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Article ; Online: Fusarium Fungemia After Electric Burn

Yasemin Ersoy / Ahmet Doğan / Yücel Duman / Cemal Fırat

Archives of Basic and Clinical Research, Vol 5, Iss 1, Pp 222-

A Case Report

2023 Volume 225

Keywords	Medicine ; R
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	AVES
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Colistin MICs and Resistance Genes of Acinetobacter Baumannii Isolated in Intensive Care Units

Yücel Duman / Mehmet Sait Tekerekoğlu

Türk Yoğun Bakım Dergisi, Vol 19, Iss 2, Pp 71-

2021 Volume 75

Abstract: Objective:Acinetobacter baumannii is an opportunistic pathogen that causes healthcare-associated infections in hospitalised patients in intensive care units. A. baumannii can quickly develop resistance to antimicrobials through different mechanisms. ... ...

Abstract	Objective:Acinetobacter baumannii is an opportunistic pathogen that causes healthcare-associated infections in hospitalised patients in intensive care units. A. baumannii can quickly develop resistance to antimicrobials through different mechanisms. Infections caused by multidrug-resistant (MDR) isolates have high morbidity and mortality and require long-term hospitalisation. Colistin is one of the last antimicrobials that can be used against MDR A. baumannii isolates. Due to the increase of these isolates, the use of colistin has increased worldwide. Our study aimed to investigate colistin resistance rates, minimum inhibitory concentration (MIC) values and plasmid-mediated resistance genes in isolates from the blood cultures of patients hospitalised in intensive care units.Materials and Methods:A total of 97 A. baumannii isolates from blood culture samples were included in our study. MIC values of the isolates were investigated by the broth microdilution method according to The European Committee for Antimicrobial Susceptibility Testing recommendations. Colistin resistance gene regions mcr 1-5 were studied by polymerase chain reaction.Results:Eight (8.2%) of the A. baumannii isolates were resistant, and 89 (91.8%) were sensitive. The colistin MIC50 value was 0.5 μg/mL, and its MIC90 value was 2 μg/mL. The plasmid-mediated mcr gene regions (1-5 mcr genes) investigated for the risk of horizontal spread of colistin resistance could not be determined.Conclusion:Colistin is an important antimicrobial that can still be used effectively to treat infections due to A. baumannii isolates in our intensive care units. However, to prevent the development of resistance against colistin, irrational antibiotic use should be prevented, and treatment according to antimicrobial susceptibility test results is required. In addition, we believe that it is important to take the necessary infection control measures to prevent the colonisation of resistant isolates in hospitals.
Keywords	acinetobacter baumannii ; colistin ; intensive care units ; Medicine ; R ; Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9
Subject code	610
Language	Turkish
Publishing date	2021-06-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Retrospective Analysis of Bacterial Meningitis Agents and Their Antimicrobial Susceptibility, in a 5-Year Period

Nur Betül Gündüz / Yücel Duman / Mehmet Sait Tekerekoğlu

Archives of Basic and Clinical Research, Vol 4, Iss 2, Pp 62-

2022 Volume 67

Keywords	Medicine ; R
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	AVES
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Novel and Revised Terms in the EUCAST 2019 Guideline

Elif Seren TANRIVERDİ / Yücel DUMAN

Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol

Susceptible, Increased Exposure and Area of Technical Uncertainty

2019 Volume 8

Keywords	european committee on antimicrobial susceptibility testing ; antibiotic resistance ; antibiotic susceptibility test ; antimicrobial agent ; rational antibiotic use ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Language	Turkish
Publishing date	2019-12-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effects of Colistin on Imipenem MICs in OXA-48 Producing Klebsiella pneumoniae Isolates

Yücel DUMAN / Mehmet Sait TEKEREKOĞLU / Çiğdem KUZUCU / Yusuf YAKUPOĞULLARI

Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 10, Iss

An In Vitro Study

2021 Volume 1

Abstract: Introduction: A new approach to carbapenem resistance-K. pneumoniae infections is to use combination drug therapies. However, little data are available about the effectiveness of the in vitro carbapenem plus colistin combination against oxacillinase-48 ( ... ...

