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Article ; Online: Role of HOX genes in cancer progression and their therapeutical aspects.

Yadav, Chetna / Yadav, Ritu / Nanda, Smiti / Ranga, Shalu / Ahuja, Parul / Tanwar, Mukesh

2024 Volume 919, Page(s) 148501

Abstract: HOX genes constitute a family of evolutionarily conserved transcription factors that play pivotal roles in embryonic development, tissue patterning, and cell differentiation. These genes are essential for the precise spatial and temporal control of body ... ...

Abstract	HOX genes constitute a family of evolutionarily conserved transcription factors that play pivotal roles in embryonic development, tissue patterning, and cell differentiation. These genes are essential for the precise spatial and temporal control of body axis formation in vertebrates. In addition to their developmental functions, HOX genes have garnered significant attention for their involvement in various diseases, including cancer. Deregulation of HOX gene expression has been observed in numerous malignancies, where they can influence tumorigenesis, progression, and therapeutic responses. This review provides an overview of the diverse roles of HOX genes in development, disease, and potential therapeutic targets, highlighting their significance in understanding biological processes and their potential clinical implications.
Language	English
Publishing date	2024-04-24
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	391792-7
ISSN	1879-0038 ; 0378-1119
ISSN (online)	1879-0038
ISSN	0378-1119
DOI	10.1016/j.gene.2024.148501
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Article ; Online: Ionic porous organic polymer (IPOP) based on twisted biphenyl Scaffold: Green and efficient heterogeneous catalytic synthesis of β-Arylthioketones and biscoumarins

Yadav, Chetna / Payra, Soumen / Moorthy, Jarugu Narasimha

Journal of Catalysis. 2022 Sept., v. 413 p.769-778

2022

Abstract: A new viologen-based ionic porous organic polymer (IPOP) has been developed based on a twisted biaryl (TMBB) as the monomer and Menshutkin reaction as the polymerization reaction. IPOP is thermally stable and insoluble in H₂O and common organic solvents ( ...

Abstract	A new viologen-based ionic porous organic polymer (IPOP) has been developed based on a twisted biaryl (TMBB) as the monomer and Menshutkin reaction as the polymerization reaction. IPOP is thermally stable and insoluble in H₂O and common organic solvents (MeOH, MeCN, EtOH, DCM, etc.). The presence of cationic sites as well as counter bromide anions in the polymeric matrix endow the IPOP with properties akin to those of the phase-transfer quaternary ammonium salt, namely TBAB, to permit its application as a recyclable heterogeneous catalyst for organic transformations. It’s shown that IPOP can be readily applied as a phase-transfer catalyst for Michael addition of thiols to α,β-unsaturated carbonyl compounds, providing access to organosulfur compounds, namely, β-arylthioketones, in excellent isolated yields. In a similar manner, IPOP is shown to be applicable as a recyclable heterogeneous catalyst for facile synthesis of biscoumarins, which are an important class of molecular systems exhibiting a variety of biological activities such as anti-coagulant, anti-anthelmintic, anti-HIV, anti-bacterial, anti-oxidant, anti-cancer, etc. Thus, a novel, efficient and ecofriendly approach in a manner mimicking the phase-transfer quaternary ammonium salts has been developed for the synthesis of β-arylthioketones and biscoumarins; the IPOP can be employed as a heterogeneous catalyst for at least 10 catalytic cycles without any loss of catalytic activity.
Keywords	ammonium salts ; anticoagulants ; antioxidants ; antiretroviral agents ; biphenyl ; catalysts ; catalytic activity ; polymerization ; polymers ; quaternary ammonium compounds ; thermal stability ; thiols ; Ionic POP ; Heterogeneous Catalysis ; Michael addition ; Biscoumarins ; and Phase-Transfer Catalyst
Language	English
Dates of publication	2022-09
Size	p. 769-778.
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	1468993-5
ISSN	1090-2694 ; 0021-9517
ISSN (online)	1090-2694
ISSN	0021-9517
DOI	10.1016/j.jcat.2022.07.012
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Article ; Online: Correction to: Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer.

