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  1. Article ; Online: Depression, anxiety, stress, and job performance among Turkish nurses in the early post-earthquake period.

    Sert, Havva / Gulbahar Eren, Merve / Koc, Ferhat / Yurumez, Yusuf

    International nursing review

    2023  

    Abstract: Background: Individual and social concerns can negatively affect nurses' mental health during a large-scale earthquake's early stages, making it challenging to perform their professional responsibilities.: Aim: This cross-sectional correlational ... ...

    Abstract Background: Individual and social concerns can negatively affect nurses' mental health during a large-scale earthquake's early stages, making it challenging to perform their professional responsibilities.
    Aim: This cross-sectional correlational study aimed to examine the relationship between depression, anxiety, and stress levels Turkish nurses experienced during an earthquake's early period. The nurses participating in this study were not directly present in the earthquake-affected area.
    Methods: The study was conducted on 232 nurses between February 10 and 25, 2023. The data were collected using the Depression, Anxiety, Stress-21 Scale and the Job Performance Evaluation Form developed by the researchers through a literature review. These were used to investigate nurses' work motivation changes due to the earthquake. The study followed the STROBE checklist for cross-sectional studies.
    Results: The participants' depression levels were severe, anxiety levels were extremely severe, and stress levels were moderate following the earthquake. Nurses who felt exhausted experienced reduced energy levels toward their work and reported a decrease in their desire, effort, and work motivation to perform well. In addition, they had higher depression, anxiety, and stress scores (p < 0.005).
    Conclusion: Psychological difficulties, including depression, anxiety, and stress experienced by nurses not directly present in an earthquake-affected area, reduced their professional efforts and motivation and negatively affected the patient care process. Further studies should focus on conducting comparative studies in different cultures affected by natural disasters on the longitudinal analysis of the impacts of nurses' psychological distress on their job performance.
    Implications for nursing and health policy: Nursing policymakers should be aware of the negative psychological effects experienced by nurses during the early post-earthquake period, even if they are not directly present in the earthquake-affected area. The study recommended that nurses should be provided with psychological support to deal with the negative effects of natural disasters and maintain job performance, including the nursing care process.
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 80342-x
    ISSN 1466-7657 ; 0020-8132
    ISSN (online) 1466-7657
    ISSN 0020-8132
    DOI 10.1111/inr.12920
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A 27-year-old Female Patient with Acute nausea/vomiting and Pelvic pain; a Photo Quiz.

    Ozsarac, Murat / Yurumez, Yusuf / Karakayali, Onur

    Archives of academic emergency medicine

    2022  Volume 10, Issue 1, Page(s) e29

    Language English
    Publishing date 2022-04-24
    Publishing country Iran
    Document type Journal Article
    ISSN 2645-4904
    ISSN (online) 2645-4904
    DOI 10.22037/aaem.v10i1.1508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Covid-19 and Management in Emergency Service ; Acil Serviste Covid-19 ve Yönetimi

    YURUMEZ, Yusuf / ALAÇAM, Mehmet

    116-122 ; 2587-1641 ; Journal of Biotechnology and Strategic Health Research

    2020  

    Abstract: One of the most important features of Covid 19 is that it can be transmitted from person to person, and the contamination can be achieved by the airbone droplets in close range infected person. For this reason, emergency services are the most risky areas. ...

    Abstract One of the most important features of Covid 19 is that it can be transmitted from person to person, and the contamination can be achieved by the airbone droplets in close range infected person. For this reason, emergency services are the most risky areas. Covid 19 patients can apply to emergency service by using an ambulance or outpatient. For outpatient applications, a triage area must be organized at the enterance or outside the emergency service and the examination room should be located in the different area then the other departments of emercengy service. Patients brought by ambulance requiring resuscitation should be taken to the resuscitation area, patients not requiring resuscitation should be taken to the examination room and evaluated. The discharge or hospitalization decisions of these patients should be considered by their clinical situations and the patients that needs intensive care must be hospitalizated quickly without waiting.

