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  1. Article ; Online: Correction to: Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan.

    Ishibashi, Yukiko / Sogawa, Rintaro / Ogata, Kenji / Matsuoka, Ayaka / Yamada, Haruna / Murakawa-Hirachi, Toru / Mizoguchi, Yoshito / Monji, Akira / Shimanoe, Chisato

    Clinical drug investigation

    2024  Volume 44, Issue 2, Page(s) 121

    Language English
    Publishing date 2024-01-10
    Publishing country New Zealand
    Document type Published Erratum
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-024-01340-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2807: Show issues Location:
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  2. Article ; Online: Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan.

    Ishibashi, Yukiko / Sogawa, Rintaro / Ogata, Kenji / Matsuoka, Ayaka / Yamada, Haruna / Murakawa-Hirachi, Toru / Mizoguchi, Yoshito / Monji, Akira / Shimanoe, Chisato

    Clinical drug investigation

    2023  Volume 44, Issue 2, Page(s) 115–120

    Abstract: Background and objective: Several associations between diabetes mellitus and delirium have been reported; however, they have been inconsistent, and evidence on the effects of antidiabetic medications on delirium is also limited. This study aimed to ... ...

    Abstract Background and objective: Several associations between diabetes mellitus and delirium have been reported; however, they have been inconsistent, and evidence on the effects of antidiabetic medications on delirium is also limited. This study aimed to investigate whether the use of antidiabetic drugs is a risk factor for delirium development.
    Methods: Using the Japanese Adverse Event Reporting Database, we analyzed 662,899 reports between 2004 and 2022. Reporting odds ratios (RORs) and 95% confidence intervals (CIs) for delirium associated with diabetes and using each antidiabetic medication were calculated after adjusting for potential confounders.
    Results: Overall, 8892 of the reports analyzed were associated with delirium. A comparison of the incidence of delirium between patients with and without diabetes showed no significant difference, with 1.34% in patients without diabetes and 1.37% in those with diabetes. In each antidiabetic medication, signals for delirium were detected for sulfonylurea (crude ROR, 1.35; 95% CI 1.21-1.51) and insulin (crude ROR, 1.28; 95% CI 1.13-1.44). These results were maintained even after adjusting for factors with potential confounders (sulfonylurea: adjusted ROR, 1.75; 95% CI 1.54-2.00, insulin: adjusted ROR, 1.35; 95% CI 1.20-1.54).
    Conclusions: Our results suggest no association between diabetes and delirium; however, using sulfonylurea and insulin may be associated with delirium development. Nonetheless, these findings should be validated in future studies.
    MeSH term(s) Humans ; Hypoglycemic Agents/adverse effects ; Japan/epidemiology ; Diabetes Mellitus/chemically induced ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Drug-Related Side Effects and Adverse Reactions ; Sulfonylurea Compounds/adverse effects ; Insulin ; Delirium/chemically induced ; Delirium/epidemiology ; Adverse Drug Reaction Reporting Systems
    Chemical Substances Hypoglycemic Agents ; Sulfonylurea Compounds ; Insulin
    Language English
    Publishing date 2023-12-23
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1220136-4
    ISSN 1179-1918 ; 0114-2402 ; 1173-2563
    ISSN (online) 1179-1918
    ISSN 0114-2402 ; 1173-2563
    DOI 10.1007/s40261-023-01337-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2807: Show issues Location:
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  3. Article ; Online: HPLC Fluorescence Method for Eugenols in Basil Products Derivatized with DIBI.

    Takada, Makoto / Sakamoto, Masashi / Yamada, Haruna / Kishikawa, Naoya / Mutoh, Junpei / Shiraishi, Yukihide / Kuroda, Naotaka / Wada, Mitsuhiro

    Chemical & pharmaceutical bulletin

    2022  Volume 70, Issue 1, Page(s) 37–42

    Abstract: Eugenols (Eugs) such as eugenol (Eug), methyleugenol (MeEug), and linalool (Lin) in basil product are the main bioactive components of basil products and have a terminal double-bond. A sensitive HPLC-fluorescence method for Eugs derivatized with 4-(4,5- ... ...

