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Article ; Online: Association between pan-immune inflammatory value and ulcerative colitis.

Mete Yıldırım, Aslıhan / Yıldırım, Oğuzhan

2024 Volume 40, Issue 4, Page(s) 599–603

Abstract: Objective: Ulcerative colitis is a chronic idiopathic disease that causes inflammation of the colon and rectum, progressing with relapses and remissions. Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) are newly developed ... ...

Abstract	Objective: Ulcerative colitis is a chronic idiopathic disease that causes inflammation of the colon and rectum, progressing with relapses and remissions. Systemic inflammatory index (SII) and pan-immune inflammatory value (PIV) are newly developed biomarkers. There are many studies in the literature showing the relationship between SII and PIV with malignancies and inflammatory diseases. In this study we aimed to determine the relationship between SII and PIV with the activity of ulcerative colitis. Materials and methods: 146 Ulcerative colitis patients were retrospectively investigated by the time of diagnosis based on clinical, endoscopic and histolopathological findings. Patients and healthy individuals SII and PIV levels were calculated and compared with each other; and Mayo, DUBLIN, UCIES endoscopic subscores of patients were also obtained. Roc curve analysis were used to determine the cut-off value for PIV. Results: SII (468.6 ± 203.5 vs. 823.1 ± 555.1; Conclusion: Based on the results of our study, we found that SII and PIV levels were significantly increased in ulcerative colitis patients at the time of diagnosis and were associated with disease severity in the endoscopic scores RACHMILEWITZ, UCEIS and DUBLIN scores, but not for MES score.
MeSH term(s)	Humans ; Colitis, Ulcerative ; Colonoscopy/methods ; Retrospective Studies ; Severity of Illness Index ; Feces
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2024.2316860
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Article ; Online: Kinetic, equilibrium and thermodynamic investigations for the bio-sorption of dyes onto crosslinked Pleurotus ostreatus-based bio-composite

Yildirim, Ayfer

International Journal of Environmental Analytical Chemistry. 2022 Dec. 23, v. 102, no. 17 p.5664-5679

2022

Abstract: Water pollution due to dyes has a significant impact on the environment and causes unfavourable risks for human health. This study aimed to synthesise a crosslinked Pleurotus ostreatus-based bio-composite as an efficient low cost biosorbent and ... ...

Abstract	Water pollution due to dyes has a significant impact on the environment and causes unfavourable risks for human health. This study aimed to synthesise a crosslinked Pleurotus ostreatus-based bio-composite as an efficient low cost biosorbent and investigate its bio-sorption performance for dyes via kinetic, isotherm and thermodynamic parameters. The characterisation of the bio-composite was determined by Fourier transform infrared spectrophotometer, field-emission scanning electron microscopy, differential scanning calorimetry and X-ray diffraction. Two reflections peaks, 2θ = 13° and 21°, were revealed in the X-ray diffraction pattern of the bio-composite. The effects of contact time, pH and initial dye concentration were investigated as the physical-chemical parameters. The neutral pH was found as an optimum pH for dyes. The reuse test revealed that the bio-sorbent was capable of using 5 times for dyes. The pseudo-first order and pseudo-second order kinetic models were applied to determine the mechanism of the adsorption process. The isotherm investigation was conducted using the Langmuir and Freundlich isotherm models. The experimental data was determined to be in the good agreement with the pseudo-second-order model and Langmuir isotherm model. The maximum adsorption capacity was measured to be 77.11 and 40.11 mg/g for the bio-sorption of malachite green and methylene blue, respectively. The thermodynamic studies of the bio-sorption showed that the adsorption process was a spontaneous endothermic process and that disorder increased during the process. This study indicated that the synthesised bio-sorbent could be used as an eco-friendly, cost-effective and recyclable bio-composite for the bio-sorption of dyes from aqueous solution.
Keywords	Fourier transform infrared spectroscopy ; Pleurotus ; X-ray diffraction ; adsorption ; analytical chemistry ; aqueous solutions ; biocomposites ; biosorbents ; biosorption ; calorimetry ; cost effectiveness ; crosslinking ; electron microscopy ; endothermy ; environmental impact ; human health ; malachite green ; methylene blue ; models ; pH ; sorption isotherms ; thermodynamics ; water pollution ; Bio-composite ; bio-sorption ; kinetic ; Pleurotus ostreatus ; thermodynamic
Language	English
Dates of publication	2022-1223
Size	p. 5664-5679.
Publishing place	Taylor & Francis
Document type	Article ; Online
ZDB-ID	120480-4
ISSN	1029-0397 ; 0306-7319 ; 0092-9085
ISSN (online)	1029-0397
ISSN	0306-7319 ; 0092-9085
DOI	10.1080/03067319.2020.1802441
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Article: An Ionic Liquid Promoted Clean and Direct Conversion of Triglycerides into Bio‐Based Thermal Energy Storage Materials

