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Article: Symptoms of Isolated Optic Neuropathy in a Patient with Systemic, Brain, and Meningeal Metastases from Breast Cancer: A Case Report.

Kyo, Akika / Yamamoto, Manabu / Kohno, Takeya / Haruna, Yusuke / Honda, Shigeru

2024 Volume 15, Issue 1, Page(s) 71–77

Abstract: Introduction: Ocular metastases from breast cancer, particularly involving the optic nerve, are rare and pose a diagnostic challenge. Typically, optic nerve metastases are believed to originate from nearby choroidal metastases or hematogenous spread ... ...

Abstract	Introduction: Ocular metastases from breast cancer, particularly involving the optic nerve, are rare and pose a diagnostic challenge. Typically, optic nerve metastases are believed to originate from nearby choroidal metastases or hematogenous spread through the posterior ciliary arteries. However, there have been some reports of metastases through leptomeningeal dissemination. The aim of this report was to describe a case of multiple brain metastases from breast cancer without subjective symptoms other than central scotoma, which was diagnosed with repeated magnetic resonance imaging (MRI). Case presentation: A 62-year-old woman who had previously undergone a mastectomy for left breast cancer complained of left ocular pain during eye movement and left visual loss. Initial contrast-enhanced MRI showed no significant abnormalities, and idiopathic optic neuritis was suspected. Despite steroid pulse therapy, her visual function did not improve. After four and a half months, her visual acuity worsened, and repeat contrast-enhanced MRI showed brain metastases involving the optic nerve sheath. Conclusion: Despite the multiple brain metastases, ultimately the patient's only symptom was unilateral visual loss. These findings highlight the usefulness of repeated contrast-enhanced MRI for detecting brain metastases, especially in cases without other apparent neurological symptoms or initial imaging abnormalities.
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2577666-6
ISSN	1663-2699
ISSN	1663-2699
DOI	10.1159/000536189
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Article ; Online: Intraoperative determination of the risky angles and safe distances for preventing deep femoral artery injury during proximal femoral nailing for hip fractures in Asian people.

Kaneoka, Takehiro / Imagama, Takashi / Yamamoto, Manabu

Acta orthopaedica et traumatologica turcica

2022 Volume 56, Issue 5, Page(s) 300–305

Abstract: Objective: During proximal femoral nailing, deep femoral artery injury, a rare condition, is often missed and found late, leading to intractable complications such as false aneurysm, hematoma, and anemia. We aimed to determine the novel indicators of ... ...

Abstract	Objective: During proximal femoral nailing, deep femoral artery injury, a rare condition, is often missed and found late, leading to intractable complications such as false aneurysm, hematoma, and anemia. We aimed to determine the novel indicators of the high-risk vertical range and axial angle for deep femoral artery injury that can be easily confirmed intraoperatively using fluoroscopy for hip fracture. Methods: In a single hospital, the lower extremity computed tomography angiographies of 88 patients (50 men and 38 women) were analyzed. A reference plane was defined as the femoral neck and shaft on the same straight line in the lateral view. Reference points were the lower end of the lesser trochanter and distal femur at 140 mm from the tip of the greater trochanter. To determine the high-risk angle for deep femoral artery injury based on the reference plane, the angle from the reference plane to the deep femoral artery (bone-arterial angle) and the shortest distance between the surfaces of the femur and the deep femoral artery (bone-artery distance) were measured at the lesser trochanter and the greater trochanter. We analyzed the bone-arterial angle and bone-artery distance values, their differences among the sexes, and their correlation with body height and body weight. Results: Overall, in the lesser trochanter, the mean bone-arterial angle and bone-artery distance were 19.2° ± 8.0° and 22.9 ± 4.7 mm, respectively. In the greater trochanter, the mean bone-arterial angle and bone-artery distance were -33.9° ± 17.0° and 11.3 ± 4.1 mm, respectively. The mean bone-artery distance of the lesser trochanter was significantly longer in men than in women (24.1 ± 4.5 mm and 21.4 ± 4.5 mm, respectively, P < 0.01), and for the lesser trochanter, positive correlations were found between body height and both bone- arterial angle and bone-artery distance (r=0.373, P < 0.001; and r=0.456, P < 0.0001, respectively), with body weight and bone-artery distance positively correlated (r=0.367, P < 0.001). At the greater trochanter, there were negative correlations between body height and bone-arterial angle (r=-0.5671, P < 0.0001), body weight, and bone-arterial angle (r=-0.338, P < 0.01). Conclusion: The knowledge of our reference plane and high-risk angles and distances allows surgeons to minimize the risk of deep femoral artery injury. These are easily confirmed intraoperatively using fluoroscopy, allowing surgeons to avoid maneuvering in the deep femoral artery range. Level of evidence: Level IV, Diagnostic Study.
MeSH term(s)	Male ; Humans ; Female ; Fracture Fixation, Intramedullary/adverse effects ; Femoral Artery/diagnostic imaging ; Femur/diagnostic imaging ; Femur/surgery ; Hip Fractures/diagnostic imaging ; Hip Fractures/surgery ; Vascular System Injuries/diagnostic imaging ; Vascular System Injuries/etiology ; Vascular System Injuries/prevention & control ; Lower Extremity ; Body Weight ; Femoral Fractures/surgery
Language	English
Publishing date	2022-10-17
Publishing country	Turkey
Document type	Journal Article
ISSN	2589-1294
ISSN (online)	2589-1294
DOI	10.5152/j.aott.2022.22061
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Article ; Online: A case of angioid streaks that produced choroidal neovascularization after the onset of unilateral acute retinopathy in pseudoxanthoma elasticum.

