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Article ; Online: Molecular Skin Cancer Diagnosis: Promise and Limitations.

Nataren, Nathalie / Yamada, Miko / Prow, Tarl

The Journal of molecular diagnostics : JMD

2022 Volume 25, Issue 1, Page(s) 17–35

Abstract: Skin cancer is a significant and increasing global health burden. Although the current diagnostic workflow is robust and able to provide clinically actionable results, it is subject to notable limitations. The training and expertise required for accurate ...

Abstract	Skin cancer is a significant and increasing global health burden. Although the current diagnostic workflow is robust and able to provide clinically actionable results, it is subject to notable limitations. The training and expertise required for accurate diagnoses using conventional skin cancer diagnostics are significant, and patient access to this workflow can be limited by geographic location or unforeseen events, such as coronavirus disease 2019 (COVID-19). Molecular biomarkers have transformed diagnostics and treatment delivery in oncology. With rapid advancements in molecular biology techniques, understanding of the underlying molecular mechanism of cancer pathologies has deepened, yielding biomarkers that can be used to monitor the course of malignant diseases. Herein, commercially available, clinically validated, and emerging skin cancer molecular biomarkers are reviewed. The qualities of an ideal molecular biomarker are defined. The potential benefits and limitations of applying molecular biomarker testing over the course of skin cancer from susceptibility to treatment are explored, with a view to outlining a future model of molecular biomarker skin cancer diagnostics.
MeSH term(s)	Humans ; COVID-19/diagnosis ; Medical Oncology/methods ; Molecular Diagnostic Techniques/methods ; Biomarkers, Tumor/genetics ; Skin Neoplasms/diagnosis ; Skin Neoplasms/genetics
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2022-10-13
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2000060-1
ISSN	1943-7811 ; 1525-1578
ISSN (online)	1943-7811
ISSN	1525-1578
DOI	10.1016/j.jmoldx.2022.09.008
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Article ; Online: Physical drug delivery enhancement for aged skin, UV damaged skin and skin cancer: Translation and commercialization.

Yamada, Miko / Prow, Tarl W

Advanced drug delivery reviews

2020 Volume 153, Page(s) 2–17

Abstract: This review analyses physical drug delivery enhancement technologies with a focus on improving UV damaged skin, actinic keratoses and non-melanoma skin cancer treatment. In recent years, physical drug delivery enhancement has been shown to enhance ... ...

Abstract	This review analyses physical drug delivery enhancement technologies with a focus on improving UV damaged skin, actinic keratoses and non-melanoma skin cancer treatment. In recent years, physical drug delivery enhancement has been shown to enhance cosmeceutical and skin cancer treatment efficacy, but there are pros and cons to each approach which we discuss in detail. Mechanisms of action, clinical efficacy, experimental design, outcomes in academic publications, clinical trial reports and patents are explored to evaluate each technology with a critical, translation focused lens. We conclude that the commercial success of cosmeceutical applications, e.g. microneedles, will drive further innovation in this arena that will impact how actinic keratoses and non-melanoma skin cancers are clinically managed.
MeSH term(s)	Administration, Cutaneous ; Clinical Trials as Topic ; Cosmetic Techniques ; Dermatologic Agents/administration & dosage ; Dermatologic Agents/adverse effects ; Dermatologic Agents/pharmacology ; Dermatologic Agents/therapeutic use ; Drug Delivery Systems/methods ; Humans ; Iontophoresis/adverse effects ; Iontophoresis/methods ; Keratosis, Actinic/drug therapy ; Laser Therapy/adverse effects ; Laser Therapy/methods ; Microinjections/adverse effects ; Microinjections/methods ; Skin/physiopathology ; Skin Aging/drug effects ; Skin Aging/physiology ; Skin Neoplasms/drug therapy ; Skin Neoplasms/physiopathology ; Ultrasonography/adverse effects ; Ultrasonography/methods ; Ultraviolet Rays/adverse effects
Chemical Substances	Dermatologic Agents
Language	English
Publishing date	2020-04-24
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2020.04.008
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Article ; Online: Advances and controversies in studying sunscreen delivery and toxicity.

