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  1. Article ; Online: COVID-19 in Children With Blood and Cancer Disorders: What Do We Know So Far?

    Yadav, Satya P

    Journal of pediatric hematology/oncology

    2020  Volume 42, Issue 6, Page(s) 413–414

    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; Child ; China/epidemiology ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Hematologic Diseases/epidemiology ; Hematologic Diseases/therapy ; Hematologic Diseases/virology ; Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; Neoplasms/virology ; New York/epidemiology ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000001872
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: NEPHRO-ZEBRA-a neonate with severe jaundice, persistent thrombocytopenia & recurrent acute kidney injury later in childhood: Joining the dots!

    Sethi, Sidharth Kumar / Yadav, Satya P / Moideen, Adel / Raina, Rupesh

    Journal of nephrology

    2024  

    Language English
    Publishing date 2024-01-25
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 1093991-x
    ISSN 1724-6059 ; 1120-3625 ; 1121-8428
    ISSN (online) 1724-6059
    ISSN 1120-3625 ; 1121-8428
    DOI 10.1007/s40620-023-01848-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: COVID-19 in Children With Blood and Cancer Disorders

    Yadav, Satya P.

    Journal of Pediatric Hematology/Oncology

    What Do We Know So Far?

    2020  Volume 42, Issue 6, Page(s) 413–414

    Keywords Pediatrics, Perinatology, and Child Health ; Oncology ; Hematology ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/mph.0000000000001872
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Successful Allogeneic Hematopoietic Stem Cell Transplant for CARMIL2 Deficiency.

    Rastogi, Neha / Thakkar, Dhwanee / Yadav, Satya P

    Journal of pediatric hematology/oncology

    2022  Volume 43, Issue 8, Page(s) e1270–e1271

    MeSH term(s) Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/complications ; Cytomegalovirus Infections/virology ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Infant ; Male ; Microfilament Proteins/deficiency ; Pneumonia, Viral/complications ; Pneumonia, Viral/virology ; Primary Immunodeficiency Diseases/genetics ; Primary Immunodeficiency Diseases/therapy ; Primary Immunodeficiency Diseases/virology ; Prognosis
    Chemical Substances CARMIL1 protein, human ; Microfilament Proteins
    Language English
    Publishing date 2022-04-01
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002311
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Langerhans Cell Histiocytosis Masquerading as Hypereosinophilia in a Child.

    Rastogi, Neha / Yadav, Satya P

    Journal of pediatric hematology/oncology

    2019  Volume 41, Issue 4, Page(s) 335–336

    MeSH term(s) Child, Preschool ; Histiocytosis, Langerhans-Cell/complications ; Histiocytosis, Langerhans-Cell/diagnosis ; Humans ; Hypereosinophilic Syndrome/etiology ; Male
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000001445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Fatal Severe Cytokine Release Syndrome Post-haploidentical Stem Cell Transplant With Post-transplant Cyclophosphamide in an Infant With Severe Combined Immunodeficiency and Disseminated Bacille Calmette-Guérin Infection.

    Arora, Sunisha / Upasana, K / Thakkar, Dhwanee / Yadav, Anjali / Rastogi, Neha / Yadav, Satya P

    Journal of pediatric hematology/oncology

    2023  Volume 45, Issue 6, Page(s) e773–e774

    Abstract: Introduction: Severe Combined Immunodeficiency (SCID) is a primary immunodeficiency disorder characterized by absent or dysfunctional T lymphocytes, leading to defective cellular and humoral immunity requiring urgent hematopoietic stem cell ... ...