    Covid-19’un en önemli özelliklerinden birisi insandan insana bulaşabilmesi ve bulaşın enfekte kişi ile yakın mesafede bulunma sırasında ortama saçılan damlacıklar yoluyla gerçekleşebilmesidir. Bu nedenle acil servisler en riskli alanlar içerisinde yer almaktadır. Covid-19 hastaları acil servise ayaktan veya ambulans ile başvurabilir. Ayaktan başvurular için acil servisin girişinde ya da dış kısmında bir triaj alanı ve acil servisin diğer alanlarından farklı bir yerde muayene alanı düzenlenmelidir. Resüsitasyon gerektiren ambulansla getirilen hastalar resüsitasyon alanına alınmalı, resüsitasyon gerektirmeyen hastalar muayene odasına alınmalı ve değerlendirilmelidir. Bu hastaların taburculuk veya yatış kararları klinik durumları dikkate alınarak verilmeli, yoğun bakım gerektiren hastalar bekletilmeksizin hızla yatırılmalıdır.AbstractOne of the most important features of Covid-19 is that it can be transmitted from person to person, and the contamination can be achieved by the airbone droplets in close range infected person. For this reason, emergency services are the most risky areas. Covid-19 patients can apply to emergency service by using an ambulance or outpatient. For outpatient applications, a triage area must be organized at the enterance or outside the emergency service and the examination room should be located in the different area then the other departments of emercengy service. Patients brought by ambulance requiring resuscitation should be taken to the resuscitation area, patients not requiring resuscitation should be taken to the examination room and evaluated. The discharge or hospitalization decisions of these patients should be considered by their clinical situations and the patients that needs intensive care must be hospitalizated quickly without waiting.Keywords: Covid-19, emergency room, infection.
    Keywords Covid-19,emergency service,infection ; Covid-19,acil servis,enfeksiyon ; covid19
    Language Turkish
    Publishing date 2020-04-30T00:00:00Z
    Publisher Deneysel, Biyoteknolojik, Klinik ve Stratejik Sağlık Araştırmaları Derneği
    Publishing country tr
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: INVESTIGATION OF HEALTH INSURANCE COSTS OF THE PATIENTS WITH MILD COVID-19 SYMPTOMS IN EMERGENCY ROOM

    Durmus Ensar / Guneysu Fatih / Guner Gokhan Necip / Aslan Nuray / Yurumez Yusuf

    Sanamed, Vol 16, Iss 2, Pp 155-

    2021  Volume 159

    Abstract: Introduction: This study aims to understand the burden of invoice costs of outpatients with mild Covid-19 symptoms on Social Security Institution (SSI); also, how it may have influenced the current economic situation. Material and Method: This research ... ...

    Abstract Introduction: This study aims to understand the burden of invoice costs of outpatients with mild Covid-19 symptoms on Social Security Institution (SSI); also, how it may have influenced the current economic situation. Material and Method: This research is a cross-sectional, retrospective, and descriptive study. The study universe includes the cases who applied to the emergency room (ER) with the symptoms of Covid-19. The sample group was the patients who applied to the Sakarya Training and Research Hospital (SEAH) pandemic ER between 01/09/2020 and 30/06/2021. Results: During the study period, 130,975 patients were admitted to the pandemic ER. The mean emergency service bill of the cases was $10.6 (± 9), and the lowest was $2.2; the highest was $201.7. There was a weak but significant positive correlation between the patients' age and invoice amount (spearman= 0.051, p=0.001). It was perceived that the emergency service bills of the inpatients (mean=21.9 $) were more than twice that of the outpatients (mean=10.3 $). Conclusion: In pandemic ER, mild symptomatic young patients' bills can be cheap. It was observed that emergency physicians did not apply too many tests and imaging methods in this patient group and were content only with Rt-PCR scanning. Also, ER bills can increase with age.
    Keywords covid-19 ; pandemics ; emergency service ; costs ; Medicine (General) ; R5-920
    Subject code 150
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher Association of medical doctors Sanamed Novi Pazar
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Investigation of Early Diagnostic Value of Glial Fibrillary Acidic Protein and Ubiquitin C-Terminal Hydrolase Blood Levels in Minor Head Trauma in Turkey.