Yamada, Miko / Mohammed, Yousuf / Prow, Tarl W

Advanced drug delivery reviews

2020 Volume 153, Page(s) 72–86

Abstract: This review critically evaluates the sunscreen delivery and toxicity field. We chose to focus on approved sunscreens in this review. Optimal sunscreen use prevents skin cancer and photoageing but there is an important knowledge gap in sunscreen/skin ... ...

Abstract	This review critically evaluates the sunscreen delivery and toxicity field. We chose to focus on approved sunscreens in this review. Optimal sunscreen use prevents skin cancer and photoageing but there is an important knowledge gap in sunscreen/skin interactions. Sunscreen delivery is a key for efficacy, but studying sunscreen delivery is not straightforward. We review the strengths and weaknesses of in vitro, excised skin and clinical approaches. Understanding positive and negative sunscreen effects on skin homeostasis is also challenging. The results in this field, especially in vitro testing, are controversial and experimental design varies widely which further supports disparities between some findings. We hypothesize that bias towards showing sunscreen toxicity to increase impact could be problematic. We explore that perception through a detailed review of experimental design, especially in cell culture models. Our conclusion is that emerging, non- and minimally invasive technologies are enabling new approaches to volunteer studies that could significantly improve knowledge of sunscreen delivery and interactions.
MeSH term(s)	Administration, Cutaneous ; Animals ; Cell Culture Techniques ; Drug Delivery Systems ; Humans ; In Vitro Techniques/methods ; In Vitro Techniques/standards ; Models, Animal ; Models, Biological ; Skin Aging ; Sunscreening Agents/administration & dosage ; Sunscreening Agents/adverse effects ; Sunscreening Agents/pharmacology ; Sunscreening Agents/therapeutic use
Chemical Substances	Sunscreening Agents
Language	English
Publishing date	2020-02-19
Publishing country	Netherlands
Document type	Journal Article ; Systematic Review
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2020.02.001
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Article ; Online: Health-related toxicity of emerging per- and polyfluoroalkyl substances: Comparison to legacy PFOS and PFOA.

Jane L Espartero, Lore / Yamada, Miko / Ford, Judith / Owens, Gary / Prow, Tarl / Juhasz, Albert

Environmental research

2022 Volume 212, Issue Pt C, Page(s) 113431

Abstract: Per- and polyfluoroalkyl substances (PFAS) are highly persistent, manufactured chemicals used in various manufacturing processes and found in numerous commercial products. With over 9000 compounds belonging to this chemical class, there is increasing ... ...

Abstract	Per- and polyfluoroalkyl substances (PFAS) are highly persistent, manufactured chemicals used in various manufacturing processes and found in numerous commercial products. With over 9000 compounds belonging to this chemical class, there is increasing concern regarding human exposure to these compounds due to their persistent, bioaccumulative, and toxic nature. Human exposure to PFAS may occur from a variety of exposure sources, including, air, food, indoor dust, soil, water, from the transfer of PFAS from non-stick wrappers to food, use of cosmetics, and other personal care products. This critical review presents recent research on the health-related impacts of PFAS exposure, highlighting compounds other than Perfluorooctanoic acid (PFOA) and Perfluoroctane sulfonate (PFOS) that cause adverse health effects, updates the current state of knowledge on PFAS toxicity, and, where possible, elucidates cause-and-effect relationships. Recent reviews identified that exposure to PFAS was associated with adverse health impacts on female and male fertility, metabolism in pregnancy, endocrine function including pancreatic dysfunction and risk of developing Type 2 diabetes, lipid metabolism and risk of childhood adiposity, hepatic and renal function, immune function, cardiovascular health (atherosclerosis), bone health including risk for dental cavities, osteoporosis, and vitamin D deficiency, neurological function, and risk of developing breast cancer. However, while cause-and-effect relationships for many of these outcomes were not able to be clearly elucidated, it was identified that 1) the evidence derived from both animal models and humans suggested that PFAS may exert harmful impacts on both animals and humans, however extrapolating data from animal to human studies was complicated due to differences in exposure/elimination kinetics, 2) PFAS precursor kinetics and toxicity mechanism data are still limited despite ongoing exposures, and 3) studies in humans, which provide contrasting results require further investigation of the long-term-exposed population to better evaluate the biological toxicity of chronic exposure to PFAS.
MeSH term(s)	Alkanesulfonic Acids/analysis ; Alkanesulfonic Acids/toxicity ; Animals ; Caprylates/toxicity ; Diabetes Mellitus, Type 2 ; Dust ; Female ; Fluorocarbons/analysis ; Fluorocarbons/toxicity ; Male ; Pregnancy
Chemical Substances	Alkanesulfonic Acids ; Caprylates ; Dust ; Fluorocarbons ; perfluorooctanoic acid (947VD76D3L)
Language	English
Publishing date	2022-05-13
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113431
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Zs.A 726: Show issues

