LIVIVO - Search results -

Search results

Result 1 - 10 of total 191

Search options

Article ; Online: Glucose-dependent insulinotropic polypeptide receptor systems in the hypothalamus and the brainstem regulate feeding and weight through distinct pathways.

Yada, Toshihiko

2023 Volume 15, Issue 3, Page(s) 282–284

Abstract: The report by Adriaenssens et al. in JCI Insight 22 May 2023 explored the role and property of the neurons that express glucose-dependent insulinotropic polypeptide receptor (GIPR) in the brainstem and hypothalamus. The chemogenetic activation of the ... ...

Abstract	The report by Adriaenssens et al. in JCI Insight 22 May 2023 explored the role and property of the neurons that express glucose-dependent insulinotropic polypeptide receptor (GIPR) in the brainstem and hypothalamus. The chemogenetic activation of the brainstem GIPR neurons and that of the hypothalamic GIPR neurons showed different feeding and behavior responses. The brainstem GIPR neurons projected to the paraventricular hypothalamus and lateral parabrachial nucleus. Fluorescent-labeled, stabilized peptide GIPR agonist (GIPRA), peripherally injected, localized to the area postrema, nucleus tractus solitarius, median eminence and arcuate hypothalamus. This report showed the role of brainstem GIPR neurons in receiving GIPRA to drive the neural circuit to reduce feeding and bodyweight. In this commentary, distinct and possible cooperative roles of the hypothalamic and the brainstem GIPR pathways will also be discussed.
MeSH term(s)	Humans ; Hypothalamus ; Receptors, Gastrointestinal Hormone ; Brain Stem ; Neurons
Chemical Substances	gastric inhibitory polypeptide receptor (D6H00MV7K8) ; Receptors, Gastrointestinal Hormone
Language	English
Publishing date	2023-12-23
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2625840-7
ISSN	2040-1124 ; 2040-1116
ISSN (online)	2040-1124
ISSN	2040-1116
DOI	10.1111/jdi.14130
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6920: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article: Status of ghrelin as an islet hormone and paracrine/autocrine regulator of insulin secretion

Dezaki, Katsuya / Yada, Toshihiko

Peptides. 2022 Feb., v. 148

2022

Abstract: Ghrelin is expressed in the pancreatic islet cells as well as the stomach. In the perfused pancreas and isolated islets, GHS-R antagonism, ghrelin immunoneutralization and ghrelin-knockout (Ghr-KO) all increase glucose-induced insulin release. Thus, ... ...

Abstract	Ghrelin is expressed in the pancreatic islet cells as well as the stomach. In the perfused pancreas and isolated islets, GHS-R antagonism, ghrelin immunoneutralization and ghrelin-knockout (Ghr-KO) all increase glucose-induced insulin release. Thus, pharmacological, immunological and genetic blockades of ghrelin in the pancreatic islets all markedly augment glucose-induced insulin release, showing that islet-derived ghrelin physiologically restricts insulin release in rodents. In this review, we focus on the current understanding of the following key questions: 1) from which islet cells ghrelin is released, 2) on which islet cells ghrelin acts, and 3) mechanisms by which the islet-derived ghrelin inhibits insulin secretion.
Keywords	antagonism ; autocrine signaling ; ghrelin ; insulin ; insulin secretion ; islets of Langerhans ; stomach
Language	English
Dates of publication	2022-02
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2021.170681
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Cologne/Königswinter

Zs.A 1649: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Status of ghrelin as an islet hormone and paracrine/autocrine regulator of insulin secretion.

Dezaki, Katsuya / Yada, Toshihiko

Peptides

2021 Volume 148, Page(s) 170681

Abstract	Ghrelin is expressed in the pancreatic islet cells as well as the stomach. In the perfused pancreas and isolated islets, GHS-R antagonism, ghrelin immunoneutralization and ghrelin-knockout (Ghr-KO) all increase glucose-induced insulin release. Thus, pharmacological, immunological and genetic blockades of ghrelin in the pancreatic islets all markedly augment glucose-induced insulin release, showing that islet-derived ghrelin physiologically restricts insulin release in rodents. In this review, we focus on the current understanding of the following key questions: 1) from which islet cells ghrelin is released, 2) on which islet cells ghrelin acts, and 3) mechanisms by which the islet-derived ghrelin inhibits insulin secretion.
MeSH term(s)	Animals ; Ghrelin/metabolism ; Humans ; Insulin/metabolism ; Insulin Secretion ; Islets of Langerhans/metabolism ; Receptors, Ghrelin/metabolism
Chemical Substances	GHRL protein, human ; Ghrelin ; Insulin ; Receptors, Ghrelin
Language	English
Publishing date	2021-10-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	769028-9
ISSN	1873-5169 ; 0196-9781
ISSN (online)	1873-5169
ISSN	0196-9781
DOI	10.1016/j.peptides.2021.170681
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1649: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: TRPV1-Mediated Sensing of Sodium and Osmotic Pressure in POMC Neurons in the Arcuate Nucleus of the Hypothalamus.

