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Article ; Online: Evaluation of factors related to Clavien Dindo 3 and above complications in patients undergoing gastrectomy due to gastric cancer.

Yalav, Orcun / Topal, Ugur

2020 Volume 91, Page(s) 617–626

Abstract: Aim: In our study, we aimed to evaluate the complications after total gastrectomy by Clavien-Dindo classification and to determine the related risk factors.: Methods: Patients who underwent total gastrectomy due to gastric cancer between 2015-2019 ... ...

Abstract	Aim: In our study, we aimed to evaluate the complications after total gastrectomy by Clavien-Dindo classification and to determine the related risk factors. Methods: Patients who underwent total gastrectomy due to gastric cancer between 2015-2019 were included in the study. Patients were divided into two groups according to postoperative complication classification Clavien Dindo, those with 3 or higher were Group 1 and the others were Group 2. Demographic and clinical features, laboratory parameters, tumor characteristics, postoperative results and mean survival were compared in the groups. Risk factors for Clavien Dindo 3 and above were analyzed by univariate analysis and multivariate logistic regression analysis. Results: A total of 104 patients participated in our study. Group1 consisted of 25 and Group2 consisted of 79 patients. Male sex was high in both groups (52% vs67.1%, p:0.130). BMI (26 vs 23, p:0.023), albumin (3.24 vs 3.51, p:0,040), postoperative mortality (%28vs% 2.5, p:0.001), postoperative duration of hospitalization (17.60vs9.25 days, p:0.000) were different between the groups, but total survival (month) was not statistically significantly different (19.60vs18.53, p:0.377). In multivariate analysis, tumor Stage 3C (OR =0.177,95% CI = (0.067-0.468), p:0.000), operation duration ≥240 min (OR =2.105,95% CI = (1.080-4.100, p:0.029) and application of neoadjuvant treatment (HR =3.026,95%CI =(1.682-5.446), p:0.000) were indepent risk factors DISCUSSION: In conclusion, obesity, hypoalbuminemia, anemia, tumor stage, duration of operation, and taking neoadjuvant therapy were closely related to postoperative complications. Although the development of postoperative complication increased the length of hospitalization and postoperative mortality, it did not decrease survival in the long term. Key words: Gastric cancer, Postoperative complication, Total gastrectomy.
MeSH term(s)	Gastrectomy/adverse effects ; Humans ; Male ; Neoadjuvant Therapy ; Postoperative Complications/classification ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors ; Stomach Neoplasms/surgery
Language	English
Publishing date	2020-10-06
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effect of D3 dissection on postoperative morbidity and early mortality in gastric cancer patients who underwent curative total gastrectomy.

Kaplan, Kuntay / Topal, Ugur / Yalav, Orcun / Parsak, Cem Kaan

Annali italiani di chirurgia

2022 Volume 94, Page(s) 147–153

Abstract: Aim: The present study presents the factors associated with early complications and mortality in patients undergoing total gastrectomy.: Material and method: The study included patients who underwent curative total gastrectomy for gastric ... ...

