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  1. Article ; Online: Author Correction: Impact of the Lorentz force on electron track structure and early DNA damage yields in magnetic resonance-guided radiotherapy.

    Yachi, Yoshie / Kai, Takeshi / Matsuya, Yusuke / Hirata, Yuho / Yoshii, Yuji / Date, Hiroyuki

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 2239

    Language English
    Publishing date 2023-02-08
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-29348-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Analytical Method for Quantifying the Yields of DNA Double-Strand Breaks Coupled with Strand Breaks by γ-H2AX Focus Formation Assay Based on Track-Structure Simulation.

    Yachi, Yoshie / Matsuya, Yusuke / Yoshii, Yuji / Fukunaga, Hisanori / Date, Hiroyuki / Kai, Takeshi

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Complex DNA double-strand break (DSB), which is defined as a DSB coupled with additional strand breaks within 10 bp in this study, induced after ionizing radiation or X-rays, is recognized as fatal damage which can induce cell death with a certain ... ...

    Abstract Complex DNA double-strand break (DSB), which is defined as a DSB coupled with additional strand breaks within 10 bp in this study, induced after ionizing radiation or X-rays, is recognized as fatal damage which can induce cell death with a certain probability. In general, a DSB site inside the nucleus of live cells can be experimentally detected using the γ-H2AX focus formation assay. DSB complexity is believed to be detected by analyzing the focus size using such an assay. However, the relationship between focus size and DSB complexity remains uncertain. In this study, using Monte Carlo (MC) track-structure simulation codes, i.e., an in-house WLTrack code and a Particle and Heavy Ion Transport code System (PHITS), we developed an analytical method for qualifying the DSB complexity induced by photon irradiation from the microscopic image of γ-H2AX foci. First, assuming that events (i.e., ionization and excitation) potentially induce DNA strand breaks, we scored the number of events in a water cube (5.03 × 5.03 × 5.03 nm
    MeSH term(s) Dose-Response Relationship, Radiation ; DNA Damage ; Cell Nucleus/metabolism ; X-Rays ; DNA/metabolism
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Inflammatory Signaling and DNA Damage Responses after Local Exposure to an Insoluble Radioactive Microparticle.

    Matsuya, Yusuke / Hamada, Nobuyuki / Yachi, Yoshie / Satou, Yukihiko / Ishikawa, Masayori / Date, Hiroyuki / Sato, Tatsuhiko

    Cancers

    2022  Volume 14, Issue 4

    Abstract: Cesium-bearing microparticles (Cs-BMPs) can reach the human respiratory system after inhalation, resulting in chronic local internal exposure. We previously investigated the spatial distribution of DNA damage induced in areas around a Cs-BMP; however, ... ...

    Abstract Cesium-bearing microparticles (Cs-BMPs) can reach the human respiratory system after inhalation, resulting in chronic local internal exposure. We previously investigated the spatial distribution of DNA damage induced in areas around a Cs-BMP; however, the biological impacts have not been fully clarified due to the limited amount of data. Here, we investigated the inflammatory signaling and DNA damage responses after local exposure to a Cs-BMP in vitro. We used two normal human lung cell lines, i.e., lung fibroblast cells (WI-38) and bronchial epithelial cells (HBEC3-KT). After 24 h exposure to a Cs-BMP, inflammation was evaluated by immunofluorescent staining for nuclear factor κB (NF-κB) p65 and cyclooxygenase 2 (COX-2). The number of DNA double-strand breaks (DSBs) was also detected by means of phospholylated histone H2AX (γ-H2AX) focus formation assay. Cs-BMP exposure significantly increased NF-κB p65 and COX-2 expressions, which were related to the number of γ-H2AX foci in the cell nuclei. Compared to the uniform (external) exposure to
    Language English
    Publishing date 2022-02-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14041045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impact of the Lorentz force on electron track structure and early DNA damage yields in magnetic resonance-guided radiotherapy.

    Yachi, Yoshie / Kai, Takeshi / Matsuya, Yusuke / Hirata, Yuho / Yoshii, Yuji / Date, Hiroyuki

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 16412

    Abstract: Magnetic resonance-guided radiotherapy (MRgRT) has been developed and installed in recent decades for external radiotherapy in several clinical facilities. Lorentz forces modulate dose distribution by charged particles in MRgRT; however, the impact of ... ...

