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Article: A status report with critical analysis of research trends in exploring medicinal plants as antiviral: Let us dig into the history to predict the future

Mukherjee, Souvik / Chouhan, Kavi Bhushan Singh / Tandey, Roshni / Yadav, Neelima / Dhobi, Mahaveer / Mandal, Vivekananda

Phytotherapy research. 2021 Aug., v. 35, no. 8

2021

Abstract: The review article serves as a mini directory of medicinal plants (662 medicinal plants have been identified) that have been investigated for antiviral property between 2015 and 2019. Data have been extracted from Scopus using specific keywords followed ... ...

Abstract	The review article serves as a mini directory of medicinal plants (662 medicinal plants have been identified) that have been investigated for antiviral property between 2015 and 2019. Data have been extracted from Scopus using specific keywords followed by manual sorting to avoid any duplication. Critical analyses of handpicked data have been presented. Mapping of medicinal plants, followed by critical analysis on the families and plant parts investigated in the said tenure, and its correlation with the participating countries and virus types have been critically analyzed. Interceptive role of phytochemicals in impeding viral replication has also been taken note of. Emphasis on India's exploration of various medicinal plants has also been given. Also presents a tutelage, which is likely to revive the interest in natural products for search of potential antivirals. This review is expected to serve as a rich data bank and as a guiding principle for researchers who are planning to explore medicinal plants in search for potential antiviral. It is time that researchers need to revisit their countries' own history of traditional medicine to predict something worthful in future.
Keywords	antiviral agents ; antiviral properties ; databases ; phytochemicals ; phytotherapy ; research ; traditional medicine ; virus replication ; viruses ; India
Language	English
Dates of publication	2021-08
Size	p. 4284-4296.
Publishing place	John Wiley & Sons, Ltd.
Document type	Article
Note	REVIEW
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7093
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: A status report with critical analysis of research trends in exploring medicinal plants as antiviral: Let us dig into the history to predict the future.

Mukherjee, Souvik / Chouhan, Kavi Bhushan Singh / Tandey, Roshni / Yadav, Neelima / Dhobi, Mahaveer / Mandal, Vivekananda

Phytotherapy research : PTR

2021 Volume 35, Issue 8, Page(s) 4284–4296

Abstract	The review article serves as a mini directory of medicinal plants (662 medicinal plants have been identified) that have been investigated for antiviral property between 2015 and 2019. Data have been extracted from Scopus using specific keywords followed by manual sorting to avoid any duplication. Critical analyses of handpicked data have been presented. Mapping of medicinal plants, followed by critical analysis on the families and plant parts investigated in the said tenure, and its correlation with the participating countries and virus types have been critically analyzed. Interceptive role of phytochemicals in impeding viral replication has also been taken note of. Emphasis on India's exploration of various medicinal plants has also been given. Also presents a tutelage, which is likely to revive the interest in natural products for search of potential antivirals. This review is expected to serve as a rich data bank and as a guiding principle for researchers who are planning to explore medicinal plants in search for potential antiviral. It is time that researchers need to revisit their countries' own history of traditional medicine to predict something worthful in future.
MeSH term(s)	Antiviral Agents/pharmacology ; Humans ; Medicine, Traditional ; Phytochemicals/pharmacology ; Phytotherapy ; Plant Extracts ; Plants, Medicinal
Chemical Substances	Antiviral Agents ; Phytochemicals ; Plant Extracts
Language	English
Publishing date	2021-04-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7093
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A one-step, one-tube real-time RT-PCR based assay with an automated analysis for detection of SARS-CoV-2

Dharavath, Bhasker / Yadav, Neelima / Desai, Sanket / Sunder, Roma / Mishra, Rohit / Ketkar, Madhura / Bhanshe, Prasanna / Gupta, Anurodh / Redhu, Archana Kumari / Patkar, Nikhil / Dutt, Shilpee / Gupta, Sudeep / Dutt, Amit

Heliyon. 2020 July, v. 6, no. 7

2020

Abstract: Early diagnosis of SARS-CoV-2 infected patients is essential to control the dynamics of the COVID-19 pandemic. We develop a rapid and accurate one-step multiplex TaqMan probe-based real-time RT-PCR assay, along with a computational tool to systematically ...