Zhang, Boyang / Kario, Kazuomi / Yada, Toshihiko / Nakata, Masanori

Nutrients

2022 Volume 14, Issue 13

Abstract: The central melanocortin system conducted by anorexigenic pro-opiomelanocortin (POMC) neurons and orexigenic agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARC) not only regulates feeding behavior but also blood ... ...

Abstract	The central melanocortin system conducted by anorexigenic pro-opiomelanocortin (POMC) neurons and orexigenic agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARC) not only regulates feeding behavior but also blood pressure. Excessive salt intake raises the Na
MeSH term(s)	Agouti-Related Protein/metabolism ; Animals ; Arcuate Nucleus of Hypothalamus/metabolism ; Hypothalamus/metabolism ; Mice ; Mice, Inbred C57BL ; Neurons/metabolism ; Osmotic Pressure ; Pro-Opiomelanocortin/metabolism ; Sodium/metabolism ; TRPV Cation Channels/genetics ; TRPV Cation Channels/metabolism
Chemical Substances	Agouti-Related Protein ; TRPV Cation Channels ; TRPV1 protein, mouse ; Pro-Opiomelanocortin (66796-54-1) ; Sodium (9NEZ333N27)
Language	English
Publishing date	2022-06-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14132600
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: TRPV1-Mediated Sensing of Sodium and Osmotic Pressure in POMC Neurons in the Arcuate Nucleus of the Hypothalamus

Zhang, Boyang / Kario, Kazuomi / Yada, Toshihiko / Nakata, Masanori

Nutrients. 2022 June 23, v. 14, no. 13

2022

Abstract	The central melanocortin system conducted by anorexigenic pro-opiomelanocortin (POMC) neurons and orexigenic agouti-related peptide (AgRP) neurons in the arcuate nucleus of the hypothalamus (ARC) not only regulates feeding behavior but also blood pressure. Excessive salt intake raises the Na⁺ concentration ([Na⁺]) in the cerebrospinal fluid (CSF) and worsens hypertension. The blood–brain barrier is immature in the ARC. Therefore, both AgRP and POMC neurons in the ARC have easy access to the electrolytes in the blood and can sense changes in their concentrations. However, the sensitivity of AgRP and POMC neurons to Na⁺ remains unclear. This study aimed to explore how the changes in the extracellular Na⁺ concentration ([Na⁺]) influence these neurons by measuring the cytosolic Ca²⁺ concentration ([Ca²⁺]ᵢ) in the single neurons isolated from the ARC that were subsequently immunocytochemically identified as AgRP or POMC neurons. Both AgRP and POMC neurons responded to increases in both [Na⁺] and osmolarity in C57BL/6 mice. In contrast, in transient receptor potential vanilloid 1 (TRPV1) knockout (KO) mice, POMC neurons failed to respond to increases in both [Na⁺] and osmolarity, while they responded to high glucose and angiotensin II levels with increases in [Ca²⁺]ᵢ. Moreover, in KO mice fed a high-salt diet, the expression of POMC was lower than that in wild-type mice. These results demonstrate that changes in [Na⁺] and osmolarity are sensed by the ARC POMC neurons via the TRPV1-dependent mechanism.
Keywords	blood ; blood pressure ; blood-brain barrier ; calcium ; cerebrospinal fluid ; diet ; glucose ; hypertension ; hypothalamus ; osmolarity ; osmotic pressure ; pro-opiomelanocortin ; sodium ; transient receptor potential vanilloid channels
Language	English
Dates of publication	2022-0623
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14132600
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: New insight into GABAergic neurons in the hypothalamic feeding regulation.

Suyama, Shigetomo / Yada, Toshihiko

The journal of physiological sciences : JPS

2018 Volume 68, Issue 6, Page(s) 717–722

Abstract: Several lines of study have suggested that GABA in the hypothalamic feeding center plays a role in promoting food intake. Recent studies revealed that not only NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) that co-express GABA but also other ...