Abstract	Introduction: A new approach to carbapenem resistance-K. pneumoniae infections is to use combination drug therapies. However, little data are available about the effectiveness of the in vitro carbapenem plus colistin combination against oxacillinase-48 (OXA-48) producing K. pneumoniae. Therefore, the aim of this study is to assess the potential synergistic activity of imipenem plus colistin in OXA-48-producing K. pneumoniae strains and investigate the changes in the imipenem minimal inhibitory concentrations (MICs) to varying MICs of colistin. Materials and Methods: Carbapenem and colistin resistance (ColR) genes were investigated by polymerase chain reaction. In the first stage, synergistic properties were determined by the checkerboard combination method. In the second step, at varying colistin concentrations, changes in the imipenem MICs were investigated. Results: Colistin MIC50 2 µg/ml, MIC90 16 µg/ml, and imipenem MIC50 32 µg/ml, MIC90 128 µg/ml were found, respectively. According to the fractional inhibitor concentration (FIC) formula, 62.2% of the isolates were synergistic, and 37.8% were indifference. When the colistin was fixed at 0.125 µg/ml, 0.25 µg/ml, 0.5 µg/ml, 1 µg/ml, and 2 µg/ml, respectively. Significant decreases were observed in the imipenem MICs, especially of colistin-sensitive isolates. However, imipenem MICs of ColR isolates did not decrease to susceptible levels. Conclusion: This information will facilitate the design of antibiotic regimens that are more suitable for treating infections due to such pathogens producing OXA-48 and prolong these antibiotics’ efficacy. Further in vitro research is required to determine which treatment combination is best and its optimal use as combination therapy to treat these infections.
Keywords	colistin ; imipenem ; combination ; klebsiella pneumoniae ; oxa-48 ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Subject code	610
Language	Turkish
Publishing date	2021-12-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A Case of Infective Endocarditis Due to Abiotrophia defectiva, and Treatment with Ertapenem

Yücel DUMAN / Sibel ALTUNIŞIK TOPLU / Elif Seren TANRIVERDİ / Yaşar BAYINDIR

Mediterranean Journal of Infection, Microbes and Antimicrobials, Vol 10, Iss

2021 Volume 1

Abstract: The most frequently reported infections due to Abiotrophia defectiva worldwide are bacteraemia and endocarditis. It is estimated that A. defectiva causes approximately 5-6% of microbiologically proven endocarditis and plays a role in the etiology of ... ...

Abstract	The most frequently reported infections due to Abiotrophia defectiva worldwide are bacteraemia and endocarditis. It is estimated that A. defectiva causes approximately 5-6% of microbiologically proven endocarditis and plays a role in the etiology of culture negative endocarditis. In this article we reported a patient with infective endocarditis (IE) due to penicillin resistant A. defectiva, which caused vegetation in the mitral valve, embolism in the spleen and successfully treated with ertapenem. A 70-year-old female patient was admitted to the emergency service with fever and abdominal pain. The patient had a pronounced widespread abdominal tenderness in the left quadrant. The body temperature was 38.9 °C, C-reactive protein (CRP) level was 12.7 mg/dl and white blood cell count was 13.3x103 mm3. The patient was hospitalized to investigate fever’s reason. It was learned in the anamnesis that she used warfarin. Considering the pre-diagnosis of urinary tract infection, empirical treatment with ceftriaxone 2x1 g/day was started. However, due to the increase in International Normalized Ratio value on the second day of ceftriaxone treatment, ertapenem 1x1 g/day was started by considering drug interaction between warfarin and ceftriaxone. Transesophageal echocardiography of the patient revealed a 1.2x1.2 cm vegetation on the posterior leaflet surface of the mitral valve, and ischemia due to embolism in the spleen was detected on abdominal computer tomography. Penicillin resistant A. defectiva grew in the blood culture. The patient was diagnosed as having IE on the seventh day of her admission. Ertapenem treatment was completed in six weeks due to the patient’s absence of fever, decreased CRP level, and the absence of A. defectiva in the seventh day control blood culture. After treatment, vegetation was not observed in the transthoracic echocardiography of the patient and no signs of ischemia was detected in the spleen. Detection of A. defectiva shaped the follow-up process of our patient by bringing the diagnosis of ...
Keywords	abiotrophia defectiva ; infective endocarditis ; ertapenem ; Medicine ; R ; Infectious and parasitic diseases ; RC109-216
Subject code	630
Language	Turkish
Publishing date	2021-12-01T00:00:00Z
Publisher	Galenos Yayinevi
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A silent outbreak due to Klebsiella pneumoniae that co-produced NDM-1 and OXA-48 carbapenemases, and infection control measures