Yadav, Chetna / Yadav, Ritu / Chhabra, Ravindresh / Nanda, Smiti / Ranga, Shalu / Kadian, Lokesh / Ahuja, Parul

Apoptosis : an international journal on programmed cell death

2023 Volume 28, Issue 9-10, Page(s) 1500

Language	English
Publishing date	2023-02-09
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	1452360-7
ISSN	1573-675X ; 1360-8185
ISSN (online)	1573-675X
ISSN	1360-8185
DOI	10.1007/s10495-023-01822-8
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Article ; Online: Overview of genetic and epigenetic regulation of human papillomavirus and apoptosis in cervical cancer.

Yadav, Chetna / Yadav, Ritu / Chabbra, Ravindresh / Nanda, Smiti / Ranga, Shalu / Kadian, Lokesh / Ahuja, Parul

Apoptosis : an international journal on programmed cell death

2023 Volume 28, Issue 5-6, Page(s) 683–701

Abstract: Cervical cancer is the fourth most common cancer affecting women worldwide after breast, colorectal and lung cancers. Owing to a lack of awareness and resources, low- and middle-income countries bear most of the burden of cervical cancer. In developed ... ...

Abstract	Cervical cancer is the fourth most common cancer affecting women worldwide after breast, colorectal and lung cancers. Owing to a lack of awareness and resources, low- and middle-income countries bear most of the burden of cervical cancer. In developed countries, the incidence rate has been halved over the past three decades due to robust screening and implementation of vaccine programs. HPV is not the sole cause of cervical cancer but acts as a principal factor in the pathogenesis of cervical cancer. By integrating into the host genome, its oncogenic proteins (E6 and E7) alter and interfere with the standard signal transduction machinery of the host. Apoptosis is a key pathway affected by aberrant genetic mutations, polymorphisms and epigenetic mechanisms during cervical carcinogenesis. Along with DNA methylation and histone modifications, non-coding RNAs have also been implicated as epigenetic modulators in various malignancies and are being explored for reversing disease severity. This review emphasizes various genetic and epigenetic approaches regulating apoptotic pathways and HPV E6 and E7 genes that can be targeted to overcome the challenges in cervical cancer treatment. In addition, it also discusses the apoptosis targeting novel drug molecules in cervical cancer which are currently undergoing clinical and pre-clinical trials.
MeSH term(s)	Humans ; Female ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology ; Human Papillomavirus Viruses ; Papillomavirus E7 Proteins/genetics ; Papillomavirus E7 Proteins/metabolism ; Papillomavirus Infections/genetics ; Papillomavirus Infections/diagnosis ; Epigenesis, Genetic ; Human papillomavirus 16/genetics ; Human papillomavirus 16/metabolism ; Apoptosis/genetics ; Oncogene Proteins, Viral/genetics
Chemical Substances	Papillomavirus E7 Proteins ; Oncogene Proteins, Viral
Language	English
Publishing date	2023-01-18
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1452360-7
ISSN	1573-675X ; 1360-8185
ISSN (online)	1573-675X
ISSN	1360-8185
DOI	10.1007/s10495-023-01812-w
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Article ; Online: Targeting epigenetic deregulations for the management of esophageal carcinoma: recent advances and emerging approaches.

Ahuja, Parul / Yadav, Ritu / Goyal, Sandeep / Yadav, Chetna / Ranga, Shalu / Kadian, Lokesh

Cell biology and toxicology

2023 Volume 39, Issue 6, Page(s) 2437–2465

Abstract: Ranking from seventh in incidence to sixth in mortality, esophageal carcinoma is considered a severe malignancy of food pipe. Later-stage diagnosis, drug resistance, and a high mortality rate contribute to its lethality. Esophageal squamous cell ... ...