Abstract	Several lines of study have suggested that GABA in the hypothalamic feeding center plays a role in promoting food intake. Recent studies revealed that not only NPY/AgRP neurons in the hypothalamic arcuate nucleus (ARC) that co-express GABA but also other GABAergic neurons act as an orexigenic. Here, we review the progress of studies on hypothalamic GABAergic neurons distributed in ARC, dorsomedial hypothalamus (DMH), and lateral hypothalamus (LH). Three advanced technologies have been applied and greatly contributed to the recent progress. Optogenetic (and chemogenetic) approaches map input and output pathways of particular subpopulations of GABAergic neurons. In vivo Ca
MeSH term(s)	Agouti-Related Protein/metabolism ; Animals ; Appetite Regulation ; Eating ; Feeding Behavior ; GABAergic Neurons/metabolism ; Humans ; Hypothalamus/cytology ; Hypothalamus/metabolism ; Neural Pathways/metabolism ; Neuroanatomical Tract-Tracing Techniques ; Neuropeptide Y/metabolism ; Optogenetics ; Pro-Opiomelanocortin/metabolism ; Sequence Analysis, RNA ; Single-Cell Analysis ; Synaptic Transmission ; gamma-Aminobutyric Acid/metabolism
Chemical Substances	AGRP protein, human ; Agouti-Related Protein ; Neuropeptide Y ; gamma-Aminobutyric Acid (56-12-2) ; Pro-Opiomelanocortin (66796-54-1)
Language	English
Publishing date	2018-07-12
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2234472-X
ISSN	1880-6562 ; 1880-6546
ISSN (online)	1880-6562
ISSN	1880-6546
DOI	10.1007/s12576-018-0622-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.360: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice

Rakhat, Yermek / Kaneko, Kentaro / Wang, Lei / Han, Wanxin / Seino, Yutaka / Yabe, Daisuke / Yada, Toshihiko

Nutrients. 2022 July 29, v. 14, no. 15

2022

Abstract: d-allulose, a rare sugar, has sweetness with few calories. d-allulose regulates feeding and glycemia, and ameliorates hyperphagia, obesity and diabetes. All these functions involve the central nervous system. However, central mechanisms underlying these ... ...

Abstract	d-allulose, a rare sugar, has sweetness with few calories. d-allulose regulates feeding and glycemia, and ameliorates hyperphagia, obesity and diabetes. All these functions involve the central nervous system. However, central mechanisms underlying these effects of d-allulose remain unknown. We recently reported that d-allulose activates the anorexigenic neurons in the hypothalamic arcuate nucleus (ARC), the neurons that respond to glucagon-like peptide-1 and that express proopiomelanocortin. However, its action on the orexigenic neurons remains unknown. This study investigated the effects of d-allulose on the ARC neurons implicated in hunger, by measuring cytosolic Ca²⁺ concentration ([Ca²⁺]ᵢ) in single neurons. d-allulose depressed the increases in [Ca²⁺]ᵢ induced by ghrelin and by low glucose in ARC neurons and inhibited spontaneous oscillatory [Ca²⁺]ᵢ increases in neuropeptide Y (NPY) neurons. d-allulose inhibited 10 of 35 (28%) ghrelin-responsive, 18 of 60 (30%) glucose-sensitive and 3 of 8 (37.5%) NPY neurons in ARC. Intracerebroventricular injection of d-allulose inhibited food intake at 20:00 and 22:00, the early dark phase when hunger is promoted. These results indicate that d-allulose suppresses hunger-associated feeding and inhibits hunger-promoting neurons in ARC. These central actions of d-allulose represent the potential of d-allulose to inhibit the hyperphagia with excessive appetite, thereby counteracting obesity and diabetes.
Keywords	blood glucose ; calcium ; central nervous system ; diabetes ; food intake ; ghrelin ; glucagon-like peptide 1 ; glucose ; hunger ; neuropeptide Y ; obesity ; overeating ; pro-opiomelanocortin ; psicose ; sweetness
Language	English
Dates of publication	2022-0729
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14153117
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article: D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice

Yermek, Rakhat / Wang, Lei / Kaneko, Kentaro / Han, Wanxin / Seino, Yutaka / Yabe, Daisuke / Yada, Toshihiko

Biochemical and biophysical research communications. 2022 July 12, v. 613

2022

Abstract: A rare sugar D-Allulose has sweetness without calorie. Previous studies have shown that D-Allulose improves glucose and energy metabolism and ameliorates obesity. However, underlying mechanisms remain elusive. This study explored the effect of central ... ...

