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Article ; Online: Survival Outcome Prediction in Glioblastoma: Insights from MRI Radiomics.

Styliara, Effrosyni I / Astrakas, Loukas G / Alexiou, George / Xydis, Vasileios G / Zikou, Anastasia / Kafritsas, Georgios / Voulgaris, Spyridon / Argyropoulou, Maria I

Current oncology (Toronto, Ont.)

2024 Volume 31, Issue 4, Page(s) 2233–2243

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Humans ; Glioblastoma/diagnostic imaging ; Glioblastoma/mortality ; Female ; Middle Aged ; Magnetic Resonance Imaging/methods ; Male ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/mortality ; Aged ; Adult ; Survival Analysis ; Prognosis ; Radiomics
Language	English
Publishing date	2024-04-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol31040165
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Article ; Online: Pituitary gland height evaluated with magnetic resonance imaging in premature twins: the impact of growth and sex.

Argyropoulou, Maria I / Xydis, Vasileios / Astrakas, Loukas G / Drougia, Aikaterini / Styliara, Effrosyni I / Kiortsis, Dimitrios-Nikiforos / Giapros, Vasileios / Kanaka-Gantenbein, Christina

Pediatric radiology

2024 Volume 54, Issue 5, Page(s) 787–794

Abstract: Background: Pituitary gland height reflects secretory activity of the hypothalamo-pituitary axis.: Objective: To assess the cumulative impact of fetal growth and sex on pituitary gland height in premature twins, dissociated from prematurity.: ... ...

Abstract	Background: Pituitary gland height reflects secretory activity of the hypothalamo-pituitary axis. Objective: To assess the cumulative impact of fetal growth and sex on pituitary gland height in premature twins, dissociated from prematurity. Materials and methods: A retrospective study was conducted, assessing the pituitary gland height in 63 pairs of preterm twins, measured from T1-weighted magnetic resonance imaging (MRI). Auxological parameters, including body weight, body length, and head circumference, at birth and at the time of MRI, were used as proxies for fetal and postnatal growth, respectively. The study population was divided into two groups, using corrected age at around term equivalent as the cutoff point. Statistical analysis was performed using mixed-effects linear regression models. Results: When pituitary gland height was evaluated at around term equivalent, a greater pituitary gland height, suggesting a more immature hypothamo-pituitary axis, was associated with the twin exhibiting lower auxological data at birth. The same association was observed when body weight and length at MRI were used as covariants. In the group evaluated after term equivalent, a smaller pituitary gland height, suggesting a more mature hypothamo-pituitary axis, was associated with male sex. This difference was observed in twin pairs with higher average body weight at birth, and in babies exhibiting higher auxological data at MRI. Conclusion: After isolating the effect of prematurity, at around term equivalent, pituitary gland height reflects the cumulative impact of fetal growth on the hypothalamo-pituitary axis. Subsequently, pituitary gland height shows effects of sex and of fetal and postnatal growth.
MeSH term(s)	Humans ; Male ; Female ; Magnetic Resonance Imaging/methods ; Infant, Newborn ; Pituitary Gland/diagnostic imaging ; Pituitary Gland/growth & development ; Infant, Premature/growth & development ; Retrospective Studies ; Sex Factors ; Twins ; Organ Size
Language	English
Publishing date	2024-02-22
Publishing country	Germany
Document type	Journal Article ; Twin Study
ZDB-ID	124459-0
ISSN	1432-1998 ; 0301-0449
ISSN (online)	1432-1998
ISSN	0301-0449
DOI	10.1007/s00247-024-05873-0
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Zs.A 927: Show issues

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Article ; Online: Structural and functional brain connectivity in moderate-late preterm infants with low-grade intraventricular hemorrhage.

Argyropoulou, Maria I / Xydis, Vasileios G / Drougia, Aikaterini / Giantsouli, Anastasia S / Giapros, Vasileios / Astrakas, Loukas G

Neuroradiology

2021 Volume 64, Issue 1, Page(s) 197–204

Abstract: Purpose: Brain functional connectivity (FC) changes and microstructural abnormalities are reported in infants born moderate and late preterm (MLPT). We evaluated the effect of low-grade (grades I, II) intraventricular hemorrhage (IVH) in MLPT babies on ... ...