Abstract	Early diagnosis of SARS-CoV-2 infected patients is essential to control the dynamics of the COVID-19 pandemic. We develop a rapid and accurate one-step multiplex TaqMan probe-based real-time RT-PCR assay, along with a computational tool to systematically analyse the data. Our assay could detect to a limit of 15 copies of SARS-CoV-2 transcripts—based on experiments performed by spiking total human RNA with in vitro synthesized viral transcripts. The assay was evaluated by performing 184 validations for the SARS-CoV-2 Nucleocapsid gene and human RNase P as an internal control reference gene with dilutions ranging from 1-100 ng for human RNA on a cohort of 26 clinical samples. 5 of 26 patients were confirmed to be infected with SARS-CoV-2, while 21 tested negative, consistent with the standards. The accuracy of the assay was found to be 100% sensitive and 100% specific based on the 26 clinical samples that need to be further verified using a large number of clinical samples. In summary, we present a rapid, easy to implement real-time PCR based assay with automated analysis using a novel COVID qPCR Analyzer tool with graphical user interface (GUI) to analyze the raw qRT-PCR data in an unbiased manner at a cost of under $3 per reaction and turnaround time of less than 2h, to enable in-house SARS-CoV-2 testing across laboratories.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; automation ; early diagnosis ; genes ; humans ; nucleocapsid ; quantitative polymerase chain reaction ; ribonucleases ; user interface
Language	English
Dates of publication	2020-07
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e04405
Database	NAL-Catalogue (AGRICOLA)

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Article: A one-step, one-tube real-time RT-PCR based assay with an automated analysis for detection of SARS-CoV-2.

Heliyon

2020 Volume 6, Issue 7, Page(s) e04405

Abstract	Early diagnosis of SARS-CoV-2 infected patients is essential to control the dynamics of the COVID-19 pandemic. We develop a rapid and accurate one-step multiplex TaqMan probe-based real-time RT-PCR assay, along with a computational tool to systematically analyse the data. Our assay could detect to a limit of 15 copies of SARS-CoV-2 transcripts-based on experiments performed by spiking total human RNA with
Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e04405
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: miR-129-2 mediates down-regulation of progesterone receptor in response to progesterone in breast cancer cells.

Godbole, Mukul / Chandrani, Pratik / Gardi, Nilesh / Dhamne, Hemant / Patel, Kuldeep / Yadav, Neelima / Gupta, Sudeep / Badwe, Rajendra / Dutt, Amit

Cancer biology & therapy

2017 Volume 18, Issue 10, Page(s) 801–805

Abstract: Objective: Hormonal therapy is an important component of first line of treatment for breast cancer. Response to hormonal therapy is influenced by the progesterone receptor (PR)-status of breast cancer patients. However as an early effect, exposure to ... ...

Abstract	Objective: Hormonal therapy is an important component of first line of treatment for breast cancer. Response to hormonal therapy is influenced by the progesterone receptor (PR)-status of breast cancer patients. However as an early effect, exposure to progesterone decreases expression of PR in breast cancer cells. An understanding of the mechanism underlying down-regulation of PR could help improve response to hormonal therapy. Methods: We performed small RNA sequencing of breast cancer cells for identification of microRNAs targeting PR in response to progesterone treatment. Biochemical approaches were used to validate the findings in breast cancer cells. Results: Analysis of small RNA sequencing of four breast cancer cell lines treated with progesterone revealed an up-regulation of miR-129-2 independent of the PR status of the cells. We show that miR-129-2 targets 3'UTR of PR to down-regulate its expression. Furthermore, inhibition of miR-129-2 expression rescues the down-regulation of PR in breast cancer cells. Also, the expression levels of miR-129-2 was observed to be elevated in patients with low expression of PR in the TCGA cohort (n = 359). Conclusion: miR-129-2 mediates down-regulation of PR in breast cancer cells in response to progesterone, while anti-miR-129-2 could potentiate PR expression levels among patients with inadequate PR levels. Thus, modulation of activity of miR-129-2 could stabilize PR expression and potentially improve response to hormonal therapy under adjuvant or neo-adjuvant settings.
MeSH term(s)	Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Chemotherapy, Adjuvant/methods ; Datasets as Topic ; Down-Regulation ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/antagonists & inhibitors ; MicroRNAs/metabolism ; Progesterone/pharmacology ; Progesterone/therapeutic use ; Progestins/pharmacology ; Progestins/therapeutic use ; Receptors, Progesterone/metabolism ; Sequence Analysis, RNA
Chemical Substances	MicroRNAs ; Mirn129 microRNA, human ; Progestins ; Receptors, Progesterone ; Progesterone (4G7DS2Q64Y)
Language	English
Publishing date	2017-09-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2146305-0
ISSN	1555-8576 ; 1538-4047
ISSN (online)	1555-8576
ISSN	1538-4047
DOI	10.1080/15384047.2017.1373216
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Awareness of Cervical Cancer Screening among Paramedical Staff and Students in An Institution of Northern India

Manisha Gupta, Megha Yadav, Neelima Agarwal, Raksha Arora

National Journal of Community Medicine, Vol 4, Iss 2, Pp 333-

2013 Volume 336

Abstract: Introduction: Cervical cancer is one of the leading causes of morbidity and mortality worldwide. Most women with cervical cancer present with advanced disease, resulting in low cure rates. Factors contributing to high burden of disease and advanced stage ...

