerve cells and the occurrence and development of DPN. Therefore, restoring autophagy balance and reducing nerve damage is one of the key ways to treat DPN. The recent studies have confirmed that some active ingredients in traditional Chinese medicines and TCM compound prescriptions can inhibit the oxidative stress, endoplasmic reticulum stress, mitochondrial damage, inflammation, and apoptosis of SCs in DPN by regulating the autophagy pathway, thus playing a role in the prevention and treatment of DPN. However, the systematic induction in this field remains to be carried out. This paper reviewed the relevant literature, explained the mechanism of TCM in the prevention and treatment of DPN by regulating autophagy, and summarized the potential targets of TCM in the treatment of DPN, with a view to providing new ideas for clinical research and drug development.
MeSH term(s)	Humans ; Autophagy ; Diabetes Mellitus ; Diabetic Neuropathies/drug therapy ; Diabetic Neuropathies/prevention & control ; Diabetic Neuropathies/complications ; Medicine, Chinese Traditional ; Oxidative Stress ; Schwann Cells/metabolism ; Schwann Cells/pathology
Language	Chinese
Publishing date	2024-01-09
Publishing country	China
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20230911.702
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Zs.A 3056: Show issues

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Article ; Online: Research on the avalanche effect of image encryption based on the Cycle-GAN.

Bao, Zhenjie / Xue, Ru

Applied optics

2021 Volume 60, Issue 18, Page(s) 5320–5334

Abstract: Aiming at the problem of the weak avalanche effect in the recently proposed deep learning image encryption algorithm, this paper analyzes the causes of weak avalanche effect in the neural network of Cycle-GAN step by step-by-step process and proposes an ... ...

Abstract	Aiming at the problem of the weak avalanche effect in the recently proposed deep learning image encryption algorithm, this paper analyzes the causes of weak avalanche effect in the neural network of Cycle-GAN step by step-by-step process and proposes an image encryption algorithm combining the traditional diffusion algorithm and deep learning neural network. In this paper, first, the neural network is used for image scrambling and slight diffusion, and then the traditional diffusion algorithm is used to further diffuse the pixels. The experiment in satellite images shows that our algorithm, with the help of the further diffusion mechanism, can compensate for the weak avalanche effect of Cycle-GAN-based image encryption and can change a pixel value to the original image, and the number of pixel change rate (NPCR) and unified average changing intensity (UACI) values can achieve 99.64% and 33.49%, respectively. In addition, our method can effectively encrypt the image where the encrypted image with high information entropy and low pixel correlation is obtained. The experiment on data loss and noise attack declares our method can identify the types and intensity of attacks. What is more, the key space is big enough, and the key sensitivity is high while the key has a certain randomness.
Language	English
Publishing date	2021-07-15
Publishing country	United States
Document type	Journal Article
ISSN	1539-4522
ISSN (online)	1539-4522
DOI	10.1364/AO.428203
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Article ; Online: Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics.

Wang, Jia-Lin / Cheng, Xue-Ru / Meng, Zhao-Yang / Wang, Yan-Ling

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 65

Abstract: Background: Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ophthalmic ... ...

Abstract	Background: Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ophthalmic artery (OA) is a direct response to ocular blood flow. However, little is known about the correlation between CSVD and characteristics of OA. We investigated the OA morphologies and hemodynamics in patients with CSVD and the correlation between these changes and the total CSVD score. Methods: This cross-sectional observational study included 34 eyes from 22 patients with CSVD and 10 eyes from 5 healthy controls. The total CSVD score was rated according to the CSVD signs on magnetic resonance imaging. OA morphological characteristics were measured on the basis of 3D OA model reconstruction. OA hemodynamic information was calculated using computational fluid dynamics simulations. Results: The total CSVD score negatively correlated with the OA diameter, blood flow velocity, and mass flow ratio (all P < 0.05). After adjusting for potential confounding factors, the total CSVD score was still independently correlated with the OA blood velocity (β = - 0.202, P = 0.005). The total CSVD score was not correlated with OA angle (P > 0.05). The presence of cerebral microbleeds and enlarged perivascular spaces was correlated with the OA diameter (both P < 0.01), while the lacunar infarcts and white matter hyperintensities were correlated with the OA blood velocity (both P < 0.001). Conclusions: The decrease of the blood velocity in the OA was associated with the increase in the total CSVD score. The changes of the OA diameter and velocity were associated with the presence of various CSVD signs. The findings suggest that more studies are needed in the future to evaluate CSVD by observing the morphologies and hemodynamics of OA.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Ophthalmic Artery/diagnostic imaging ; Cerebral Small Vessel Diseases/diagnostic imaging ; Cerebral Small Vessel Diseases/complications ; Stroke, Lacunar/complications ; Magnetic Resonance Imaging ; Hemodynamics
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-03908-y
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Article ; Online: Attention to Detail by Single-cell Sequencing.

