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  1. Article ; Online: The role of axillary reverse mapping in intraoperative nodal palpation during sentinel lymph node biopsy.

    Noguchi, Masakuni / Morioka, Emi / Noguchi, Miki / Inokuchi, Masafumi / Kurose, Nozomu / Shioya, Akihiro / Yamada, Sousuke

    The breast journal

    2021  Volume 27, Issue 8, Page(s) 651–656

    Abstract: Intraoperative nodal palpation in the axilla is a mandatory part of sentinel lymph node biopsy. However, there is no consensus regarding the definition of suspicious palpable node. The sampling rate and involvement rate of suspicious palpable nodes are ... ...

    Abstract Intraoperative nodal palpation in the axilla is a mandatory part of sentinel lymph node biopsy. However, there is no consensus regarding the definition of suspicious palpable node. The sampling rate and involvement rate of suspicious palpable nodes are inconsistent. We hypothesized that axillary reverse mapping is helpful to select suspicious palpable sentinel lymph nodes more accurately. Patients with clinically negative nodes underwent sentinel lymph node biopsy with intraoperative nodal palpation and axillary reverse mapping. Blue and hot nodes were removed as sentinel lymph nodes. Suspicious palpable nodes that were neither blue nor hot were removed as palpable sentinel lymph nodes. Nodes around blue and hot sentinel lymph node were incidentally removed as para-sentinel lymph nodes. Fluorescent nodes were considered axillary reverse mapping nodes. Patients with positive sentinel lymph node underwent axillary lymph node dissection. Palpable sentinel lymph nodes and para-sentinel lymph nodes were removed in 130 (15%) of 850 patients with clinically negative nodes. Although palpable sentinel lymph nodes and para-sentinel lymph nodes were involved in 19 (15%) of 130 patients, fluorescent palpable sentinel lymph nodes were involved only in 2 patients and fluorescent para-sentinel lymph nodes were not involved. When excluding fluorescent palpable sentinel lymph nodes and para-sentinel lymph nodes, the sampling rate of suspicious palpable nodes significantly decreased (15% vs. 5%, p < 0.01) and the involvement rate of palpable sentinel lymph nodes significantly increased (15% vs. 31%, p < 0.05). Axillary reverse mapping is helpful to avoid an unnecessary removal of palpable nodes without metastases.
    MeSH term(s) Axilla ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/surgery ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/surgery ; Lymphatic Metastasis/diagnostic imaging ; Palpation ; Sentinel Lymph Node Biopsy
    Language English
    Publishing date 2021-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/tbj.14260
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Effectiveness of prophylactic HPV vaccines against cervical abnormalities and HPV infection in Japan: The J-HERS 2021 multicenter study.

    Saeki, Yoshihiko / Saito, Mayumi / Irie, Takuya / Itoh, Fujiko / Enatsu, Akiko / Komura, Hiroko / Fujii, Miho / Fujii, Ryota / Hidaka, Natsuko / Maehama, Toshiyuki / Shirasu, Nobuhiko / Waseda, Tomoo / Shibata, Takeo / Takada, Emi / Mibe, Kazuki / Sakamoto, Jinichi / Yamada, Sousuke / Takakura, Masahiro / Sasagawa, Toshiyuki

    Journal of medical virology

    2024  Volume 96, Issue 2, Page(s) e29413

    Abstract: This study investigated the efficacy of the prophylactic human papillomavirus (HPV) vaccine, which was initiated between 2009 and 2013 in Japan. The study involved 1529 eligible women aged 16-39 years who visited 11 outpatient clinics in Japan for ... ...

