LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 4 of total 4

Search options

  1. Article ; Online: Soluble signal inhibitory receptor on leukocytes-1 reflects disease activity and assists diagnosis of patients with rheumatoid arthritis.

    Xv, Zhen / Xv, Xuejing / Chen, Nianzhen / Yuan, Jiayi / Li, Jing / Wang, Lan / Yu, Shanshan / Li, Gen / Ding, Menglei / Zong, Ming / Fan, Lieying

    Clinica chimica acta; international journal of clinical chemistry

    2024  Volume 556, Page(s) 117808

    Abstract: Background: SIRL-1, an immunosuppressive receptor encoded by the VSTM1 gene, has recently been linked to rheumatoid arthritis (RA) due to its association with activated polymorphonuclear neutrophils (PMNs). Considering that the activated PMNs play a ... ...

    Abstract Background: SIRL-1, an immunosuppressive receptor encoded by the VSTM1 gene, has recently been linked to rheumatoid arthritis (RA) due to its association with activated polymorphonuclear neutrophils (PMNs). Considering that the activated PMNs play a crucial role in the pathogenesis of rheumatoid arthritis (RA), we aimed to measure the levels of soluble SIRL-1, investigating whether they add value to RA in the clinical diagnosis.
    Methods: Utilizing an enzyme-linked immunosorbent assay, the concentration of sSIRL-1 was measured in serum samples from cohort 1 diagnosed with RA (n = 96), gout (n = 54), osteoarthritis (n = 47), healthy controls (n = 86) and synovial fluid samples from OA (n = 8) and RA (n = 8) patients, respectively. Additionally, an external validation in cohort 2 (n = 156) comprising various inflammatory diseases was employed.
    Results: The study revealed a distinctive upregulation of sSIRL-1 in the serum of RA compared to HC and other arthralgia diseases (p < 0.0001), which also displayed a significant elevation in synovial fluid from RA compared to OA (p < 0.05). Notably, sSIRL-1 levels exhibited a significant decrease in patients who achieved disease remission (p < 0.05). Furthermore, the diagnostic accuracy of RA was enhanced when sSIRL-1 was combined with anti-CCP and RF, yielding an impressive AUC value of 0.950.
    Conclusion: The expression pattern of sSIRL-1 in RA, coupled with its correlation with disease activity, underscores its potential clinical utility for both diagnosis and disease monitoring in RA patients. This study offers valuable insights into the evolving diagnostic landscape of RA.
    MeSH term(s) Humans ; Arthritis, Rheumatoid/diagnosis ; Osteoarthritis/diagnosis ; Synovial Fluid/metabolism ; Leukocytes
    Language English
    Publishing date 2024-02-01
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2024.117808
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.173: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Effective Neutralizing Antibody Produced in Mice Directly Immunized with Integrated

    Xv, Zhen / Lv, Jinhui / Jiang, Jie / Wang, Wenhuan / Feng, Fangfang / Zhang, Lifang / Xue, Xiangyang / Li, Wenshu

    Viral immunology

    2019  Volume 32, Issue 7, Page(s) 308–317

    Abstract: The human papillomavirus (HPV) vaccine has not been widely used in developing countries because of its high cost and multiple subtype restrictions. The present study aimed to develop an economical, convenient, and effective vaccine to produce ... ...

    Abstract The human papillomavirus (HPV) vaccine has not been widely used in developing countries because of its high cost and multiple subtype restrictions. The present study aimed to develop an economical, convenient, and effective vaccine to produce neutralizing antibodies. Using
    MeSH term(s) Animals ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/blood ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/administration & dosage ; Antibodies, Viral/blood ; Antibodies, Viral/immunology ; Capsid Proteins/genetics ; Capsid Proteins/immunology ; Capsid Proteins/metabolism ; Cell Line, Tumor ; Female ; Human papillomavirus 16/immunology ; Humans ; Immunization ; Mice ; Neoplasms, Experimental/prevention & control ; Oncogene Proteins, Viral/genetics ; Oncogene Proteins, Viral/immunology ; Oncogene Proteins, Viral/metabolism ; Papillomavirus Vaccines/administration & dosage ; Papillomavirus Vaccines/immunology ; Pichia/genetics ; Pichia/metabolism ; Vaccines, Synthetic/administration & dosage ; Vaccines, Synthetic/immunology
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; Capsid Proteins ; Oncogene Proteins, Viral ; Papillomavirus Vaccines ; Vaccines, Synthetic ; L1 protein, Human papillomavirus type 16 (6LTE2DNX63)
    Language English
    Publishing date 2019-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639075-4
    ISSN 1557-8976 ; 0882-8245
    ISSN (online) 1557-8976
    ISSN 0882-8245
    DOI 10.1089/vim.2019.0055
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 2227: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Acute Exercise-Induced Mitochondrial Stress Triggers an Inflammatory Response in the Myocardium via NLRP3 Inflammasome Activation with Mitophagy.

    Li, Haiying / Miao, Weiguo / Ma, Jingfen / Xv, Zhen / Bo, Hai / Li, Jianyu / Zhang, Yong / Ji, Li Li

    Oxidative medicine and cellular longevity

    2016  Volume 2016, Page(s) 1987149

    Abstract: Increasing evidence has indicated that acute strenuous exercise can induce a range of adverse reactions including oxidative stress and tissue inflammation. However, little is currently known regarding the mechanisms that underlie the regulation of the ... ...