Abstract	Aim: The present study presents the factors associated with early complications and mortality in patients undergoing total gastrectomy. Material and method: The study included patients who underwent curative total gastrectomy for gastric adenocarcinoma between January 2001 and December 2016 in the General Surgery Department of the Çukurova University Medical Faculty Hospital. The patients were divided into D1, D2, and D3 groups depending on the lymph node dissection width, and the demographic and clinical data and mortality were compared. In addition, mortality-associated factors were analyzed. Results: The study sample included 148 (62.7%) males and 88 (37.3%) females, with a mean age of 65.5±11.4 years. There were 87 patients in the D1 group, 117 in the D2 group, and 23 in the D3 group. As expected, the duration of the operation was longer in the D2 and D3 groups (179 vs. 224 vs. 252; p<0.001), and these groups had also higher numbers of lymph nodes dissected (8 vs. 20 vs. 32; p<0.001) and metastatic lymph nodes (2.6 vs. 7.5 vs. 9.2; p<0.001). The analysis of the operation type in terms of complications revealed a significant relationship only with stump blowout, which was significantly more common after D3 dissection than following D2 and D1 dissections (p:0.01). The male gender (87.5 vs 60.9 p:0.03) was more associated with mortality. Conclusion: D1, D2 and D3 Lymph node dissection in gastric cancer surgery can be safely performed with low mortality and morbidity rates by surgeons with sufficient technical knowledge, and in centers with sufficient hospital volume. Key words: Complications, Gastric Cancer, Mortality, Lymph Node Dissection.
MeSH term(s)	Female ; Humans ; Male ; Middle Aged ; Aged ; Stomach Neoplasms/pathology ; Dissection ; Adenocarcinoma/pathology ; Lymph Node Excision ; Gastrectomy ; Retrospective Studies
Language	English
Publishing date	2022-12-09
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Synchronous and metachronous neoplasms of different histogenesis with gastrointestinal stromal tumor (GIST): 10 years experience of a single institution.

Teke, Zafer / Rencuzogullari, Ahmet / Yalav, Orcun / Erdogan, Osman / Gumus, Serdar / Doran, Figen

Annali italiani di chirurgia

2023 Volume 94, Page(s) 358–366

Abstract: Aim: Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal neoplasms of the gastrointestinal tract. Significant advances have been made in its pathogenesis, diagnosis, and treatment over the past few decades. However, little is ...

Abstract	Aim: Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal neoplasms of the gastrointestinal tract. Significant advances have been made in its pathogenesis, diagnosis, and treatment over the past few decades. However, little is known about the occurrence of synchronous or methacronous tumors with other histogenesis in addition to GISTs. The aim of this study was to present a series of 15 patients diagnosed with a second primary neoplasm in addition to GIST. Material and methods: Patients who were diagnosed with both GIST and other primary neoplasm between January 2010 and December 2019 were included in the study. Demographic, clinicopathologic and immunohistochemical parameters of the patients were analyzed along with the follow-up results RESULTS: This study included 12 men and 3 women with a median age of 68 years (range: 57-83 years). Of the GISTs, 93.3% were localized in the stomach and 73.3% were at very low / low risk category. Of the second primary tumors, 66.6% were in the gastrointestinal tract. Detection of the GIST was synchronous in 9 cases, metachronous in 2 cases and preceded the GIST diagnosis in 4 cases. GIST was incidentally found intra-operatively in 3 of the cases. The mean size of the synchronous GISTs was 20 mm while the most common GIST-associated malignancy was gastric adenocarcinoma. The median follow-up times was 62 months (range: 13-129 months). Conclusions: The prevalence of secondary malignancies in GIST patients is significantly higher than the healthy population. The high occurrence rate of additional primary tumors in GIST patients has focused the attention of surgeons on this problem. While it is not yet clear if there is a causal association or a common genetic mechanism for the concomitant occurrence of GIST with other malignancies, a closer surveillance of GIST patients is needed due to their proved increased prevalence of a second primary tumor especially during the first year after diagnosis. Key words: Gastrointestinal stromal tumor, Coexistence, Synchronous malignancy, Second neoplasm, Gastric adenocarcinoma.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Gastrointestinal Stromal Tumors/epidemiology ; Gastrointestinal Stromal Tumors/surgery ; Gastrointestinal Stromal Tumors/diagnosis ; Neoplasms, Second Primary/pathology ; Stomach Neoplasms/epidemiology ; Stomach Neoplasms/surgery ; Stomach Neoplasms/diagnosis ; Adenocarcinoma/epidemiology ; Adenocarcinoma/surgery ; Adenocarcinoma/complications ; Risk Factors ; Gastrointestinal Neoplasms/epidemiology ; Gastrointestinal Neoplasms/surgery ; Neoplasms, Multiple Primary/epidemiology ; Neoplasms, Multiple Primary/surgery
Language	English
Publishing date	2023-10-18
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Squamous cell skin carcinoma due to chronic sacrococcygeal diseases