    Abstract This study investigated the efficacy of the prophylactic human papillomavirus (HPV) vaccine, which was initiated between 2009 and 2013 in Japan. The study involved 1529 eligible women aged 16-39 years who visited 11 outpatient clinics in Japan for various reasons. These patients underwent HPV genotype analysis and a Pap test of cervical cell samples. A total of 299 women (19.6%) had received the prophylactic HPV vaccine (bivalent:quadrivalent vaccine ratio = 2:1). Of the 5062 participants in the Japanese Human Papillomavirus Disease Education and Research Survey (J-HERS 2011), which was conducted in the pre-vaccination era, 3236 eligible participants were included as controls. In this study (J-HERS 2021), the highest rate of HPV vaccination (53%) was observed in patients aged 22-27 years. Vaccinated individuals exhibited a 49% rate of protection against low-grade intraepithelial lesions (LSILs) and atypical squamous cells, not excluding high-grade squamous intraepithelial lesions (ASCH) or worse (LSIL/ASCH+), and a 100% rate of protection against high-grade squamous intraepithelial lesions (HSILs) or worse (HSIL+). Significant reductions in HPV16 (95%) and HPV18 (100%) infections were noted, but no differences were observed in HPV6 and HPV11 infections. The prevalences of HPV51 and HPV59 increased with vaccination, although these changes were not confirmed in the comparative study with J-HERS 2011. Comparing the prevaccination (J-HERS 2011) and postvaccination (J-HERS 2021) periods, 43%, 51%, 88%, and 62% reductions in HPV16, HPV18, HPV16/18, and HPV31/58 infection rates were observed, respectively. Similarly, 62% and 71% reductions in LSIL/ASCH+ and HSIL+ rates were noted, respectively. There were 88% and 87% reductions in LSIL/ASCH+ and HSIL+ rates in 16-21- and 28-33-year-old patients, respectively. Bivalent or quadrivalent vaccines provided 100% protection against high-grade squamous cell lesions (suggestive of CIN2 or CIN3) in young women aged <39 years at 9-12 years after initiation of Japan's first nationwide HPV vaccination program. Cross-protection against HPV31 and HPV58 is likely to occur, although some HPV-type replacements are inconsistent across vaccination regimens. This demonstrates the effectiveness of the HPV vaccine. However, continuous monitoring of cervical cancer and precancer is necessary in younger generations (born 1997-2007), who were rarely vaccinated due to the prolonged suspension of the vaccine recommendations in Japan.
    MeSH term(s) Humans ; Female ; Uterine Cervical Dysplasia ; Papillomavirus Vaccines ; Papillomavirus Infections/epidemiology ; Papillomavirus Infections/prevention & control ; Japan/epidemiology ; Human papillomavirus 16 ; Human papillomavirus 18 ; Uterine Cervical Neoplasms/epidemiology ; Uterine Cervical Neoplasms/prevention & control ; Uterine Cervical Neoplasms/pathology ; Papillomaviridae/genetics ; Squamous Intraepithelial Lesions ; Human papillomavirus 31 ; Vaccines, Combined
    Chemical Substances Papillomavirus Vaccines ; Vaccines, Combined
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Multicenter Study ; Journal Article
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.29413
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Gallbladder metastasis from renal cell carcinoma: a case report with review of the literature.

    Ueda, Issei / Aoki, Takatoshi / Oki, Hodaka / Takahashi, Hiroyuki / Hayashida, Yoshiko / Minagawa, Noritaka / Yamaguchi, Koji / Fujimoto, Naohiro / Matsumoto, Tetsuro / Yamada, Sousuke / Korogi, Yukunori

    Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine

    2015  Volume 14, Issue 2, Page(s) 133–138

    Abstract: We experienced a rare case of gallbladder metastasis from renal cell carcinoma (RCC). Ultrasound, computed tomographic, and magnetic resonance findings showed a hypervascular polypoid mass and correlated well with histopathologic findings. The mass ... ...