Yıldırım, Ayhan

European journal of lipid science and technology. 2022 June, v. 124, no. 6

2022

Abstract: In the present study, triglycerides are subjected to an ionic liquid (IL) catalyzed and solventless transesterification reaction with a series of fatty alcohols in a 1:3 ratio, respectively. In order to prepare the corresponding wax esters, triglycerides ...

Abstract	In the present study, triglycerides are subjected to an ionic liquid (IL) catalyzed and solventless transesterification reaction with a series of fatty alcohols in a 1:3 ratio, respectively. In order to prepare the corresponding wax esters, triglycerides trilaurin, trimyristin, and tristearin are treated with fatty alcohols such as lauryl, myristyl, and stearyl alcohol via 1,3‐disulfonic acid imidazolium chloride catalyzed transesterification reaction under environmentally friendly conditions. The optimum duration of the transesterification reaction is determined by proton nuclear magnetic resonance spectroscopy and the progress of the reaction can also be easily followed by thin layer chromatography. According to these studies, the reaction takes about 2 h to complete and the corresponding wax esters are obtained successfully by recrystallization from suitable solvent mixture without tedious work‐up in good to excellent yields (86–100%). Practical Applications: With this sustainable method, a homologous series of wax esters can be successfully synthesized as bio‐based thermal energy storage materials. The prominent aspect of this solventless method is that it allows the preparation of wax esters directly from triglycerides via an ionic liquid catalyzed process both in laboratory and industrial scale.
Keywords	catalytic activity ; crystallization ; imidazole ; ionic liquids ; nuclear magnetic resonance spectroscopy ; technology ; thermal energy ; thin layer chromatography ; transesterification
Language	English
Dates of publication	2022-06
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2003265-1
ISSN	1438-7697
ISSN	1438-7697
DOI	10.1002/ejlt.202200032
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Article: Influence of temperature, ultrasound, and variety on moisture diffusivity and thermodynamic properties of some durum wheat varieties during hydration

Yıldırım, Ali

Journal of food processing and preservation. 2022 Apr., v. 46, no. 4

2022

Abstract: This study covers the effect of temperature, ultrasound, and variety on moisture diffusivity and thermodynamic properties of durum wheat varieties during hydration. The process was performed at hydration temperatures of 25, 35, 45, and 55°C during ... ...

Abstract	This study covers the effect of temperature, ultrasound, and variety on moisture diffusivity and thermodynamic properties of durum wheat varieties during hydration. The process was performed at hydration temperatures of 25, 35, 45, and 55°C during conventional and ultrasound‐assisted soaking. The Fick’s diffusion model fitted the experimental data satisfactorily with average coefficient of determination of 0.9946, root mean square error (%, d.b) of 0.0296, Chi‐square of 0.0013, and relative mean error (%) of 0.0205, respectively. Dₑff of wheat varieties during hydration process increased with the ultrasound treatment and temperature increase. Activation energy of wheat varieties decreased with the ultrasound (40 kHz, 200 W) treatment. Increase in Gibbs free energy and negative values of enthalpy and entropy changes with increasing temperature and ultrasonication process confirming the effect of temperature and ultrasound on Dₑff of wheat varieties during hydration process. NOVELTY IMPACT STATEMENT: The results of this investigation can assist wheat products industry in understanding heat and mass transfer phenomena during ultrasound‐assisted hydration process of different wheat varieties in tempering, cooking, milling, fermentation, formulation of meals, and storage processes. The results of this study can also be useful in optimizing ultrasound‐assisted hydration process and improving the thermodynamic properties of different wheat varieties. New derived generalized hydration equations can be useful for temperature and time‐dependent moisture content detection during ultrasound‐assisted and conventional hydration processes of wheat varieties.
Keywords	Gibbs free energy ; activation energy ; durum wheat ; enthalpy ; entropy ; fermentation ; heat ; industry ; mass transfer ; models ; moisture diffusivity ; temperature ; ultrasonic treatment ; ultrasonics ; water content
Language	English
Dates of publication	2022-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	243448-9
ISSN	1745-4549 ; 0145-8892
ISSN (online)	1745-4549
ISSN	0145-8892
DOI	10.1111/jfpp.16463
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Article ; Online: Mid-term results of autologous matrix-induced chondrogenesis surgery with or without scaffolds for arthroscopic treatment of deep talus osteochondral lesions: A comparative study.