    Polat, Zeynep M / Yucel, Murat / Cikriklar, Halil I / Altındiş, Mustafa / Yurumez, Yusuf

    Clinical laboratory

    2022  Volume 68, Issue 8

    Abstract: Background: The aim was to investigate the early diagnostic value of serum glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) levels in adults with minor head trauma (MHT) and whether it could be an alternative diagnostic ...

    Abstract Background: The aim was to investigate the early diagnostic value of serum glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) levels in adults with minor head trauma (MHT) and whether it could be an alternative diagnostic method to computed tomography (CT). This is the first study with the combination of GFAP and UCH-L1 in the first 3 hours of MHT.
    Methods: The study comprised 88 patients, 60 patients and 28 controls, who were evaluated as having MHT, were admitted to the emergency department of our hospital within the first 3 hours of the trauma and met the inclusion criteria. CT was performed on all patients. Serum GFAP and UCH-L1 levels were measured within the first 3 hours of the trauma.
    Results: The median serum GFAP level was 1.07 ng/mL in the group with pathology on CT and 0.42 ng/mL in the group with no pathology on CT. The median serum UCH-L1 level was 0.40 ng/mL in the group with pathology on CT and 0.39 ng/mL in the group with no pathology on CT. A statistically significant difference was found between the serum GFAP levels of the CT (+) group and the CT (-) group (p = 0.021). GFAP levels were compared according to the CT (+) and CT (-) groups with a cutoff value of ≥ 1.56 ng/mL for GFAP, which had 50% sensitivity and 97.5% specificity. This was statistically significant (p = 0.008). It was found that the UCH-L1 level of the control group was lower than the UCH-L1 levels of the CT (+) and CT (-) groups, and this difference was found to be statistically significant (p = 0.003 and p = 0.018, respectively).
    Conclusions: GFAP was found to be more specific than UCH-L1 in demonstrating the presence of intracranial pathology in patients with head trauma who were admitted to the emergency department in the first 3 hours after trauma.
    MeSH term(s) Adult ; Biomarkers/blood ; Craniocerebral Trauma/diagnosis ; Glial Fibrillary Acidic Protein/blood ; Humans ; Turkey ; Ubiquitin Thiolesterase/blood
    Chemical Substances Biomarkers ; Glial Fibrillary Acidic Protein ; Ubiquitin Thiolesterase (EC 3.4.19.12)
    Language English
    Publishing date 2022-08-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1307629-2
    ISSN 1433-6510 ; 0941-2131
    ISSN 1433-6510 ; 0941-2131
    DOI 10.7754/Clin.Lab.2021.211042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Abdominal Pain Management and Point-of-care Ultrasound in the Emergency Department: A Randomised, Prospective, Controlled Study.

    Durgun, Yesim / Yurumez, Yusuf / Guner, Necip Gokhan / Aslan, Nuray / Durmus, Ensar / Kahraman, Yavuz

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2022  Volume 32, Issue 10, Page(s) 1260–1265

    Abstract: Objective: To determine the effect of point-of-care ultrasound (POCUS) performed during the initial evaluation phase of patients with acute abdominal pain.: Study design: Randomised controlled, parallel-group trial.: Place and duration of study: ... ...

