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  1. Article ; Online: An iPSC line derived from a human acute myeloid leukemia cell line (HL-60-iPSC) retains leukemic abnormalities and displays myeloid differentiation defects.

    Yamasaki, Amanda E / Warshaw, Jane N / Kyalwazi, Beverly L / Matsui, Hiroko / Jepsen, Kristen / Panopoulos, Athanasia D

    Stem cell research

    2020  Volume 49, Page(s) 102096

    Abstract: Cancer-derived iPSCs have provided valuable insight into oncogenesis, but human cancer cells can often be difficult to reprogram, especially in cases of complex genetic abnormalities. Here we report, to our knowledge, the first successful generation of ... ...

    Abstract Cancer-derived iPSCs have provided valuable insight into oncogenesis, but human cancer cells can often be difficult to reprogram, especially in cases of complex genetic abnormalities. Here we report, to our knowledge, the first successful generation of an iPSC line from a human immortalized acute myeloid leukemia (AML) cell line, the cell line HL-60. This iPSC line retains a majority of the leukemic genotype and displays defects in myeloid differentiation, thus providing a tool for modeling and studying AML.
    MeSH term(s) Cell Differentiation ; HL-60 Cells ; Hematopoiesis ; Humans ; Induced Pluripotent Stem Cells ; Leukemia, Myeloid, Acute/genetics
    Language English
    Publishing date 2020-11-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1876-7753
    ISSN (online) 1876-7753
    DOI 10.1016/j.scr.2020.102096
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Understanding the genetics behind complex human disease with large-scale iPSC collections.

    Yamasaki, Amanda E / Panopoulos, Athanasia D / Belmonte, Juan Carlos Izpisua

    Genome biology

    2017  Volume 18, Issue 1, Page(s) 135

    Abstract: Three recent studies analyzing large-scale collections of human induced pluripotent stem cell lines provide valuable insight into how genetic regulatory variation affects cellular and molecular traits. ...

    Abstract Three recent studies analyzing large-scale collections of human induced pluripotent stem cell lines provide valuable insight into how genetic regulatory variation affects cellular and molecular traits.
    MeSH term(s) Cell Differentiation ; Disease ; Genetic Variation ; Humans ; Induced Pluripotent Stem Cells ; Models, Genetic
    Language English
    Publishing date 2017-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1465-6914 ; 1465-6906
    ISSN (online) 1474-760X ; 1465-6914
    ISSN 1465-6906
    DOI 10.1186/s13059-017-1276-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Two iPSC lines generated from the bone marrow of a relapsed/refractory AML patient display normal karyotypes and myeloid differentiation potential.

    Yamasaki, Amanda E / King, Nicholas E / Matsui, Hiroko / Jepsen, Kristen / Panopoulos, Athanasia D

    Stem cell research

    2019  Volume 41, Page(s) 101587

    Abstract: Using iPSCs to study cancer has been complicated by the fact that many cancer cells are difficult to reprogram, which has been attributed to the genomic abnormalities present. Acute Myeloid Leukemia (AML) is a complex disease that presents with various ... ...

    Abstract Using iPSCs to study cancer has been complicated by the fact that many cancer cells are difficult to reprogram, which has been attributed to the genomic abnormalities present. Acute Myeloid Leukemia (AML) is a complex disease that presents with various types of genomic aberrations that affect prognosis. Here we reprogrammed CD34+ cells from an AML patient containing a rare der(7)t(7;13) translocation associated with poor prognosis, who had relapsed and was refractory to current treatments. The generated AML-iPSCs displayed normal karyotypes and myeloid differentiation potential. These findings have implications for modeling and treating AML disease.
    MeSH term(s) Aged ; Bone Marrow/pathology ; Cell Differentiation ; Drug Resistance, Neoplasm ; Humans ; Induced Pluripotent Stem Cells/pathology ; Karyotype ; Leukemia, Myeloid, Acute/pathology ; Male ; Myeloid Cells/pathology ; Neoplasm Recurrence, Local/pathology ; Tumor Cells, Cultured
    Language English
    Publishing date 2019-10-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 1876-7753
    ISSN (online) 1876-7753
    DOI 10.1016/j.scr.2019.101587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Inter-library loan at ZB MED

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  4. Article: Understanding the genetics behind complex human disease with large-scale iPSC collections

    Yamasaki, Amanda E / Belmonte, Juan Carlos Izpisua / Panopoulos, Athanasia D

    Genome biology. 2017 Dec., v. 18, no. 1

    2017  

    Abstract: Three recent studies analyzing large-scale collections of human induced pluripotent stem cell lines provide valuable insight into how genetic regulatory variation affects cellular and molecular traits. ...

    Abstract Three recent studies analyzing large-scale collections of human induced pluripotent stem cell lines provide valuable insight into how genetic regulatory variation affects cellular and molecular traits.
    Keywords cell lines ; genetic variation ; human diseases ; stem cells
    Language English
    Dates of publication 2017-12
    Size p. 135.
    Publishing place BioMed Central
    Document type Article
    ZDB-ID 2040529-7
    ISSN 1474-760X ; 1465-6914 ; 1465-6906
    ISSN (online) 1474-760X ; 1465-6914
    ISSN 1465-6906
    DOI 10.1186/s13059-017-1276-1
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Cell surface GRP78 promotes stemness in normal and neoplastic cells.

    Conner, Clay / Lager, Tyson W / Guldner, Ian H / Wu, Min-Zu / Hishida, Yuriko / Hishida, Tomoaki / Ruiz, Sergio / Yamasaki, Amanda E / Gilson, Robert C / Belmonte, Juan Carlos Izpisua / Gray, Peter C / Kelber, Jonathan A / Zhang, Siyuan / Panopoulos, Athanasia D

    Scientific reports

    2020  Volume 10, Issue 1, Page(s) 3474

    Abstract: Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like ... ...

    Abstract Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of embryonic signatures in metastatic cancers. However, how to best identify and target stem-like mechanisms aberrantly acquired by cancer cells has been challenging. We harnessed the power of reprogramming to examine GRP78, a chaperone protein generally restricted to the endoplasmic reticulum in normal tissues, but which is expressed on the cell surface of human embryonic stem cells and many cancer types. We have discovered that (1) cell surface GRP78 (sGRP78) is expressed on iPSCs and is important in reprogramming, (2) sGRP78 promotes cellular functions in both pluripotent and breast cancer cells (3) overexpression of GRP78 in breast cancer cells leads to an induction of a CD24
    MeSH term(s) Animals ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Differentiation ; Cell Line, Tumor ; Cell Self Renewal ; Cell Transformation, Neoplastic ; Cellular Reprogramming ; Female ; HEK293 Cells ; Heat-Shock Proteins/antagonists & inhibitors ; Heat-Shock Proteins/genetics ; Heat-Shock Proteins/metabolism ; Humans ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Mice ; Mice, Knockout ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transplantation, Heterologous
    Chemical Substances Heat-Shock Proteins ; RNA, Small Interfering ; Transcription Factors ; molecular chaperone GRP78 (YCYIS6GADR)
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-020-60269-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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