Kyo, Akika / Yamamoto, Manabu / Honda, Shigeru

American journal of ophthalmology case reports

2022 Volume 27, Page(s) 101591

Abstract: Purpose: To report a case of angioid streaks that showed non-exudative choroidal neovascularization (CNV) after the onset of acute retinopathy in pseudoxanthoma elasticum (PXE).: Observations: A 64-year-old woman with PXE visited our department for ... ...

Abstract	Purpose: To report a case of angioid streaks that showed non-exudative choroidal neovascularization (CNV) after the onset of acute retinopathy in pseudoxanthoma elasticum (PXE). Observations: A 64-year-old woman with PXE visited our department for an ophthalmologic evaluation. Her decimal best-corrected visual acuity (BCVA) was 1.5, with angioid streaks (AS) around the optic disc in either eye at the first visit. Seven years later, her left eye's BCVA suddenly decreased by 0.3, and the fundus showed blurring of the Ellipsoid zone and vitreous cells along with the retinal pigment streaks on the nasal fovea. Diagnosed as acute retinopathy in PXE, twenty-two weeks after the start of oral prednisolone, the Ellipsoid zone became clear and the BCVA improved to 1.2, but CNV gradually developed. After intravitreal injection of bevacizumab, the CNV was decreased. Conclusions and importance: CNV on the AS lesion may occur after acute retinopathy in PXE.
Language	English
Publishing date	2022-05-19
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2022.101591
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Article ; Online: Fundus white spots associated with graft-versus-host disease in the remission phase of acute myeloid leukemia.

Kyo, Akika / Yamamoto, Manabu / Nagatomi, Yuri / Kohno, Takeya / Honda, Shigeru

American journal of ophthalmology case reports

2022 Volume 27, Page(s) 101609

Abstract: Purpose: To report a case of fundus white spots associated with graft-versus-host disease (GVHD) during the remission phase of acute myelogenous leukemia (AML).: Observations: A 60-year-old woman was diagnosed with AML 7 months earlier, and after 3 ... ...

Abstract	Purpose: To report a case of fundus white spots associated with graft-versus-host disease (GVHD) during the remission phase of acute myelogenous leukemia (AML). Observations: A 60-year-old woman was diagnosed with AML 7 months earlier, and after 3 months of chemotherapy, she underwent bone marrow transplantation 2 months earlier and was in remission. When she first came to our department with the chief complaint of persistent bilateral floaters before she developed AML, she had a skin rash caused by GVHD that had been diagnosed 4 days earlier, and the fundi of both eyes showed multiple white spots in the deep retinal layers. One month later, the GVHD skin rash had resolved with topical steroid treatment, and the fundus white spots had mostly disappeared. Fifteen months after the initial visit, the fundus white spots had completely disappeared, with remaining hypofluorescent dots on fundus autofluorescence. Her best-corrected visual acuity was 1.2 in each eye at the first visit and remained at 1.0 in the right eye and 1.2 in the left eye at the final visit 15 months later. Conclusions and importance: Fundus white spots may occur in the early phase of GVHD, causing focal retinal pigment epithelium atrophy after resolution.
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Case Reports
ISSN	2451-9936
ISSN (online)	2451-9936
DOI	10.1016/j.ajoc.2022.101609
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Article: An Intrahepatic Fluorodeoxyglucose (FDG)-PET/CT False-Positive Tumor Secondary to Foreign Body Granuloma Masquerading as Colon Cancer Liver Metastasis: A Case Report.