Kekeç, Ahmet Fevzi / Yıldırım, Ahmet

Joint diseases and related surgery

2023 Volume 34, Issue 3, Page(s) 613–619

Abstract: Objectives: This study aims to investigate the effectiveness of arthroscopic autologous matrix-induced chondrogenesis (AMIC) procedure with or without polyglycolic acid-hyaluronic acid (PGA-HA)-based cell-free scaffold (CFS) in Bristol Stage 4 and Stage ...

Abstract	Objectives: This study aims to investigate the effectiveness of arthroscopic autologous matrix-induced chondrogenesis (AMIC) procedure with or without polyglycolic acid-hyaluronic acid (PGA-HA)-based cell-free scaffold (CFS) in Bristol Stage 4 and Stage 5 osteochondral lesion of the talus (OLT) ranging between 1.5 and 3 cm Patients and methods: Between March 2018 and March 2021, a total of 47 patients with OLTs (29 males, 18 females; mean age: 22.8±2.3 years; range, 18 to 65 years) were retrospectively analyzed. The patients were divided into two groups based on the procedures applied. Patients in the first group (Group 1, n=23) underwent the AMIC procedure alone (curettage, microfracture, and grafting), while patients in the second group (Group 2, n=24) underwent AMIC procedure with PGA-HA-based CFS. The localization of the lesions was evaluated. All OLTs were diagnosed with preoperative radiography and magnetic resonance imaging (MRI). During the preoperative period, lesion stages were evaluated based on the Bristol staging system, and the postoperative results were evaluated based on the Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) scoring system. Results: The mean follow-up was 36.2±5.6 months. In the early period, the three-month functional scores were comparable between the groups. While a significant increase was observed in the American Orthopaedic Foot and Ankle Society (AOFAS) scores from the mean preoperative of 62.71±4.44 points to the postoperative of 86.00±6.58 points in Group 1, a significant increase in the AOFAS score was observed from 65.28±7.91 points to 95.42±4.41 points in Group 2 at 12-month follow-up (p=0.016, p=0.011, respectively). The functional scores tended to progress after 12 months. Radiologically, a complete defect filling was observed in a mean of 10.5±2.7 months. No graft hypertrophy was recorded in any patients. The AOFAS and MOCART scores in Group 2 were found to be statistically significantly higher than that in Group 1 (p=0.034 for AOFAS 1/AOFAS 2 and p=0.006 for MOCART 1/MOCART 2). Overall, there was a positive, but weak, significant correlation between the final AOFAS scores and MOCART scores (r=0.347, p<0.001). Conclusion: Arthroscopic AMIC procedure in deep OLTs between 1.5 cm
MeSH term(s)	Male ; Female ; Humans ; Young Adult ; Adult ; Treatment Outcome ; Follow-Up Studies ; Talus/diagnostic imaging ; Talus/surgery ; Chondrogenesis ; Retrospective Studies
Language	English
Publishing date	2023-08-22
Publishing country	Turkey
Document type	Journal Article
ISSN	2687-4792
ISSN (online)	2687-4792
DOI	10.52312/jdrs.2023.1197
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Article: Non-stationary neural signal to image conversion framework for image-based deep learning algorithms.

Patel, Sahaj Anilbhai / Yildirim, Abidin

Frontiers in neuroinformatics

2023 Volume 17, Page(s) 1081160

Abstract: This paper presents a time-efficient preprocessing framework that converts any given 1D physiological signal recordings into a 2D image representation for training image-based deep learning models. The non-stationary signal is rasterized into the 2D ... ...