Wu, Xue-Ru

European urology

2017 Volume 71, Issue 1, Page(s) 13–14

Language	English
Publishing date	2017-01
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	193790-x
ISSN	1873-7560 ; 1421-993X ; 0302-2838
ISSN (online)	1873-7560 ; 1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2016.09.005
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 294: Show issues

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Article ; Online: Knowledge graph analysis and visualization of AI technology applied in COVID-19

Wu, Zongsheng / Xue, Ru / Shao, Meiyun

Environ Sci Pollut Res. 2022 Apr., v. 29, no. 18 p.26396-26408

2022

Abstract: With the global outbreak of coronavirus disease (COVID-19) all over the world, artificial intelligence (AI) technology is widely used in COVID-19 and has become a hot topic. In recent 2 years, the application of AI technology in COVID-19 has developed ... ...

Abstract	With the global outbreak of coronavirus disease (COVID-19) all over the world, artificial intelligence (AI) technology is widely used in COVID-19 and has become a hot topic. In recent 2 years, the application of AI technology in COVID-19 has developed rapidly, and more than 100 relevant papers are published every month. In this paper, we combined with the bibliometric and visual knowledge map analysis, used the WOS database as the sample data source, and applied VOSviewer and CiteSpace analysis tools to carry out multi-dimensional statistical analysis and visual analysis about 1903 pieces of literature of recent 2 years (by the end of July this year). The data is analyzed by several terms with the main annual article and citation count, major publication sources, institutions and countries, their contribution and collaboration, etc. Since last year, the research on the COVID-19 has sharply increased; especially the corresponding research fields combined with the AI technology are expanding, such as medicine, management, economics, and informatics. The China and USA are the most prolific countries in AI applied in COVID-19, which have made a significant contribution to AI applied in COVID-19, as the high-level international collaboration of countries and institutions is increasing and more impactful. Moreover, we widely studied the issues: detection, surveillance, risk prediction, therapeutic research, virus modeling, and analysis of COVID-19. Finally, we put forward perspective challenges and limits to the application of AI in the COVID-19 for researchers and practitioners to facilitate future research on AI applied in COVID-19.
Keywords	COVID-19 infection ; artificial intelligence ; databases ; economics ; medicine ; monitoring ; prediction ; risk ; statistical analysis ; therapeutics ; viruses ; China
Language	English
Dates of publication	2022-04
Size	p. 26396-26408.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-021-17800-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparison of the application of high-flow nasal oxygen with two different oxygen concentrations in infant and child laryngotracheal surgery

Jianxia Liu / Ling Xiong / Haisu Li / Min Du / Xue Ru / Ying Xu

Frontiers in Medicine, Vol

2023 Volume 10

Abstract: BackgroundThis study aimed to compare the use of the STRIVE Hi technique with 70 and 100% oxygen concentrations in children with 1st or 2nd degree laryngeal obstruction undergoing suspension laryngoscopic surgery.MethodsChildren aged 1 month to 6 years ... ...

Abstract	BackgroundThis study aimed to compare the use of the STRIVE Hi technique with 70 and 100% oxygen concentrations in children with 1st or 2nd degree laryngeal obstruction undergoing suspension laryngoscopic surgery.MethodsChildren aged 1 month to 6 years scheduled for suspension laryngoscopic surgery with spontaneous respiration were randomly divided into the 70% oxygen concentration group (HFNO70% group) and the 100% oxygen concentration group (HFNO100% group). The data recorded for all the patients included age and sex, comorbidities, preoperative physiological status, methods of induction and maintenance of anesthesia, course of the disease and surgical options, and duration of operation. The primary endpoint was the lowest oxygen saturations during the surgery. The secondary endpoints included the partial pressure of oxygen PaO2, the arterial pressure of carbon dioxide PaCO2, the peak transcutaneous carbon dioxide PtcCO2, and the incidence of desaturation (defined as SpO2 < 90%) or hypercarbia (PtcCO2 > 65 mmHg).ResultsA total of 80 children with 1st or 2nd degree laryngeal obstruction were included in the analysis. The median [IQR (range)] duration of spontaneous ventilation using STRIVE Hi was 52.5 [40–60 (30–170)]min and 62.5 [45–81 (20–200)]min in the HFNO 70% and HFNO 100% groups, respectively (p = 0.99); the lowest oxygen saturation recorded during the operation was 97.8 ± 2.1% and 96.8 ± 2.5%, respectively (p = 0.053); the mean PaO2 at the end of surgery was 184.6 ± 56.3 mmHg and 315.2 ± 101.3 mmHg, respectively (p < 0.001); and the peak transcutaneous CO2 was 58.0 ± 13.0 mmHg and 60.4 ± 10.9 mmHg, respectively (p = 0.373), despite a long operation time.ConclusionSTRIVE Hi had a positive effect on children undergoing tubeless laryngeal surgery with spontaneous ventilation, and for children with 1st or 2nd degree laryngeal obstruction, there was no significant difference in maintaining the intraoperative oxygenation between the 70 and 100% oxygen concentration groups. The 100% oxygen ...
Keywords	high-flow nasal oxygenation ; hyperoxia ; oxygenation ; STRIVE Hi ; suspension laryngoscopic surgery ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impact of total cerebral small vessel disease score on ophthalmic artery morphologies and hemodynamics

