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  1. Article: [A new treatment option for complex perianal fistulas in Crohn's disease patients; development of darvadstrocel (allogeneic expanded adipose-derived mesenchymal stem cells) in Japan].

    Yamaguchi, Takayoshi

    Nihon yakurigaku zasshi. Folia pharmacologica Japonica

    2024  Volume 159, Issue 3, Page(s) 150–155

    Abstract: Crohn's disease (CD) is a chronic and relapsing inflammatory bowel disease affecting the entire gastrointestinal tract. The prevalence of CD among Japanese people is increasing. One of the most frequent complications of CD is perianal fistulas. People ... ...

    Abstract Crohn's disease (CD) is a chronic and relapsing inflammatory bowel disease affecting the entire gastrointestinal tract. The prevalence of CD among Japanese people is increasing. One of the most frequent complications of CD is perianal fistulas. People living with CD may experience complex perianal fistulas, which can cause intense pain, bleeding, swelling, infection, and anal discharge. Despite medical and surgical advancements, complex perianal fistulas in CD remain challenging for clinicians to treat. CD patients living with perianal fistulas reported a negative impact on many aspects of their quality of life. Darvadstrocel is a cell therapy product containing a suspension of allogeneic expanded adipose-derived mesenchymal stem cells. It has been approved in Europe and Japan for the treatment of complex perianal fistulas that have shown an inadequate response to at least one conventional or biologic therapy in adult patients with non-active/mildly active luminal CD. By exhibiting immunomodulatory and local anti-inflammatory effects at the site of inflammation, it offers a new treatment option for complex perianal fistulas in CD patients. In this manuscript, the characteristic of darvadstrocel, the summary of results from the pivotal phase 3 studies in Europe and Japan, and the development strategy in Japan were introduced.
    MeSH term(s) Crohn Disease/therapy ; Crohn Disease/complications ; Humans ; Rectal Fistula/therapy ; Rectal Fistula/etiology ; Japan ; Mesenchymal Stem Cell Transplantation ; Mesenchymal Stem Cells ; Adipose Tissue
    Language Japanese
    Publishing date 2024-05-02
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 1097532-9
    ISSN 1347-8397 ; 0015-5691
    ISSN (online) 1347-8397
    ISSN 0015-5691
    DOI 10.1254/fpj.23046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 439: Show issues Location:
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  2. Article ; Online: Knowing the learning strategy is not enough to use it: Example in reading strategies for Japanese undergraduates.

    Yamaguchi, Tsuyoshi

    PloS one

    2023  Volume 18, Issue 11, Page(s) e0293875

    Abstract: Learning strategies are an important component of self-regulated learning. Learners are expected to use multiple strategies appropriately. This study focused on metacognitive knowledge in the use of learning strategies and attempted to clarify the ... ...

    Abstract Learning strategies are an important component of self-regulated learning. Learners are expected to use multiple strategies appropriately. This study focused on metacognitive knowledge in the use of learning strategies and attempted to clarify the hierarchical nature of multiple knowledge. Furthermore, the study provided suggestions that could lead to further efficient acquisition of learning strategies. Responses were obtained from 184 Japanese university students regarding the degree of strategy use, knowledge regarding strategy, and perceived benefit and cost of 28 reading strategies. Results of the hierarchical Bayesian modeling showed that strategy use was influenced by knowledge regarding strategy and perceived benefit and cost. Furthermore, the effects of perceived benefit and cost were lower in the absence of knowledge regarding strategy. This implies that to use a learning strategy, the learner must first be aware of it and the degree to which it is used (apart from its theoretical usefulness) is determined by subjective benefit and cost. Therefore, in classroom situations, it is desirable to explicitly teach not only the course content but also strategies appropriate for learning the content. Dependence of the effects of perceived benefit and cost of strategy use on the presence or absence of knowledge regarding strategy suggests a hierarchy of metacognitive knowledge regarding usage of learning strategies.
    MeSH term(s) Humans ; Reading ; Bayes Theorem ; East Asian People ; Learning/physiology ; Students/psychology
    Language English
    Publishing date 2023-11-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293875
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Atrial Fibrillation Ablation and the ABC-Death Score: Beyond Rhythm Outcomes.

    Yamaguchi, Takanori

    JACC. Asia

    2023  Volume 3, Issue 5, Page(s) 802–804

    Language English
    Publishing date 2023-10-17
    Publishing country United States
    Document type Editorial
    ISSN 2772-3747
    ISSN (online) 2772-3747
    DOI 10.1016/j.jacasi.2023.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Axillary lymph node pigmentation in tattooed patients.

    Yamaguchi, Toshiyuki

    Clinical case reports

    2023  Volume 11, Issue 12, Page(s) e8293

    Abstract: Key clinical message: Tattooed pigments often migrate to the regional lymph nodes, leading to staining and swelling of these nodes. This migration can create confusion for surgeons when evaluating regional lymph nodes for staging of malignant disease ... ...

