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Article ; Online: A national survey assessing public readiness for digital health strategies against COVID-19 within the United Kingdom.

Sounderajah, Viknesh / Clarke, Jonathan / Yalamanchili, Seema / Acharya, Amish / Markar, Sheraz R / Ashrafian, Hutan / Darzi, Ara

Scientific reports

2021 Volume 11, Issue 1, Page(s) 5958

Abstract: There is concern that digital public health initiatives used in the management of COVID-19 may marginalise certain population groups. There is an overlap between the demographics of groups at risk of digital exclusion (older, lower social grade, low ... ...

Abstract	There is concern that digital public health initiatives used in the management of COVID-19 may marginalise certain population groups. There is an overlap between the demographics of groups at risk of digital exclusion (older, lower social grade, low educational attainment and ethnic minorities) and those who are vulnerable to poorer health outcomes from SARS-CoV-2. In this national survey study (n = 2040), we assessed how the UK population; particularly these overlapping groups, reported their preparedness for digital health strategies. We report, with respect to using digital information to make health decisions, that those over 60 are less comfortable (net comfort: 57%) than those between 18 and 39 (net comfort: 78%) and lower social grades are less comfortable (net comfort: 63%) than higher social grades (net comfort: 75%). With respect to a preference for digital over non-digital sources in seeking COVID-19 health information, those over 60 (net preference: 21%) are less inclined than those between 18 and 39 (net preference: 60%) and those of low educational attainment (net preference: 30%) are less inclined than those of high educational attainment (net preference: 52%). Lastly, with respect to distinguishing reliable digital COVID-19 information, lower social grades (net confidence: 55%) are less confident than higher social grades (net confidence: 68%) and those of low educational attainment (net confidence: 51%) are less confident than those of high educational attainment (net confidence: 71%). All reported differences are statistically significant (p < 0.01) following multivariate regression modelling. This study suggests that digital public health approaches to COVID-19 have the potential to marginalise groups who are concurrently at risk of digital exclusion and poor health outcomes from SARS-CoV-2.
MeSH term(s)	Adolescent ; Adult ; Aged ; COVID-19/pathology ; COVID-19/virology ; Educational Status ; Ethnicity ; Female ; Health Surveys ; Humans ; Male ; Middle Aged ; Risk Factors ; SARS-CoV-2/isolation & purification ; Social Class ; Telemedicine ; United Kingdom ; Young Adult
Language	English
Publishing date	2021-03-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-85514-w
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Article ; Online: The Reliability and Quality of YouTube Videos as a Source of Public Health Information Regarding COVID-19 Vaccination: Cross-sectional Study.

Chan, Calvin / Sounderajah, Viknesh / Daniels, Elisabeth / Acharya, Amish / Clarke, Jonathan / Yalamanchili, Seema / Normahani, Pasha / Markar, Sheraz / Ashrafian, Hutan / Darzi, Ara

JMIR public health and surveillance

2021 Volume 7, Issue 7, Page(s) e29942

Abstract: Background: Recent emergency authorization and rollout of COVID-19 vaccines by regulatory bodies has generated global attention. As the most popular video-sharing platform globally, YouTube is a potent medium for the dissemination of key public health ... ...