Abstract	Purpose: Brain functional connectivity (FC) changes and microstructural abnormalities are reported in infants born moderate and late preterm (MLPT). We evaluated the effect of low-grade (grades I, II) intraventricular hemorrhage (IVH) in MLPT babies on brain structural connectivity (SC) and FC. Methods: Babies born MLPT between January 2014 and May 2017 underwent brain ultrasound (US) at 72 h and 7 days after birth, and MRI at around term equivalent. The MRI protocol comprised T1- and T2-weighted sequences, diffusion tensor imaging (DTI), and resting-state functional MRI (fMRI). SC and FC were assessed using graph analysis. Results: Of 350 MLPT neonates, 15 showed low-grade IVH on US at 72 h, for which brain MRI was available in 10. These 10 infants, with mean gestational age (GA) 34.0 ± 0.8 weeks, comprised the study group, and 10 MLPT infants of mean GA 33.9 ± 1.1 weeks, with no abnormalities on brain US and MRI, were control subjects. All study subjects presented modularity, small world topology, and rich club organization for both SC and FC. The patients with low-grade IVH had lower FC rich club coefficient and lower SC betweenness centrality in the left frontoparietal operculum, and lower SC rich club coefficient in the right superior orbitofrontal cortex than the control subjects. Conclusions: Topological and functional properties of mature brain connectivity are present in MLPT infants. IVH in these infants was associated with structural and functional abnormalities in the left frontoparietal operculum and right orbitofrontal cortex, regions related to language and cognition.
MeSH term(s)	Brain/diagnostic imaging ; Cerebral Hemorrhage/diagnostic imaging ; Diffusion Tensor Imaging ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Magnetic Resonance Imaging
Language	English
Publishing date	2021-08-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	123305-1
ISSN	1432-1920 ; 0028-3940
ISSN (online)	1432-1920
ISSN	0028-3940
DOI	10.1007/s00234-021-02770-3
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Zs.A 658: Show issues

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Article ; Online: Can maternal hormones play a significant role in delivery mode?

Pappa, Christina / Gkrozou, Fani / Dimitriou, Evangelos / Tsonis, Orestis / Kitsouli, Aikaterini / Varvarousis, Dimitrios / Xydis, Vasileios / Paschopoulos, Minas / Kitsoulis, Panagiotis

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

2022 , Page(s) 1–8

Abstract: The aim of this study was primarily to evaluate the levels of progesterone, oestradiol and relaxin during different delivery modes and secondarily to assess specific traits and changes in maternal pelvic dimensions during pregnancy and childbirth, in ... ...

Abstract	The aim of this study was primarily to evaluate the levels of progesterone, oestradiol and relaxin during different delivery modes and secondarily to assess specific traits and changes in maternal pelvic dimensions during pregnancy and childbirth, in correlation with foetal size and maternal hormonal profile. Nulliparous women (
Language	English
Publishing date	2022-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	604639-3
ISSN	1364-6893 ; 0144-3615
ISSN (online)	1364-6893
ISSN	0144-3615
DOI	10.1080/01443615.2022.2109139
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Article ; Online: A case of painless exercise-induced gross hematuria in a 9-year-old boy: Questions.

Zisi, Anna / Kosmeri, Chrysoula / Siatara, Ioanna / Giantsouli, Anastasia / Xydis, Vasileios / Siomou, Ekaterini

Pediatric nephrology (Berlin, Germany)

2020 Volume 36, Issue 7, Page(s) 1967

Language	English
Publishing date	2020-10-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-020-04803-0
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Zs.A 2196: Show issues

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Article ; Online: A case of painless exercise-induced gross hematuria in a 9-year-old boy: Answers.