Abstract	Introduction: Cervical cancer is one of the leading causes of morbidity and mortality worldwide. Most women with cervical cancer present with advanced disease, resulting in low cure rates. Factors contributing to high burden of disease and advanced stage at presentation include poor knowledge about the disease furthermore and lack of screening among general population. Objective: To assess the knowledge and awareness of cervical cancer and explore attitudes and practices of Pap smear screening among paramedical staff and students in Santosh Medical College & Hospitals, Ghaziabad. Methods: A pretested self administered questionnaire based survey was done on 500 paramedical staff and students of Santosh Medical College & Hospitals, Ghaziabad, UP containing simple questions about demographics, knowledge about cervical cancer, its risk factors, screening techniques, attitudes towards cervical cancer screening and its practices. Results: In this study, about 20% were not aware of cervical cancer as a disease.19% knew that Pap smear is used for detection of preinvasive cervical cancer. O About 80% of subjects did not know that it was possible to detect cervical cancer early nor were they aware of different screening methods like Paps smear and had limited understanding of the types of cervical cancer screening techniques and poor disposition towards undergoing cervical cancer screening. 30% of the respondents knew about HPV Vaccine. Conclusion: This study serves to highlight that majority of para-medical staff was ill equipped with knowledge concerning cervical cancer.
Keywords	Cervical cancer ; Pap smear ; Screening attitude ; Public aspects of medicine ; RA1-1270 ; Medicine ; R
Subject code	610 ; 027
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	National Journal of Community Medicine
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: A one-step, one-tube real-time RT-PCR based assay with an automated analysis for detection of SARS-CoV-2

Heliyon

Abstract	Early diagnosis of SARS-CoV-2 infected patients is essential to control the dynamics of the COVID-19 pandemic. We develop a rapid and accurate one-step multiplex TaqMan probe-based real-time RT-PCR assay, along with a computational tool to systematically analyse the data. Our assay could detect to a limit of 15 copies of SARS-CoV-2 transcripts—based on experiments performed by spiking total human RNA with in vitro synthesized viral transcripts. The assay was evaluated by performing 184 validations for the SARS-CoV-2 Nucleocapsid gene and human RNase P as an internal control reference gene with dilutions ranging from 1-100 ng for human RNA on a cohort of 26 clinical samples. 5 of 26 patients were confirmed to be infected with SARS-CoV-2, while 21 tested negative, consistent with the standards. The accuracy of the assay was found to be 100% sensitive and 100% specific based on the 26 clinical samples that need to be further verified using a large number of clinical samples. In summary, we present a rapid, easy to implement real-time PCR based assay with automated analysis using a novel COVID qPCR Analyzer tool with graphical user interface (GUI) to analyze the raw qRT-PCR data in an unbiased manner at a cost of under $3 per reaction and turnaround time of less than 2h, to enable in-house SARS-CoV-2 testing across laboratories.Infectious disease; Microbial genomics; Genomics; Molecular biology; Virology; Diagnostics; SARS-CoV-2; Real-time RT- PCR; COVID-19 detection assay; COVID qPCR analyzer; Graphical user interface (GUI)
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #634144
Database	COVID19

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Article ; Online: A one-step, one-tube real-time RT-PCR based assay with an automated analysis for detection of SARS-CoV-2

Heliyon

2020 Volume 6, Issue 7, Page(s) e04405

Keywords	covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2020.e04405
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

2018 Volume 293, Issue 50, Page(s) 19263–19276

Abstract: Preoperative progesterone intervention has been shown to confer a survival benefit to breast cancer patients independently of their progesterone receptor (PR) status. This observation raises the question how progesterone affects the outcome of PR- ... ...

Abstract	Preoperative progesterone intervention has been shown to confer a survival benefit to breast cancer patients independently of their progesterone receptor (PR) status. This observation raises the question how progesterone affects the outcome of PR-negative cancer. Here, using microarray and RNA-Seq-based gene expression profiling and ChIP-Seq analyses of breast cancer cells, we observed that the serum- and glucocorticoid-regulated kinase gene (
MeSH term(s)	Breast Neoplasms/pathology ; Cell Cycle Proteins/metabolism ; Cell Line, Tumor ; Cell Movement/drug effects ; ErbB Receptors/metabolism ; Humans ; Immediate-Early Proteins/genetics ; Immediate-Early Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; MAP Kinase Signaling System/drug effects ; Neoplasm Invasiveness ; Progesterone/pharmacology ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Receptors, Progesterone/metabolism ; Transcription Factor AP-1/metabolism ; Up-Regulation/drug effects
Chemical Substances	Cell Cycle Proteins ; Immediate-Early Proteins ; Intracellular Signaling Peptides and Proteins ; N-myc downstream-regulated gene 1 protein ; Receptors, Progesterone ; Transcription Factor AP-1 ; Progesterone (4G7DS2Q64Y) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; serum-glucocorticoid regulated kinase (EC 2.7.11.1)
Language	English
Publishing date	2018-10-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.RA118.002894
Database	MEDical Literature Analysis and Retrieval System OnLINE

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