Abstract	Background: Recent emergency authorization and rollout of COVID-19 vaccines by regulatory bodies has generated global attention. As the most popular video-sharing platform globally, YouTube is a potent medium for the dissemination of key public health information. Understanding the nature of available content regarding COVID-19 vaccination on this widely used platform is of substantial public health interest. Objective: This study aimed to evaluate the reliability and quality of information on COVID-19 vaccination in YouTube videos. Methods: In this cross-sectional study, the phrases "coronavirus vaccine" and "COVID-19 vaccine" were searched on the UK version of YouTube on December 10, 2020. The 200 most viewed videos of each search were extracted and screened for relevance and English language. Video content and characteristics were extracted and independently rated against Health on the Net Foundation Code of Conduct and DISCERN quality criteria for consumer health information by 2 authors. Results: Forty-eight videos, with a combined total view count of 30,100,561, were included in the analysis. Topics addressed comprised the following: vaccine science (n=18, 58%), vaccine trials (n=28, 58%), side effects (n=23, 48%), efficacy (n=17, 35%), and manufacturing (n=8, 17%). Ten (21%) videos encouraged continued public health measures. Only 2 (4.2%) videos made nonfactual claims. The content of 47 (98%) videos was scored to have low (n=27, 56%) or moderate (n=20, 42%) adherence to Health on the Net Foundation Code of Conduct principles. Median overall DISCERN score per channel type ranged from 40.3 (IQR 34.8-47.0) to 64.3 (IQR 58.5-66.3). Educational channels produced by both medical and nonmedical professionals achieved significantly higher DISCERN scores than those of other categories. The highest median DISCERN scores were achieved by educational videos produced by medical professionals (64.3, IQR 58.5-66.3) and the lowest median scores by independent users (18, IQR 18-20). Conclusions: The overall quality and reliability of information on COVID-19 vaccines on YouTube remains poor. Videos produced by educational channels, especially by medical professionals, were higher in quality and reliability than those produced by other sources, including health-related organizations. Collaboration between health-related organizations and established medical and educational YouTube content producers provides an opportunity for the dissemination of high-quality information on COVID-19 vaccination. Such collaboration holds potential as a rapidly implementable public health intervention aiming to engage a wide audience and increase public vaccination awareness and knowledge.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines/administration & dosage ; Consumer Health Information/standards ; Cross-Sectional Studies ; Humans ; Information Dissemination/methods ; Public Health ; Reproducibility of Results ; Social Media ; United Kingdom/epidemiology ; Video Recording
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2021-07-08
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2369-2960
ISSN (online)	2369-2960
DOI	10.2196/29942
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Article ; Online: Penetrating gluteal injuries in North West London: a retrospective cohort study and initial management guideline.

McKnight, Gerard Hywel Owen / Yalamanchili, Seema / Sanchez-Thompson, Natalia / Guidozzi, Nadia / Dunhill-Turner, Natasha / Holborow, Alex / Batrick, Nicola / Hettiaratchy, Shehan / Khan, Mansoor / Kashef, Elika / Aylwin, Chris / Frith, Dan

Trauma surgery & acute care open

2021 Volume 6, Issue 1, Page(s) e000727

Abstract: Background: Penetrating gluteal injuries (PGIs) are an increasingly common presentation to major trauma centers (MTCs) in the UK and especially in London. PGIs can be associated with mortality and significant morbidity. There is a paucity of consistent ... ...

Abstract	Background: Penetrating gluteal injuries (PGIs) are an increasingly common presentation to major trauma centers (MTCs) in the UK and especially in London. PGIs can be associated with mortality and significant morbidity. There is a paucity of consistent guidance on how best to investigate and manage these patients. Methods: A retrospective cohort study was performed by interrogating prospectively collected patient records for PGI presenting to a level 1 MTC in London between 2017 and 2019. Results: There were 125 presentations with PGI, accounting for 6.86% of all penetrating injuries. Of these, 95.2% (119) were male, with a median age of 21 (IQR 18-29), and 20.80% (26) were under 18. Compared with the 3 years prior to this study, the number of PGI increased by 87%. The absolute risk (AR) of injury to a significant structure was 27.20%; the most frequently injured structure was a blood vessel (17.60%), followed by the rectum (4.80%) and the urethra (1.60%). The AR by anatomic quadrant of injury was highest in the lower inner quadrant (56%) and lowest in the upper outer quadrant (14%). CT scanning had an overall sensitivity of 50% and specificity of 92.38% in identifying rectal injury. Discussion: The anatomic quadrant of injury can be helpful in stratifying risk of rectal and urethral injuries when assessing a patient in the emergency department. Given the low sensitivity in identifying rectal injury on initial CT, this data supports assesing any patients considered at high risk of rectal injury with an examination under general anesthetic with or without rigid sigmoidoscopy. The pathway has created a clear tool that optimizes investigation and treatment, minimizing the likelihood of missed injury or unnecessary use of resources. It therefore represents a potential pathway other centers receiving a similar trauma burden could consider adopting. Level of evidence: 2b.
Language	English
Publishing date	2021-07-23
Publishing country	England
Document type	Journal Article
ISSN	2397-5776
ISSN (online)	2397-5776
DOI	10.1136/tsaco-2021-000727
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Article ; Online: Impact of the COVID-19 Pandemic on Emergency Adult Surgical Patients and Surgical Services: An International Multi-center Cohort Study and Department Survey.

Winter Beatty, Jasmine / Clarke, Jonathan M / Sounderajah, Viknesh / Acharya, Amish / Rabinowicz, Simon / Martin, Guy / Warren, Leigh R / Yalamanchili, Seema / Scott, Alasdair J / Burgnon, Elizabeth / Purkayastha, Sanjay / Markar, Sheraz / Kinross, James M

Annals of surgery

2021 Volume 274, Issue 6, Page(s) 904–912

Abstract: Objectives: The PREDICT study aimed to determine how the COVID-19 pandemic affected surgical services and surgical patients and to identify predictors of outcomes in this cohort.: Background: High mortality rates were reported for surgical patients ... ...