Yucel Duman / Yasemin Ersoy / Nafia Gursoy / Sibel Altunisik Toplu / Baris Otlu

Iranian Journal of Basic Medical Sciences, Vol 23, Iss 1, Pp 46-

2020 Volume 50

Abstract: Objective(s): Infections due to carbapenemase-producing Klebsiella pneumoniae are associated with high morbidity and mortality. In this study, we report a hospital outbreak due to co-producing OXA-48 and NDM-1 K. pneumoniae clone. The aim of the study is ...

Abstract	Objective(s): Infections due to carbapenemase-producing Klebsiella pneumoniae are associated with high morbidity and mortality. In this study, we report a hospital outbreak due to co-producing OXA-48 and NDM-1 K. pneumoniae clone. The aim of the study is to investigate the clonal relationship of strains, risk factors of outbreak and infection control measures. Materials and Methods: Once an outbreak was suspected at the end of December 2017 in our intensive care unit (ICU), carbapenem resistance K. pneumoniae identified in patients’ specimens. An outbreak analysis was begun to determine the risk factors and dissemination of the cases. A case-control study was conducted to determine the risk factors. To control the outbreak; tight contact prevention, good clean-up the medical devices and hospital environment, were done. Staff training programs such as hand hygiene, disinfection, wearing aprons, good cleaning were created. Carbapenem resistance genes determined by PCR. Clonal relationships of strains investigated by PFGE. Results: We investigate 21 carbapenem-resistant K. pneumonia strains. Nine of them were found co-produced NDM-1 and OXA-48, 11 strains produced OXA-48, and one strain produced NDM-1. Seven strains of co-producing NDM-1 and OXA-48 were found clonally related with PFGE. We could not determine any risk factor except rectal colonization in the case-control study. Conclusion: The interventions that successfully controlled this outbreak were hand hygiene, tight contact prevention, good clean-up of the hospital environment and medical devices. As a result, we believe that it would be beneficial to take infection control measures to prevent the spread of these strains to the community and hospital settings.
Keywords	carbapenemase ; klebsiella pneumoniae ; ndm ; oxa-48 ; outbreak ; Medicine ; R
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Mashhad University of Medical Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparison of minimal inhibitory concentrations (MICs) of tigecycline in 2011 and 2015 years against multidrug-resistance acinetobacter baumannii strains

Yucel Duman / Cigdem Kuzucu / Mehmet Sait Tekerekoglu

Medicine Science, Vol 6, Iss 1, Pp 26-

2017 Volume 9

Abstract: Acinetobacter baumannii is an opportunistic pathogen that causing nosocomial infections. The microorganisms can be developed resistance to antimicrobials very quickly by different mechanisms. Infections defend by MDR strains, caused require long-term ... ...

Abstract	Acinetobacter baumannii is an opportunistic pathogen that causing nosocomial infections. The microorganisms can be developed resistance to antimicrobials very quickly by different mechanisms. Infections defend by MDR strains, caused require long-term hospitalization high morbidity and mortality. Tigecycline is one of the few antimicrobials which have activity against MDR A. baumannii strains. In Meta-analyzes and clinical study reported that a rising risk of mortality in tigecycline-treated patients due to an increase in resistance of these strains. In our study, we aimed to compare the MICs values of tigecycline and determine the resistance rates of tigecycline against to MDR A. baumannii strains in 2011 and 2015. Tigecycline MIC values of 200 A. baumannii isolates were determined by the broth microdilution method. Final concentrations were prepared as 16μg/ml to 0.06μg/ml. Tigecycline MICs breakpoint values comments on breakpoint values of Enterobacteriaceae that have been proposed by FDA. In 2011, tigecycline values of MIC50 and MIC 90 found 0.5μg/ml, 1μg/ml, respectively against to MDR A. baumannii strains. In 2015, tigecycline values of MIC50 and MIC90 found 1μg/ml, 4μg/ml, respectively. In 2011 the 4%, while in 2015, 16% of A. baumannii strains tigecycline MICs were determined over 2μg/ml. and that this was interpreted as the resistance. Tigecycline can be still use as an alternative antimicrobial for treatment of A. baumannii strains, especially in our hospitals intensive care units. However, to avoid the development of resistance against tigecycline, we should prevent the irrational use of antibiotics. The implementation of treatment should be based on antimicrobial susceptibility test results. [Med-Science 2017; 6(1.000): 26-9]
Keywords	Acinetobacter baumannii ; tigecycline ; resistance ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2017-03-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Investigation of HBV DNA in HBsAg positive patients

