Article ; Online: Biology and therapeutic potential of mesenchymal stem cell-derived exosomes.
2020 Volume 111, Issue 9, Page(s) 3100–3110
Abstract: Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects ... ...
| Abstract | Mesenchymal stem cells (MSC) are multipotent stromal cells with the potential to differentiate into several cell types. MSC-based therapy has emerged as a promising strategy for various diseases. Accumulating evidence suggests that the paracrine effects of MSC are partially exerted by the secretion of soluble factors, in particular exosomes. MSC-derived exosomes are involved in intercellular communication through transfer of proteins, RNA, DNA and bioactive lipids, which might constitute a novel intercellular communication mode. This review illustrates the current knowledge on the composition and biological functions as well as the therapeutic potential of MSC-derived exosomes in cancer, with a focus on clinical translation opportunities. |
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| MeSH term(s) | Animals ; Biological Products/therapeutic use ; Cell Communication ; Cell-Derived Microparticles/metabolism ; Cellular Microenvironment ; Clinical Trials as Topic ; Drug Delivery Systems ; Exosomes/metabolism ; Humans ; Immunomodulation ; Mesenchymal Stem Cells/metabolism |
| Chemical Substances | Biological Products |
| Language | English |
| Publishing date | 2020-07-28 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 2115647-5 |
| ISSN | 1349-7006 ; 1347-9032 |
| ISSN (online) | 1349-7006 |
| ISSN | 1347-9032 |
| DOI | 10.1111/cas.14563 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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