Abstract	Ranking from seventh in incidence to sixth in mortality, esophageal carcinoma is considered a severe malignancy of food pipe. Later-stage diagnosis, drug resistance, and a high mortality rate contribute to its lethality. Esophageal squamous cell carcinoma and esophageal adenocarcinoma are the two main histological subtypes of esophageal carcinoma, with squamous cell carcinoma alone accounting for more than eighty percent of its cases. While genetic anomalies are well known in esophageal cancer, accountability of epigenetic deregulations is also being explored for the recent two decades. DNA methylation, histone modifications, and functional non-coding RNAs are the crucial epigenetic players involved in the modulation of different malignancies, including esophageal carcinoma. Targeting these epigenetic aberrations will provide new insights into the development of biomarker tools for risk stratification, early diagnosis, and effective therapeutic intervention. This review discusses different epigenetic alterations, emphasizing the most significant developments in esophageal cancer epigenetics and their potential implication for the detection, prognosis, and treatment of esophageal carcinoma. Further, the preclinical and clinical status of various epigenetic drugs has also been reviewed.
MeSH term(s)	Humans ; Esophageal Neoplasms/genetics ; Esophageal Neoplasms/drug therapy ; Esophageal Squamous Cell Carcinoma/genetics ; Carcinoma, Squamous Cell/drug therapy ; Carcinoma, Squamous Cell/genetics ; Epigenesis, Genetic/genetics ; DNA Methylation/genetics
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	48824-0
ISSN	1573-6822 ; 0742-2091
ISSN (online)	1573-6822
ISSN	0742-2091
DOI	10.1007/s10565-023-09818-5
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Zs.B 3024: Show issues

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Article ; Online: Genetic Diversity of Autosomal STR Markers in the Brahmin Population of Rajasthan and Haryana: Significance in Population and Forensic Genetics.

Sharma, Shivkant / Sahajpal, Vivek / Singh, Abhishek / Yadav, Ritu / Thakur, Mukesh / Bhandari, Deepika / Ranga, Shalu / Kadian, Lokesh / Yadav, Chetna

Sovremennye tekhnologii v meditsine

2023 Volume 15, Issue 1, Page(s) 63–72

Abstract: The aim of the study: Materials and methods: A total of 203 male DNA samples from various districts of Haryana (n=104) and Rajasthan (n=99) were genotyped using the GlobalFiler: Results: More than 200 alleles were present in both populations, ... ...

Abstract	The aim of the study Materials and methods: A total of 203 male DNA samples from various districts of Haryana (n=104) and Rajasthan (n=99) were genotyped using the GlobalFiler Results: More than 200 alleles were present in both populations, ranging from 6.0 to 35.2 and SE33 was the most polymorphic marker. The combined power of discrimination was 1. To know the relatedness with other Indian Brahmin populations, the UPGMA dendrogram and principal component analysis plot were visualized to show that both populations are close to each other and in nearby Saraswat Brahmins of Himachal Pradesh. This study showed a genetic relationship and forensic examination in the Haryana and Rajasthan Brahmin populations and various ethno-linguistically diverse populations of India. Conclusion: The results imply that the highly polymorphic 21 autosomal STR loci might be applied for individuals' forensic identification and parentage testing. This study also suggests that the kit having both autosomal and Y-STR markers is appropriate for a better understanding of the genetic and forensic examination in the Brahmin population of Haryana and Rajasthan.
MeSH term(s)	Humans ; Male ; Forensic Genetics ; India ; Alleles ; Asian People ; Genetic Variation/genetics
Language	English
Publishing date	2023-01-28
Publishing country	Russia (Federation)
Document type	Journal Article
ISSN	2309-995X
ISSN (online)	2309-995X
DOI	10.17691/stm2023.15.1.07
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Article ; Online: Long non-coding RNAs as critical regulators and novel targets in cervical cancer: current status and future perspectives.