Abstract	Objectives: The PREDICT study aimed to determine how the COVID-19 pandemic affected surgical services and surgical patients and to identify predictors of outcomes in this cohort. Background: High mortality rates were reported for surgical patients with COVID-19 in the early stages of the pandemic. However, the indirect impact of the pandemic on this cohort is not understood, and risk predictors are yet to be identified. Methods: PREDICT is an international longitudinal cohort study comprising surgical patients presenting to hospital between March and August 2020, conducted alongside a survey of staff redeployment and departmental restructuring. A subgroup analysis of 3176 adult emergency patients, recruited by 55 teams across 18 countries is presented. Results: Among adult emergency surgical patients, all-cause in-hospital mortality (IHM) was 3.6%, compared to 15.5% for those with COVID-19. However, only 14.1% received a COVID-19 test on admission in March, increasing to 76.5% by July.Higher Clinical Frailty Scale scores (CFS >7 aOR 18.87), ASA grade above 2 (aOR 4.29), and COVID-19 infection (aOR 5.12) were independently associated with significantly increased IHM.The peak months of the first wave were independently associated with significantly higher IHM (March aOR 4.34; April aOR 4.25; May aOR 3.97), compared to non-peak months.During the study, UK operating theatre capacity decreased by a mean of 63.6% with a concomitant 27.3% reduction in surgical staffing. Conclusion: The first wave of the COVID-19 pandemic significantly impacted surgical patients, both directly through co-morbid infection and indirectly as shown by increasing mortality in peak months, irrespective of COVID-19 status.Higher CFS scores and ASA grades strongly predict outcomes in surgical patients and are an important risk assessment tool during the pandemic.
MeSH term(s)	Adult ; Aged ; COVID-19/epidemiology ; Comorbidity ; Emergencies/epidemiology ; Emergency Service, Hospital/statistics & numerical data ; Female ; Follow-Up Studies ; General Surgery/statistics & numerical data ; Global Health ; Hospital Mortality/trends ; Humans ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2 ; Surveys and Questionnaires
Language	English
Publishing date	2021-08-18
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000005152
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Article ; Online: The changing face of the paediatric microlaryngobronchoscopy (MLB): A two year prospective study.

Cadd, Brandon / Yalamanchili, Seema / Virk, Jagdeep Singh / Bajaj, Yogesh

International journal of pediatric otorhinolaryngology

2015 Volume 79, Issue 7, Page(s) 1111–1114

Abstract: Background: Changes in the management and survival of paediatric patients with airway complaints combined with improving survival rates of premature babies have resulted in a different patient population for the paediatric airway surgeon than that ... ...

Abstract	Background: Changes in the management and survival of paediatric patients with airway complaints combined with improving survival rates of premature babies have resulted in a different patient population for the paediatric airway surgeon than that previously described in the literature. Objectives: To examine the presentation, diagnosis, clinical course and outcomes for patients undergoing microlaryngobronchoscopy (MLB). Study design: 2 year prospective longitudinal study. Study population: 210 microlaryngobronchoscopy examinations were performed on a total of 102 patients. Mean age at initial examination was 29.4 months with a male preponderance (68%). Results: 72 (71%) patients had other documented medical co-morbidities with 30 children having no previous medical history. Of the 102 patients the primary diagnoses were: Subglottic Stenosis (29.4%), Laryngomalacia (20.6%), Laryngeal Cleft (16.7%), Normal Anatomy (11.8%) and Vocal Cord pathology (5.9%). The average rate of diagnoses per patient for the whole cohort was 1.57. Of those patients with a diagnosis on examination, 40 had a solitary diagnosis whilst 50 patients (55.5%) were found to have multiple diagnoses, equating to 2.35 diagnoses per patient. Children with a history of prematurity accounted for 18.6% of our cohort with a 100% rate of laryngo-tracheal pathology on examination and an average number of diagnoses per child of 2.21. Conclusion: Our cohort illustrates the varied population served by today's paediatric airway surgeon alongside common diagnoses and co-pathologies affecting our patients.
MeSH term(s)	Bronchoscopy ; Child ; Female ; Humans ; Infant ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/diagnosis ; Laryngeal Diseases/diagnosis ; Laryngoscopy ; Longitudinal Studies ; Male ; Prospective Studies
Language	English
Publishing date	2015-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	754501-0
ISSN	1872-8464 ; 0165-5876
ISSN (online)	1872-8464
ISSN	0165-5876
DOI	10.1016/j.ijporl.2015.04.042
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Article ; Online: Changing the Paradigm of Surgical Research During a Pandemic.