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Article ; Online: PEDOT coated microneedles towards electrochemically assisted skin sampling.

Ajmal Mokhtar, Siti Musliha / Yamada, Miko / Prow, Tarl W / Moore, Mark / Strudwick, Xanthe L / Evans, Drew R

Journal of materials chemistry. B

2023 Volume 11, Issue 22, Page(s) 5021–5031

Abstract: Skin sampling is a diagnostic procedure based on the analysis of extracted skin tissues and/or the observation of biomarkers in bodily fluids. Sampling using microneedles (MNs) that minimize invasiveness is gaining attention over conventional biopsy/ ... ...

Abstract	Skin sampling is a diagnostic procedure based on the analysis of extracted skin tissues and/or the observation of biomarkers in bodily fluids. Sampling using microneedles (MNs) that minimize invasiveness is gaining attention over conventional biopsy/blood lancet. In this study, new MNs for electrochemically assisted skin sampling are reported, specifically tailored for combined skin tissue biopsy and interstitial fluid (ISF) extraction. To overcome risks associated with using metal MNs, a highly electroactive, mechanically flexible, and biocompatible organic conducting polymer (CP) coated onto plastic is chosen as an alternative. Two different variants of doped poly(3,4-ethylenedioxythiophene) are coated on polymethyl methacrylate and used in combination as a MN pair with subsequent testing
MeSH term(s)	Needles ; Polymers ; Bridged Bicyclo Compounds, Heterocyclic ; Plastics
Chemical Substances	poly(3,4-ethylene dioxythiophene) ; Polymers ; Bridged Bicyclo Compounds, Heterocyclic ; Plastics
Language	English
Publishing date	2023-06-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb00485f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Health-related toxicity of emerging per- and polyfluoroalkyl substances: Comparison to legacy PFOS and PFOA

Jane L Espartero, Lore / Yamada, Miko / Ford, Judith / Owens, Gary / Prow, Tarl / Juhasz, Albert