    Abstract Eugenols (Eugs) such as eugenol (Eug), methyleugenol (MeEug), and linalool (Lin) in basil product are the main bioactive components of basil products and have a terminal double-bond. A sensitive HPLC-fluorescence method for Eugs derivatized with 4-(4,5-diphenyl-1H-imidazol-2-yl)iodobenzene (DIBI) was developed. Good separation of DIB-Eugs was achieved within 20 min on an Atlantis T3 column (50 × 2.1 mm i.d., 3 µm) with a mobile phase of methanol-water. The calibration curves obtained with Eug standards showed good linearities in the range of 0.1-50 µM (r ≥ 0.999). The limits of detection at a signal-to-noise ratio (S/N) = 3 for Eug, MeEug, and Lin were 1.0, 6.0, and 4.8 nM, respectively. The limits of quantitation (S/N = 10) of the Eugs were lower than 19.9 nM. The accuracies for the Eugs were within 96.8-104.6%. The intra- and inter-day precisions as relative standard deviations for the Eugs were less than 1.2 and 9.6% (n = 3). The recoveries of Eug, MeEug, and Lin were 99.0 ± 0.1, 98.0 ± 0.2, and 96.0 ± 0.4% (n = 3), respectively. The DIB-Eugs were confirmed to be stable for 2 h (>90%) at room temperature and 24 h (>95%) at 4 °C. These parameters of the proposed method were useful for the simultaneous determination of Eugs in basil products. Therefore, the developed method may be a powerful tool for the quality evaluation of dried commercially available basil products.
    MeSH term(s) Chromatography, High Pressure Liquid ; Eugenol/analysis ; Fluorescence ; Imidazoles/analysis ; Iodobenzenes/analysis ; Molecular Structure ; Ocimum basilicum/chemistry
    Chemical Substances 4-(4,5-diphenyl-1H-imidazol-2-yl)iodobenzene ; Imidazoles ; Iodobenzenes ; Eugenol (3T8H1794QW)
    Language English
    Publishing date 2022-01-03
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 213307-6
    ISSN 1347-5223 ; 0009-2363
    ISSN (online) 1347-5223
    ISSN 0009-2363
    DOI 10.1248/cpb.c21-00575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 770: Show issues Location:
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  4. Article ; Audio / Video: Matrix Metalloproteinase-2 Inhibitors from Clinopodium chinense var. parviflorum

    Murata, Toshihiro / Sasaki, Kenroh / Sato, Kumiko / Yoshizaki, Fumihiko / Yamada, Haruna / Mutoh, Hiromichi / Umehara, Kaoru / Miyase, Toshio / Warashina, Tsutomu / Aoshima, Hiroaki / Tabata, Homare / Matsubara, Kouichi

    Journal of natural products. 2009 Aug. 28, v. 72, no. 8

    2009  

    Language English
    Dates of publication 2009-0828
    Size p. 1379–1384.
    Document type Article ; Audio / Video
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/np800781t
    Database NAL-Catalogue (AGRICOLA)

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    Zs.A 1144: Show issues Location:
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  5. Article ; Online: Matrix metalloproteinase-2 inhibitors from Clinopodium chinense var. parviflorum.

    Murata, Toshihiro / Sasaki, Kenroh / Sato, Kumiko / Yoshizaki, Fumihiko / Yamada, Haruna / Mutoh, Hiromichi / Umehara, Kaoru / Miyase, Toshio / Warashina, Tsutomu / Aoshima, Hiroaki / Tabata, Homare / Matsubara, Kouichi

    Journal of natural products

    2009  Volume 72, Issue 8, Page(s) 1379–1384

    Abstract: From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the ...

    Abstract From the aerial parts of Clinopodium chinense var. parviflorum, nine new phenylpropanoids, clinopodic acids A-I (2-10), were isolated together with a known phenylpropanoid, rosmarinic acid (1). The structures of these new compounds were elucidated on the basis of spectroscopic analysis. Clinopodic acid C (4) showed MMP-2 inhibitory activity (IC(50) 3.26 microM).
    MeSH term(s) Cinnamates/chemistry ; Cinnamates/isolation & purification ; Cinnamates/pharmacology ; Depsides/chemistry ; Depsides/isolation & purification ; Depsides/pharmacology ; Dioxanes/chemistry ; Dioxanes/isolation & purification ; Dioxanes/pharmacology ; Japan ; Lamiaceae/chemistry ; Matrix Metalloproteinase Inhibitors ; Molecular Structure ; Nuclear Magnetic Resonance, Biomolecular ; Rosmarinic Acid
    Chemical Substances Cinnamates ; Depsides ; Dioxanes ; Matrix Metalloproteinase Inhibitors ; clinopodic acid C
    Language English
    Publishing date 2009-08-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 304325-3
    ISSN 1520-6025 ; 0163-3864
    ISSN (online) 1520-6025
    ISSN 0163-3864
    DOI 10.1021/np800781t
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1144: Show issues Location:
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