Ranga, Shalu / Yadav, Ritu / Chhabra, Ravindresh / Chauhan, Meenakshi B / Tanwar, Mukesh / Yadav, Chetna / Kadian, Lokesh / Ahuja, Parul

Apoptosis : an international journal on programmed cell death

2023 Volume 28, Issue 7-8, Page(s) 925–942

Abstract: Cervical cancer is among the leading causes of cancer-associated mortality in women. In spite of vaccine availability, improved screening procedures, and chemoradiation therapy, cervical cancer remains the most commonly diagnosed cancer in 23 countries ... ...

Abstract	Cervical cancer is among the leading causes of cancer-associated mortality in women. In spite of vaccine availability, improved screening procedures, and chemoradiation therapy, cervical cancer remains the most commonly diagnosed cancer in 23 countries and the leading cause of cancer deaths in 36 countries. There is, therefore, a need to come up with novel diagnostic and therapeutic targets. Long non-coding RNAs (lncRNAs) play a remarkable role in genome regulation and contribute significantly to several developmental and disease pathways. The deregulation of lncRNAs is often observed in cancer patients, where they are shown to affect multiple cellular processes, including cell cycle, apoptosis, angiogenesis, and invasion. Many lncRNAs are found to be involved in the pathogenesis as well as progression of cervical cancer and have shown potency to track metastatic events. This review provides an overview of lncRNA mediated regulation of cervical carcinogenesis and highlights their potential as diagnostic and prognostic biomarkers as well as therapeutic targets for cervical cancer. In addition, it also discusses the challenges associated with the clinical implication of lncRNAs in cervical cancer.
MeSH term(s)	Humans ; Female ; RNA, Long Noncoding/genetics ; Uterine Cervical Neoplasms/genetics ; Uterine Cervical Neoplasms/pathology ; Apoptosis/genetics ; Carcinogenesis/genetics
Chemical Substances	RNA, Long Noncoding
Language	English
Publishing date	2023-04-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1452360-7
ISSN	1573-675X ; 1360-8185
ISSN (online)	1573-675X
ISSN	1360-8185
DOI	10.1007/s10495-023-01840-6
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Article ; Online: Awareness data on cervical cancer among females of rural and urban areas of Haryana, India.

Yadav, Ritu / Chauhan, Meenakshi B / Yadav, Chetna / Ranga, Shalu / Ahuja, Parul / Tanwar, Mukesh / Balhara, Nikita / Kadian, Lokesh / Chauhan, Preeti / Tanwar, Neha / Ahlawat, Chavi

Data in brief

2024 Volume 53, Page(s) 110168

Abstract: A cross-sectional study was done to assess the degree of current awareness and behaviors about cervical cancer among females in urban and rural areas of North India. This survey was conducted on one thousand females (500 rural and 500 urban). A well- ... ...

Abstract	A cross-sectional study was done to assess the degree of current awareness and behaviors about cervical cancer among females in urban and rural areas of North India. This survey was conducted on one thousand females (500 rural and 500 urban). A well-structured questionnaire was designed to collect information about participants' knowledge on cancer of cervix uteri such as age, height and weight measurements, marital status, menstrual status, personal hygiene, age at menarche, sexual history, pregnancy and abortion history, use of contraceptive pills for birth-control, smoking, alcohol consumption, and other relevant information. The data was collected by conducting face-to-face interviews after obtaining the verbal consent of the participants. The data has the potential to reduce disease burden by spreading awareness about symptoms and risk factors of cervical cancer as well as implementation of effective early screening strategies.
Language	English
Publishing date	2024-02-07
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2024.110168
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Article ; Online: Y-23 mediated genetic data analysis of endogamous Brahmin population of Rajasthan, India.

