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Article: Developing technologies and areas of interest in lung cancer screening adjuncts.

Park, Ju Ae / Pham, Duy / Yalamanchili, Sriya / Twardus, Shaina / Suzuki, Kei

2024 Volume 16, Issue 2, Page(s) 1552–1564

Abstract: Lung cancer remains the leading cause of cancer mortality. Screening guidelines have been implemented in the past decade to aid in earlier detection of at-risk groups. Nevertheless, computed tomography (CT) scans, the principal screening modality in use ... ...

Abstract	Lung cancer remains the leading cause of cancer mortality. Screening guidelines have been implemented in the past decade to aid in earlier detection of at-risk groups. Nevertheless, computed tomography (CT) scans, the principal screening modality in use today, are still low yield, with 3.6% of lung cancer confirmed amongst 39.1% of lesions detected over a 3-year period. They also carry relatively high false positive rates, between 9% and 27%, which can bear unnecessary financial and emotional costs to patients. As such, research efforts have been dedicated to the development of lung cancer screening adjuncts to improve detection reliability. We herein review several emerging technologies in this specific arena and their efficacy. These include plasma markers (microDNA, DNA methylation, and tumor-associated antibodies), breath/sputum biomarkers [volatile organic compounds (VOCs) and exhaled breath condensate (EBC)], proteomics, metabolomics, and machine learning, such as radiomics technology. We find that, across the board, they offer promising results in terms of non-invasive diagnostics, genetic sequencing for higher-risk individuals, and accessibility for a diverse cohort of patients. While these screening adjuncts are unlikely to completely replace the current standard of care at the moment, continued research into these technologies is crucial to improve and personalize the identification, treatment, and outcome of lung cancer patients in the near future.
Language	English
Publishing date	2024-02-27
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2573571-8
ISSN	2077-6624 ; 2072-1439
ISSN (online)	2077-6624
ISSN	2072-1439
DOI	10.21037/jtd-23-1326
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Further Characterizing Cardiomyopathy Mortality in Young Adults to Elucidate Health Disparities.

Yalamanchili, Samshita / Shih, Jeffrey A / Kovell, Lara C

JAMA cardiology

2022 Volume 8, Issue 2, Page(s) 205

MeSH term(s)	Humans ; Young Adult ; Risk Factors ; Cardiomyopathies
Language	English
Publishing date	2022-12-14
Publishing country	United States
Document type	Letter ; Comment
ISSN	2380-6591
ISSN (online)	2380-6591
DOI	10.1001/jamacardio.2022.4792
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Article ; Online: Why should disorders of the ear, nose and throat be treated by the same specialty? Can this situation persist?

Yalamanchili, S

The Journal of laryngology and otology

2009 Volume 123, Issue 4, Page(s) 367–371

Abstract: The surgical specialty of otorhinolaryngology has its origins in the nineteenth century. Subsequently, the specialty also incorporated allied disciplines such as plastics and head and neck surgery. Following World War II, the survival of the specialty ... ...

Abstract	The surgical specialty of otorhinolaryngology has its origins in the nineteenth century. Subsequently, the specialty also incorporated allied disciplines such as plastics and head and neck surgery. Following World War II, the survival of the specialty was threatened by the advent of antibiotics and the rise of the general surgeon. Despite this, the specialty of ENT was strengthened by strong post-war leadership and robust training.Today, with ENT knowledge ever increasing, the subspecialties have again begun to subdivide. Specialisation brings improved efficiency and outcomes; however, there remains a great need for the ENT generalist. Not all cases require subspecialist attention, and the generalist remains the basis of competent emergency cover. The natural development of otorhinolaryngology has brought the invaluable synergistic knowledge required to comprehensively treat disorders of the ear, nose and throat, knowledge that must not be overlooked when shaping the future of the specialty.
MeSH term(s)	History, 19th Century ; History, 20th Century ; History, 21st Century ; Humans ; Medicine ; Otolaryngology/history ; Otolaryngology/trends ; Specialization
Language	English
Publishing date	2009-04
Publishing country	England
Document type	Historical Article ; Journal Article
ZDB-ID	218299-3
ISSN	1748-5460 ; 0022-2151
ISSN (online)	1748-5460
ISSN	0022-2151
DOI	10.1017/S0022215108003769
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Ul II Zs.64: Show issues