Hanaki, Takehiko / Honjo, Soichiro / Kishino, Mikiya / Murakami, Yuki / Yamamoto, Manabu / Naruo, Tokuyasu / Sakamoto, Teruhisa / Hasegawa, Toshimichi / Fujiwara, Yoshiyuki

Cureus

2024 Volume 16, Issue 1, Page(s) e52657

Abstract: A suture placed next to a dissected liver section during the initial hepatectomy may become an unlikely intrahepatic foreign body granuloma. In this report, we describe a case where a silk suture in the liver section plane placed during initial ... ...

Abstract	A suture placed next to a dissected liver section during the initial hepatectomy may become an unlikely intrahepatic foreign body granuloma. In this report, we describe a case where a silk suture in the liver section plane placed during initial hepatectomy for synchronous colon cancer metastasis became an intrahepatic foreign body granuloma that exhibited fluorodeoxyglucose (FDG) accumulation on positron emission tomography/computed tomography (PET/CT). The granuloma was resected as the second metachronous liver metastatic lesion. A 73-year-old female was referred for a planned second hepatectomy. She had undergone colectomy and hepatectomy for advanced cancer of the ascending colon and synchronous liver metastasis approximately two years ago. However, two possible liver metastases with FDG accumulation were identified in hepatic segments IV and V after one year and nine months after the initial resection. A second hepatectomy was planned after administering systemic chemotherapy. She underwent a left lobectomy with a middle hepatic vein and partial segment V hepatectomy six months after liver lesion identification. The segment IV lesion was histologically proven to be a liver metastasis adenocarcinoma. The segment V lesion revealed a silk thread on the residual liver side at the initial hepatectomy, which was histologically diagnosed as a foreign body granuloma. The possibility of intrahepatic foreign body granuloma development should be considered in subsequent follow-ups in cases where sutures were applied to the dissected residual liver plane during the initial hepatectomy. Additionally, a thorough second hepatectomy should be considered if recurrence is suspected.
Language	English
Publishing date	2024-01-21
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.52657
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Article: Efficacy of Touch Imprint Cytology in Intraoperative Diagnosis of Invasive Mucinous Adenocarcinoma of the Lung: A Case Report and Literature Review.

Kato, Toshihiko / Higuchi, Yumiko / Oshima, Mei / Endo, Fuki / Sato, Fuminori / Sugihara, Shiro / Yamamoto, Manabu / Imai, Yasuo

Clinics and practice

2024 Volume 14, Issue 1, Page(s) 242–249

Abstract: A preoperative diagnosis of the peripheral small lung nodule is often difficult, and an intraoperative frozen section diagnosis (FSD) is performed to guide treatment strategy. However, invasive mucinous adenocarcinoma (IMA) is prone to be overlooked ... ...

Abstract	A preoperative diagnosis of the peripheral small lung nodule is often difficult, and an intraoperative frozen section diagnosis (FSD) is performed to guide treatment strategy. However, invasive mucinous adenocarcinoma (IMA) is prone to be overlooked because of the low sample quality and weak atypia. We herein report a case of IMA, in which touch imprint cytology (TIC) revealed diagnostic efficacy. A 74-year-old male with a small, subsolid nodule in the right upper lobe underwent a thoracoscopic wedge resection. A grayish brown, 10 × 7 mm-sized nodule was observed on the cut surface. Intraoperative FSD revealed lung tissue with mild alveolar septal thickening and stromal fibrosis but without overt atypia. Meanwhile, TIC revealed mucus and a few epithelial cells with intranuclear inclusions, which pathologists evaluated as reactive. Finally, focal organizing pneumonia was tentatively diagnosed, and surgery was finished without any additional resection. However, permanent section diagnosis revealed a microinvasive mucinous adenocarcinoma. Nuclear inclusions were confirmed in tumor cells. In the intraoperative setting, TIC may be more advantageous than FSD in observing nuclear inclusions and mucus. Mucinous background and nuclear inclusion on TIC may suggest IMA even if FSD does not suggest malignancy in an intraoperative diagnosis of the peripheral small lung nodule.
Language	English
Publishing date	2024-01-29
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2605724-4
ISSN	2039-7283 ; 2039-7275
ISSN (online)	2039-7283
ISSN	2039-7275
DOI	10.3390/clinpract14010019
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Article ; Online: Practical treatment options for persistent central serous chorioretinopathy and early visual and anatomical outcomes.

Yamada-Okahara, Naoko / Kyo, Akika / Hirayama, Kumiko / Yamamoto, Manabu / Kohno, Takeya / Honda, Shigeru

Japanese journal of ophthalmology

2023 Volume 67, Issue 3, Page(s) 295–300

Abstract: Purpose: Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the ...

