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  1. Book ; Online ; E-Book: C-type lectins in immune homeostasis

    Akira, S. / Yamasaki, Sho

    (Current topics in microbiology and immunology ; Volume 429)

    2020  

    Abstract: This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors’ role in the recognition of pathogen- ... ...

    Author's details Sho Yamasaki, editor, responsible series editor: Shizuo Akira
    Series title Current topics in microbiology and immunology ; Volume 429
    Abstract This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors’ role in the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) – one of the first steps in responding to foreign and potentially dangerous structures in the human body. The respective chapters chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the latest research, they may also provide novel points of departure for future drug development.
    Keywords Immunology
    Subject code 616.079
    Language English
    Size 1 online resource (V, 203 p. 60 illus., 30 illus. in color.)
    Edition 1st ed. 2020.
    Publisher Springer
    Publishing place Cham, Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 3-030-62237-1 ; 3-030-62236-3 ; 978-3-030-62237-4 ; 978-3-030-62236-7
    DOI 10.1007/978-3-030-62237-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book: C-type lectin receptors in immunity

    Yamasaki, Sho

    2016  

    Author's details Sho Yamasaki editor
    Language English
    Size vi, 215 Seiten, Illustrationen
    Publisher Springer
    Publishing place Tokyo
    Publishing country Japan
    Document type Book
    HBZ-ID HT018938701
    ISBN 978-4-431-56013-5 ; 978-4-431-56015-9 ; 4-431-56013-0 ; 4-431-56015-7
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2016 A 802 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: Lectin recruits pathogenic bugs.

    Schutt, Charles R / Yamasaki, Sho

    The Journal of experimental medicine

    2022  Volume 220, Issue 1

    Abstract: Colitis is an irritable bowel disorder affecting about 7 million patients worldwide, but the causes are diverse and not fully understood. In this issue, Matute et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211938) found that a stress-induced ... ...

    Abstract Colitis is an irritable bowel disorder affecting about 7 million patients worldwide, but the causes are diverse and not fully understood. In this issue, Matute et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20211938) found that a stress-induced lectin, intelectin-1, recruits pathogenic bacteria to the gut and exacerbates colitis.
    MeSH term(s) Humans ; Lectins ; Colitis ; Bacteria
    Chemical Substances Lectins
    Language English
    Publishing date 2022-11-22
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 218343-2
    ISSN 1540-9538 ; 0022-1007
    ISSN (online) 1540-9538
    ISSN 0022-1007
    DOI 10.1084/jem.20221732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  4. Article: Current understanding of T cell immunity against SARS-CoV-2.

    Lu, Xiuyuan / Yamasaki, Sho

    Inflammation and regeneration

    2022  Volume 42, Issue 1, Page(s) 51

    Abstract: As an important part of adaptive immunity, T cells are indispensable in the defense against pathogens including viruses. SARS-CoV-2 is a new human coronavirus that occurred at the end of 2019 and has caused the COVID-19 pandemic. Nevertheless, most of ... ...

    Abstract As an important part of adaptive immunity, T cells are indispensable in the defense against pathogens including viruses. SARS-CoV-2 is a new human coronavirus that occurred at the end of 2019 and has caused the COVID-19 pandemic. Nevertheless, most of the infected patients recovered without any antiviral therapies, suggesting an effective immunity developed in the bodies. T cell immunity responds upon SARS-CoV-2 infection or vaccination and plays crucial roles in eliminating the viruses and generating T cell memory. Specifically, a subpopulation of CD4
    Language English
    Publishing date 2022-11-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2051471-2
    ISSN 1880-9693 ; 0389-4290
    ISSN 1880-9693 ; 0389-4290
    DOI 10.1186/s41232-022-00242-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Myeloid C-type lectin receptors in innate immune recognition.

    Reis E Sousa, Caetano / Yamasaki, Sho / Brown, Gordon D

    Immunity

    2024  Volume 57, Issue 4, Page(s) 700–717

    Abstract: C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from ... ...

    Abstract C-type lectin receptors (CLRs) expressed by myeloid cells constitute a versatile family of receptors that play a key role in innate immune recognition. Myeloid CLRs exhibit a remarkable ability to recognize an extensive array of ligands, from carbohydrates and beyond, and encompass pattern-associated molecular patterns (PAMPs), damage-associated molecular patterns (DAMPs), and markers of altered self. These receptors, classified into distinct subgroups, play pivotal roles in immune recognition and modulation of immune responses. Their intricate signaling pathways orchestrate a spectrum of cellular responses, influencing processes such as phagocytosis, cytokine production, and antigen presentation. Beyond their contributions to host defense in viral, bacterial, fungal, and parasitic infections, myeloid CLRs have been implicated in non-infectious diseases such as cancer, allergies, and autoimmunity. A nuanced understanding of myeloid CLR interactions with endogenous and microbial triggers is starting to uncover the context-dependent nature of their roles in innate immunity, with implications for therapeutic intervention.
    MeSH term(s) Humans ; Lectins, C-Type/metabolism ; Immunity, Innate ; Myeloid Cells/metabolism ; Signal Transduction ; Neoplasms/metabolism ; Receptors, Pattern Recognition/metabolism
    Chemical Substances Lectins, C-Type ; Receptors, Pattern Recognition
    Language English
    Publishing date 2024-04-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1217235-2
    ISSN 1097-4180 ; 1074-7613
    ISSN (online) 1097-4180
    ISSN 1074-7613
    DOI 10.1016/j.immuni.2024.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: The kinetics of signaling through the common FcRγ chain determine cytokine profiles in dendritic cells.