Abstract	This paper presents a time-efficient preprocessing framework that converts any given 1D physiological signal recordings into a 2D image representation for training image-based deep learning models. The non-stationary signal is rasterized into the 2D image using Bresenham's line algorithm with time complexity O(n). The robustness of the proposed approach is evaluated based on two publicly available datasets. This study classified three different neural spikes (multi-class) and EEG epileptic seizure and non-seizure (binary class) based on shapes using a modified 2D Convolution Neural Network (2D CNN). The multi-class dataset consists of artificially simulated neural recordings with different Signal-to-Noise Ratios (SNR). The 2D CNN architecture showed significant performance for all individual SNRs scores with (SNR/ACC): 0.5/99.69, 0.75/99.69, 1.0/99.49, 1.25/98.85, 1.5/97.43, 1.75/95.20 and 2.0/91.98. Additionally, the binary class dataset also achieved 97.52% accuracy by outperforming several others proposed algorithms. Likewise, this approach could be employed on other biomedical signals such as Electrocardiograph (EKG) and Electromyography (EMG).
Language	English
Publishing date	2023-03-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2452979-5
ISSN	1662-5196
ISSN	1662-5196
DOI	10.3389/fninf.2023.1081160
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Article ; Online: Investigation of

Yıldırım, Ayşenur / Ataş, Ahmet Duran

Turkiye parazitolojii dergisi

2023 Volume 47, Issue 4, Page(s) 209–213

Abstract: Objective: Toxoplasma gondii: Methods: In this study, 176 pregnant women who applied to our hospital between January 2019 and December 2020 were included. 88 (50%) of the pregnant women had pre-eclampsia and 88 (50%) were normotensive. The presence ... ...

Title translation	Preeklampsili Gebelerde
Abstract	Objective: Toxoplasma gondii Methods: In this study, 176 pregnant women who applied to our hospital between January 2019 and December 2020 were included. 88 (50%) of the pregnant women had pre-eclampsia and 88 (50%) were normotensive. The presence of Results: Because of the study, both groups were found to be seronegative in terms of Conclusion: Because of the study, no statistically significant difference was found between pregnant women with pre-eclampsia and those with toxoplasmosis. It was thought that further studies should be conducted to discuss the hormonal, vascular, etc. factors occurring in the pathogenesis of preeclampsia of
MeSH term(s)	Female ; Pregnancy ; Humans ; Toxoplasma ; Pre-Eclampsia/epidemiology ; Seroepidemiologic Studies ; Antibodies, Protozoan ; Immunoglobulin M ; Toxoplasmosis/complications ; Toxoplasmosis/epidemiology ; Pregnancy Complications, Parasitic/epidemiology ; Risk Factors ; Immunoglobulin G
Chemical Substances	Antibodies, Protozoan ; Immunoglobulin M ; Immunoglobulin G
Language	English
Publishing date	2023-12-07
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2651106-X
ISSN	2146-3077 ; 2146-3077
ISSN (online)	2146-3077
ISSN	2146-3077
DOI	10.4274/tpd.galenos.2023.80664
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Article: Predictive Performance of Triglyceride-Glucose Index on Asymptomatic Multiple Organ Damage in Patients with Newly Diagnosed Hypertension.

Kivrak, Ahmet / Yildirim, Alp

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

2023 Volume 75, Issue 5, Page(s) 221–232

Abstract: Background: Insulin resistance (IR) contributes to the development of hypertension and mediated organ damage (HMOD) through various mechanisms.: Objectives: The objective of the study was to assess the diagnostic performance of the triglyceride- ... ...

Abstract	Background: Insulin resistance (IR) contributes to the development of hypertension and mediated organ damage (HMOD) through various mechanisms. Objectives: The objective of the study was to assess the diagnostic performance of the triglyceride-glucose (TyG) index, a surrogate marker of IR, in predicting the presence and severity of HMOD in newly diagnosed untreated hypertensive patients from an academic training and research hospital Methods: The study included 438 patients with newly diagnosed, untreated hypertension. The control group comprised normotensive individuals matched on a 1:1 ratio based on age, gender, body mass index, and smoking using the nearest neighbor method. The presence of HMOD was defined by renal damage (microalbuminuria > 30 mg/day or proteinuria > 150 mg/day), vascular damage (carotid intima-media thickness > 0.9 mm or presence of plaque), or cardiac damage (left ventricular mass index > 95 g/m2 in women and > 115 g/m2 in men). The severity of HMOD was considered as single-, two-, or triple-organ damage. Results: TyG index values were higher in the hypertensive group than the normotensive group. An increased TyG index was independently associated with HMOD (OR: 1.33, p < 0.001). The TyG index exhibited gradually increasing threshold values for distinguishing patients with single-organ HMOD (> 8.8 with 77.8% sensitivity and 74.3% specificity), two-organ HMOD (> 9.1 with 77.6% sensitivity and 71.4% specificity), and triple-organ HMOD (> 9.4 with 71.5% sensitivity and 87.7% specificity). Conclusions: In newly diagnosed hypertensive patients, the TyG index exhibits significant diagnostic performance in predicting multiple-organ damage beyond the presence of HMOD. Since the detection of multiple-organ HMOD requires a multidisciplinary approach, the TyG index can serve as a simple and inexpensive screening tool.
MeSH term(s)	Male ; Humans ; Female ; Glucose ; Carotid Intima-Media Thickness ; Triglycerides ; Hypertension/complications ; Insulin Resistance ; Biomarkers ; Blood Glucose
Chemical Substances	Glucose (IY9XDZ35W2) ; Triglycerides ; Biomarkers ; Blood Glucose
Language	English
Publishing date	2023-10-11
Publishing country	Mexico
Document type	Journal Article
ZDB-ID	138348-6
ISSN	0034-8376
ISSN	0034-8376
DOI	10.24875/RIC.23000113
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Article ; Online: A very rare interarterial communication: total occlusion of right coronary artery with antegrade collateral supply from left circumflex artery through conus branch.