Abstract	A rare sugar D-Allulose has sweetness without calorie. Previous studies have shown that D-Allulose improves glucose and energy metabolism and ameliorates obesity. However, underlying mechanisms remain elusive. This study explored the effect of central injection of D-Allulose on feeding behavior in mice. We also examined direct effects of D-Allulose on the neurons in the hypothalamic arcuate nucleus (ARC) that regulate feeding, including the anorexigenic glucagon-like peptide-1 (GLP-1)-responsive neurons and proopiomelanocortin (POMC) neurons. Single neurons were isolated from ARC and cytosolic Ca²⁺ concentration ([Ca²⁺]ᵢ) was measured by fura-2 microfluorometry. Administration of D-Allulose at 5.6, 16.7 and 56 mM concentration-dependently increased [Ca²⁺]ᵢ in ARC neurons. The [Ca²⁺]ᵢ increases took place similarly when the osmolarity of superfusion solution was kept constant. The majority (40%) of the D-Allulose-responsive neurons also responded to GLP-1 with [Ca²⁺]ᵢ increases. D-Allulose increased [Ca²⁺]ᵢ in 33% of POMC neurons in ARC. D-Allulose potentiated the GLP-1 action to increase [Ca²⁺]ᵢ in ARC neurons including POMC neurons. Intracerebroventricular injection of D-Allulose significantly decreased food intake at 1 and 2 h after injection. These results demonstrate that D-Allulose cooperates with glucagon-like peptide-1 and activates the ARC neurons including POMC neurons. Furthermore, central injection of D-Allulose inhibits feeding. These central actions of D-Allulose may underlie the ability of D-Allulose to counteract obesity and diabetes.
Keywords	calcium ; diabetes ; energy metabolism ; food intake ; glucagon-like peptide 1 ; glucose ; obesity ; osmolarity ; pro-opiomelanocortin ; psicose ; research ; sweetness
Language	English
Dates of publication	2022-0712
Size	p. 159-165.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205723-2
ISSN	0006-291X ; 0006-291X
ISSN (online)	0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.04.027
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 71/706: Show issues
Z 3.8: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: D-Allulose cooperates with glucagon-like peptide-1 and activates proopiomelanocortin neurons in the arcuate nucleus and central injection inhibits feeding in mice.

Yermek, Rakhat / Wang, Lei / Kaneko, Kentaro / Han, Wanxin / Seino, Yutaka / Yabe, Daisuke / Yada, Toshihiko

Biochemical and biophysical research communications

2022 Volume 613, Page(s) 159–165

Abstract	A rare sugar D-Allulose has sweetness without calorie. Previous studies have shown that D-Allulose improves glucose and energy metabolism and ameliorates obesity. However, underlying mechanisms remain elusive. This study explored the effect of central injection of D-Allulose on feeding behavior in mice. We also examined direct effects of D-Allulose on the neurons in the hypothalamic arcuate nucleus (ARC) that regulate feeding, including the anorexigenic glucagon-like peptide-1 (GLP-1)-responsive neurons and proopiomelanocortin (POMC) neurons. Single neurons were isolated from ARC and cytosolic Ca
MeSH term(s)	Animals ; Arcuate Nucleus of Hypothalamus/metabolism ; Fructose ; Glucagon-Like Peptide 1/metabolism ; Mice ; Neurons/metabolism ; Obesity/drug therapy ; Obesity/metabolism ; Pro-Opiomelanocortin/metabolism
Chemical Substances	psicose (23140-52-5) ; Fructose (30237-26-4) ; Pro-Opiomelanocortin (66796-54-1) ; Glucagon-Like Peptide 1 (89750-14-1)
Language	English
Publishing date	2022-04-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.04.027
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 116: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: d-Allulose Inhibits Ghrelin-Responsive, Glucose-Sensitive and Neuropeptide Y Neurons in the Arcuate Nucleus and Central Injection Suppresses Appetite-Associated Food Intake in Mice.

Rakhat, Yermek / Kaneko, Kentaro / Wang, Lei / Han, Wanxin / Seino, Yutaka / Yabe, Daisuke / Yada, Toshihiko

Nutrients

2022 Volume 14, Issue 15

Abstract	d-allulose, a rare sugar, has sweetness with few calories. d-allulose regulates feeding and glycemia, and ameliorates hyperphagia, obesity and diabetes. All these functions involve the central nervous system. However, central mechanisms underlying these effects of d-allulose remain unknown. We recently reported that d-allulose activates the anorexigenic neurons in the hypothalamic arcuate nucleus (ARC), the neurons that respond to glucagon-like peptide-1 and that express proopiomelanocortin. However, its action on the orexigenic neurons remains unknown. This study investigated the effects of d-allulose on the ARC neurons implicated in hunger, by measuring cytosolic Ca
MeSH term(s)	Animals ; Appetite ; Arcuate Nucleus of Hypothalamus/physiology ; Eating ; Fructose ; Ghrelin/pharmacology ; Glucose/pharmacology ; Hyperphagia/prevention & control ; Mice ; Neurons/metabolism ; Neuropeptide Y/metabolism ; Obesity/drug therapy ; Rats ; Rats, Sprague-Dawley
Chemical Substances	Ghrelin ; Neuropeptide Y ; psicose (23140-52-5) ; Fructose (30237-26-4) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-07-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14153117
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito