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  1. Article: Pulmonary segmentectomy for early stage non-small cell lung cancer: when, for which cases and how.

    Matsuura, Natsumi / Yajima, Toshiki

    Journal of thoracic disease

    2023  Volume 15, Issue 3, Page(s) 956–959

    Language English
    Publishing date 2023-02-20
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2573571-8
    ISSN 2077-6624 ; 2072-1439
    ISSN (online) 2077-6624
    ISSN 2072-1439
    DOI 10.21037/jtd-23-66
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma.

    Yoshida, Chihiro / Kadota, Kyuichi / Ibuki, Emi / Ishikawa, Ryou / Haba, Reiji / Yajima, Toshiki

    Anticancer research

    2024  Volume 44, Issue 3, Page(s) 1289–1297

    Abstract: Background/aim: Prognostic indicators for postoperative lung adenocarcinoma are elusive. The interaction between CD24 on tumor cells and sialic-acid-binding Ig-like lectin 10 (Siglec10) on tumor-associated macrophages (TAMs) is implicated in immune ... ...

    Abstract Background/aim: Prognostic indicators for postoperative lung adenocarcinoma are elusive. The interaction between CD24 on tumor cells and sialic-acid-binding Ig-like lectin 10 (Siglec10) on tumor-associated macrophages (TAMs) is implicated in immune evasion in distinct tumors. However, the therapeutic significance of phagocytic checkpoints in lung adenocarcinoma remains unknown. We aimed to investigate the clinical relevance and prognostic significance of phagocytosis checkpoints mediated by Siglec10 in TAMs of patients with lung adenocarcinoma who underwent curative resection.
    Patients and methods: In this single-center retrospective study, we analyzed the data of 423 patients with stage I lung adenocarcinoma resected between 1999 and 2016. Tissue microarrays were constructed, and CD24, CD68, and Siglec10 immunohistochemistry was performed. Additionally, we assessed the clinical significance and prognostic associations of these markers.
    Results: CD24 expression was higher in the Siglec10-high expression group than that in the -low expression group. Multivariate analysis showed that combined high Siglec10 and CD24 expression was an independent predictor of recurrence-free probability. The combined high Siglec10 and CD68 expression was a significant independent predictor of overall survival. Univariate analysis demonstrated that the 5-year probability of post-recurrence survival of patients with combined high Siglec10 and CD68 expression was lower than that of the other patients.
    Conclusion: High TAM Siglec10 expression and tumor CD24 expression are correlated, and the high Siglec10+CD24 combination is a major risk factor for recurrence. CD68+Siglec10 TAMs are important prognostic factors. Siglec10 expression on TAMs is essential for tumor microenvironment immunoregulation and offers a promising new immunotherapeutic approach for lung adenocarcinoma.
    MeSH term(s) Humans ; Adenocarcinoma of Lung/pathology ; Lung Neoplasms/pathology ; Neoplasm Staging ; Prognosis ; Retrospective Studies ; Tumor Microenvironment ; Tumor-Associated Macrophages/metabolism
    Chemical Substances SIGLEC10 protein, human
    Language English
    Publishing date 2024-02-29
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16924
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: Congenital Tracheoesophageal Fistula in an Adult.

    Nakazawa, Seshiru / Yajima, Toshiki / Shirabe, Ken

    American journal of respiratory and critical care medicine

    2021  Volume 203, Issue 7, Page(s) e27–e28

    MeSH term(s) Aged ; Esophagus/surgery ; Humans ; Male ; Trachea/surgery ; Tracheoesophageal Fistula/diagnosis ; Tracheoesophageal Fistula/diagnostic imaging ; Tracheoesophageal Fistula/surgery ; Treatment Outcome
    Language English
    Publishing date 2021-01-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202003-0689IM
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  4. Article ; Online: Pneumothorax in Long-term Ventilator Users With Neuromuscular or Neurodegenerative Disease.

    Nakazawa, Seshiru / Atsumi, Jun / Yajima, Toshiki / Shirabe, Ken

    Chest

    2021  Volume 160, Issue 3, Page(s) e323–e324

    MeSH term(s) Home Care Services ; Humans ; Neurodegenerative Diseases/complications ; Pneumothorax/etiology ; Pneumothorax/therapy ; Respiration, Artificial ; Ventilators, Mechanical
    Language English
    Publishing date 2021-09-06
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2021.04.073
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    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  5. Article ; Online: Thoracoscopic S

    Obayashi, Kai / Yajima, Toshiki / Shimizu, Kimihiro / Shirabe, Ken

    JTCVS techniques

    2020  Volume 4, Page(s) 309–311

    Language English
    Publishing date 2020-08-26
    Publishing country United States
    Document type Journal Article
    ISSN 2666-2507
    ISSN (online) 2666-2507
    DOI 10.1016/j.xjtc.2020.08.048
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  6. Article ; Online: Changing and Unchanging Trends for an Old Disease.

    Nakazawa, Seshiru / Yajima, Toshiki / Shirabe, Ken

    Chest

    2020  Volume 158, Issue 6, Page(s) 2701

    MeSH term(s) Empyema, Pleural ; Humans ; Ontario
    Language English
    Publishing date 2020-11-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2020.06.084
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    Ui III Zs.45: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 349: Show issues

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  7. Article ; Online: Superior S

    Nakazawa, Seshiru / Yajima, Toshiki / Shirabe, Ken

    The Annals of thoracic surgery

    2020  Volume 112, Issue 2, Page(s) 686–687

    Language English
    Publishing date 2020-12-24
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2020.09.081
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    Zs.A 252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  8. Article ; Online: Role of surgical resection and its alternative local therapy for pulmonary metastasis of colorectal cancer.

    Ogawa, Hiroomi / Yajima, Toshiki / Sohda, Makoto / Shirabe, Ken / Saeki, Hiroshi

    Annals of gastroenterological surgery

    2021  Volume 5, Issue 6, Page(s) 747–753

    Abstract: We reviewed surgical and alternative treatments for pulmonary metastasis of colorectal cancer, focusing on recent reports. The standard treatment for pulmonary metastasis of colorectal cancer is pulmonary resection, if resectable, despite the fact that ... ...

    Abstract We reviewed surgical and alternative treatments for pulmonary metastasis of colorectal cancer, focusing on recent reports. The standard treatment for pulmonary metastasis of colorectal cancer is pulmonary resection, if resectable, despite the fact that the metastasis is hematogenous to distant organs. Guidelines in several countries, including Japan, have described pulmonary resection as a useful option because of the favorable long-term prognosis reported in various studies pertaining to pulmonary resection. The indications for pulmonary resection have been reviewed in several studies; additionally, the number of metastases, pretreatment carcinoembryonic antigen value, and disease-free interval from the primary resection to pulmonary recurrence have been proposed. However, no consensus has been reached to date. Contrastingly, recent advances in chemotherapy have remarkably improved the outcome of distant metastases, indicating that it is time to reconsider the significance of local treatment, including pulmonary resection. In addition to surgical resection, minimally invasive therapies, such as stereotactic body radiation therapy and radiofrequency ablation have been developed as local treatments for pulmonary metastases, and their long-term results have been reported. Prospective controlled trials and large-scale data analyses are needed to determine the best local treatment for pulmonary metastases and to find the appropriate indication for each treatment.
    Language English
    Publishing date 2021-05-24
    Publishing country Japan
    Document type Journal Article ; Review
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12472
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  9. Article ; Online: Clinical and anatomical features of the lateral costal artery and vein.

    Nakazawa, Seshiru / Kawatani, Natsuko / Obayashi, Kai / Ohtaki, Yoichi / Ito, Tomokazu / Yajima, Toshiki / Shirabe, Ken

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 10589

    Abstract: The lateral costal artery and vein are under recognized yet potentially important vessels for physicians, especially cardiothoracic surgeons. This study sought to determine the prevalence and clinical, anatomical, and radiological features of lateral ... ...

    Abstract The lateral costal artery and vein are under recognized yet potentially important vessels for physicians, especially cardiothoracic surgeons. This study sought to determine the prevalence and clinical, anatomical, and radiological features of lateral costal vessels. We retrospectively analyzed lateral costal vessels based on intraoperative images in patients who underwent thoracic surgery at our institute between January 2016 and March 2020. Clinical data and surgical videos were analyzed for patient characteristics, prevalence, length, laterality, and additional anatomical and radiological features. The overall prevalence of lateral costal vessels was 19% and was significantly higher in males than females (22% vs. 14%, p = 0.003). The lateral costal vessels extended beyond the 2nd intercostal space in 74% of the cases, with differing length between the right and left sides in bilateral cases. Lateral costal vessels could be identified intraoperatively using indocyanine green or preoperatively through three-dimensional computed tomography. The prevalence of lateral costal vessels is relatively high and should be acknowledged by physicians prior to procedures involving the vessels.
    MeSH term(s) Arteries/diagnostic imaging ; Female ; Humans ; Male ; Retrospective Studies ; Ribs ; Tomography, X-Ray Computed ; Veins
    Language English
    Publishing date 2022-06-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-14318-3
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  10. Article ; Online: Taste disorder in a patient with invasive thymoma without myasthenia gravis: a rare case report.

    Kosaka, Takayuki / Nakahashi, Hirotaka / Nakazawa, Seshiru / Ibe, Takashi / Yajima, Toshiki / Shirabe, Ken

    Mediastinum (Hong Kong, China)

    2022  Volume 6, Page(s) 9

    Abstract: Taste disorder has been reported as a non-motor symptom caused by myasthenia gravis (MG)-related autoimmune mechanism. Taste disorder in some cases recovered along with MG treatment, such as thymothymectomy or immunosuppressive treatment. However, ... ...

    Abstract Taste disorder has been reported as a non-motor symptom caused by myasthenia gravis (MG)-related autoimmune mechanism. Taste disorder in some cases recovered along with MG treatment, such as thymothymectomy or immunosuppressive treatment. However, symptom of taste disorder in thymoma patients without MG is very rare. Here, we reported a case of invasive thymoma without MG which had concurrent taste disorder. The taste disorder was successfully treated with cyclosporine. A female in her seventies had an anterior mediastinal tumor of 78-mm in diameter and pleural dissemination. She also had taste disorder, limited to sweet taste, and pure red cell aplasia (PRCA). Symptoms and physical findings showed no feature of MG. Pre-operative blood examination revealed no elevation of anti-acetylcholine receptor antibody . Extended total thymothymectomy and resection of all detectable pleural disseminations was performed. Pathological examination showed type B3 thymoma. Clinical stage was Masaoka stage IVa. After operation, there was no improvement in taste disorder and PRCA. Six months after operation, cyclosporine was administered for PRCA. In parallel with gradual improvement of anemia, taste disorder also gradually improved. Three months after the first administration of cyclosporine, taste disorder had completely recovered. This is the first case of taste disorder without any myasthenic status, which recovered with immunosuppressive drug. Our case suggested the potency of immunosuppressive treatment for taste disorder associate with thymoma without MG.
    Language English
    Publishing date 2022-03-25
    Publishing country China
    Document type Case Reports
    ISSN 2522-6711
    ISSN (online) 2522-6711
    DOI 10.21037/med-21-28
    Database MEDical Literature Analysis and Retrieval System OnLINE

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