Environmental research. 2022 Sept., v. 212

2022

Abstract	Per- and polyfluoroalkyl substances (PFAS) are highly persistent, manufactured chemicals used in various manufacturing processes and found in numerous commercial products. With over 9000 compounds belonging to this chemical class, there is increasing concern regarding human exposure to these compounds due to their persistent, bioaccumulative, and toxic nature. Human exposure to PFAS may occur from a variety of exposure sources, including, air, food, indoor dust, soil, water, from the transfer of PFAS from non-stick wrappers to food, use of cosmetics, and other personal care products. This critical review presents recent research on the health-related impacts of PFAS exposure, highlighting compounds other than Perfluorooctanoic acid (PFOA) and Perfluoroctane sulfonate (PFOS) that cause adverse health effects, updates the current state of knowledge on PFAS toxicity, and, where possible, elucidates cause-and-effect relationships. Recent reviews identified that exposure to PFAS was associated with adverse health impacts on female and male fertility, metabolism in pregnancy, endocrine function including pancreatic dysfunction and risk of developing Type 2 diabetes, lipid metabolism and risk of childhood adiposity, hepatic and renal function, immune function, cardiovascular health (atherosclerosis), bone health including risk for dental cavities, osteoporosis, and vitamin D deficiency, neurological function, and risk of developing breast cancer. However, while cause-and-effect relationships for many of these outcomes were not able to be clearly elucidated, it was identified that 1) the evidence derived from both animal models and humans suggested that PFAS may exert harmful impacts on both animals and humans, however extrapolating data from animal to human studies was complicated due to differences in exposure/elimination kinetics, 2) PFAS precursor kinetics and toxicity mechanism data are still limited despite ongoing exposures, and 3) studies in humans, which provide contrasting results require further investigation of the long-term-exposed population to better evaluate the biological toxicity of chronic exposure to PFAS.
Keywords	adiposity ; air ; atherosclerosis ; bone health ; breast neoplasms ; childhood ; chronic exposure ; cosmetics ; dust ; females ; humans ; immune response ; lipid metabolism ; male fertility ; noninsulin-dependent diabetes mellitus ; osteoporosis ; perfluorooctanoic acid ; pharmacokinetics ; pregnancy ; renal function ; research ; risk ; soil ; sulfonates ; toxicity
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113431
Database	NAL-Catalogue (AGRICOLA)

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Zs.A 726: Show issues

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Article ; Online: Nanoparticle enhanced blue light therapy.

Akasov, Roman / Khaydukov, Evgeny V / Yamada, Miko / Zvyagin, Andrei V / Leelahavanichkul, Asada / Leanse, Leon G / Dai, Tianhong / Prow, Tarl

Advanced drug delivery reviews

2022 Volume 184, Page(s) 114198

MeSH term(s)	Humans ; Light ; Nanoparticles ; Photochemotherapy ; Photosensitizing Agents ; Phototherapy
Chemical Substances	Photosensitizing Agents
Language	English
Publishing date	2022-03-14
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	639113-8
ISSN	1872-8294 ; 0169-409X
ISSN (online)	1872-8294
ISSN	0169-409X
DOI	10.1016/j.addr.2022.114198
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Article: Motion Capture Quantification of User Variation in Topical Microparticle Application.

Snoswell, Aaron J / Yamada, Miko / Kirby, Giles T S / Singh, Surya P N / Prow, Tarl W

Frontiers in pharmacology

2020 Volume 11, Page(s) 1343

Abstract: Motion capture has the potential to shed light on topical drug delivery application. This approach holds promise both as a training tool, and for the development of skin technology, but first, this approach requires validation. Elongated microparticles ( ... ...

Abstract	Motion capture has the potential to shed light on topical drug delivery application. This approach holds promise both as a training tool, and for the development of skin technology, but first, this approach requires validation. Elongated microparticles (EMP) are a physical delivery enhancement technology that relies on a user working in the microparticles using a textured applicator. We used this approach to test the hypothesis that motion capture data can be used to characterize the topical application process. Motion capture was used to record participants while applying a mixture of EMP and sodium fluorescein to ex-vivo porcine skin samples. Treated skin was assessed using reflectance confocal and fluorescence microscopy. Image analysis was used to quantify the microparticle density and the presence of a fluorescent drug surrogate, sodium fluorescein. A strong correlation was present between applicator motion and microparticle and drug delivery profiles. There were quantitative and qualitative differences in the intra- and inter- user application methods that went beyond the level of training. Frequency and velocity of the applicator motion were key factors that correlated with EMP density. Our quantitative analysis of an experimental dermatological device supports the hypothesis that self-application may benefit from some form of digital monitoring or training with feedback. Our conclusion is that the integration of motion capture into experimental dermatological research offers an improved and quantifiable perspective that could be broadly useful with respect to topical applications, and with respect to the instruction provided to patients and clinicians.
Language	English
Publishing date	2020-09-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.01343
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Article ; Online: Microbiopsy-based minimally invasive skin sampling for molecular analysis is acceptable to Epidermolysis Bullosa Simplex patients where conventional diagnostic biopsy was refused.