    Abstract Magnetic resonance-guided radiotherapy (MRgRT) has been developed and installed in recent decades for external radiotherapy in several clinical facilities. Lorentz forces modulate dose distribution by charged particles in MRgRT; however, the impact of Lorentz forces on low-energy electron track structure and early DNA damage induction remain unclear. In this study, we estimated features of electron track structure and biological effects in a static magnetic field (SMF) using a general-purpose Monte Carlo code, particle and heavy ion transport code system (PHITS) that enables us to simulate low-energy electrons down to 1 meV by track-structure mode. The macroscopic dose distributions by electrons above approximately 300 keV initial energy in liquid water are changed by both perpendicular and parallel SMFs against the incident direction, indicating that the Lorentz force plays an important role in calculating dose within tumours. Meanwhile, DNA damage estimation based on the spatial patterns of atomic interactions indicates that the initial yield of DNA double-strand breaks (DSBs) is independent of the SMF intensity. The DSB induction is predominantly attributed to the secondary electrons below a few tens of eV, of which energy deposition patterns are not considerably affected by the Lorentz force. Our simulation study suggests that treatment planning for MRgRT can be made with consideration of only changed dose distribution.
    MeSH term(s) DNA/chemistry ; DNA Damage ; Electrons ; Magnetic Resonance Spectroscopy ; Monte Carlo Method ; Water/chemistry
    Chemical Substances Water (059QF0KO0R) ; DNA (9007-49-2)
    Language English
    Publishing date 2022-09-30
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-18138-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Modelling oxygen effects on the in- and out-of-field radiosensitivity of cells exposed to intensity-modulated radiation fields.

    Matsuya, Yusuke / McMahon, Stephen J / Butterworth, Karl T / Yachi, Yoshie / Saga, Ryo / Sato, Tatsuhiko / Prise, Kevin M

    Physics in medicine and biology

    2023  Volume 68, Issue 9

    Abstract: ... ...

    Abstract Objective
    MeSH term(s) Male ; Humans ; Oxygen ; Carcinoma, Non-Small-Cell Lung ; Cell Line, Tumor ; Lung Neoplasms ; Radiation Tolerance ; Cell Survival/radiation effects ; Hypoxia ; Dose-Response Relationship, Radiation ; DNA Damage
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2023-04-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/acc720
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Track Structure Study for Energy Dependency of Electrons and X-rays on DNA Double-Strand Break Induction.

    Yachi, Yoshie / Yoshii, Yuji / Matsuya, Yusuke / Mori, Ryosuke / Oikawa, Joma / Date, Hiroyuki

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 17649

    Abstract: Radiation weighting factor ... ...

    Abstract Radiation weighting factor w
    MeSH term(s) Computer Simulation ; DNA Breaks, Double-Stranded/radiation effects ; Electrons ; Linear Energy Transfer ; Photons ; Relative Biological Effectiveness ; X-Rays
    Language English
    Publishing date 2019-11-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-54081-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Oxygen enhancement ratios of cancer cells after exposure to intensity modulated x-ray fields: DNA damage and cell survival.

    Matsuya, Yusuke / McMahon, Stephen J / Butterworth, Karl T / Naijo, Shingo / Nara, Isshi / Yachi, Yoshie / Saga, Ryo / Ishikawa, Masayori / Sato, Tatsuhiko / Date, Hiroyuki / Prise, Kevin M

    Physics in medicine and biology

    2021  Volume 66, Issue 7

    Abstract: Hypoxic cancer cells within solid tumours show radio-resistance, leading to malignant progression in fractionated radiotherapy. When prescribing dose to tumours under heterogeneous oxygen pressure with intensity-modulated radiation fields, intercellular ... ...

    Abstract Hypoxic cancer cells within solid tumours show radio-resistance, leading to malignant progression in fractionated radiotherapy. When prescribing dose to tumours under heterogeneous oxygen pressure with intensity-modulated radiation fields, intercellular signalling could have an impact on radiosensitivity between in-field and out-of-field (OF) cells. However, the impact of hypoxia on radio-sensitivity under modulated radiation intensity remains to be fully clarified. Here, we investigate the impact of hypoxia on in-field and OF radio-sensitivities using two types of cancer cells, DU145 and H1299. Using a nBIONIX hypoxic culture kit and a shielding technique to irradiate 50% of a cell culture flask, oxygen enhancement ratios for double-strand breaks (DSB) and cell death endpoints were determined. These
    MeSH term(s) Cell Line, Tumor ; Cell Survival ; DNA Damage ; Dose-Response Relationship, Radiation ; Humans ; Neoplasms/radiotherapy ; Oxygen ; X-Rays
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-04-06
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/abf011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 199: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

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