Markar, Sheraz R / Martin, Guy / Penna, Marta / Yalamanchili, Seema / Beatty, Jasmine Winter / Clarke, Jonathan / Erridge, Simon / Sounderajah, Viknesh / Denning, Max / Scott, Alasdair / Purkayastha, Sanjay / Kinross, James

Annals of surgery

2020 Volume 272, Issue 2, Page(s) e170–e171

MeSH term(s)	COVID-19 ; Coronavirus Infections/epidemiology ; Female ; General Surgery ; Humans ; Male ; Pandemics/statistics & numerical data ; Pneumonia, Viral/epidemiology ; Research Design/statistics & numerical data ; United Kingdom
Keywords	covid19
Language	English
Publishing date	2020-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000004000
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Article ; Online: Insights from a global snapshot of the change in elective colorectal practice due to the COVID-19 pandemic.

Mason, Sam E / Scott, Alasdair J / Markar, Sheraz R / Clarke, Jonathan M / Martin, Guy / Winter Beatty, Jasmine / Sounderajah, Viknesh / Yalamanchili, Seema / Denning, Max / Arulampalam, Thanjakumar / Kinross, James M

PloS one

2020 Volume 15, Issue 10, Page(s) e0240397

Abstract: Background: There is a need to understand the impact of COVID-19 on colorectal cancer care globally and determine drivers of variation.: Objective: To evaluate COVID-19 impact on colorectal cancer services globally and identify predictors for ... ...

Abstract	Background: There is a need to understand the impact of COVID-19 on colorectal cancer care globally and determine drivers of variation. Objective: To evaluate COVID-19 impact on colorectal cancer services globally and identify predictors for behaviour change. Design: An online survey of colorectal cancer service change globally in May and June 2020. Participants: Attending or consultant surgeons involved in the care of patients with colorectal cancer. Main outcome measures: Changes in the delivery of diagnostics (diagnostic endoscopy), imaging for staging, therapeutics and surgical technique in the management of colorectal cancer. Predictors of change included increased hospital bed stress, critical care bed stress, mortality and world region. Results: 191 responses were included from surgeons in 159 centers across 46 countries, demonstrating widespread service reduction with global variation. Diagnostic endoscopy was reduced in 93% of responses, even with low hospital stress and mortality; whilst rising critical care bed stress triggered complete cessation (p = 0.02). Availability of CT and MRI fell by 40-41%, with MRI significantly reduced with high hospital stress. Neoadjuvant therapy use in rectal cancer changed in 48% of responses, where centers which had ceased surgery increased its use (62 vs 30%, p = 0.04) as did those with extended delays to surgery (p<0.001). High hospital and critical care bed stresses were associated with surgeons forming more stomas (p<0.04), using more experienced operators (p<0.003) and decreased laparoscopy use (critical care bed stress only, p<0.001). Patients were also more actively prioritized for resection, with increased importance of co-morbidities and ICU need. Conclusions: The COVID-19 pandemic was associated with severe restrictions in the availability of colorectal cancer services on a global scale, with significant variation in behaviours which cannot be fully accounted for by hospital burden or mortality.
MeSH term(s)	Betacoronavirus/physiology ; COVID-19 ; Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/therapy ; Coronavirus Infections/epidemiology ; Elective Surgical Procedures/statistics & numerical data ; Female ; Gastroenterology/organization & administration ; Gastroenterology/statistics & numerical data ; Health Care Rationing ; Health Services Needs and Demand ; Humans ; Male ; Pandemics ; Patient Safety ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0240397
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Article ; Online: What Has Been the Impact of Covid-19 on Safety Culture? A Case Study from a Large Metropolitan Healthcare Trust.

Denning, Max / Goh, Ee Teng / Scott, Alasdair / Martin, Guy / Markar, Sheraz / Flott, Kelsey / Mason, Sam / Przybylowicz, Jan / Almonte, Melanie / Clarke, Jonathan / Winter Beatty, Jasmine / Chidambaram, Swathikan / Yalamanchili, Seema / Tan, Benjamin Yong-Qiang / Kanneganti, Abhiram / Sounderajah, Viknesh / Wells, Mary / Purkayastha, Sanjay / Kinross, James

International journal of environmental research and public health

2020 Volume 17, Issue 19

Abstract: Covid-19 has placed an unprecedented demand on healthcare systems worldwide. A positive safety culture is associated with improved patient safety and, in turn, with patient outcomes. To date, no study has evaluated the impact of Covid-19 on safety ... ...