    Abstract Introduction: Severe Combined Immunodeficiency (SCID) is a primary immunodeficiency disorder characterized by absent or dysfunctional T lymphocytes, leading to defective cellular and humoral immunity requiring urgent hematopoietic stem cell transplantation (HSCT). We report a case of SCID with disseminated Bacille Calmette-Guérin (BCG) infection who developed cytokine release syndrome (CRS) and possible Immune reconstitution inflammatory syndrome (IRIS) after Haploidentical HSCT with post-transplant cyclophosphamide.
    Methods: Data were retrospectively retrieved from electronic medical records.
    Result: A 5-month-old male infant was referred with fever, cough, and generalized maculopapular rash for 15 days, and had pallor without hepatosplenomegaly or lymphadenopathy. He had a history of previous male sibling death at 6 months of age due to pneumonia. Investigations: hemoglobin: 4.7 g/dL, TLC-6.37×103/uL, absolute lymphocytes: 0.98×103/uL, platelets: 319×103/uL, bilateral patchy opacities in both lung fields, and low immunoglobulin levels. Lymphocyte subset analysis revealed T-, B+, NK- SCID. Genetic analysis showed a hemizygous mutation in IL2RG (c.314A>G). The child received intravenous (IV) antibiotics, antifungal, antitubercular drugs, irradiated blood products, and IV immunoglobulins. Urgent haploidentical HSCT from the mother was planned. Conditioning was Fludarabine-40 mg/m2/d for 4 days, cyclophosphamide: 14.5 mg/kg/d for 2 days. He received peripheral blood hematopoietic stem cells with CD34- 15×106 cells/kg and CD3- 805×106 cells/kg. Within 2 hours of stem cell infusion, he developed respiratory distress, fever, shock, and flaring of rash. Methylprednisolone was started in view of CRS. On day+2, he had sudden desaturation and bradycardia needing mechanical ventilation and inotropes. His inflammatory markers were elevated (Ferritin: 3640 ng/mL, IL-6:5000 pg/mL, CRP:255 mg/L). In view of high-grade CRS, he received an injection of tocilizumab 8 mg/kg on day +2 and day +4. He received post-transplant cyclophosphamide 5 mg/kg on day +3. The endotracheal secretion GeneXpert was positive for Mycobacterium supporting the diagnosis of disseminated tuberculosis. Our patient had disseminated BCG infection which could also be contributory in the initiation of IRIS as the mother was immunized with the BCG vaccine in childhood so she must be having cytotoxic T cells specific for BCG, which were transferred to the infant with peripheral blood stem cell product. He succumbed to severe acute respiratory distress syndrome and multiorgan dysfunction on day +5 post-transplant.
    Conclusions: In haploidentical HSCT of SCID, post-transplant course can be complicated by CRS and IRIS as these patients are inefficient in mounting any response to infused donor lymphocytes resulting in their unregulated growth.
    MeSH term(s) Humans ; Infant ; Male ; Cyclophosphamide/adverse effects ; Cytokine Release Syndrome/complications ; Cytokine Release Syndrome/drug therapy ; Exanthema ; Hematopoietic Stem Cell Transplantation/adverse effects ; Retrospective Studies ; Severe Combined Immunodeficiency/drug therapy
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2023-06-26
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000002700
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Methods to investigate nucleosome structure and dynamics with single-molecule FRET.

    Das, Subhra K / Huynh, Mai T / Gao, Jia / Sengupta, Bhaswati / Yadav, Satya P / Lee, Tae-Hee

    Methods (San Diego, Calif.)

    2023  Volume 215, Page(s) 17–27

    Abstract: The nucleosome is the fundamental building block of chromatin. Changes taking place at the nucleosome level are the molecular basis of chromatin transactions with various enzymes and factors. These changes are directly and indirectly regulated by ... ...

    Abstract The nucleosome is the fundamental building block of chromatin. Changes taking place at the nucleosome level are the molecular basis of chromatin transactions with various enzymes and factors. These changes are directly and indirectly regulated by chromatin modifications such as DNA methylation and histone post-translational modifications including acetylation, methylation, and ubiquitylation. Nucleosomal changes are often stochastic, unsynchronized, and heterogeneous, making it very difficult to monitor with traditional ensemble averaging methods. Diverse single-molecule fluorescence approaches have been employed to investigate the structure and structural changes of the nucleosome in the context of its interactions with various enzymes such as RNA Polymerase II, histone chaperones, transcription factors, and chromatin remodelers. We utilize diverse single-molecule fluorescence methods to study the nucleosomal changes accompanying these processes, elucidate the kinetics of these processes, and eventually learn the implications of various chromatin modifications in directly regulating these processes. The methods include two- and three-color single-molecule fluorescence resonance energy transfer (FRET), single-molecule fluorescence correlation spectroscopy, and fluorescence (co-)localization. Here we report the details of the two- and three-color single-molecule FRET methods we currently use. This report will help researchers design their single-molecule FRET approaches to investigating chromatin regulation at the nucleosome level.
    MeSH term(s) Nucleosomes ; Fluorescence Resonance Energy Transfer/methods ; Histones/metabolism ; Chromatin/genetics ; DNA Methylation
    Chemical Substances Nucleosomes ; Histones ; Chromatin
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2023.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Methods to investigate nucleosome structure and dynamics with single-molecule FRET