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Article: Comparative Evaluation of Four Different Obturating Techniques in Primary Teeth Using Cone-beam Computed Tomography: An

Ali, Syed M / Mukthineni, Sridhar / Sankar, Aj Sai / Enuganti, Sridevi / Kundeti, Siva Sankar / Yalamanchili, Samatha

International journal of clinical pediatric dentistry

2023 Volume 16, Issue 2, Page(s) 218–222

Abstract: Background: The quality of the obturation plays a significant role in the success of endodontic treatment. To date, various technologies have been used to evaluate the quality of obturation, but all of them have their own limitations. In order to ... ...

Abstract	Background: The quality of the obturation plays a significant role in the success of endodontic treatment. To date, various technologies have been used to evaluate the quality of obturation, but all of them have their own limitations. In order to overcome those limitations, recent technological advancements like cone-beam computed tomography (CBCT) can be helpful. Aim: To compare and evaluate the efficiency of different root canal obturation techniques in primary teeth using CBCT. Materials and methods: A total of 80 root canals in 30 children aged between 4 and 9 years were selected and divided into four groups, with 20 root canals in each. Obturation in group I was performed using the endodontic pressure syringe; group II-hand spreaders; group III-Lentulo spirals mounted on slow-speed handpiece; and group IV-insulin syringe. The quality of obturation was evaluated using a CBCT scan. Results: Group I samples showed the most optimally filled canals followed by II and III; least in group IV. A maximum number of overfilled canals was exhibited in group III samples. Voids were minimal in all four groups and the values obtained were not statistically significant. Conclusion: Obturation with an endodontic pressure syringe reported the highest number of optimally filled root canals and the insulin syringe showed the least number of optimally filled canals. How to cite this article: Ali SM, Mukthineni S, Sai Sankar AJ,
Language	English
Publishing date	2023-07-19
Publishing country	India
Document type	Journal Article
ISSN	0974-7052
ISSN	0974-7052
DOI	10.5005/jp-journals-10005-2566
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Article ; Online: Osteomyelitis of the mandible in patients with a history of COVID-19 infection: clinical, histologic, and radiographic presentations.

Pingili, Shruthi / Yalamanchili, Samatha / Alaparthi, Ravi Kiran / Rao Naik, Purna Chandra / Juluri, Suneetha

Quintessence international (Berlin, Germany : 1985)

2023 Volume 54, Issue 6, Page(s) 510–515

Abstract: COVID-19 is a serious global infectious disease impairing the quality of life of people across the world. SARS-CoV-2 may reside in nasopharyngeal and salivary secretions of COVID-19-infected patients and spreads mainly through respiratory droplets and ... ...

Abstract	COVID-19 is a serious global infectious disease impairing the quality of life of people across the world. SARS-CoV-2 may reside in nasopharyngeal and salivary secretions of COVID-19-infected patients and spreads mainly through respiratory droplets and fomites. It has presented a challenge to dentistry, as many dental procedures generate aerosols that could lead to cross-contamination. It also presents many post-infection complications that may continue to debilitate patients, even after successful management of the virus. One such complication may be osteomyelitis of the jaw. Two cases of post-COVID-19 osteomyelitis of the jaw are presented that were determined to be unrelated to mucormycosis in otherwise healthy individuals with no prior dental complaints. An attempt is made to shed light on clinical signs in post-COVID cases that may point to a diagnosis of the condition. The pathophysiology is also discussed, which may help in formulating guidelines to prevent and manage post-COVID osteomyelitis of the jaw.
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Quality of Life ; Respiratory Aerosols and Droplets ; Osteomyelitis/diagnostic imaging ; Osteomyelitis/etiology ; Mandible
Language	English
Publishing date	2023-02-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	7436-6
ISSN	1936-7163 ; 0033-6572
ISSN (online)	1936-7163
ISSN	0033-6572
DOI	10.3290/j.qi.b4014521
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Zs.B 1210: Show issues

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Article ; Online: Experimental study of occlusion break surge volume in 3 different phacoemulsification systems.