Abstract	Covid-19 has placed an unprecedented demand on healthcare systems worldwide. A positive safety culture is associated with improved patient safety and, in turn, with patient outcomes. To date, no study has evaluated the impact of Covid-19 on safety culture. The Safety Attitudes Questionnaire (SAQ) was used to investigate safety culture at a large UK healthcare trust during Covid-19. Findings were compared with baseline data from 2017. Incident reporting from the year preceding the pandemic was also examined. SAQ scores of doctors and "other clinical staff", were relatively higher than the nursing group. During Covid-19, on univariate regression analysis, female gender, age 40-49 years, non-White ethnicity, and nursing job role were all associated with lower SAQ scores. Training and support for redeployment were associated with higher SAQ scores. On multivariate analysis, non-disclosed gender (-0.13), non-disclosed ethnicity (-0.11), nursing role (-0.15), and support (0.29) persisted to a level of significance. A significant decrease (
MeSH term(s)	Adult ; Attitude of Health Personnel ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Female ; Humans ; Male ; Middle Aged ; Organizational Culture ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Safety Management ; United Kingdom
Keywords	covid19
Language	English
Publishing date	2020-09-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph17197034
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Article ; Online: Insights from a global snapshot of the change in elective colorectal practice due to the COVID-19 pandemic

Mason, Sam E. / Scott, Alasdair J. / Markar, Sheraz R. / Clarke, Jonathan M. / Martin, Guy / Winter Beatty, Jasmine / Sounderajah, Viknesh / Yalamanchili, Seema / Denning, Max / Arulampalam, Thanjakumar / Kinross, James M.

PLOS ONE

2020 Volume 15, Issue 10, Page(s) e0240397

Keywords	General Biochemistry, Genetics and Molecular Biology ; General Agricultural and Biological Sciences ; General Medicine ; covid19
Language	English
Publisher	Public Library of Science (PLoS)
Publishing country	us
Document type	Article ; Online
ISSN	1932-6203
DOI	10.1371/journal.pone.0240397
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Insights from a global snapshot of the change in elective colorectal practice due to the COVID-19 pandemic

PLoS One

Abstract: BACKGROUND: There is a need to understand the impact of COVID-19 on colorectal cancer care globally and determine drivers of variation. OBJECTIVE: To evaluate COVID-19 impact on colorectal cancer services globally and identify predictors for behaviour ... ...

Abstract	BACKGROUND: There is a need to understand the impact of COVID-19 on colorectal cancer care globally and determine drivers of variation. OBJECTIVE: To evaluate COVID-19 impact on colorectal cancer services globally and identify predictors for behaviour change. DESIGN: An online survey of colorectal cancer service change globally in May and June 2020. PARTICIPANTS: Attending or consultant surgeons involved in the care of patients with colorectal cancer. MAIN OUTCOME MEASURES: Changes in the delivery of diagnostics (diagnostic endoscopy), imaging for staging, therapeutics and surgical technique in the management of colorectal cancer. Predictors of change included increased hospital bed stress, critical care bed stress, mortality and world region. RESULTS: 191 responses were included from surgeons in 159 centers across 46 countries, demonstrating widespread service reduction with global variation. Diagnostic endoscopy was reduced in 93% of responses, even with low hospital stress and mortality; whilst rising critical care bed stress triggered complete cessation (p = 0.02). Availability of CT and MRI fell by 40-41%, with MRI significantly reduced with high hospital stress. Neoadjuvant therapy use in rectal cancer changed in 48% of responses, where centers which had ceased surgery increased its use (62 vs 30%, p = 0.04) as did those with extended delays to surgery (p<0.001). High hospital and critical care bed stresses were associated with surgeons forming more stomas (p<0.04), using more experienced operators (p<0.003) and decreased laparoscopy use (critical care bed stress only, p<0.001). Patients were also more actively prioritized for resection, with increased importance of co-morbidities and ICU need. CONCLUSIONS: The COVID-19 pandemic was associated with severe restrictions in the availability of colorectal cancer services on a global scale, with significant variation in behaviours which cannot be fully accounted for by hospital burden or mortality.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #841010
Database	COVID19

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