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  1. Article ; Online: Gehua Jiejiu Dizhi decoction ameliorates alcoholic fatty liver in mice by regulating lipid and bile acid metabolism and with exertion of antioxidant stress based on 4DLabel-free quantitative proteomic study.

    Min, Han / Xu, Y I / Shaowei, You / Xueli, W U / Shuoshi, Wang / Diancheng, H E

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2024  Volume 44, Issue 2, Page(s) 277–288

    Abstract: Objective: To analyze the effect and molecular mechanism of Gehua Jiejiu Dizhi decoction (, GJDD) on alcoholic fatty live disease (AFLD) by using proteomic methods.: Methods: The male C57BL/6J mouse were randomly divided into four groups: control ... ...

    Abstract Objective: To analyze the effect and molecular mechanism of Gehua Jiejiu Dizhi decoction (, GJDD) on alcoholic fatty live disease (AFLD) by using proteomic methods.
    Methods: The male C57BL/6J mouse were randomly divided into four groups: control group, model group, GJDD group and resveratrol group. After the AFLD model was successfully prepared by intragastric administration of alcohol once on the basis of the Lieber-DeCarli classical method, the GJDD group and resveratrol group were intragastrically administered with GJDD (4900 mg/kg) and resveratrol (400 mg/kg) respectively, once a day for 9 d. The fat deposition of liver tissue was observed and evaluated by oil red O (ORO) staining. 4DLabel-free quantitative proteome method was used to determine and quantify the protein expression in liver tissue of each experimental group. The differentially expressed proteins were screened according to protein expression differential multiples, and then analyzed by Gene ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway enrichment. Finally, expression validation of the differentially co-expressed proteins from control group, model group and GJDD group were verified by targeted proteomics quantification techniques.
    Results: In semiquantitative analyses of ORO, all kinds of steatosis (ToS, MaS, and MiS) were evaluated higher in AFLD mice compared to those in GJDD or resveratrol-treated mice. 4DLabel-free proteomics analysis results showed that a total of 4513 proteins were identified, of which 3763 proteins were quantified and 946 differentially expressed proteins were screened. Compared with the control group, 145 proteins were up-regulated and 148 proteins were down-regulated in the liver tissue of model group. In addition, compared with the model group, 92 proteins were up-regulated and 135 proteins were down-regulated in the liver tissue of the GJDD group. 15 differentially co-expressed proteins were found between every two groups (model group
    Conclusions: Our study provided proteomics-based evidence that GJDD alleviated AFLD by modulating liver protein expression, likely through the modulation of lipid metabolism, bile acid metabolism and with exertion of antioxidant stress.
    MeSH term(s) Mice ; Male ; Animals ; Fatty Liver, Alcoholic/drug therapy ; Fatty Liver, Alcoholic/genetics ; Fatty Liver, Alcoholic/metabolism ; Antioxidants/metabolism ; Proteomics/methods ; Resveratrol/metabolism ; Physical Exertion ; Mice, Inbred C57BL ; Liver/metabolism ; Lipid Metabolism ; Bile Acids and Salts/metabolism ; Lipids ; Serpins/metabolism ; Aldehyde Oxidoreductases/metabolism
    Chemical Substances Antioxidants ; Resveratrol (Q369O8926L) ; Bile Acids and Salts ; Lipids ; Serpinb1a protein, mouse ; Serpins ; Aox3 protein, mouse (EC 1.2.3.-) ; Aldehyde Oxidoreductases (EC 1.2.-)
    Language English
    Publishing date 2024-03-19
    Publishing country China
    Document type Journal Article
    ZDB-ID 603186-9
    ISSN 2589-451X ; 0254-6272 ; 0255-2922
    ISSN (online) 2589-451X ; 0254-6272
    ISSN 0255-2922
    DOI 10.19852/j.cnki.jtcm.20231018.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Research on UAV route planning based on adaptive multi heuristic ant colony algorithm

    Yanan YIN / Ran ZHEN / Xiaojing WU / Chunyue ZHANG / Xueli WU

    Journal of Hebei University of Science and Technology, Vol 42, Iss 1, Pp 38-

    2021  Volume 47

    Abstract: In order to solve the problem that ant colony algorithm is easy to fall into local optimum in UAV route planning, an improved ant colony algorithm was proposed. The upper and lower limits of pheromone volatilization factor and pheromone were set to ... ...