Gumus Serdar / Gul Mehmet Onur / Eray Ismail Cem / Tabakan Ibrahim / Rencuzogullari Ahmet / Yalav Orcun

Srpski Arhiv za Celokupno Lekarstvo, Vol 150, Iss 3-4, Pp 170-

2022 Volume 176

Abstract: Introduction/Objective. Sacrococcygeal region squamous cell cancers (SCC) due to chronic sacrococcygeal diseases of skin are rare malignancies. The anatomical relation with the anus represents a challenge for diagnosis and surgical treatment. The ... ...

Abstract	Introduction/Objective. Sacrococcygeal region squamous cell cancers (SCC) due to chronic sacrococcygeal diseases of skin are rare malignancies. The anatomical relation with the anus represents a challenge for diagnosis and surgical treatment. The oncological treatment algorithm is still controversial. Here, we investigated the clinicopathologic features of skin cancer of the sacrococcygeal region in a total of 10 cases from a surgical oncology reference center. Methods. We retrospectively analyzed the patients who underwent surgery for sacrococcygeal region skin SCC between January 2010 and July 2020. Results. All patients were male, and the mean age was 52.9±10.5 years. In the etiology, five patients had hidradenitis suppurativa, 2 had Human papillomavirus associated condyloma (Buschke-Lowenstein tumor), and 3 had pilonidal sinus disease. The mean time between the development of the lesion and malignancy diagnosis was 21.7±5.8 years. In the preoperative evaluation, three patients had bone invasion. None of the patients had anal sphincter or rectal invasion. Also, no patient had lymph node metastasis or distant metastasis. Wide local excision (WLE) was performed in all patients; 3 of them with bone resection. Adjuvant chemoradiotherapy was applied to five patients. In a 28.5±13.7 months follow-up, local recurrence occurred in 5 patients and WLE has performed again in these patients. Of these 5 patients, 2 eventually became metastatic. Finally, 3 patients died due to disease and 6 patients are still free of diseases. Conclusion. Sacrococcygeal region SCCs may rarely develop after a long interval from hidradenitis suppurativa, pilonidal sinus disease, and condyloma acuminata. Anal sphincter-sparing WLE can be applied, but sphincter dysfunction may occur. The disease is associated with a high risk of relapse and poor survival.
Keywords	hidradenitis suppurativa ; human papillomavirus ; pilonidal sinus disease ; skin cancer ; sacrococcygeal region ; Medicine ; R
Subject code	610 ; 616
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Serbian Medical Society
Document type	Article ; Online
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Article ; Online: Primary mesenteric fibromatosis: A single Center experience.

Yalav, Orcun / Erdogan, Osman / Teke, Zafer / Doran, Figen

Annali italiani di chirurgia

2020 Volume 91, Page(s) 283–290

Abstract: Aim: Primary mesenteric fibromatosis is a rare, locally invasive, non-metastasizing type of intra-abdominal fibromatoses with a very high rate of recurrence. In this study, we aimed to present our surgical approach, tumor characteristics, clinical ... ...

Abstract	Aim: Primary mesenteric fibromatosis is a rare, locally invasive, non-metastasizing type of intra-abdominal fibromatoses with a very high rate of recurrence. In this study, we aimed to present our surgical approach, tumor characteristics, clinical presentation and long-term follow-up results in cases of primary mesenteric fibromatosis. Material and metods: The data collected from 11 patients who underwent surgery due to primary mesenteric fibromatosis in our clinic between 2010 and 2019 were analyzed retrospectively. Results: Abdominal ipain, abdominal distention, and two patients (18.2%) were operated on with a diagnosis of acute abdomen in the emergency setting due to mechanical bowel obstruction in one patient There were 11 patients in our study. Six patients were female and 5 were male. The mean age was 44.2±15.8 years. Abdominal mass was detected in 5 patients (45.5%) who had complaints of mechanical bowel obstruction such as nausea and vomitingand gastrointestinal perforation in other patient. Mesenteric mass was detected in 3 patients (27.3%) with vague abdominal pain. One patient (9.1%) presented with abdominal pain and swelling of the right leg. After a mean follow-up period of 43.4±28.4 months, only 1 patient (9.1%) had recurrence and required reoperation approximately 80 months after the first operation. One patient (9.1%) died of anastomotic leakage and sepsis in the first 30 days postoperatively, and other patient (9.1%) idied of other reasons 1 year later postoperatively. Conclusions: Although mesenteric fibromatosis is a benign tumor pathologically, the main principle in the treatment of this tumor which is clinically aggressive and has high recurrence rate is wide surgical resection. Mesenteric fibromatoses have a varied clinical presentation. Radiological imaging methods helps diagnosis and planning the surgical treatment. Immunohistochemical characteristics confirms the diagnosis and differentiates from other similar tumors. Key words: Desmoid tumor, Fibromatosis, Mesentery, Mesenteric tumor,Mesenteric fibromatosis.
MeSH term(s)	Adult ; Female ; Fibroma/diagnostic imaging ; Fibroma/surgery ; Fibromatosis, Abdominal/diagnosis ; Fibromatosis, Abdominal/surgery ; Fibromatosis, Aggressive ; Humans ; Male ; Mesentery/surgery ; Middle Aged ; Neoplasm Recurrence, Local ; Retrospective Studies
Language	English
Publishing date	2020-03-13
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Giant pedunculated colonic lipoma causing colo-colic intussusception in a patient with mechanical ileus.

Gumus, Serdar / Yalav, Orcun / Erdogan, Osman / Teke, Zafer

Annali italiani di chirurgia

2020 Volume 9

Abstract: A giant colonic lipoma causing colo-colonic intussusception is extremely rare in adults. A 35-year-old woman visited our emergency room with abdominal pain, abdominal distension, nausea and vomiting. Physical examination showed a painful distended ... ...

Abstract	A giant colonic lipoma causing colo-colonic intussusception is extremely rare in adults. A 35-year-old woman visited our emergency room with abdominal pain, abdominal distension, nausea and vomiting. Physical examination showed a painful distended abdomen. Abdominal computed tomography revealed that there was a soft-tissue mass with a fat density of approximately 6 cm in diameter in the distal part of the transverse colon. Since the clinical presentation was that of a mechanical ileus, a laparotomy was performed. An intussusception was detected in the transvers colon. A soft and mobile mass was palpated in the transverse colon. Therefore, an extended right hemicolectomy with ileo-transversostomy was performed. Pathological examination revealed a giant pedunculated lipoma of 7 cm in diameter with no evidence of malignancy. Colonic lipomas are the third most common benign pathology seen in the colon. They are more common in women with a peak incidence between 50 and 60 years of age. The most common site of lipomas in the large bowel is the right hemicolon. Colonic lipomas are usually asymptomatic but may cause bleeding, obstruction, intussusception, or abdominal pain. Colonic lipoma causing colo-colic intussusception is extremely rare in the current literature. Surgical approach remains the treatment of choice for giant colonic lipomas. A colonic lipoma causing colo-colic intussusception should be considered in the differential diagnosis of mechanical bowel obstruction. The most important factor for establishing the diagnosis of intussusception caused by a colonic lipoma is awareness of the possibility, especially in adult patients with abdominal symptoms and episodes of intestinal obstruction. KEY WORDS: Colon, Lipoma, Colonic lipoma, Intussusception, Intestinal obstruction, Ileus.
MeSH term(s)	Adult ; Colonic Diseases/diagnostic imaging ; Colonic Diseases/etiology ; Colonic Diseases/surgery ; Colonic Neoplasms/complications ; Colonic Neoplasms/diagnostic imaging ; Colonic Neoplasms/surgery ; Female ; Humans ; Intestinal Obstruction/diagnostic imaging ; Intestinal Obstruction/etiology ; Intestinal Obstruction/surgery ; Intussusception/diagnostic imaging ; Intussusception/etiology ; Intussusception/surgery ; Lipoma/complications ; Lipoma/diagnostic imaging ; Lipoma/surgery
Language	English
Publishing date	2020-03-03
Publishing country	Italy
Document type	Case Reports ; Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laparoscopic revisional surgery for failed anti-reflux procedures.

Yalav, Orcun / Gumus, Serdar / Erdogan, Osman / Teke, Zafer / Rencuzogullari, Ahmet

Annali italiani di chirurgia

2021 Volume 92, Page(s) 353–360

Abstract: Aim: Failure ratio of an anti-reflux surgery is 2-17% in adults. After unsuccessful fundoplications, if necessary, revisional surgeries can be performed. Revisional surgeries are technically difficult to perform and require professionally advanced ... ...

Abstract	Aim: Failure ratio of an anti-reflux surgery is 2-17% in adults. After unsuccessful fundoplications, if necessary, revisional surgeries can be performed. Revisional surgeries are technically difficult to perform and require professionally advanced experience. On the other hand, it is still controversial which technique should be used in revisional surgery. The aim of this study is to present our experience with revisional surgical procedures for complications or recurrences after anti-reflux surgeries. Material and metods: A total of 18 patients, 16 of whom were referred to our clinic from other centers, and who underwent revisional surgery for failed fundoplication between 2014 and 2019 were retrospectively analyzed RESULTS: Five patients were male and 13 were female. The mean age was 40.3±11.7 years. The most common symptom was the persistence of reflux symptoms (61.2%). Indications for revisional surgery were recurrent hiatal hernia in 10 patients, thightness in 4 patients, mesh migration in 2 patients, mesh migration with recurrent hiatal hernia in 1 patient, and mesh migration with thightness in 1 patient. The mean operative time was 107.2+29.2 minutes. The median hospital stay was 2.9 days (range: 1-6 days). The most common surgical procedure performed was the repair of hiatal crura with mesh, and reconstruction of fundoplication and fixation of neo-fundoplication to the right crus (44.4%). In addition, other surgical procedures performed were takedown of the previous fundoplication (16.6%), takedown of the previous fundoplication and reconstruction of fundoplication (11.1%), cruroplasty and fundoplication with gastric wedge resection (11.1%), removal of the mesh and takedown of the previous fundoplication (5.6%), removal of sutures from the hiatal crura (5.6%), and gastric wedge resection (5.6%). Four patients (27.8%) developed morbidity due to gastric perforation and pleural opening during these procedures. The median follow-up period was 29 months (range: 6-69 months). Two cases (11.1%) who underwent revisional surgery failed, and re-revisional surgery was performed. Conclusions: Revisionary surgical procedures performed for failed anti-reflux surgery are not limited to re-fundoplication. Different procedures such as takedown of the previous fundoplication, reconstruction of fundoplication, removal of the mesh, removal of the sutures or wedge resection may be necessary. These procedures can successfully be performed laparoscopically by experienced surgeons in well-equipped centers. Key words: Fundoplication, Gastroesophageal reflux, Laparoscopy, Revisional Surgery, Antireflux surgery.
MeSH term(s)	Adult ; Female ; Fundoplication ; Gastroesophageal Reflux/surgery ; Hernia, Hiatal/surgery ; Humans ; Laparoscopy ; Male ; Middle Aged ; Recurrence ; Reoperation ; Retrospective Studies
Language	English
Publishing date	2021-03-31
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Surgical myotomy and anterior fundoplication for achalasia disease. Short-term outcomes.

Yalav, Orçun / Topal, Ugur / Yavuz, Burak / Gumus, Serdar / Rencuzogullari, Ahmet

Annali italiani di chirurgia

2021 Volume 92, Page(s) 149–154

Abstract: Aim: Achalasia is a well-known disease among esophageal motility disorders, and all treatments for this disease are aimed at relaxing the lower esophageal sphincter (LES). Recently, endoscopic and surgical myotomy techniques are used more frequently ... ...

Abstract	Aim: Achalasia is a well-known disease among esophageal motility disorders, and all treatments for this disease are aimed at relaxing the lower esophageal sphincter (LES). Recently, endoscopic and surgical myotomy techniques are used more frequently because they give better results than other conservative techniques. In this study, we aimed to present the early results of surgical myotomy and anterior fundoplication techniques in the treatment of achalasia-related dysphagia. Methods: Our study enrolled patients who operated with laparoscopic myotomy and anterior fundoplication for achalasia between 2014 and 2019. Patients' demographic and clinical properties, operative details, and postoperative shortterm outcomes were retrospectively analyzed. Results: A total of 25 patients (11 women, 14 men) were enrolled. The mean age was 40.72±13.6 (range 18-66) years. The mean LES pressure was 26.6±11.2 (range 16-50) mmHg. The mean esophageal myotomy length was 7.83±1.88 (range 7-12 cm). Esophagus perforation developed in one patient during myotomy. The mean time to start oral feeding was 2.56±0.76 (range 2-4) days, and the mean length of hospital stay was 4.96±1.17 (range 3-8) days. During the follow-up, symptom regression was observed in 92 % of patients at the end of a 1-year. Conclusion: According to our results and available literature, myotomy with Dor fundoplication is an effective technique that can be used to treat achalasia disease. Key words: Achalasia, Dor fundoplication, Heller myotomy.
MeSH term(s)	Adolescent ; Adult ; Aged ; Esophageal Achalasia/surgery ; Female ; Fundoplication/methods ; Humans ; Laparoscopy ; Male ; Middle Aged ; Myotomy/methods ; Retrospective Studies ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-05-25
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Prognostic significance of preoperative hemoglobin and albumin levels and lymphocyte and platelet counts (HALP) in patients undergoing curative resection for colorectal cancer.

Yalav, Orcun / Topal, Ugur / Unal, Ayse Gizem / Eray, Ismail Cem

Annali italiani di chirurgia

2021 Volume 92, Page(s) 283–292

Abstract: Background/objective: In this study, we aimed to determine the relationship between HALP score and postoperative complications (According to Clavien-Dindo classification 3 and above), in patients with colo-rectal cancer who underwent curative surgical ... ...

