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Article ; Online: Advances in Acute Severe Hepatitis of Unknown Etiology in Children

Xuefeng Zhou / Hongzhou Lu

Zoonoses, Vol 2, Iss 1, p

2022 Volume 981

Abstract: Since the International Health Regulations National Focal Point for the United Kingdom alerted the WHO of ten cases of acute severe hepatitis of unknown etiology in children on April 5, 2022, relevant cases have been reported worldwide. These patients ... ...

Abstract	Since the International Health Regulations National Focal Point for the United Kingdom alerted the WHO of ten cases of acute severe hepatitis of unknown etiology in children on April 5, 2022, relevant cases have been reported worldwide. These patients had acute hepatitis (negative for hepatitis viruses A–E) and elevated aminotransferase (AST) or alanine aminase (ALT) exceeding 500 U/L. Furthermore, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) and/or adenovirus type F41 have been detected in some cases. This unknown hepatitis has been hypothesized to be induced by a viral reservoir of novel coronavirus superantigen, which repeatedly stimulates the intestines and leads to a multisystem inflammatory syndrome in children (MIS-C), which causes immune abnormalities in the presence of human adenovirus. Although this hypothesis has not been confirmed by any in vivo experimental or clinical studies, it may provide ideas for possible intervention strategies.
Keywords	Infectious and parasitic diseases ; RC109-216 ; Veterinary medicine ; SF600-1100
Subject code	610
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Compuscript Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Revealing Cavin-2 Gene Function in Lung Based on Multi-Omics Data Analysis Method

Changsheng Li / Jingyu Huang / Hexiao Tang / Bing Liu / Xuefeng Zhou

Frontiers in Cell and Developmental Biology, Vol

2022 Volume 9

Abstract: Research points out that it is particularly important to comprehensively evaluate immune microenvironmental indicators and gene mutation characteristics to select the best treatment plan. Therefore, exploring the relevant genes of pulmonary injury is an ... ...

Abstract	Research points out that it is particularly important to comprehensively evaluate immune microenvironmental indicators and gene mutation characteristics to select the best treatment plan. Therefore, exploring the relevant genes of pulmonary injury is an important basis for the improvement of survival. In recent years, with the massive production of omics data, a large number of computational methods have been applied in the field of biomedicine. Most of these computational methods are devel-oped for a certain type of diseases or whole diseases. Algorithms that specifically identify genes associated with pulmonary injury have not yet been developed. To fill this gap, we developed a novel method, named AdaRVM, to identify pulmonary injury-related genes in large scale. AdaRVM is the fusion of Adaboost and Relevance Vector Machine (RVM) to achieve fast and high-precision pattern recognition of pulmonary injury genetic mechanism. AdaRVM found that Cavin-2 gene has strong potential to be related to pulmonary injury. As we known, the formation and function of Caveolae are mediated by two family proteins: Caveolin and Cavin. Many studies have explored the role of Caveolin proteins, but people still knew little about Cavin family members. To verify our method and reveal the functions of cavin-2, we integrated six genome-wide association studies (GWAS) data related to lung function traits, four expression Quantitative Trait Loci (eQTL) data, and one methylation Quantitative Trait Loci (mQTL) data by Summary data level Mendelian Randomization (SMR). We found strong relationship between cavin-2 and canonical signaling pathways ERK1/2, AKT, and STAT3 which are all known to be related to lung injury.
Keywords	relevance vector machine ; adaboost ; lung cancer ; pulmonary injury ; cavin-2 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Local atomic structure studies of Zr55Cu35Al10 alloy around T g

Jingfeng Zhao / Yuhang Chen / Chucheng Shao / Jiang Liu / Genyu Zhu / Xuefeng Zhou

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 7

Abstract: Abstract As a result of examining the structure of Zr55Cu35Al10 alloy around the glass transition temperature (T g ) using the classical molecular dynamics simulations, it was proven that the atomic bonds in the interconnecting zones (i-zones) became ... ...

Abstract	Abstract As a result of examining the structure of Zr55Cu35Al10 alloy around the glass transition temperature (T g ) using the classical molecular dynamics simulations, it was proven that the atomic bonds in the interconnecting zones (i-zones) became loose with the small amount of energy absorption, and it became free volumes easily when the temperature approached T g . Instead of i-zones, when clusters were largely separated by free volume networks, the solid amorphous structure was converted into supercooled liquid state, resulting in a sharp strength reduce and the great plasticity change from a limited plastic deformation to superplasticity.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A pancancer analysis of the oncogenic role of cyclin B1 (CCNB1) in human tumors

Peng Dai / Lecai Xiong / Yanhong Wei / Xiaoyan Wei / Xuefeng Zhou / Jinping Zhao / Hexiao Tang

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 12

Abstract: Abstract Aberrant levels of the G2/M cyclin cyclin B1 (gene CCNB1) have been associated with multiple cancers; however, the literature lacks a focused and comprehensive analysis of the regulation of this important regulator of cell proliferation in ... ...