    Abstract In order to solve the problem that ant colony algorithm is easy to fall into local optimum in UAV route planning, an improved ant colony algorithm was proposed. The upper and lower limits of pheromone volatilization factor and pheromone were set to prevent ants from falling into local optimum because pheromone on short path was too high or pheromone on long path was too low. At the same time, under the influence of multiple heuristic factors, the overall length of the path was taken as an adaptive heuristic function factor to determine the state transition probability. When the path length was large, the adaptive heuristic function factor was small, which reduced the probability of choosing the path by the ant colony. The experimental results show that the improved algorithm reduces the path length by 6.4% and the variance of the optimal path length by 85.78%, which increases the consideration of environmental integrity, shortens the path length, reduces the number of iterations, and jumps out of the local optimum. In the case of increasing environmental complexity, the algorithm can effectively choose a better path and provide a theoretical basis for UAV route planning after introducing the adaptive heuristic function factor.
    Keywords basic science and technology of aeronautics and astronautics other disciplines ; uav ; ant colony algorithm ; route planning ; heuristic factors ; Technology ; T
    Subject code 000
    Language Chinese
    Publishing date 2021-02-01T00:00:00Z
    Publisher Hebei University of Science and Technology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Homeomorphism Mapping Based Neural Networks for Finite Time Constraint Control of a Class of Nonaffine Pure-Feedback Nonlinear Systems

    Jianhua Zhang / Quanmin Zhu / Yang Li / Xueli Wu

    Complexity, Vol

    2019  Volume 2019

    Abstract: This paper proposes a new scheme for solving finite time neural networks adaptive tracking control issue for the nonaffine pure-feedback nonlinear system. The procedure, based on homeomorphism mapping and backstepping, effectively deals with constraint ... ...

    Abstract This paper proposes a new scheme for solving finite time neural networks adaptive tracking control issue for the nonaffine pure-feedback nonlinear system. The procedure, based on homeomorphism mapping and backstepping, effectively deals with constraint control and design difficulty induced by pure-feedback structure. The most outstanding novelty is that finite time adaptive law is proposed for training weights of neural networks. Furthermore, by combining finite time adaptive law and Lyapunov-based arguments, a valid finite time adaptive neural networks controller design algorithm is presented to ensure that system is practical finite stable (PFS) rather than uniformly ultimately bounded (UUB). Because of using the finite time adaptive law to training weights of neural networks, the closed-loop error system signals are in assurance of bounded in finite time. Benchmark simulations have well demonstrated effectiveness and efficiency of the proposed approach.
    Keywords Electronic computers. Computer science ; QA75.5-76.95
    Subject code 629
    Language English
    Publishing date 2019-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Dynamic step BI-RRT UAV path planning algorithm

    Xiaojing WU / Lei XU / Ran ZHEN / Xueli WU

    Journal of Hebei University of Science and Technology, Vol 40, Iss 5, Pp 414-

    2019  Volume 422

    Abstract: To solve the problems of traditional RRT algorithm, such as slow convergence and long path length, the dynamic step BI-RRT algorithm is proposed. The sampling efficiency of the RRT algorithm is improved by using a target-oriented sampling strategy. The ... ...

    Abstract To solve the problems of traditional RRT algorithm, such as slow convergence and long path length, the dynamic step BI-RRT algorithm is proposed. The sampling efficiency of the RRT algorithm is improved by using a target-oriented sampling strategy. The dynamic step algorithm improves the local smoothness of the path in the obstacle environment. A new tree cutting strategy is proposed to make the growth trend of random trees more obvious and improve the convergence rate of the algorithm. For the initial path, the path nodes are filtered by applying greedy algorithm to reduce the invalid nodes and path length of the unmanned aerial vehicle (UAV). Finally, a feasible smooth path is obtained by using B-Spline. The simulation maps in 2D and 3D environment are built to verify the effectiveness of the algorithm. Compared to the segmentated optimization RRT algorithm, the dynamic step BI-RRT algorithm proposed in this paper improves the convergence rate and reduces the path distance, while ensuring that the number of path nodes is optimal. This path planning algorithm has some advantages such as good real-time performance and smoothness of path.
    Keywords basic science and technology of aeronautics and astronautics other disciplines ; bidirectional rapidly-exploring random tree (BI-RRT) ; probability search ; target oriented dynamic step size ; branch cutting strategy ; Technology ; T
    Subject code 629
    Language Chinese
    Publishing date 2019-10-01T00:00:00Z
    Publisher Hebei University of Science and Technology
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors

    Wang, Yi / Xueli Wu / Yiyu Cheng / Xiaoping Zhao

    Chemical communications. 2016 Feb. 18, v. 52, no. 17

    2016  

    Abstract: A novel fluorescent probe for in vitro and in vivo imaging of dipeptidyl peptidase-4 (DPP-4) was designed and synthesized. This probe is successfully utilized to screen DPP-4 inhibitors in living 3T3-L1 cells and zebrafish, which provides a novel ... ...

    Abstract A novel fluorescent probe for in vitro and in vivo imaging of dipeptidyl peptidase-4 (DPP-4) was designed and synthesized. This probe is successfully utilized to screen DPP-4 inhibitors in living 3T3-L1 cells and zebrafish, which provides a novel approach for the discovery of anti-diabetes drugs.
    Keywords Danio rerio ; chemical compounds ; chemical reactions ; drugs ; fluorescence ; fluorescent dyes ; image analysis ; screening
    Language English
    Dates of publication 2016-0218
    Size p. 3478-3481.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/c5cc08921b
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: n-Butyllithium Catalyzed Selective Hydroboration of Aldehydes and Ketones

    Zhu, Zhangye / Mingqiang Xue / Qi Shen / Xiaoguang Bao / Xiaojuan Xu / Xueli Wu / Yingming Yao / Zhenjie Wu

    Journal of organic chemistry. 2018 Aug. 02, v. 83, no. 17

    2018  

    Abstract: Highly efficient and selective hydroboration of aldehydes and ketones with HBpin is achieved by using the simple and convenient n-BuLi as a catalyst. The reaction proceeds rapidly with low catalyst loading (0.1–0.5 mol %) under mild conditions. Key ... ...

    Abstract Highly efficient and selective hydroboration of aldehydes and ketones with HBpin is achieved by using the simple and convenient n-BuLi as a catalyst. The reaction proceeds rapidly with low catalyst loading (0.1–0.5 mol %) under mild conditions. Key features include the high catalytic efficiency, exceptional functional group compatibility, ample substrate scope, and high selectivity for aldehydes over ketones. Computational studies were carried out to provide a mechanistic insight into the n-BuLi catalyzed hydroboration of aldehydes/ketones with HBpin.
    Keywords aldehydes ; catalysts ; catalytic activity ; chemical reactions ; ketones ; moieties ; organic chemistry
    Language English
    Dates of publication 2018-0802
    Size p. 10677-10683.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/acs.joc.8b01495
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  7. Article: [3 + 2] Cycloaddition of Nitrile Ylides with Diazonium Salts: Copper-Catalyzed One-Pot Synthesis of Fully Substituted 1,2,4-Triazoles

    Li, Huihuang / Haiyan Li / Pengcheng Lian / Weiwei Hao / Xiaobing Wan / Xiaoguang Bao / Xueli Wu / Yanwei Zhao / Yaxiong Wang / Yonggao Zheng

    Organic letters. 2018 Aug. 27, v. 20, no. 17

    2018  

    Abstract: A novel [3 + 2] cycloaddition between nitrile ylides and diazonium salts was well-established. This copper-catalyzed three-component reaction was distinguished by mild conditions, ready availability, and operational simplicity, thus opening access to 1,2, ...