Yamada, Miko / Melville, Elizabeth / Cowin, Allison J / Prow, Tarl W / Kopecki, Zlatko

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

2020 Volume 27, Issue 3, Page(s) 461–463

MeSH term(s)	Biopsy ; Epidermolysis Bullosa Simplex/diagnosis ; Epidermolysis Bullosa Simplex/pathology ; Humans ; Skin/pathology ; Specimen Handling
Language	English
Publishing date	2020-10-22
Publishing country	England
Document type	Letter
ZDB-ID	1229160-2
ISSN	1600-0846 ; 0909-752X ; 1397-1344
ISSN (online)	1600-0846
ISSN	0909-752X ; 1397-1344
DOI	10.1111/srt.12971
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Article ; Online: Comparison of physical enhancement technologies in the skin permeation of methyl amino levulinic acid (mALA).

Jhanker, Yeakuty / Mbano, Melinda N / Ponto, Thellie / Espartero, Lore Jane L / Yamada, Miko / Prow, Tarl / Benson, Heather A E

International journal of pharmaceutics

2021 Volume 610, Page(s) 121258

Abstract: Physical drug delivery enhancement in skin has been shown to enhance cosmeceutical actives efficacy. Among the physical drug delivery enhancement technologies, microneedle is the most commercially successful technology. However, there are pros and cons ... ...

Abstract	Physical drug delivery enhancement in skin has been shown to enhance cosmeceutical actives efficacy. Among the physical drug delivery enhancement technologies, microneedle is the most commercially successful technology. However, there are pros and cons like other physical enhancement technologies including variabilities in penetration depth and lack of efficacy. In this study, three physical topical dug delivery enhancements, elongated microparticles, microneedles and dermaroller, were applied to ex vivo pig skin and compared. The model topical drug that was used is 5-Aminolevulinic acid, the most commonly used photosensitiser prodrug. The skin was pre-treated before mounting on to Franz cell diffusion apparatus. Transdermal epidermal water loss was measured, and receptor fluids were collected at 7 time points for HPLC analysis. The results show that all three technologies disrupted the skin surface. All microporation pre-treatments significantly enhanced mALA cumulative permeation over 8 h (p < 0.001), with the 24x dermaroller significantly greater than 12x dermaroller (p < 0.001) and both dermaroller treatments significantly greater than microneedles and elongated microparticles (p < 0.05). The microporation pre-treatments all significantly increased mALA deposition in the stratum corneum and deeper skin tissues compared to passive administration, with deposition increases ranging from 3.6x to 15.1x that of passive administration. The DR pretreatment showed highest enhancement ratios (amount 5-Aminolevulinic acid in skin at 8 h following pretreatment v passive) with the following order of enhancement: 24x dermaroller > 12x dermaroller > microneedles > elongated microparticles. In conclusion, physical enhancement tools such as microneedles, dermarollers and elongated microparticles demonstrated significant penetration and retention of mALA through/into piglet skin. Further study is needed to determine the cost, dose and patient compliance.
MeSH term(s)	Administration, Cutaneous ; Aminolevulinic Acid ; Animals ; Biomedical Enhancement ; Skin/metabolism ; Skin Absorption ; Swine
Chemical Substances	Aminolevulinic Acid (88755TAZ87)
Language	English
Publishing date	2021-11-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	428962-6
ISSN	1873-3476 ; 0378-5173
ISSN (online)	1873-3476
ISSN	0378-5173
DOI	10.1016/j.ijpharm.2021.121258
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