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  1. Article: Commentary: On the need for metaphysics in psychedelic therapy and research.

    Cheung, Katherine / Yaden, David B

    Frontiers in psychology

    2024  Volume 14, Page(s) 1341566

    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article ; Comment
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2023.1341566
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  2. Article ; Online: Valuing the Acute Subjective Experience.

    Cheung, Katherine / Earp, Brian D / Yaden, David B

    Perspectives in biology and medicine

    2024  Volume 67, Issue 1, Page(s) 155–165

    Abstract: Psychedelics, including psilocybin, and other consciousness-altering compounds such as 3,4-methylenedioxymethamphetamine (MDMA), currently are being scientifically investigated for their potential therapeutic uses, with a primary focus on measurable ... ...

    Abstract Psychedelics, including psilocybin, and other consciousness-altering compounds such as 3,4-methylenedioxymethamphetamine (MDMA), currently are being scientifically investigated for their potential therapeutic uses, with a primary focus on measurable outcomes: for example, alleviation of symptoms or increases in self-reported well-being. Accordingly, much recent discussion about the possible value of these substances has turned on estimates of the magnitude and duration of persisting positive effects in comparison to harms. However, many have described the value of a psychedelic experience with little or no reference to such therapeutic benefits, instead seeming to find the experience valuable in its own right. How can we make sense of such testimony? Could a psychedelic experience be valuable even if there were no persisting beneficial effects? If so, how? Using the concept of psychological richness, combined with insights from the philosophy of aesthetics and the enhancement literature, this essay explores potential sources of value in the acute subjective experience, apart from the value derived from persisting beneficial effects.
    MeSH term(s) Humans ; Hallucinogens/therapeutic use ; Consciousness/drug effects ; Psilocybin/therapeutic use ; N-Methyl-3,4-methylenedioxyamphetamine
    Chemical Substances Hallucinogens ; Psilocybin (2RV7212BP0) ; N-Methyl-3,4-methylenedioxyamphetamine (KE1SEN21RM)
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80373-x
    ISSN 1529-8795 ; 0031-5982
    ISSN (online) 1529-8795
    ISSN 0031-5982
    DOI 10.1353/pbm.2024.a919717
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  3. Article ; Online: Does the trip matter? Investigating the role of the subjective effects of psychedelics in persisting therapeutic effects.

    Nautiyal, Katherine M / Yaden, David B

    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

    2022  Volume 48, Issue 1, Page(s) 215–216

    MeSH term(s) Hallucinogens/pharmacology ; Hallucinogens/therapeutic use
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2022-08-15
    Publishing country England
    Document type News ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 639471-1
    ISSN 1740-634X ; 0893-133X
    ISSN (online) 1740-634X
    ISSN 0893-133X
    DOI 10.1038/s41386-022-01424-z
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    Zs.A 2379: Show issues Location:
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  4. Article ; Online: Psilocybin in Bipolar II Study Provides Preliminary Data on Safety.

    Yaden, David B / Gukasyan, Natalie / Nayak, Sandeep M

    JAMA psychiatry

    2023  

    Language English
    Publishing date 2023-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2023.4680
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  5. Article ; Online: Acute Subjective Effects of Psychedelics within and Beyond WEIRD Contexts.

    Graziosi, Marianna / Singh, Manvir / Nayak, Sandeep M / Yaden, David B

    Journal of psychoactive drugs

    2023  Volume 55, Issue 5, Page(s) 558–569

    Abstract: Reports of psychedelic experiences may contain similarities and differences across cultural contexts, but most current characterizations and quantifications of psychedelic experiences come from Western medical and naturalistic settings. In this article, ... ...

    Abstract Reports of psychedelic experiences may contain similarities and differences across cultural contexts, but most current characterizations and quantifications of psychedelic experiences come from Western medical and naturalistic settings. In this article, we begin with a brief history of the diversity of psychedelic use in non-Western settings. We then compare and contrast accounts of psychedelic experiences within and beyond Western, educated, industrialized, rich, and democratic (WEIRD) contexts. We focus on specific reports of direct testimony of the acute subjective effects of psychedelics experienced across these contexts. We compare themes from each of these various contexts, with special emphasis on psychometric measures such as the mystical experiences questionnaire (MEQ), the five-dimensional altered states of consciousness (5D-ASC) scale, the Survey of God Encounters, and the Survey of Entity Encounters, the Challenging Experiences Questionnaire, and the Inventory of Nonordinary Experiences (INOE). Finally, we offer recommendations for future research to quantify these similarities and differences across cultures to assess them empirically in the future.
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Mysticism ; Consciousness ; Surveys and Questionnaires ; Psychometrics
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2023-09-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2023.2255274
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    Zs.B 1121: Show issues Location:
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  6. Article ; Online: Psychedelics, Meaningfulness, and the "Proper Scope" of Medicine: Continuing the Conversation.

    Cheung, Katherine / Patch, Kyle / Earp, Brian D / Yaden, David B

    Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees

    2023  , Page(s) 1–7

    Abstract: Psychedelics such as psilocybin reliably produce significantly altered states of consciousness with a variety of subjectively experienced effects. These include certain changes to perception, cognition, and affect, ...