    Abstract Objective: To determine the effect of point-of-care ultrasound (POCUS) performed during the initial evaluation phase of patients with acute abdominal pain.
    Study design: Randomised controlled, parallel-group trial.
    Place and duration of study: Sakarya University Training and Research Hospital, Sakarya, Turkey, from October 2019 to March 2020.
    Methodology: Patients who presented to the Emergency Department (ED) with acute abdominal pain were included in the study. Exclusion criteria were permanent mental disability, age <18 years, abdominal trauma within the last 24 hours, pregnancy, morbid obesity, repeated admissions, referral from an external centre to the ED, and missing patient information. Patients were divided randomly into two groups: The control group where standard diagnostic strategies were applied and the POCUS group where POCUS was performed together with standard diagnostic strategies. The length of stay (LOS), differential diagnoses, cost and hospitalisation or discharge from ED were compared.
    Results: The application of POCUS reduced the average number of preliminary differential diagnoses from four to two (p <0.001). Regarding patient outcomes, POCUS reduced LOS in ED in both the discharged and hospitalised patients (p = 0.003, and p = 0.049, respectively). In all patients, POCUS reduced LOS in ED but led to no significant changes in cost (p <0.001, p = and 0.403, respectively).
    Conclusion: POCUS in patients with acute abdominal pain is very useful in reducing the number of differential diagnoses and LOS in ED.
    Key words: Abdominal pain, Cost, Emergency department, Length of stay, Point-of-care ultrasound.
    MeSH term(s) Abdominal Pain/diagnostic imaging ; Abdominal Pain/etiology ; Adolescent ; Emergency Service, Hospital ; Female ; Humans ; Pain Management ; Point-of-Care Systems ; Pregnancy ; Prospective Studies ; Ultrasonography
    Language English
    Publishing date 2022-09-29
    Publishing country Pakistan
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2022.10.1260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparison of saliva and oro-nasopharyngeal swab sample in the molecular diagnosis of COVID-19

    Güçlü, Ertuğrul / Koroglu, Mehmet / Yürümez, Yusuf / Toptan, Hande / Kose, Elif / Güneysu, Fatih / Karabay, Oğuz

    Revista da Associação Médica Brasileira v.66 n.8 2020

    2020  

    Abstract: SUMMARY BACKGROUND Healthcare personnel are at risk of becoming infected while taking upper and/or lower respiratory tract specimens. Therefore, there is a need for sampling methods that do not risk infecting them. In this study, we aimed to compare the ... ...

    Abstract SUMMARY BACKGROUND Healthcare personnel are at risk of becoming infected while taking upper and/or lower respiratory tract specimens. Therefore, there is a need for sampling methods that do not risk infecting them. In this study, we aimed to compare the saliva and Oro-Nasopharyngeal Swab (ONS) sampling methods. METHODS Patients were divided into three groups. Group 1 included patients whose diagnosis of COVID-19 was confirmed by polymerase chain reaction (PCR). Group 2 included patients with COVID-19 compatible findings in lung computed tomography (CT), but with a negative PCR. Group 3 included patients who presented to the emergency department with COVID-19 compatible complaints but had normal CT. Saliva and ONS samples were taken on the third day of hospitalization in groups 1 and 2, whereas in group 3, they were taken at the time of admission to the hospital. RESULTS A total of 64 patients were included in the study. The average age was 51.04 ± 17.9 years, and 37 (57.8%) were male. SARS-CoV-2 was detected in 27 (42.2%) patients’ saliva samples. While the sensitivity and positive predictive value of saliva samples were 85.2%, specificity and negative predictive value were 89.2%. The value of kappa was in substantial agreement (0.744), and it was found statistically significant (<0.001). CONCLUSIONS Saliva samples can be used instead of ONS samples in detecting SARS-CoV-2. Investigating SARS-CoV-2 with saliva is cheaper, easier for the patient and overall, and, most importantly, it poses much less risk of SARS-CoV-2 contamination to healthcare personnel.
    Keywords Coronavirus Infections/diagnosis ; Saliva ; Health Personnel ; Betacoronavirus ; covid19
    Subject code 610
    Language English
    Publishing date 2020-08-01
    Publisher Associação Médica Brasileira
    Publishing country br
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Effects of Point-of-care Ultrasonography on the Diagnostic Process of Patients Admitted to the Emergency Department with Chest Pain: A Randomised Controlled Trial.