Miller, Kevin M / Dyk, David W / Yalamanchili, Satish

Journal of cataract and refractive surgery

2021 Volume 47, Issue 11, Page(s) 1466–1472

Abstract: Purpose: To evaluate surge volume after occlusion breaks in 3 different phacoemulsification systems.: Setting: Alcon Research LLC, Lake Forest, California.: Design: Experimental study.: Methods: A mechanical spring eye model was used to test ... ...

Abstract	Purpose: To evaluate surge volume after occlusion breaks in 3 different phacoemulsification systems. Setting: Alcon Research LLC, Lake Forest, California. Design: Experimental study. Methods: A mechanical spring eye model was used to test the Centurion with Active Sentry, WhiteStar Signature Pro, and Stellaris PC. Raw oscilloscope data were converted to volumetric and pressure measurements. Fitted average surge traces were generated for each test condition and used to develop an interpolation algorithm to predict transient occlusion break surge events. Two-dimensional heat maps were generated. Results: During occlusion break surge, the Centurion with Active Sentry had smaller aqueous volume losses than the WhiteStar or Stellaris PC. Maximum surge volumes within the mechanical spring eye model displacement limit were 74.7 μL, 157.5 μL, and 151.7 μL using Centurion with Active Sentry, WhiteStar, and Stellaris PC, respectively. In the aphakic state, heat maps showed that Centurion with Active Sentry had less than 20% aqueous volume loss across all vacuum limits and target intraocular pressure; WhiteStar and Stellaris PC systems had up to 35% and 50% aqueous volume losses, respectively, at the higher vacuum limits. In the phakic state, Centurion with Active Sentry had up to 30% aqueous volume loss and WhiteStar and Stellaris PC systems had up to 50% aqueous volume losses. In addition, predicted transient traces demonstrated that Centurion with Active Sentry had the lowest percentage simulated aqueous volume loss compared with WhiteStar or Stellaris PC. Conclusions: Centurion with Active Sentry had lower aqueous volume losses after occlusion break than WhiteStar and Stellaris PC systems at all surgical settings.
MeSH term(s)	Hot Temperature ; Humans ; Intraocular Pressure ; Phacoemulsification ; Tonometry, Ocular ; Vacuum
Language	English
Publishing date	2021-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000000651
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Article ; Online: Insights into the Biological Properties of Ligands and Identity of Operator Site for LanK Protein Involved in Landomycin Production.

Deneka, Maksym / Ostash, Iryna / Yalamanchili, Subbarao / Bennett, Clay S / Ostash, Bohdan

Current microbiology

2023 Volume 81, Issue 1, Page(s) 5

Abstract: LanK is a TetR type regulatory protein that coordinates the late steps of the biosynthesis of the landomycin family of antitumor angucyclic polyketides and their export from the cells of Streptomyces cyanogenus S136. We recently described the structure ... ...

Abstract	LanK is a TetR type regulatory protein that coordinates the late steps of the biosynthesis of the landomycin family of antitumor angucyclic polyketides and their export from the cells of Streptomyces cyanogenus S136. We recently described the structure of LanK and showed that it is the carbohydrate portion of the landomycins that is responsible for abrogating the repressing effect of LanK on landomycin production and export. The effect has been established in a series of in vitro tests using synthetic analogs of the landomycin carbohydrate chains. Whether such synthetic compounds would function as effector molecules for LanK under in vivo conditions remained unknown. Furthermore, the location and identity of LanK operator sites within the lanK-lanJ intergenic region (lanKJp) was unknown. Here we report that methoxyphenyl analogs of tri- and hexasaccharide chains of landomycins cannot function as LanK ligands when applied externally to the reporter strain. The lability of these compounds to cellular media and/or their poor penetration into the cells could explain our observations. The LanK operator site has been mapped to a 14-bp region of lanKJp that includes a plausible -35 site upstream of the lanK start codon in a series of electrophoretic DNA mobility shift assays. This opens the door to studies of the DNA-LanK interaction at a single nucleotide resolution level.
MeSH term(s)	Aminoglycosides/chemistry ; Transcription Factors/genetics ; DNA
Chemical Substances	Aminoglycosides ; Transcription Factors ; DNA (9007-49-2)
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	134238-1
ISSN	1432-0991 ; 0343-8651
ISSN (online)	1432-0991
ISSN	0343-8651
DOI	10.1007/s00284-023-03528-1
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Article ; Online: Wound Healing Complications With Tranexamic Acid: Not the Silver Bullet After All.