Zisi, Anna / Kosmeri, Chrysoula / Siatara, Ioanna / Giantsouli, Anastasia / Xydis, Vasileios / Siomou, Ekaterini

Pediatric nephrology (Berlin, Germany)

2020 Volume 36, Issue 7, Page(s) 1969–1971

Language	English
Publishing date	2020-10-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	631932-4
ISSN	1432-198X ; 0931-041X
ISSN (online)	1432-198X
ISSN	0931-041X
DOI	10.1007/s00467-020-04807-w
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Article: Subcortical Band Heterotopia Shows Increased Perfusion on Arterial Spin Labeling Maps.

Xydis, Vasileios G / Giantsouli, Anastasia / Styliara, Effrosyni / Alexiou, George A / Nakou, Iliada / Astrakas, Loukas G / Argyropoulou, Maria I

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques

2021 Volume 49, Issue 5, Page(s) 703

MeSH term(s)	Cerebrovascular Circulation ; Classical Lissencephalies and Subcortical Band Heterotopias ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Perfusion ; Spin Labels
Chemical Substances	Spin Labels
Language	English
Publishing date	2021-08-12
Publishing country	England
Document type	Journal Article
ZDB-ID	197622-9
ISSN	0317-1671
ISSN	0317-1671
DOI	10.1017/cjn.2021.194
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Zs.A 1203: Show issues

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Article ; Online: Functional connectivity and microstructural changes of the brain in primary Sjögren syndrome: the relationship with depression.

Andrianopoulou, Artemis / Zikou, Anastasia K / Astrakas, Loukas G / Gerolymatou, Nafsika / Xydis, Vasileios / Voulgari, Paraskevi / Kiortsis, Dimitris-Nikiforos / Argyropoulou, Maria I

Acta radiologica (Stockholm, Sweden : 1987)

2020 Volume 61, Issue 12, Page(s) 1684–1694

Abstract: Background: Fatigue and depression are among the most common manifestations of primary Sjögren syndrome (pSS), but information is lacking on the relationship with brain function and microstructural changes.: Purpose: To investigate microstructural ... ...

Abstract	Background: Fatigue and depression are among the most common manifestations of primary Sjögren syndrome (pSS), but information is lacking on the relationship with brain function and microstructural changes. Purpose: To investigate microstructural changes and brain connectivity in pSS, and to evaluate their relationship with fatigue and depression. Material and methods: The study included 29 patients with pSS (mean age 61.2 ± 12.1 years; disease duration 10.5 ± 5.9 years) and 28 controls (mean age 58.4 ± 9.2 years). All the patients completed the Beck's depression and Fatigue Assessment Scale questionnaires. The imaging protocol consisted of: (i) standard magnetic resonance imaging (MRI) pulse sequences (FLAIR, 3D T1W); (ii) a diffusion tensor imaging pulse sequence; and (iii) a resting state functional MRI pulse sequence. Resting state brain networks and maps of diffusion metrics were calculated and compared between patients and controls. Results: Compared with the controls, the patients with pSS and depression showed increased axial, radial, and mean diffusivity and decreased fractional anisotropy; those without depression showed decreased axial diffusivity in major white matter tracts (superior longitudinal fasciculus, inferior longitudinal fasciculus, corticospinal tract, anterior thalamic radiation, inferior fronto-occipital fasciculus, cingulum, uncinate fasciculus, and forceps minor-major). Decreased brain activation in the sensorimotor network was observed in the patients with pSS compared with the controls. No correlation was found between fatigue and structural or functional changes of the brain. Conclusion: pSS is associated with functional connectivity abnormalities of the somatosensory cortex and microstructural abnormalities in major white matter tracts, which are more pronounced in depression.
MeSH term(s)	Depression/physiopathology ; Diffusion Tensor Imaging/methods ; Female ; Humans ; Image Processing, Computer-Assisted ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Sjogren's Syndrome/physiopathology ; Wallerian Degeneration/diagnostic imaging ; Wallerian Degeneration/pathology ; White Matter/diagnostic imaging ; White Matter/pathology
Language	English
Publishing date	2020-03-25
Publishing country	England
Document type	Journal Article
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/0284185120909982
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Article: Liver perivascular epithelioid cell tumor in a patient with systemic lupus erythematosus.