    Abstract Key clinical message: Tattooed pigments often migrate to the regional lymph nodes, leading to staining and swelling of these nodes. This migration can create confusion for surgeons when evaluating regional lymph nodes for staging of malignant disease like breast cancer.
    Abstract: A 50-year-old woman with left breast carcinoma underwent left mastectomy and sentinel lymph node (SLN) biopsy. A cherry blossom tattoo was observed on the left pectoral region, which she had acquired 6 years prior. Two lymph nodes were excised as SLNs and one of the two SLNs exhibited partial pink staining. Serial sections were performed on the block, revealing pinkish particles within the colored area on pathological examination. However, no metastasis was detected.
    Language English
    Publishing date 2023-12-05
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.8293
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  5. Article ; Online: Laser scattering centrifugal liquid sedimentation method for the accurate quantitative analysis of mass-based size distributions of colloidal silica.

    Yamaguchi, Tetsuji

    Analytical sciences : the international journal of the Japan Society for Analytical Chemistry

    2023  Volume 39, Issue 7, Page(s) 1115–1128

    Abstract: This paper proposes a laser scattering centrifugal liquid sedimentation (LS-CLS) method for the accurate quantitative analysis of the mass-based size distributions of colloidal silica. The optics comprised a laser diode light source and multi-pixel ... ...

    Abstract This paper proposes a laser scattering centrifugal liquid sedimentation (LS-CLS) method for the accurate quantitative analysis of the mass-based size distributions of colloidal silica. The optics comprised a laser diode light source and multi-pixel photon-counting detector for detecting scattered light intensity. The unique optics can only detect the light scattered by a sample through the interception of irradiated light. The developed centrifugal liquid sedimentation (CLS) method comprised a light-emitting diode and silicon photodiode detector for detecting transmittance light attenuation. The CLS apparatus could not accurately measure quantitative volume- or mass-based size distribution of poly-dispersed suspensions, such as colloidal silica, because the detecting signal includes both transmitted and scattered light. The LS-CLS method exhibited improved quantitative performance. Moreover, the LS-CLS system allowed the injection of samples with concentrations higher than that permitted by other particle size distribution measurement systems with particle size classification units using size-exclusion chromatography or centrifugal field-flow fractionation. The proposed LS-CLS method achieved an accurate quantitative analysis of the mass-based size distribution using both centrifugal classification and laser scattering optics. In particular, the system could measure the mass-based size distribution of approximately 20 mg mL
    Language English
    Publishing date 2023-03-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1483376-1
    ISSN 1348-2246 ; 1348-2246
    ISSN (online) 1348-2246
    ISSN 1348-2246
    DOI 10.1007/s44211-023-00321-9
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  6. Article ; Online: A consideration of cross-disciplinary collaboration.

    Yamaguchi, Tadashi

    Journal of medical ultrasonics (2001)

    2023  Volume 50, Issue 2, Page(s) 119

    Language English
    Publishing date 2023-05-12
    Publishing country Japan
    Document type Editorial
    ZDB-ID 1396630-3
    ISSN 1613-2254 ; 0287-0592 ; 1346-4523
    ISSN (online) 1613-2254
    ISSN 0287-0592 ; 1346-4523
    DOI 10.1007/s10396-023-01303-0
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2695: Show issues Location:
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  7. Article ; Online: Exploration and utilization of novel aldoxime, nitrile, and nitro compounds metabolizing enzymes from plants and arthropods.

    Yamaguchi, Takuya

    Bioscience, biotechnology, and biochemistry

    2023  Volume 88, Issue 2, Page(s) 138–146

    Abstract: Aldoxime (R1R2C=NOH) and nitrile (R-C≡N) are nitrogen-containing compounds that are found in species representing all kingdoms of life. The enzymes discovered from the microbial "aldoxime-nitrile" pathway (aldoxime dehydratase, nitrile hydratase, amidase, ...

    Abstract Aldoxime (R1R2C=NOH) and nitrile (R-C≡N) are nitrogen-containing compounds that are found in species representing all kingdoms of life. The enzymes discovered from the microbial "aldoxime-nitrile" pathway (aldoxime dehydratase, nitrile hydratase, amidase, and nitrilase) have been thoroughly studied because of their industrial importance. Although plants utilize cytochrome P450 monooxygenases to produce aldoxime and nitrile, many biosynthetic pathways are yet to be studied. Cyanogenic millipedes accumulate various nitrile compounds, such as mandelonitrile. However, no such aldoxime- and nitrile-metabolizing enzymes have been identified in millipedes. Here, I review the exploration of novel enzymes from plants and millipedes with characteristics distinct from those of microbial enzymes, the catalysis of industrially useful reactions, and applications of these enzymes for nitrile compound production.
    MeSH term(s) Animals ; Arthropods/metabolism ; Nitriles/metabolism ; Hydro-Lyases ; Oximes ; Catalysis
    Chemical Substances Nitriles ; Hydro-Lyases (EC 4.2.1.-) ; acetaldehyde oxime (ME6U10SD7D) ; Oximes
    Language English
    Publishing date 2023-11-28
    Publishing country England
    Document type Review ; Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbad168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4647: Show issues Location:
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  8. Article ; Online: Learning processes in hierarchical pairs regulate entire gene expression in cells.