Yıldırım, Alp / Sökmen, Erdoğan

Surgical and radiologic anatomy : SRA

2023 Volume 45, Issue 8, Page(s) 1027–1030

Abstract: Purpose: The purpose of the present case report is to describe an extremely rare and unusual coronary interarterial communication.: Methods: A 65-year-old female patient admitted with acute coronary syndrome underwent a coronary angiography performed ...

Abstract	Purpose: The purpose of the present case report is to describe an extremely rare and unusual coronary interarterial communication. Methods: A 65-year-old female patient admitted with acute coronary syndrome underwent a coronary angiography performed with Judkins technique to obtain standard angiographic views. Results: We have demonstrated a very rare interarterial communication traversing an unusual retroaortic path between the body of left circumflex artery and the conus branch of the right coronary artery. Conclusion: Coronary interarterial communications are rarely encountered; however, may fulfill important tasks in the coronary circulation. Therefore, invasive cardiologists and cardiovascular surgeons should be aware of their presence.
MeSH term(s)	Female ; Animals ; Humans ; Aged ; Coronary Vessels/diagnostic imaging ; Conus Snail ; Coronary Angiography/methods ; Coronary Circulation ; Heart ; Coronary Vessel Anomalies ; Collateral Circulation
Language	English
Publishing date	2023-06-04
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	632839-8
ISSN	1279-8517 ; 0930-312X ; 0930-1038
ISSN (online)	1279-8517
ISSN	0930-312X ; 0930-1038
DOI	10.1007/s00276-023-03173-0
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Article ; Online: Effect of Repeated Multipatient Simulations on Professional Readiness Among Senior Nursing Students.

Tarhan, Merve / Yıldırım, Aytolan

Nurse educator

2023 Volume 48, Issue 4, Page(s) 197–203

Abstract: Background: Senior nursing students are expected to be ready in terms of professional decisions and practices as soon as possible after graduation. Quality and Safety Education for Nurses (QSEN) is a framework to prepare nursing students for practice in ...

Abstract	Background: Senior nursing students are expected to be ready in terms of professional decisions and practices as soon as possible after graduation. Quality and Safety Education for Nurses (QSEN) is a framework to prepare nursing students for practice in the health care system. Purpose: This study aimed to explore the effect of repeated exposure to multipatient simulations on senior nursing students' pregraduation transition views, QSEN knowledge level and self-competency, professional readiness, and postgraduation transition shock. Methods: A randomized controlled trial of intervention and control groups with pretest, posttest, and a follow-up was conducted with 78 senior nursing students at a private, accredited, nursing program in Istanbul, Turkey. Results: There was a statistically significant improvement in the intervention group between the pretest and the posttest for self-confidence ( P < .01), QSEN knowledge level ( P < .01), and professional readiness ( P < .01). The QSEN knowledge level ( P < .01) and professional competency ( P < .05) of the intervention group were higher than those of the control group. Conclusion: These results suggest that multipatient simulations may be an effective strategy to better prepare students for the health care system's demands.
MeSH term(s)	Humans ; Students, Nursing ; Nursing Education Research ; Delivery of Health Care ; Education, Nursing, Baccalaureate/methods
Language	English
Publishing date	2023-02-06
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1034267-9
ISSN	1538-9855 ; 0363-3624
ISSN (online)	1538-9855
ISSN	0363-3624
DOI	10.1097/NNE.0000000000001373
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