    Abstract We experienced a rare case of gallbladder metastasis from renal cell carcinoma (RCC). Ultrasound, computed tomographic, and magnetic resonance findings showed a hypervascular polypoid mass and correlated well with histopathologic findings. The mass showed high intensity on diffusion-weighted images, and the apparent diffusion coefficient was relatively low. These imaging findings are considered characteristic and may assist preoperative diagnosis in patients with history of RCC.
    MeSH term(s) Adult ; Carcinoma, Renal Cell/diagnosis ; Carcinoma, Renal Cell/secondary ; Diffusion Magnetic Resonance Imaging/methods ; Follow-Up Studies ; Gallbladder Neoplasms/diagnosis ; Gallbladder Neoplasms/secondary ; Humans ; Kidney Neoplasms/pathology ; Male ; Multimodal Imaging/methods ; Positron-Emission Tomography/methods ; Tomography, X-Ray Computed/methods ; Ultrasonography, Doppler, Color
    Language English
    Publishing date 2015
    Publishing country Japan
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 2217833-8
    ISSN 1880-2206 ; 1347-3182
    ISSN (online) 1880-2206
    ISSN 1347-3182
    DOI 10.2463/mrms.2013-0130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Cytokine production of lung cancer cell lines: Correlation between their production and the inflammatory/immunological responses both in vivo and in vitro.

    Fukuyama, Takashi / Ichiki, Yoshinobu / Yamada, Sousuke / Shigematsu, Yoshiki / Baba, Tetsuro / Nagata, Yoshika / Mizukami, Makiko / Sugaya, Masakazu / Takenoyama, Mitsuhiro / Hanagiri, Takeshi / Sugio, Kenji / Yasumoto, Kosei

    Cancer science

    2007  Volume 98, Issue 7, Page(s) 1048–1054

    Abstract: Cytokines produced by tumor cells may have various effects on antitumor immune responses and tumor growth. In the present study, the cytokine production of 31 lung cancer cell lines was evaluated, while any correlation with the histological type, the ... ...

    Abstract Cytokines produced by tumor cells may have various effects on antitumor immune responses and tumor growth. In the present study, the cytokine production of 31 lung cancer cell lines was evaluated, while any correlation with the histological type, the induction of tumor-specific cytotoxic T lymphocytes (CTL) in vitro, and angiogenesis and the infiltration of inflammatory cells in tumor tissues were also examined. Production of interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-alpha, granulocyte macrophage colony stimulating factor (GM-CSF), granulocyte colony stimulating factor, transforming growth factor (TGF)-beta and vascular endothelial growth factor (VEGF) in the culture supernatant was measured using enzyme-linked immunosorbent assay. Each cytokine was produced in a substantial number of the tumor cell lines. In particular, IL-6, IL-8, TGF-beta and VEGF were produced in 18 (55%), 29 (94%), 31 (100%) and 28 (90%) of 31 cell lines, respectively. However, neither IL-4 nor TNF-alpha was produced at all by any tumor cell line. TGF-beta production was significantly higher in adenocarcinoma than in squamous cell carcinoma (P = 0.03). Immunohistochemical staining revealed the magnitude of macrophage infiltration, and angiogenesis in surgically resected tumor tissue specimens correlated well with GM-CSF and IL-8 production from the corresponding cell lines. Among six lung cancer cell lines, CTL were induced in the three lung cancer cell lines that produced a lower amount of TGF-beta (<100 pg/mL). These findings suggested that TGF-beta produced by tumor cells could inhibit the induction of CTL in vitro. The present results suggest that the production of various cytokines from tumor cells might exert various paracrine effects both in vivo and in vitro.
    MeSH term(s) Adenocarcinoma/immunology ; Adenocarcinoma/pathology ; Adenocarcinoma/physiopathology ; Carcinoma, Non-Small-Cell Lung/immunology ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/physiopathology ; Carcinoma, Squamous Cell/immunology ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/physiopathology ; Cell Line, Tumor ; Cytokines/biosynthesis ; Humans ; Inflammation ; Lung Neoplasms/immunology ; Lung Neoplasms/pathology ; Lung Neoplasms/physiopathology
    Chemical Substances Cytokines
    Language English
    Publishing date 2007-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2111204-6
    ISSN 1347-9032
    ISSN 1347-9032
    DOI 10.1111/j.1349-7006.2007.00507.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.14: Show issues Location:
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