    Yamaguchi, Tomoyuki

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7549

    Abstract: Expression of numerous genes is precisely controlled in a cell in various contexts. While genetic and epigenetic mechanisms contribute to this regulation, how each mechanism cooperates to ensure the proper expression patterns of the whole gene remains ... ...

    Abstract Expression of numerous genes is precisely controlled in a cell in various contexts. While genetic and epigenetic mechanisms contribute to this regulation, how each mechanism cooperates to ensure the proper expression patterns of the whole gene remains unclear. Here, I theoretically show that the repetition of simple biological processes makes cells functional with the appropriate expression patterns of all genes if the inappropriateness of current expression ratios is roughly fed back to the epigenetic states. A learning pair model is developed, in which two factors autonomously approach the target ratio by repeating two stochastic processes; competitive amplification with a small addition term and decay depending on the difference between the current and target ratios. Furthermore, thousands of factors are self-regulated in a hierarchical-pair architecture, in which the activation degrees competitively amplify, while transducing the activation signal, and decay at four different probabilities. Changes in whole-gene expression during human early embryogenesis and hematopoiesis are reproduced in simulation using this epigenetic learning process in a single genetically-determined hierarchical-pair architecture of gene regulatory cascades. On the background of this learning process, I propose the law of biological inertia, which means that a living cell basically maintains the expression pattern while renewing its contents.
    MeSH term(s) Computer Simulation ; Epigenesis, Genetic ; Gene Expression ; Gene Expression Regulation ; Humans ; Stochastic Processes
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10998-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acalculous Cholecystitis Secondary to Epstein-Barr Virus Infection

    Yamaguchi, Toshimasa

    Balkan medical journal

    2022  Volume 39, Issue 5, Page(s) 374–375

    MeSH term(s) Acalculous Cholecystitis/diagnosis ; Acalculous Cholecystitis/diagnostic imaging ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/diagnosis ; Herpesvirus 4, Human ; Humans
    Language English
    Publishing date 2022-08-15
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2612982-6
    ISSN 2146-3131 ; 2146-3131
    ISSN (online) 2146-3131
    ISSN 2146-3131
    DOI 10.4274/balkanmedj.galenos.2022.2022-5-46
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A paradigm shift in learning strategy research: Illustration and example of a within-person examination.

    Yamaguchi, Tsuyoshi

    PloS one

    2022  Volume 17, Issue 9, Page(s) e0274548

    Abstract: Although research on learning strategies has contributed to improving learners' performance, most studies only described the characteristics of learners. These approaches have focused on inter-individual differences and their correlations, making it ... ...

    Abstract Although research on learning strategies has contributed to improving learners' performance, most studies only described the characteristics of learners. These approaches have focused on inter-individual differences and their correlations, making it difficult to examine the process of selecting learning strategies in individuals. To examine the correlations within individual learners, such as the variables that influence the use of a strategy by a specific learner, two surveys were conducted in this study. Perceived cost and perceived benefit of using each strategy as the influential variables on choosing a strategy were adopted with reference to decision-making research. Perceived cost consisted of the time perspective for learning outcomes by the learning strategy and the method of learning strategy implementation. In Study 1, cognitive strategies that have a direct impact on the acquisition of learning content were measured, and metacognitive strategies that monitor and regulate one's own learning behavior were examined in Study 2. The variables were treated for each individual to calculate intra-class and within-person correlations, although data were collected using a typical questionnaire survey in learning strategy studies. Hierarchical Bayesian modeling was conducted with use of the learning strategy as the objective variable and the perceived costs and benefits as explanatory variables. The analysis revealed that, in terms of cognitive strategies (Study 1), learners avoided using learning strategies perceived to have a high cost in the short term; however, they used cognitive strategies regardless of the circumstances. Furthermore, regarding metacognitive strategies (Study 2), students avoided using learning strategies that they perceived as costly to use in the short term and used them only when they suited the circumstances. On the other hand, in metacognitive strategies (Study 2), students avoided using learning strategies that they perceived as costly to use for the next test and use as appropriate for the situation. Focusing on within-individual variance and correlation made the interpretation of factors that influence the choice of learning strategies more intuitive and provided more suggestions for educational practice.
    MeSH term(s) Bayes Theorem ; Humans ; Learning ; Metacognition ; Students ; Surveys and Questionnaires
    Language English
    Publishing date 2022-09-15
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0274548
    Database MEDical Literature Analysis and Retrieval System OnLINE

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