Nihal Secil Bati / Mehmet Sait Tekerekoglu / Yucel Duman

Medicine Science, Vol 6, Iss 4, Pp 706-

2017 Volume 709

Abstract: Hepatitis B virus is an important health problem which about 400 million people are infected chronically and 500,000 to 1,200,000 people die every year due to HBV-related diseases. In the study we aimed to investigate the HBV DNA results in HBsAg ... ...

Abstract	Hepatitis B virus is an important health problem which about 400 million people are infected chronically and 500,000 to 1,200,000 people die every year due to HBV-related diseases. In the study we aimed to investigate the HBV DNA results in HBsAg positive patients. HBsAg positivity was detected by ELISA method in patients who were admitted to our hospital with suspicion of hepatitis. HBV DNA was performed by real time PCR. In this context, the presence of HBV DNA in serum sample results of 2437 HBsAg-positive patients which were sent to our Microbiology laboratory between August 2014 and August 2015 was retrospectively examined. HBV DNA was positive in 1037 (42.5%) and 1400 (57.5%) of the HBsAg positive cases. 42.2% of male patients and 43% of female patients HBV DNA was positive. HBV DNA positivity was detected in 42% of adult patients and 55% of children in child age group. As a result; we suggest that viral replication should be demonstrated in HBsAg-positive cases and HBV DNA level should be determined for follow-up the antiviral therapy. [Med-Science 2017; 6(4.000): 706-709]
Keywords	HBV ; HBsAg ; HBV DNA ; Real-time PCR ; Medicine ; R ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2017-12-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Seroprevalence of Hepatitis A Virus in Inonu University Medical Faculty Hospital, 2015

Yucel Duman / Mehmet Sait Tekerekoglu / Selma Ay / Ayfer Serindag

Medicine Science, Vol 6, Iss 2, Pp 233-

2017 Volume 5

Abstract: Hepatitis A is the most common pathogen that causes acute viral hepatitis in humans. HAV infection is considered as an important public health concern. The aim of this study was to assess the seroprevalence of anti-HAV IgG and IgM antibodies in our ... ...

Abstract	Hepatitis A is the most common pathogen that causes acute viral hepatitis in humans. HAV infection is considered as an important public health concern. The aim of this study was to assess the seroprevalence of anti-HAV IgG and IgM antibodies in our hospital. The presence of anti-HAV IgG and IgM antibodies were evaluated retrospectively from 7275 serum samples which sent to our hospitals microbiology laboratory in 2015. The presence of anti-HAV IgG and IgM antibodies in serum samples were studied by using macro ELISA Abbott - Architect i2000 system test kits. The 7275 patients serum samples were analyzed. The 74.4% of analyzed samples were positive for anti-HAV IgG antibodies. Anti-HAV IgM antibody positivity rate was found as 1.3%. The 87.4% of anti-HAV IgM positive cases were under the age of 16 and 12.6% were at adulthood stage. The incidence of acute viral hepatitis disease could be reduced by improving hygiene conditions, personal hygiene education, routine vaccination activities, correcting infrastructure and informing people about HAV. We believe that; the data contributes to evaluate the preventive measures, immunization program studies and determination of vaccine efficacy studies. [Med-Science 2017; 6(2.000): 233-5]
Keywords	Hepatitis A ; seroprevalence ; anti-HAV IgG ; Medicine ; R ; Medicine (General) ; R5-920
Language	English
Publishing date	2017-06-01T00:00:00Z
Publisher	Society of TURAZ AKADEMI
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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