    Das, Subhra K. / Huynh, Mai T. / Gao, Jia / Sengupta, Bhaswati / Yadav, Satya P. / Lee, Tae-Hee

    Methods. 2023 July, v. 215 p.17-27

    2023  

    Abstract: The nucleosome is the fundamental building block of chromatin. Changes taking place at the nucleosome level are the molecular basis of chromatin transactions with various enzymes and factors. These changes are directly and indirectly regulated by ... ...

    Abstract The nucleosome is the fundamental building block of chromatin. Changes taking place at the nucleosome level are the molecular basis of chromatin transactions with various enzymes and factors. These changes are directly and indirectly regulated by chromatin modifications such as DNA methylation and histone post-translational modifications including acetylation, methylation, and ubiquitylation. Nucleosomal changes are often stochastic, unsynchronized, and heterogeneous, making it very difficult to monitor with traditional ensemble averaging methods. Diverse single-molecule fluorescence approaches have been employed to investigate the structure and structural changes of the nucleosome in the context of its interactions with various enzymes such as RNA Polymerase II, histone chaperones, transcription factors, and chromatin remodelers. We utilize diverse single-molecule fluorescence methods to study the nucleosomal changes accompanying these processes, elucidate the kinetics of these processes, and eventually learn the implications of various chromatin modifications in directly regulating these processes. The methods include two- and three-color single-molecule fluorescence resonance energy transfer (FRET), single-molecule fluorescence correlation spectroscopy, and fluorescence (co–)localization. Here we report the details of the two- and three-color single-molecule FRET methods we currently use. This report will help researchers design their single-molecule FRET approaches to investigating chromatin regulation at the nucleosome level.
    Keywords DNA methylation ; DNA-directed RNA polymerase ; acetylation ; energy transfer ; fluorescence ; fluorescence correlation spectroscopy ; histones ; nucleosomes ; Single-molecule FRET ; smFRET ; Nucleosome ; Chromatin ; Histone modifications
    Language English
    Dates of publication 2023-07
    Size p. 17-27.
    Publishing place Elsevier Inc.
    Document type Article ; Online
    ZDB-ID 1066584-5
    ISSN 1095-9130 ; 1046-2023
    ISSN (online) 1095-9130
    ISSN 1046-2023
    DOI 10.1016/j.ymeth.2023.05.003
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Haploidentical Hematopoietic Stem Cell Transplantation for Relapsed Metastatic Retinoblastoma.

    Rastogi, Neha / Kapoor, Rohit / Yadav, Satya P

    Journal of pediatric hematology/oncology

    2020  Volume 42, Issue 8, Page(s) 499

    MeSH term(s) Child, Preschool ; Cyclophosphamide/therapeutic use ; Hematopoietic Stem Cell Transplantation/methods ; Humans ; Male ; Neoplasm Recurrence, Local/therapy ; Retinal Neoplasms/therapy ; Retinoblastoma/secondary ; Retinoblastoma/therapy ; Transplantation, Haploidentical/methods
    Chemical Substances Cyclophosphamide (8N3DW7272P)
    Language English
    Publishing date 2020-09-18
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 1231152-2
    ISSN 1536-3678 ; 1077-4114 ; 0192-8562
    ISSN (online) 1536-3678
    ISSN 1077-4114 ; 0192-8562
    DOI 10.1097/MPH.0000000000001955
    Database MEDical Literature Analysis and Retrieval System OnLINE

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