    Abstract Increasing evidence has indicated that acute strenuous exercise can induce a range of adverse reactions including oxidative stress and tissue inflammation. However, little is currently known regarding the mechanisms that underlie the regulation of the inflammatory response in the myocardium during acute heavy exercise. This study evaluated the mitochondrial function, NLRP3 inflammasome activation, and mitochondrial autophagy-related proteins to investigate the regulation and mechanism of mitochondrial stress regarding the inflammatory response of the rat myocardium during acute heavy exercise. The results indicated that the mitochondrial function of the myocardium was adaptively regulated to meet the challenge of stress during acute exercise. The exercise-induced mitochondrial stress also enhanced ROS generation and triggered an inflammatory reaction via the NLRP3 inflammasome activation. Moreover, the mitochondrial autophagy-related proteins including Beclin1, LC3, and Bnip3 were all significantly upregulated during acute exercise, which suggests that mitophagy was stimulated in response to the oxidative stress and inflammatory response in the myocardium. Taken together, our data suggest that, during acute exercise, mitochondrial stress triggers the rat myocardial inflammatory response via NLRP3 inflammasome activation and activates mitophagy to minimize myocardial injury.
    MeSH term(s) Animals ; Antioxidants/pharmacology ; Autophagy/drug effects ; Carrier Proteins/metabolism ; Cell Respiration/drug effects ; Inflammasomes/drug effects ; Inflammasomes/metabolism ; Inflammation/pathology ; Interleukin-1beta/metabolism ; Male ; Membrane Potential, Mitochondrial/drug effects ; Mitochondrial Degradation/drug effects ; Mitochondrial Proton-Translocating ATPases/metabolism ; Myocardium/metabolism ; Myocardium/pathology ; NLR Family, Pyrin Domain-Containing 3 Protein ; Oxidants/toxicity ; Oxidative Stress/drug effects ; Physical Conditioning, Animal ; Rats, Sprague-Dawley ; Stress, Physiological/drug effects
    Chemical Substances Antioxidants ; Carrier Proteins ; Inflammasomes ; Interleukin-1beta ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; Oxidants ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1942-0994
    ISSN (online) 1942-0994
    DOI 10.1155/2016/1987149
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Expression changes of thrombospondin-1 and neuropeptide Y in myocardium of STZ-induced rats.

    Zhang, Xiao-Ming / Shen, Fang / Xv, Zhen-Yu / Yan, Zhi-Yu / Han, Shu

    International journal of cardiology

    2005  Volume 105, Issue 2, Page(s) 192–197

    Abstract: Diabetic cardiomyopathy was the most dangerous diabetic complication facing diabetics, with its exact mechanisms remaining obscure. Our study was conducted to investigate the expression of thrombospondin-1 (TSP-1) and neuropeptide Y (NPY) in myocardium ... ...

    Abstract Diabetic cardiomyopathy was the most dangerous diabetic complication facing diabetics, with its exact mechanisms remaining obscure. Our study was conducted to investigate the expression of thrombospondin-1 (TSP-1) and neuropeptide Y (NPY) in myocardium of streptozotocin (STZ)-induced diabetic rats. We employed streptozotocin (STZ)-induced diabetic rats to study the alteration of the TSP-1 and NPY expression in the left ventricle myocardium in diabetic and normal group by immunohistochemistry and immunofluorescence. The data of weight, blood sugar and urine sugar indicated no significant difference between the two groups before the animal model was induced. Four weeks after the induction of diabetes the weight of the diabeteic animals was 189.1+/-18.4 g, plasma glucose was 23.7+/-3.25 mmol/L and urine glucose was (++) to (+++); whereas the weight of the control animals was 260.5+/-32.1 g, plasma glucose was 4.9+/-0.5 mmol/L and urine glucose undetectable (-). The differences between the control and the diabetes group were distinct. A significant increase of the TSP-1 and NPY expression was also observed in the diabetic rat's heart. The number of the NPY positive myocardium and the light density of the positive myocardium in the left ventricle of the diabetic model were 17.3+/-2.1 and 102.5+/-9.3/mm(2), respectively, which were considered as increased when compared with the control that were 10.1+/-2.6 and 61.2+/-6.7, respectively. Our results support the view that high glucose conditions can induce an increased synthesis of TSP-1 through the PKC-TGF-beta-TSP-1 pathway, which in turn facilitate TGF-beta activation. Additionally, the activation of PKC may further lead to the over-expression of NPY. This may be involved in diabetic cardiomyopathy.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Blood Glucose/metabolism ; Diabetes Mellitus, Experimental/blood ; Diabetes Mellitus, Experimental/complications ; Disease Models, Animal ; Disease Progression ; Heart Ventricles/metabolism ; Heart Ventricles/pathology ; Immunohistochemistry ; Myocardium/metabolism ; Neuropeptide Y/biosynthesis ; Rats ; Rats, Sprague-Dawley ; Streptozocin/toxicity ; Thrombospondin 1/biosynthesis ; Ventricular Dysfunction, Left/complications ; Ventricular Dysfunction, Left/etiology ; Ventricular Dysfunction, Left/metabolism
    Chemical Substances Biomarkers ; Blood Glucose ; Neuropeptide Y ; Thrombospondin 1 ; Streptozocin (5W494URQ81)
    Language English
    Publishing date 2005-11-02
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2004.12.065
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1673: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top