    Guner, Necip Gokhan / Yurumez, Yusuf / Yucel, Murat / Alacam, Mehmet / Guner, Seda Turkmen / Ercan, Bilge

    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP

    2021  Volume 30, Issue 12, Page(s) 1262–1268

    Abstract: Objective: To evaluate the effect of point of care ultrasonography (POCUS) performed for heart, lung, aorta, hepatobiliary and deep veins on the diagnosis, length of stay (LOS) in emergency department (ED) and cost in patients admitted to the ED with ... ...

    Abstract Objective: To evaluate the effect of point of care ultrasonography (POCUS) performed for heart, lung, aorta, hepatobiliary and deep veins on the diagnosis, length of stay (LOS) in emergency department (ED) and cost in patients admitted to the ED with chest pain.
    Study design: Prospective randomised controlled, parallel-group trial.
    Place and duration of study: Sakarya University Training and Research Hospital, Sakarya Turkey, from September 2018 to March 2019.
    Methodology: Patients (≥18 years) with chest pain were randomly assigned at a 1:1 ratio to a standard diagnostic strategy (control group) or to standard diagnostic strategy supplemented with POCUS (POCUS group). Data obtained from the study were analysed using IBM SPSS Statistics 21.
    Results: Two hundred and eight patients were randomly assigned to the control (n=104) and POCUS groups (n=104), respectively. The mean age was 50.42 ± 16.15, and 54% were men. The most common comorbidity was hypertension (43%). Non-ST elevation myocardial infarction and musculoskeletal pain were the most common presumptive diagnoses. POCUS significantly reduced the LOS in ED. Detection of pathology in the POCUS increased the rate of hospitalisation. In addition, POCUS significantly shortened the LOS in the ED in patients who were discharged. The median LOS in the ED for the POCUS group was 133 min (91-279), which was significantly shorter than that of the control group at 215 min (118-372) (p=0.006). Although the average costs were also reduced, the difference was not statistically significant (p=0.269).
    Conclusion: POCUS is a repeatable, practical imaging method which does not require radiation, reduces LOS in the ED statistically significant. However, further studies are needed to determine its usefulness in the ED. Key Words: Chest pain, Cost, Emergency medicine, Length of stay, Point of care ultrasound.
    MeSH term(s) Adult ; Aged ; Chest Pain/diagnostic imaging ; Chest Pain/etiology ; Emergency Service, Hospital ; Female ; Humans ; Length of Stay ; Male ; Middle Aged ; Point-of-Care Systems ; Prospective Studies ; Turkey ; Ultrasonography
    Language English
    Publishing date 2021-01-04
    Publishing country Pakistan
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2276646-7
    ISSN 1681-7168 ; 1022-386X
    ISSN (online) 1681-7168
    ISSN 1022-386X
    DOI 10.29271/jcpsp.2020.12.1262
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparison of saliva and oro-nasopharyngeal swab sample in the molecular diagnosis of COVID-19.

    Güçlü, Ertuğrul / Koroglu, Mehmet / Yürümez, Yusuf / Toptan, Hande / Kose, Elif / Güneysu, Fatih / Karabay, Oğuz

    Revista da Associacao Medica Brasileira (1992)

    2020  Volume 66, Issue 8, Page(s) 1116–1121

    Abstract: Background: Healthcare personnel are at risk of becoming infected while taking upper and/or lower respiratory tract specimens. Therefore, there is a need for sampling methods that do not risk infecting them. In this study, we aimed to compare the saliva ...