Voulgari, Paraskevi V / Tatsi, Vissaria / Milionis, Haralampos J / Goussia, Anna / Xydis, Vasileios / Glantzounis, George K

International journal of surgery case reports

2018 Volume 53, Page(s) 193–195

Abstract: Introduction: Perivascular epithelioid cell tumor (PECOMA) is a rare mesenchymal neoplasm which expresses both myogenic and melanocytic markers showing a benign course,although malignant tumors have also been reported. To date there are approximately 33 ...

Abstract	Introduction: Perivascular epithelioid cell tumor (PECOMA) is a rare mesenchymal neoplasm which expresses both myogenic and melanocytic markers showing a benign course,although malignant tumors have also been reported. To date there are approximately 33 cases of published hepatic pecomas. Presentation of case: We describe a 47-year-old man with a 27-year past medical history of systemic lupus erythematosus (SLE) who underwent left liver lobectomy due to a liver pecoma. His postoperative course complicated with infection, thrombosis of hepatic artery and liver ischemia as well as drug fever. Discussion: Treatment protocol especially for hepatic PECOMA has not reached a consensus although surgical resection is the preferred therapy. Conclusion: This is the first case of coexistence of liver pecoma and SLE.
Language	English
Publishing date	2018-11-01
Publishing country	Netherlands
Document type	Journal Article
ISSN	2210-2612
ISSN	2210-2612
DOI	10.1016/j.ijscr.2018.10.063
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Article ; Online: The association between multiple sclerosis and spondylosis: When and why.

Xydis, Vasileios G / Zikou, Anastasia K / Kostadima, Vassiliki / Astrakas, Loukas G / Kosta, Paraskevi / Argyropoulou, Maria I

European journal of radiology

2017 Volume 91, Page(s) 47–51

Abstract: Objectives: To evaluate risk factors for the development of cervical spine spondylosis (CSS) in patients with multiple sclerosis (MS) and to propose a pathogenetic mechanism.: Methods: Forty-two consecutive patients aged 23-66 years with MS and 42 ... ...

Abstract	Objectives: To evaluate risk factors for the development of cervical spine spondylosis (CSS) in patients with multiple sclerosis (MS) and to propose a pathogenetic mechanism. Methods: Forty-two consecutive patients aged 23-66 years with MS and 42 age and sex matched controls were evaluated retrospectively; Clinical disability was evaluated with the expanded disability status scale (EDSS) and spasticity with the Asworth score. Total brain lesion volume (BLV), total grey matter (GM) volume and deep GM volume were assessed. In the cervical spine CSS indices (disk dehydration, disk protrusion, abnormal posture and osteophytosis) and the spinal cord lesion load (SLL) was evaluated. The association of CSS indices with the presence of MS, the clinical scales and the brain and spinal cord imaging measurements were assessed. Results: Presence of MS was positively associated with abnormal posture (P=0.002), disk dehydration at C6-C7 (P=0.049) and posterior disk protrusion at C5-C6 (P=0.033) and C6-C7 (P=0.001). All patients had spasticity. Patients with abnormal posture were younger (37.5±11.1years) than those with normal (45.4±8.6years), P=0.024. Age (P=0.008), EDSS (P=0.045) and BLV (P=0.084) were significant independent predictors of abnormal posture. Younger age combined with worse EDSS and increased BLV predicted abnormal posture. Conclusions: Patients with MS present more frequently spondylosis which is associated with younger age, more severe disability and extensive lesions in the brain. Spasticity induced by the brain lesions and abnormal expression of extracellular matrix proteins in the brain and the intervertebral disk constitute a possible pathogenetic mechanism.
Language	English
Publishing date	2017-06
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	138815-0
ISSN	1872-7727 ; 0720-048X
ISSN (online)	1872-7727
ISSN	0720-048X
DOI	10.1016/j.ejrad.2017.03.017
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