Abstract	Background/objective: In this study, we aimed to determine the relationship between HALP score and postoperative complications (According to Clavien-Dindo classification 3 and above), in patients with colo-rectal cancer who underwent curative surgical resection and to determine its clinical value in predicting prognosis. Methods: 279 patients who underwent curative surgery for colorectal cancer between 2015-2018 were included in the study. The HALP value was calculated by dividing the product of hemoglobin (g/L), albumin (g/L), lymphocytes (/ L) by the number of platelets (/ L). In order to generate a cut off value for the HALP value, ROC analysis and ROC curve were created. The patients were divided into two groups according to survival, and cut off value was found by ROC analysis: Group 1 (Low HALP) and Group 2 (High HALP). Demographic, clinical characteristics, intraoperative , postoperative results and mean survival were compared between the groups. Results: The patients were divided into two groups according to cut off value of 15.73. Group 1 consisted of 113 patients; Group 2 consisted of 166 patients. Average age was similar in the groups (62vs61, p:0.480). Patients in Group 1 received more neoadjuvant therapy (31%vs21%, p:0.064). CEA levels were higher in Group 1 (7.6vs4.3 p:0.034). Mucinous adenocarcinoma histological type was more common in Group 1 (24%vs13% ,p:0.040). Pathological grade poorly differentiated was more common in Group 1 (27%vs13%). Postoperative outcomes was similar to groups We found the HALP score as a risk factor for survival in multivariate analysis (HR=0.8552 95% (CI:0.6575-1.1125, p:0.007). If the HALP value is below 15.73, it is assumed that the average survival is 28 months with 45.4% sensitivity and 66.938% specificity. Conclusion: Our results showed that the HALP score is closely related to clinic pathological features and is an independent prognostic factor for survival. Its value in estimating mean survival is limited. Key words: Colorectal cancer, HALP score, Immunity, Nutrition.
MeSH term(s)	Blood Platelets ; Colorectal Neoplasms/blood ; Colorectal Neoplasms/mortality ; Colorectal Neoplasms/pathology ; Colorectal Neoplasms/surgery ; Hemoglobins/analysis ; Humans ; Lymphocyte Count ; Lymphocytes ; Middle Aged ; Platelet Count ; Predictive Value of Tests ; Preoperative Period ; Prognosis ; Retrospective Studies ; Serum Albumin/analysis
Chemical Substances	Hemoglobins ; Serum Albumin
Language	English
Publishing date	2021-05-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laparoscopic versus open total radical gastrectomy for advanced gastric cancer: surgical outcomes.

Yalav, Orcun / Topal, Ugur / Gumus, Serdar / Unal, Ayse Gizem / Rencuzogullari, Ahmet

Annali italiani di chirurgia

2022 Volume 92, Page(s) 609–615

Abstract: Aim: The aim of this study is to compare the oncologic efficacy of laparoscopic total gastrectomy (LTG) versus open total gastrectomy (OTG) for gastric cancer and to provide our experiences regarding this surgery.: Methods: A total of 107 patients ... ...

Abstract	Aim: The aim of this study is to compare the oncologic efficacy of laparoscopic total gastrectomy (LTG) versus open total gastrectomy (OTG) for gastric cancer and to provide our experiences regarding this surgery. Methods: A total of 107 patients who underwent curative total gastrectomy for gastric adenocarcinoma between September 2015 and September 2018 were included in this study. Demographic characteristics, operative parameters, histopathological results, postoperative morbidity and mortality results of the patients were evaluated. Results: Of 107 patients, 70 were men and 37 women. OTG consisted of 89 patients and LTG consisted of 18 patients. The mean age in OTG was 59.4 years, the mean age in LTG was 57.3 years. The mean number of lymph nodes harvested was 30.5 14.6 in OTG and 33.0 10.1 in LTG. The number of metastatic lymph nodes harvested was 7.4 10.5 in OTG and 10.0 11.8 in LTG (p= 0.366), and there was no statistical difference between the two groups. The time of onset of oral intake, anastomotic leakage, and postoperative mortality was similar in both groups. Operative duration and length of hospital stay were significantly higher in LTG. Postoperative survival duration was similar in both procedures CONCLUSION: Laparoscopic total gastrectomy for gastric cancer is an oncologically safe procedure but had a longer operation time and a longer hospital stay. There was no significant difference number of harvested lymph nodes, number of metastatic lymph nodes, and tumor localization between the two groups KEY WORDS: Gastric cancer, Laparoscopy, Gastrectomy.
MeSH term(s)	Female ; Gastrectomy ; Humans ; Laparoscopy ; Lymph Node Excision ; Male ; Middle Aged ; Operative Time ; Retrospective Studies ; Stomach Neoplasms/surgery ; Treatment Outcome
Language	English
Publishing date	2022-02-15
Publishing country	Italy
Document type	Journal Article
ZDB-ID	418927-9
ISSN	2239-253X ; 0003-469X
ISSN (online)	2239-253X
ISSN	0003-469X
Database	MEDical Literature Analysis and Retrieval System OnLINE

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