    Abstract Background: Healthcare personnel are at risk of becoming infected while taking upper and/or lower respiratory tract specimens. Therefore, there is a need for sampling methods that do not risk infecting them. In this study, we aimed to compare the saliva and Oro-Nasopharyngeal Swab (ONS) sampling methods.
    Methods: Patients were divided into three groups. Group 1 included patients whose diagnosis of COVID-19 was confirmed by polymerase chain reaction (PCR). Group 2 included patients with COVID-19 compatible findings in lung computed tomography (CT), but with a negative PCR. Group 3 included patients who presented to the emergency department with COVID-19 compatible complaints but had normal CT. Saliva and ONS samples were taken on the third day of hospitalization in groups 1 and 2, whereas in group 3, they were taken at the time of admission to the hospital.
    Results: A total of 64 patients were included in the study. The average age was 51.04 ± 17.9 years, and 37 (57.8%) were male. SARS-CoV-2 was detected in 27 (42.2%) patients' saliva samples. While the sensitivity and positive predictive value of saliva samples were 85.2%, specificity and negative predictive value were 89.2%. The value of kappa was in substantial agreement (0.744), and it was found statistically significant (<0.001).
    Conclusions: Saliva samples can be used instead of ONS samples in detecting SARS-CoV-2. Investigating SARS-CoV-2 with saliva is cheaper, easier for the patient and overall, and, most importantly, it poses much less risk of SARS-CoV-2 contamination to healthcare personnel.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/diagnosis ; Humans ; Male ; Middle Aged ; Nasopharynx ; Pandemics ; Pneumonia, Viral/diagnosis ; SARS-CoV-2 ; Saliva
    Keywords covid19
    Language English
    Publishing date 2020-09-16
    Publishing country Brazil
    Document type Comparative Study ; Journal Article
    ZDB-ID 731969-1
    ISSN 1806-9282 ; 0104-4230 ; 0004-5241 ; 0102-843X
    ISSN (online) 1806-9282
    ISSN 0104-4230 ; 0004-5241 ; 0102-843X
    DOI 10.1590/1806-9282.66.8.1116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Thiol/disulfide homeostasis as a novel indicator of oxidative stress in children with simple febrile seizures.

    Elmas, Bahri / Erel, Özcan / Ersavaş, Dilek / Yürümez, Yusuf

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2017  Volume 38, Issue 11, Page(s) 1969–1975

    Abstract: Simple febrile seizures are generally benign, but during the seizure, elevated levels of glutamate and high levels of oxygen use due to the high metabolic brain activity result in oxidative stress. However, the relationship between febrile seizures and ... ...

    Abstract Simple febrile seizures are generally benign, but during the seizure, elevated levels of glutamate and high levels of oxygen use due to the high metabolic brain activity result in oxidative stress. However, the relationship between febrile seizures and oxidative stress remains unclear. In this study, we investigated thiol/disulfide homeostasis as a new oxidative stress parameter in patients with simple febrile seizures. This study was performed between February 2016 and May 2016 at the Pediatric Emergency Unit. The study population consisted of 40 patients with a diagnosis of simple febrile seizure and 30 control participants aged 8-59 months. Total thiol, native thiol and disulfide levels, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were used as thiol/disulfide homeostasis parameters and were quantified in patient and control groups. Furthermore, correlations with seizure duration were investigated. In the patient group, native and total thiol levels and native thiol/total thiol ratios were low, and disulfide levels, disulfide/native thiol, and disulfide/total thiol ratios were significantly higher than in the control group. Negative correlations were observed between seizure duration, total and native thiol levels, and native thiol/total thiol ratio, whereas positive correlations were observed between seizure duration and disulfide/native thiol and disulfide/total thiol ratio. The sensitivities of both disulfide/native thiol and disulfide/total thiol ratios were high for simple febrile seizures. Simple febrile seizures may cause impairment in favor of disulfide bonds in thiol/disulfide homeostasis. Overall, these changes may contribute to neuronal cell damage after simple febrile seizures.
    Language English
    Publishing date 2017-11
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-017-3087-2
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