Abstract	Abstract Aberrant levels of the G2/M cyclin cyclin B1 (gene CCNB1) have been associated with multiple cancers; however, the literature lacks a focused and comprehensive analysis of the regulation of this important regulator of cell proliferation in cancer. Through this work, we performed a pancancer analysis of the levels of CCNB1 and dissected aspects of regulation and how this correlates with cancer prognosis. We comprehensively evaluated the expression and promoter methylation of CCNB1 across 38 cancers based on RNA sequencing data obtained from the Cancer Genome Atlas (TCGA). The correlation of CCNB1 with prognosis and the tumor microenvironment was explored. Using lung adenocarcinoma data, we studied the potential upstream noncoding RNAs involved in the regulation of CCNB1 and validated the protein levels and prognostic value of CCNB1 for this disease site. CCNB1 was highly expressed, and promoter methylation was reduced in most cancers. Gene expression of CCNB1 correlated positively with poor prognosis of tumor patients, and these results were confirmed at the protein level using lung adenocarcinoma. CCNB1 expression was associated with the infiltration of T helper cells, and this further correlated with poor prognosis for certain cancers, including renal clear cell carcinoma and lung adenocarcinoma. Subsequently, we identified a specific upstream noncoding RNA contributing to CCNB1 overexpression in lung adenocarcinoma through correlation analysis, expression analysis and survival analysis. This study provides a comprehensive analysis of the expression and methylation status of CCNB1 across several forms of cancer and provides further insight into the mechanistic pathways regulating Cyclin B1 in the tumorigenesis process.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Hypoxia-associated prognostic markers and competing endogenous RNA coexpression networks in lung adenocarcinoma

Lecai Xiong / Xueyu He / Le Wang / Peng Dai / Jinping Zhao / Xuefeng Zhou / Hexiao Tang

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 14

Abstract: Abstract Lung adenocarcinoma (LUAD) is the most common form of non-small cell lung cancer (NSCLC). Hypoxia has been found in 50–60% of locally advanced solid tumors and is associated with poor prognosis in various tumors, including NSCLC. This study ... ...

Abstract	Abstract Lung adenocarcinoma (LUAD) is the most common form of non-small cell lung cancer (NSCLC). Hypoxia has been found in 50–60% of locally advanced solid tumors and is associated with poor prognosis in various tumors, including NSCLC. This study focused on hypoxia-associated molecular hallmarks in LUAD. Fifteen hypoxia-related genes were selected to define the hypoxia status of LUAD by ConsensusClusterPlus based on data from The Cancer Genome Atlas (TCGA). Then, we investigated the immune status under different hypoxia statuses. Subsequently, we constructed prognostic models based on hypoxia-related differentially expressed genes (DEGs), identified hypoxia-related microRNAs, lncRNAs and mRNAs, and built a network based on the competing endogenous RNA (ceRNA) theory. Two clusters (Cluster 1 and Cluster 2) were identified with different hypoxia statuses. Cluster 1 was defined as the hypoxia subgroup, in which all 15 hypoxia-associated genes were upregulated. The infiltration of CD4+ T cells and Tfh cells was lower, while the infiltration of regulatory T (Treg) cells, the expression of PD-1/PD-L1 and TMB scores were higher in Cluster 1, indicating an immunosuppressive status. Based on the DEGs, a risk signature containing 7 genes was established. Furthermore, three differentially expressed microRNAs (hsa-miR-9, hsa-miR-31, hsa-miR-196b) associated with prognosis under different hypoxia clusters and their related mRNAs and lncRNAs were identified, and a ceRNA network was built. This study showed that hypoxia was associated with poor prognosis in LUAD and explored the potential mechanism from the perspective of the gene signature and ceRNA theory.
Keywords	Medicine ; R ; Science ; Q
Subject code	610
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Butenolides from the Coral-Derived Fungus Aspergillius terreus SCSIO41404

Qingyun Peng / Weihao Chen / Xiuping Lin / Jiao Xiao / Yonghong Liu / Xuefeng Zhou

Marine Drugs, Vol 20, Iss 212, p

2022 Volume 212

Abstract: Five undescribed butenolides including two pairs of enantiomers, (+)-asperteretal G ( 1a ), (−)-asperteretal G ( 1b ), (+)-asperteretal H ( 2a ), (−)-asperteretal H ( 2b ), asperteretal I ( 3 ), and para -hydroxybenzaldehyde derivative, ( S )-3-(2,3- ... ...