    Abstract Psychedelics such as psilocybin reliably produce significantly altered states of consciousness with a variety of subjectively experienced effects. These include certain changes to perception, cognition, and affect,
    Language English
    Publishing date 2023-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146581-5
    ISSN 1469-2147 ; 0963-1801
    ISSN (online) 1469-2147
    ISSN 0963-1801
    DOI 10.1017/S0963180123000270
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  7. Article ; Online: Preparing for the Bursting of the Psychedelic Hype Bubble.

    Yaden, David B / Potash, James B / Griffiths, Roland R

    JAMA psychiatry

    2022  Volume 79, Issue 10, Page(s) 943–944

    MeSH term(s) Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Humans
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701203-7
    ISSN 2168-6238 ; 2168-622X
    ISSN (online) 2168-6238
    ISSN 2168-622X
    DOI 10.1001/jamapsychiatry.2022.2546
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  8. Article ; Online: Ethical Issues Regarding Nonsubjective Psychedelics as Standard of Care.

    Yaden, David B / Earp, Brian D / Griffiths, Roland R

    Cambridge quarterly of healthcare ethics : CQ : the international journal of healthcare ethics committees

    2022  Volume 31, Issue 4, Page(s) 464–471

    Abstract: Evidence suggests that psychedelics bring about their therapeutic outcomes in part through the subjective or qualitative effects they engender and how the individual interprets the resulting experiences. However, psychedelics are contraindicated for ... ...

    Abstract Evidence suggests that psychedelics bring about their therapeutic outcomes in part through the subjective or qualitative effects they engender and how the individual interprets the resulting experiences. However, psychedelics are contraindicated for individuals who have been diagnosed with certain mental illnesses, on the grounds that these subjective effects may be disturbing or otherwise counter-therapeutic. Substantial resources are therefore currently being devoted to creating psychedelic substances that produce many of the same biological changes as psychedelics, but without their characteristic subjective effects. In this article, we consider ethical issues arising from the prospect of such potential "nonsubjective" psychedelics. We are broadly supportive of efforts to produce such substances for both scientific and clinical reasons. However, we argue that such nonsubjective psychedelics should be reserved for those special cases in which the subjective effects of psychedelics are specifically contraindicated, whereas classic psychedelics that affect subjective experience should be considered the default and standard of care. After reviewing evidence regarding the subjective effects of psychedelics, we raise a number of ethical concerns around the prospect of withholding such typically positive, meaningful, and therapeutic experiences from most patients.
    MeSH term(s) Humans ; Hallucinogens/pharmacology ; Hallucinogens/therapeutic use ; Standard of Care ; Mental Disorders/drug therapy
    Chemical Substances Hallucinogens
    Language English
    Publishing date 2022-11-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1146581-5
    ISSN 1469-2147 ; 0963-1801
    ISSN (online) 1469-2147
    ISSN 0963-1801
    DOI 10.1017/S096318012200007X
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  9. Article ; Online: The Subjective Effects of Psychedelics Are Necessary for Their Enduring Therapeutic Effects.

    Yaden, David B / Griffiths, Roland R

    ACS pharmacology & translational science

    2020  Volume 4, Issue 2, Page(s) 568–572

    Abstract: Classic psychedelics produce altered states of consciousness that individuals often interpret as meaningful experiences. Across a number of human studies, when the participant-rated intensity of the overall drug effects are statistically controlled for, ... ...

    Abstract Classic psychedelics produce altered states of consciousness that individuals often interpret as meaningful experiences. Across a number of human studies, when the participant-rated intensity of the overall drug effects are statistically controlled for, certain subjective effects predict therapeutic and other desirable outcomes. Underlying neurobiological mechanisms are likely necessary but not sufficient to confer full and enduring beneficial effects. We propose that the subjective effects of psychedelics are necessary for their enduring beneficial effects and that these subjective effects account for the majority of their benefit.
    Language English
    Publishing date 2020-12-10
    Publishing country United States
    Document type Journal Article
    ISSN 2575-9108
    ISSN (online) 2575-9108
    DOI 10.1021/acsptsci.0c00194
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  10. Article: The Psychedelic Integration Scales: Tools for Measuring Psychedelic Integration Behaviors and Experiences.

    Frymann, Tomas / Whitney, Sophie / Yaden, David B / Lipson, Joshua

    Frontiers in psychology

    2022  Volume 13, Page(s) 863247

    Abstract: In this study, we describe the development and initial validation of two psychometric scales for measuring psychedelic integration. Psychedelic integration refers to the post-acute period of time following psychedelic drug administration. We created the ... ...

    Abstract In this study, we describe the development and initial validation of two psychometric scales for measuring psychedelic integration. Psychedelic integration refers to the post-acute period of time following psychedelic drug administration. We created the Integration Engagement Scale (IES) to capture positive behavioral engagement with integration and the Experienced Integration Scale (EIS) to capture internal aspects of feeling integrated. These scales were developed to measure post-acute psychedelic administration dynamics in order to inform the creation of enhanced integration support and to help refine a general conceptual understanding of the construct of psychedelic integration. The scales are brief and face valid instruments designed for practical use in applied and research settings. Scale items were generated and refined using the Iterative Process Model of scale development, with input from psychedelics experts and clinicians. Content validity, internal structure, and reliability were assessed
    Language English
    Publishing date 2022-05-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.863247
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