Abstract	Purpose: Persistent central serous chorioretinopathy (pCSC) may be treated by laser photocoagulation (PC), selective retina therapy (SRT), or photodynamic therapy (PDT). We conducted retrospective analyses regarding the choice of therapy for pCSC in the best clinical practice and the outcomes of these modalities. Study design: A retrospective interventional study. Methods: The records of 71 eyes of 68 treatment naïve pCSC cases who underwent PC, SRT, or PDT were reviewed. First, the baseline clinical parameters were evaluated to find significant factors associated with the choice of treatment option. Second, the 3 months' visual and anatomical outcomes of each modality were assessed. Results: The PC, SRT, and PDT groups included 7, 22, and 42 eyes, respectively. The leakage pattern in fluorescein angiography (FA) was significantly associated with the choice of treatment (p<0.005). The dry macula ratio at 3 months post-treatment was 29%, 59%, and 81% in the PC, SRT, and PDT groups, respectively, which significantly differed among the groups (p<0.01). The best-corrected visual acuities tended to be improved after the treatments in all groups. Central choroidal thickness (CCT) was significantly decreased in all groups (p<0.05, p<0.01, and p<0.00001, in PC, SRT, and PDT groups, respectively). Logistic regression analysis for dry macula revealed that SRT (p<0.05), PDT (p<0.05), and the changes in CCT (p<0.01)were the significant association factors. Conclusion: The leakage pattern in FA was associated with the choice of treatment option for pCSC. PDT achieved a significantly higher dry macula ratio than PC, 3 months after the treatment.
MeSH term(s)	Humans ; Central Serous Chorioretinopathy/therapy ; Central Serous Chorioretinopathy/drug therapy ; Photosensitizing Agents/therapeutic use ; Photochemotherapy ; Retrospective Studies ; Visual Acuity ; Fluorescein Angiography ; Tomography, Optical Coherence ; Chronic Disease ; Porphyrins
Chemical Substances	Photosensitizing Agents ; Porphyrins
Language	English
Publishing date	2023-03-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	82032-5
ISSN	1613-2246 ; 0021-5155
ISSN (online)	1613-2246
ISSN	0021-5155
DOI	10.1007/s10384-023-00978-9
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Article: Low psoas major muscle area as a risk factor for contralateral hip fracture following intertrochanteric fracture.

Kawakami, Takehiro / Imagama, Takashi / Murakami, Tomotoshi / Kaneoka, Takehiro / Yamamoto, Manabu

Journal of musculoskeletal & neuronal interactions

2021 Volume 21, Issue 4, Page(s) 495–500

Abstract: Objective: This study aimed to investigate the relationship between the psoas major muscle area as a risk factor and subsequent contralateral hip fractures in patients with initial intertrochanteric fractures.: Methods: Of 136 treated for ... ...

Abstract	Objective: This study aimed to investigate the relationship between the psoas major muscle area as a risk factor and subsequent contralateral hip fractures in patients with initial intertrochanteric fractures. Methods: Of 136 treated for intertrochanteric fractures, 104 female patients had computed tomography done to assess their fractures at initial stage and had been followed up for more than 2 years. These patients were then divided into 2 groups: i.e. those who had a contralateral hip fracture (CF) (n=16) and those who did not (NF) (n=88) groups. We mainly assessed the relationship between the corrected psoas major muscle area (CPMA) at initial fracture and the occurrence of contralateral hip fracture. Results: The CF group had significantly lower CPMA than the NF group (p=0.001). There was positive correlation between the CPMA and the period from the initial to the contralateral hip fracture in the CF group. The CPMA cutoff value of 480.98 mm2/m2, was showed sensitivity of 63.6% and specificity of 87.5% in receiver operating characteristic curve analysis for all patients. Conclusions: The lower CPMA was associated with the contralateral hip fracture within 2 years from initial intertrochanteric fracture. The low CPMA would be a risk factor for contralateral hip fracture.
MeSH term(s)	Female ; Hip Fractures/diagnostic imaging ; Hip Fractures/epidemiology ; Hip Fractures/etiology ; Humans ; Muscles ; Retrospective Studies ; Risk Factors ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-12-01
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2041366-X
ISSN	1108-7161
ISSN	1108-7161
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Article ; Online: Early anatomical changes and association with photodynamic therapy induced acute exudative maculopathy in patients with macular diseases.