Abstract	Five undescribed butenolides including two pairs of enantiomers, (+)-asperteretal G ( 1a ), (−)-asperteretal G ( 1b ), (+)-asperteretal H ( 2a ), (−)-asperteretal H ( 2b ), asperteretal I ( 3 ), and para -hydroxybenzaldehyde derivative, ( S )-3-(2,3-dihydroxy-3-methylbutyl)-4-hydroxybenzaldehyde ( 14 ), were isolated together with ten previously reported butenolides 4 – 13 , from the coral-derived fungus Aspergillus terreus SCSIO41404. Enantiomers 1a / 1b and 2a / 2b were successfully purified by high performance liquid chromatography (HPLC) using a chiral column, and the enantiomers 1a and 1b were new natural products. Structures of the unreported compounds, including the absolute configurations, were elucidated by NMR and MS data, optical rotation, experimental and calculated electronic circular dichroism, induced circular dichroism, and X-ray crystal data. The isolated butenolides were evaluated for antibacterial, cytotoxic, and enzyme inhibitory activities. Compounds 7 and 12 displayed weak antibacterial activity, against Enterococcus faecalis (IC 50 = 25 μg/mL) and Klebsiella pneumoniae (IC 50 = 50 μg/mL), respectively, whereas 6 showed weak inhibitory effect on acetylcholinesterase. Nevertheless, most of the butenolides showed inhibition against pancreatic lipase (PL) with an inhibition rate of 21.2–73.0% at a concentration of 50 μg/mL.
Keywords	butenolides ; enantiomers ; Aspergillus terreus ; pancreatic lipase ; Biology (General) ; QH301-705.5
Subject code	540
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Arthproliferins A–D, Four New Sesterterpenes from the Mangrove-Sediment-Derived Fungus Arthrinium sp. SCSIO41221

Bin Yang / Cuitian Li / Ying Chen / Yanchun He / Jianglian She / Xuefeng Zhou / Huangming Tao / Bo Peng

Molecules, Vol 28, Iss 21, p

2023 Volume 7246

Abstract: Four new sesterterpenes, arthproliferins A–D ( 1 – 4 ), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear ... ...

Abstract	Four new sesterterpenes, arthproliferins A–D ( 1 – 4 ), together with four known derivatives, were isolated and characterized from the mangrove-sediment-derived fungus Arthrinium sp. SCSIO41221. Their structures were determined using detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. Some of the isolated compounds were evaluated for their cytotoxicity in vitro. The results revealed that terpestacin ( 6 ) exhibited significant activity with an IC 50 value of 20.3 μM, and compounds 2 and 5 were found to show weak inhibitory effects against U87MG-derived GSCs.
Keywords	Arthrinium sp ; mangrove-sediment-derived fungus ; sesterterpenes ; cytotoxicity ; Organic chemistry ; QD241-441
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cyclic Peptides from the Soft Coral-Derived Fungus Aspergillus sclerotiorum SCSIO 41031

Jieyi Long / Yaqi Chen / Weihao Chen / Junfeng Wang / Xuefeng Zhou / Bin Yang / Yonghong Liu

Marine Drugs, Vol 19, Iss 701, p

2021 Volume 701

Abstract: Three novel cyclic hexapeptides, sclerotides C–E ( 1 – 3 ), and a new lipodepsipeptide, scopularide I ( 4 ), together with a known cyclic hexapeptide sclerotide A ( 5 ), were isolated from fermented rice cultures of a soft coral-derived fungus: ... ...