    Abstract A novel [3 + 2] cycloaddition between nitrile ylides and diazonium salts was well-established. This copper-catalyzed three-component reaction was distinguished by mild conditions, ready availability, and operational simplicity, thus opening access to 1,2,4-triazoles with a diverse set of substitution patterns.
    Keywords chemical structure ; cycloaddition reactions ; diazonium compounds ; salts ; synthesis ; triazoles
    Language English
    Dates of publication 2018-0827
    Size p. 5224-5227.
    Publishing place American Chemical Society
    Document type Article
    ISSN 1523-7052
    DOI 10.1021/acs.orglett.8b02172
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: On the Problem of Energy Balanced Relay Sensor Placement in Wireless Sensor Networks

    Jie Jia / Guiyuan Zhang / Xueli Wu / Jian Chen / Xingwei Wang / Xiaolei Yan

    International Journal of Distributed Sensor Networks, Vol

    2013  Volume 9

    Abstract: Balanced energy depletion is an important way to prolong network lifetime for wireless sensor networks. Traditional algorithms mainly aim at maximizing network coverage rate with uniform sensor node distribution. However, wireless sensor network is ... ...

    Abstract Balanced energy depletion is an important way to prolong network lifetime for wireless sensor networks. Traditional algorithms mainly aim at maximizing network coverage rate with uniform sensor node distribution. However, wireless sensor network is characterized by many-to-one traffic pattern and multihop communication, which usually lead to the energy hole problem in the region around the sink node. In this paper, we investigate the problem of joint placement for both relays and sensors to eliminate energy hole. We first theoretically conclude that balanced energy depletion is achievable with rational designed deployment density for relay nodes. We then propose a novel relay deploying strategy as well as a data routing scheme to eliminate uneven energy depletion. Extensive simulations are presented to verify that our approach outperforms other schemes in terms of both network lifetime and unused energy ratio.
    Keywords Electronic computers. Computer science ; QA75.5-76.95
    Subject code 003
    Language English
    Publishing date 2013-10-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
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  9. Article ; Online: Identification of compound heterozygous variants in the noncoding RNU4ATAC gene in a Chinese family with two successive foetuses with severe microcephaly

    Ye Wang / Xueli Wu / Liu Du / Ju Zheng / Songqing Deng / Xin Bi / Qiuyan Chen / Hongning Xie / Claude Férec / David N. Cooper / Yanmin Luo / Qun Fang / Jian-Min Chen

    Human Genomics, Vol 12, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: Abstract Background Whole-exome sequencing (WES) over the last few years has been increasingly employed for clinical diagnosis. However, one caveat with its use is that it inevitably fails to detect disease-causative variants that occur within noncoding ... ...

    Abstract Abstract Background Whole-exome sequencing (WES) over the last few years has been increasingly employed for clinical diagnosis. However, one caveat with its use is that it inevitably fails to detect disease-causative variants that occur within noncoding RNA genes. Our experience in identifying pathogenic variants in the noncoding RNU4ATAC gene, in a Chinese family where two successive foetuses had been affected by severe microcephaly, is a case in point. These foetuses exhibited remarkably similar phenotypes in terms of their microcephaly and brain abnormalities; however, the paucity of other characteristic phenotypic features had made a precise diagnosis impossible. Given that no external causative factors had been reported/identified during the pregnancies, we sought a genetic cause for the phenotype in the proband, the second affected foetus. Results A search for chromosomal abnormalities and pathogenic copy number variants proved negative. WES was also negative. These initial failures prompted us to consider the potential role of RNU4ATAC, a noncoding gene implicated in microcephalic osteodysplastic primordial dwarfism type-1 (MOPD1), a severe autosomal recessive disease characterised by dwarfism, severe microcephaly and neurological abnormalities. Subsequent targeted sequencing of RNU4ATAC resulted in the identification of compound heterozygous variants, one being the most frequently reported MOPD1-causative mutation (51G>A), whereas the other was a novel 29T>A variant. Four distinct lines of evidence (allele frequency in normal populations, evolutionary conservation of the affected nucleotide, occurrence within a known mutational hotspot for MOPD1-causative variants and predicted effect on RNA secondary structure) allowed us to conclude that 29T>A is a new causative variant for MOPD1. Conclusions Our findings highlight the limitations of WES in failing to detect variants within noncoding RNA genes and provide support for a role for whole-genome sequencing as a first-tier genetic test in paediatric ...
    Keywords Genetic counselling ; Microcephalic osteodysplastic primordial dwarfism type 1 ; MOPD1 ; Noncoding RNU4ATAC gene ; Prenatal diagnosis ; RNA secondary structure ; Medicine ; R ; Genetics ; QH426-470
    Subject code 610
    Language English
    Publishing date 2018-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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