Honda, Satoshi / Kohno, Takeya / Yamamoto, Manabu / Hirayama, Kumiko / Kyo, Akika / Hirabayashi, Michiko / Honda, Shigeru

Scientific reports

2022 Volume 12, Issue 1, Page(s) 9105

Abstract: The purpose of this study was to investigate the occurrence rate and predictors of photodynamic therapy (PDT) induced acute exudative maculopathy (PAEM). This retrospective study included 39 eyes of 39 patients (32 males and 7 females), who were treated ... ...

Abstract	The purpose of this study was to investigate the occurrence rate and predictors of photodynamic therapy (PDT) induced acute exudative maculopathy (PAEM). This retrospective study included 39 eyes of 39 patients (32 males and 7 females), who were treated with initial PDT. PAEM was defined as an increase in central retinal thickness (CRT) of 15% or more measured by OCT on day 3 after PDT compared with baseline. Sixteen of 39 eyes (41%) were classified in the PAEM+ group. CRT and central choroidal thickness (CCT) were significantly increased at 3 days in the PAEM+ group and significantly decreased at 1 month after PDT in the PAEM- group. In a multiple comparison, neovascular age-related macular degeneration (nAMD) had a significantly higher incidence of PAEM compared to polypoidal choroidal vasculopathy (PCV) and central serous chorioretinopathy (CSC). The incidence of PAEM was lower in PCV and CSC, and higher in nAMD. BCVA at 1 month was significantly worse in the PAEM group, which may be related to visual prognosis after PDT. Since both CRT and CCT decrease at 1 month, the detection of PAEM needs to be assessed a few days after PDT.
MeSH term(s)	Central Serous Chorioretinopathy/complications ; Female ; Humans ; Macular Degeneration/diagnosis ; Male ; Photochemotherapy/adverse effects ; Retrospective Studies ; Visual Acuity
Language	English
Publishing date	2022-06-01
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-13208-y
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Article ; Online: Safety and efficacy of 27-gauge transconjunctival vitrectomy for the diagnosis of posterior uveitis or pan uveitis of unknown origin.

Sakai, Atsushi / Tagami, Mizuki / Misawa, Norihiko / Yamamoto, Manabu / Kohno, Takeya / Honda, Shigeru

BMC ophthalmology

2022 Volume 22, Issue 1, Page(s) 178

Abstract: Background: Diagnostic vitrectomy is an important method for evaluating uveitis, and its diagnostic utility is high regardless of whether the uveitis is infectious or non-infectious. The course of diagnostic vitreous surgery with 27-gauge pars plana ... ...

Abstract	Background: Diagnostic vitrectomy is an important method for evaluating uveitis, and its diagnostic utility is high regardless of whether the uveitis is infectious or non-infectious. The course of diagnostic vitreous surgery with 27-gauge pars plana vitrectomy and perioperative complications is reported. Methods: An observational retrospective study of patients who underwent 27-gauge diagnostic vitrectomy due to atypical intraocular inflammation was conducted. The final diagnosis rate, complications due to surgery, preoperative visual acuity, and postoperative visual acuity (1 month and 6 months after surgery) were examined retrospectively. Results: Diagnostic vitreous surgery was performed in 32 patients and 35 eyes (14 males and 18 females, age 14-85 years, median 67 years) during the study period. The average operation time was 52 min for 19 eyes with cataract surgery and 35 min for 16 eyes without cataract surgery. Preoperative log(minimum angle of resolution [MAR]) visual acuity was 0.84 ± 0.87, 1-month postoperative logMAR visual acuity was 0.41 ± 0.55 (p = 0.004, n = 28), and 6-month postoperative average logMAR visual acuity was 0.45 ± 0.73 (p = 0.012, n = 15). The diagnosis was made by diagnostic vitrectomy in 19 cases (54%). Postoperative complications were observed in 2 of 35 postoperative patients (5%); one involved increased intraocular pressure, and the other case involved vitreous hemorrhage of the eye, necessitating reoperation. Conclusion: Diagnostic 27-gauge vitrectomy could be effective for evaluating intraocular inflammation.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cataract/etiology ; Female ; Humans ; Inflammation ; Male ; Middle Aged ; Postoperative Complications/surgery ; Retrospective Studies ; Uveitis/complications ; Uveitis/diagnosis ; Uveitis/surgery ; Uveitis, Posterior ; Vitrectomy/adverse effects ; Vitrectomy/methods ; Young Adult
Language	English
Publishing date	2022-04-19
Publishing country	England
Document type	Journal Article ; Observational Study
ZDB-ID	2050436-6
ISSN	1471-2415 ; 1471-2415
ISSN (online)	1471-2415
ISSN	1471-2415
DOI	10.1186/s12886-022-02405-y
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