Abstract	Three novel cyclic hexapeptides, sclerotides C–E ( 1 – 3 ), and a new lipodepsipeptide, scopularide I ( 4 ), together with a known cyclic hexapeptide sclerotide A ( 5 ), were isolated from fermented rice cultures of a soft coral-derived fungus: Aspergillus sclerotiorum SCSIO 41031. The structures of the new peptides were determined by 1D and 2D NMR spectroscopic analysis, Marfey’s method, ESIMS/MS analysis, and single crystal X-ray diffraction analysis. Scopularide I ( 4 ) exhibited acetylcholinesterase inhibitory activity with an IC 50 value of 15.6 μM, and weak cytotoxicity against the human nasopharyngeal carcinoma cell line HONE-EBV with IC 50 value of 10.1 μM.
Keywords	sclerotides ; lipodepsipeptide ; Aspergillus sclerotiorum ; nasopharyngeal carcinoma ; AChE inhibitory ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Phenol Derivatives From the Sponge-Derived Fungus Didymellaceae sp. SCSIO F46

Yongqi Tian / Xiuping Lin / Xuefeng Zhou / Yonghong Liu

Frontiers in Chemistry, Vol

2018 Volume 6

Abstract: Seven new phenol derivatives named coleophomones E and F (1, 2), diorcinols L and M (3, 4), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone (5), porric acid E (6), and 7-(2-hydroxyphenyl) butane-7,8,9-triol (7), were isolated from the EtOAc extract ...

Abstract	Seven new phenol derivatives named coleophomones E and F (1, 2), diorcinols L and M (3, 4), 1-hydroxy-6-methyl-11-methoxy-8-hydroxymethylxanthone (5), porric acid E (6), and 7-(2-hydroxyphenyl) butane-7,8,9-triol (7), were isolated from the EtOAc extract of the marine sponge-derived fungus Didymellaceae sp. SCSIO F46, together with 10 known compounds. Their structures were determined by spectroscopic analyses, including NMR, MS, X-ray diffraction, and theoretical calculations. Each of 1 and 2 contains an unusual spiro [cyclohexane-1,2′-inden] moiety, which is relatively seldom in nature products. Cytotoxic and COX-2 inhibitory activities of all purified compounds were tested and evaluated. Compound 3 displayed obvious cytotoxicities against Huh-7, HeLa, DU145 and HL60 cells (IC50 values 5.7–9.6 μM) and weak activities against other five cell lines, while 8 showed weak cytotoxicities against HeLa and HL7702 cells. Compound 6 displayed COX-2 inhibitory activity with IC50 value of 3.3 μM.
Keywords	sponge-derived fungus ; Didymellaceae sp ; Phenol derivatives ; cytotoxic ; COX-2 inhibitory ; Chemistry ; QD1-999
Language	English
Publishing date	2018-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Improving nitrogen management for zero-tillage rice in China

Min Huang / Xuefeng Zhou / Yingbin Zou

Crop Journal, Vol 6, Iss 4, Pp 406-

2018 Volume 412

Abstract: Zero-tillage has become increasingly attractive in rice production in China. This study was conducted to determine the feasibility of two possible improved N management practices with fewer N applications in zero-tillage rice: (1) two split applications ... ...

Abstract	Zero-tillage has become increasingly attractive in rice production in China. This study was conducted to determine the feasibility of two possible improved N management practices with fewer N applications in zero-tillage rice: (1) two split applications of urea at 75 kg N ha−1 at mid-tillering and 45 kg N ha−1 at panicle initiation (U120–2), and (2) a single application of cross-linked polyacrylamide-coated urea (a slow-release fertilizer) at mid-tillering at a rate of 150 kg N ha−1 (PCU150–1). Three field experiments were conducted to compare grain yield and N-use efficiency among several N treatments: a zero-N control (CK), U120–2, PCU150–1, a single application of urea at mid-tillering at a rate of 150 kg N ha−1 (U150–1), and a commonly recommended N management practice for conventional tillage rice (three split applications of urea with 75 kg N ha−1 as basal, 30 kg N ha−1 at mid-tillering, and 45 kg N ha−1 at panicle initiation) (U150–3). Treatments with N application (U120–2, PCU150–1, U150–1, and U150–3) produced 1.08–3.16 t ha−1 higher grain yields than CK. Grain yields under both U120–2 and PCU150–1 were comparable to that in U150–3. Recovery efficiency of N (REN), agronomic N-use efficiency (AEN) and partial factor productivity of applied N (PFPN) were increased under U120–2 and were similar under PCU150–1 to those under U150–3. U150–1 showed lower grain yield, REN, AEN, and PFPN than U150–3. These results suggest that U150–3 can be replaced with U120–2 to achieve both an increase in N-use efficiency and a reduction in number of N applications and or by PCU150–1 to achieve a maximum reduction in number of N applications in zero-tillage rice production in China. Keywords: Grain yield, N management, N-use efficiency, Rice, Zero-tillage
Keywords	Agriculture ; S ; Agriculture (General) ; S1-972
Subject code	630
Language	English
Publishing date	2018-08-01T00:00:00Z
Publisher	KeAi Communications Co., Ltd.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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