Yalamanchili, Suma / Talei, Ben / Azizzadeh, Babak / Auersvald, Andre / Frankel, Andrew S

Aesthetic surgery journal

2023 Volume 43, Issue 12, Page(s) 1409–1415

MeSH term(s)	Humans ; Tranexamic Acid/adverse effects ; Antifibrinolytic Agents/adverse effects ; Anesthetics, Local ; Blood Loss, Surgical/prevention & control ; Administration, Topical ; Wound Healing
Chemical Substances	Tranexamic Acid (6T84R30KC1) ; Antifibrinolytic Agents ; Anesthetics, Local
Language	English
Publishing date	2023-05-22
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2087022-X
ISSN	1527-330X ; 1090-820X ; 1084-0761
ISSN (online)	1527-330X
ISSN	1090-820X ; 1084-0761
DOI	10.1093/asj/sjad177
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Zs.A 5721: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A novel pathway for insurance-based breast reductions: A method for identifying appropriate surgical candidates.

Hogan, Elise / Yalamanchili, Suma / Farley, Ellie / Guibord, Sarah Beth / Strauss, Sarah / Gobble, Ryan

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 81, Page(s) 132–137

Abstract: Breast reductions are one of the most common plastic surgery procedures performed. The purpose of this study was to streamline the evaluation of patients requiring breast reduction by using a nurse practitioner (NP)-led class to funnel appropriate ... ...

Abstract	Breast reductions are one of the most common plastic surgery procedures performed. The purpose of this study was to streamline the evaluation of patients requiring breast reduction by using a nurse practitioner (NP)-led class to funnel appropriate surgical candidates through the preoperative process. We performed a retrospective review of patients interested in breast reduction who enrolled in this class from March 2015 to August 2021. Of the 1310 unique patients enrolled in the initial class, 386 patients passed the initial screening and were scheduled with the NP, whereas 924 were screened out at this stage either for being an inadequate surgical candidate or not showing up for clinical visits (36.7%). An additional 185 were screened out after the consultation with NP for reasons such as lack of insurance coverage and no-show visits (20.2%). MD visits had a no-show rate of 7.08%. The decrease in no-show rates between the class-NP visit and the NP-MD visit were both significant (p < 0.001). There was no significant difference in gram estimates between providers and pathology (p = 0.5). In total, 171 patients underwent breast reduction (13.05% of the patients screened). The average time from class to surgery was 278.15 days, NP consultation to surgery was 171.48 days, and MD consultation to surgery was 59.51 days. Using a screening pathway allows for early identification of inadequate surgical candidates and therefore streamlines the screening process for optimized breast reduction candidates. Appropriate use of NP visits functions to streamline the funnel, thus decreasing the number of visits and no-show appointments for a surgeon.
MeSH term(s)	Humans ; Insurance Coverage ; Mammaplasty ; Nurse Practitioners ; Retrospective Studies ; Referral and Consultation
Language	English
Publishing date	2023-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.02.022
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Article ; Online: How to grow a resident cosmetic clinic at an academic medical center.

Yalamanchili, Suma / Inchauste, Suzanne / Lawera, Nathan / Roberto, Amy / Morrison, Jillian / John Kitzmiller, W

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2023 Volume 82, Page(s) 118–120

MeSH term(s)	Humans ; Surgery, Plastic/education ; Plastic Surgery Procedures ; Academic Medical Centers ; Internship and Residency ; Education, Medical, Graduate
Language	English
Publishing date	2023-04-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2023.04.042
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