Jia-lin Wang / Xue-ru Cheng / Zhao-yang Meng / Yan-ling Wang

Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-

2023 Volume 9

Abstract: Abstract Background Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ... ...

Abstract	Abstract Background Cerebral small vessel disease (CSVD) is a systemic disease, affecting not only the brain, but also eyes and other organs. The total CSVD score is a tool for comprehensive evaluation of brain lesions in patients with CSVD. The ophthalmic artery (OA) is a direct response to ocular blood flow. However, little is known about the correlation between CSVD and characteristics of OA. We investigated the OA morphologies and hemodynamics in patients with CSVD and the correlation between these changes and the total CSVD score. Methods This cross-sectional observational study included 34 eyes from 22 patients with CSVD and 10 eyes from 5 healthy controls. The total CSVD score was rated according to the CSVD signs on magnetic resonance imaging. OA morphological characteristics were measured on the basis of 3D OA model reconstruction. OA hemodynamic information was calculated using computational fluid dynamics simulations. Results The total CSVD score negatively correlated with the OA diameter, blood flow velocity, and mass flow ratio (all P < 0.05). After adjusting for potential confounding factors, the total CSVD score was still independently correlated with the OA blood velocity (β = − 0.202, P = 0.005). The total CSVD score was not correlated with OA angle (P > 0.05). The presence of cerebral microbleeds and enlarged perivascular spaces was correlated with the OA diameter (both P < 0.01), while the lacunar infarcts and white matter hyperintensities were correlated with the OA blood velocity (both P < 0.001). Conclusions The decrease of the blood velocity in the OA was associated with the increase in the total CSVD score. The changes of the OA diameter and velocity were associated with the presence of various CSVD signs. The findings suggest that more studies are needed in the future to evaluate CSVD by observing the morphologies and hemodynamics of OA.
Keywords	Cerebral small vessel disease ; Ophthalmic artery ; Computational fluid dynamics ; Medicine ; R
Subject code	610
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Clinical Characteristics and Prognosis of Multiple Myeloma Patients with Myelofibrosis].

Cheng, Lu / Song, Li-Min / Xue, Ru / Ma, Yan-Ping

Zhongguo shi yan xue ye xue za zhi

2022 Volume 30, Issue 1, Page(s) 141–145

Abstract: Objective: To investigate the clinical characteristics and prognosis of multiple myeloma patients with myelofibrosis.: Methods: The clinical data of 263 patients with multiple myeloma (including 92 patients with myelofibrosis) treated in the ... ...

Abstract	Objective: To investigate the clinical characteristics and prognosis of multiple myeloma patients with myelofibrosis. Methods: The clinical data of 263 patients with multiple myeloma (including 92 patients with myelofibrosis) treated in the department of hematology of our hospital from January 1, 2016 to June 31, 2020 were collected and retrospectively analyzed, the patients were divided into combined group and uncombined group. The MM stage, MM type, genetic characteristics and therapeutic effect of the patients in combined group and uncombined group were observed, and the relationship between the curative effect and the degree of myelofibrosis change of the patients in combined group was analyzed. Results: There was no statistically difference in the MM staging and classification between multiple myeloma patients with or without myelofibrosis (P>0.05). The positive rate of FISH results of the patients in combined group was significantly higher than those in uncombined group, and was significantly correlated to 1q21 amplification, D13S319 deletion, and IgH breakage (P<0.05). After treatment, the effective rate of the patients in uncombined group was significantly higher than those in combined group, and the degree of fibrosis in the effective patients in combined group was significantly reduced. Conclusion: The survival rate of the patients with multiple myeloma complicated with myelofibrosis is shorter than that of the patients without myelofibrosis, and the overall prognosis is poor.
MeSH term(s)	Chromosome Aberrations ; Humans ; Multiple Myeloma/complications ; Primary Myelofibrosis/complications ; Prognosis ; Retrospective Studies
Language	Chinese
Publishing date	2022-02-05
Publishing country	China
Document type	Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2022.01.023
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