Sharma, Shivkant / Yadav, Ritu / Sahajpal, Vivek / Singh, Mugdha / Ranga, Shalu / Kadian, Lokesh / Yadav, Chetna / Patial, Ankush / Devi, Nisha / Ahuja, Parul

Data in brief

2022 Volume 42, Page(s) 108061

Abstract: India's largest state Rajasthan is known for its variable population groups including castes, communities and tribes. In the present article, Y-STR polymorphisms of hundred unrelated healthy male volunteers from the Brahmin population of Rajasthan, India ...

Abstract	India's largest state Rajasthan is known for its variable population groups including castes, communities and tribes. In the present article, Y-STR polymorphisms of hundred unrelated healthy male volunteers from the Brahmin population of Rajasthan, India were investigated using the Powerplex® Y-23 PCR amplification kit. Total 94 distinct haplotypes were obtained out of them 93 were singletons. Haplotype Diversity (HD) and Discrimination Capacity (DC) for the population were 0.644 and 0.9894 respectively. The Intra-population relationship between the present population data and other reported Indian populations was examined through Multidimensional Scaling (MDS) Plot, which shows the Brahmin population of Rajasthan lies in a cluster with the Brahmin populations of Haryana and Maharashtra. Data generated with 23 Y-STR markers is submitted on Y chromosome haplotype reference database (YHRD) (yhrd.org) and it will robust the forensic database of the Rajasthan population of India.
Language	English
Publishing date	2022-03-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2786545-9
ISSN	2352-3409 ; 2352-3409
ISSN (online)	2352-3409
ISSN	2352-3409
DOI	10.1016/j.dib.2022.108061
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Article: Multifunctional porous organic polymers (POPs): Inverse adsorption of hydrogen over nitrogen, stabilization of Pd(0) nanoparticles, and catalytic cross-coupling reactions and reductions

Yadav, Chetna / Maka, Vijay Kumar / Moorthy, Jarugu Narasimha / Payra, Soumen

Journal of catalysis. 2020 Apr., v. 384

2020

Abstract: In spite of the fact that a variety of reactions have been exploited for creation of innumerable porous organic polymers (POPs), aldol condensation reactions between aldehydes and ketones leading to enones remain unutilized quite inexplicably. We ... ...

Abstract	In spite of the fact that a variety of reactions have been exploited for creation of innumerable porous organic polymers (POPs), aldol condensation reactions between aldehydes and ketones leading to enones remain unutilized quite inexplicably. We surmised that the enone functionality can be exploited for stabilization of Pd akin to the manner of Pd(0) in Pd2(dba)3 by developing POPs based on aldol condensation reactions of polycarbonyl compounds with dialdehydes, and that such materials can be employed for catalytic transformations. By subjecting rationally designed tri-/tetraacetyl-functionalized aryl amines to aldol condensations with terephthalaldehyde, three different POPs, i.e., TPAPOPs 1–3, that feature enone functionalities have been synthesized and shown to exhibit palpable gas sorption properties. Remarkably, inverse uptake for sorption of H2 over N2 was observed for all POPs. As surmised, the representative POP, i.e., TPAPOP-1, was found to stabilize in situ-generated Pd(0) nanoparticles to enable application of the resultant material, i.e., Pd@TPAPOP-1, as a recyclable heterogeneous catalyst for a number of organic transformations. It is shown that coupling reactions such as Suzuki and Heck, and reductions such as nitro-to-amine and hydrogenation of olefins can be accomplished in a facile manner by employing Pd@TPAPOP-1 as a heterogeneous recyclable catalyst; the aforementioned transformations have been demonstrated on a broad set of substrates for each type.
Keywords	adsorption ; aldehydes ; alkenes ; amines ; aromatic compounds ; catalysts ; catalytic activity ; condensation reactions ; cross-coupling reactions ; hydrogen ; hydrogenation ; ketones ; nanoparticles ; nitrogen ; palladium ; polymers
Language	English
Dates of publication	2020-04
Size	p. 61-71.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1468993-5
ISSN	1090-2694 ; 0021-9517
ISSN (online)	1090-2694
ISSN	0021-9517
DOI	10.1016/j.jcat.2020.02.002
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