    Watanabe, Miyuki / Motooka, Daisuke / Yamasaki, Sho

    Science signaling

    2023  Volume 16, Issue 775, Page(s) eabn9909

    Abstract: The common Fc receptor γ (FcRγ) chain is a signaling subunit common to several immune receptors, but cellular responses induced by FcRγ-coupled receptors are diverse. We investigated the mechanisms by which FcRγ generates divergent signals when coupled ... ...

    Abstract The common Fc receptor γ (FcRγ) chain is a signaling subunit common to several immune receptors, but cellular responses induced by FcRγ-coupled receptors are diverse. We investigated the mechanisms by which FcRγ generates divergent signals when coupled to Dectin-2 and Mincle, structurally similar C-type lectin receptors that induce the release of different cytokines from dendritic cells. Chronological tracing of transcriptomic and epigenetic changes upon stimulation revealed that Dectin-2 induced early and strong signaling, whereas Mincle-mediated signaling was delayed, which reflects their expression patterns. Generation of early and strong FcRγ-Syk signaling by engineered chimeric receptors was sufficient to recapitulate a Dectin-2-like gene expression profile. Early Syk signaling selectively stimulated the activity of the calcium ion-activated transcription factor NFAT, which rapidly altered the chromatin status and transcription of the
    MeSH term(s) Receptors, Fc ; Kinetics ; Signal Transduction ; Receptors, IgG/genetics ; Cytokines ; Dendritic Cells
    Chemical Substances Receptors, Fc ; Receptors, IgG ; Cytokines
    Language English
    Publishing date 2023-03-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2417226-1
    ISSN 1937-9145 ; 1945-0877
    ISSN (online) 1937-9145
    ISSN 1945-0877
    DOI 10.1126/scisignal.abn9909
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Crystal structure of the complex of CLEC12A and an antibody that interferes with binding of diverse ligands.

    Mori, Shotaro / Nagae, Masamichi / Yamasaki, Sho

    International immunology

    2023  Volume 36, Issue 6, Page(s) 279–290

    Abstract: C-type lectin receptors (CLRs) are a family of pattern recognition receptors, which detect a broad spectrum of ligands via small carbohydrate-recognition domains (CRDs). CLEC12A is an inhibitory CLR that recognizes crystalline structures such as ... ...

    Abstract C-type lectin receptors (CLRs) are a family of pattern recognition receptors, which detect a broad spectrum of ligands via small carbohydrate-recognition domains (CRDs). CLEC12A is an inhibitory CLR that recognizes crystalline structures such as monosodium urate crystals. CLEC12A also recognizes mycolic acid, a major component of mycobacterial cell walls, and suppresses host immune responses. Although CLEC12A could be a therapeutic target for mycobacterial infection, structural information on CLEC12A was not available. We report here the crystal structures of human CLEC12A (hCLEC12A) in ligand-free form and in complex with 50C1, its inhibitory antibody. 50C1 recognizes human-specific residues on the top face of hCLEC12A CRD. A comprehensive alanine scan demonstrated that the ligand-binding sites of mycolic acid and monosodium urate crystals may overlap with each other, suggesting that CLEC12A utilizes a common interface to recognize different types of ligands. Our results provide atomic insights into the blocking and ligand-recognition mechanisms of CLEC12A and leads to the design of CLR-specific inhibitors.
    MeSH term(s) Lectins, C-Type/immunology ; Lectins, C-Type/chemistry ; Lectins, C-Type/metabolism ; Humans ; Receptors, Mitogen/chemistry ; Receptors, Mitogen/immunology ; Receptors, Mitogen/metabolism ; Crystallography, X-Ray ; Ligands ; Protein Binding ; Binding Sites ; Models, Molecular ; Uric Acid/chemistry ; Uric Acid/metabolism ; Uric Acid/immunology
    Chemical Substances Lectins, C-Type ; CLEC12A protein, human ; Receptors, Mitogen ; Ligands ; Uric Acid (268B43MJ25)
    Language English
    Publishing date 2023-12-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013745-2
    ISSN 1460-2377 ; 0953-8178
    ISSN (online) 1460-2377
    ISSN 0953-8178
    DOI 10.1093/intimm/dxae006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  8. Book: C-type lectin receptors in immunity

    Yamasaki, Sho

    2016  

    Author's details Sho Yamasaki, editor
    Keywords Rezeptor ; Immunität ; Lectine
    Language English
    Size vi, 215 Seiten, Illustrationen
    Document type Book
    Note Literaturangaben
    ISBN 9784431560135 ; 9784431560159 ; 4431560130 ; 4431560157
    Database Special collection on veterinary medicine and general parasitology

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  9. Book: C-type lectin receptors in immunity

    Yamasaki, Sho

    2016  

    Author's details Sho Yamasaki, editor
    MeSH term(s) Receptors, Mitogen/immunology ; T-Lymphocytes/immunology ; B-Lymphocytes/immunology
    Language English
    Size vi, 215 pages :, illustrations
    Document type Book
    ISBN 9784431560135 ; 9784431560159 ; 4431560130 ; 4431560157
    Database Catalogue of the US National Library of Medicine (NLM)

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  10. Article ; Online: Chimeric NOD2 Mincle Agonists as Vaccine Adjuvants.

    Dangerfield, Emma M / Ishizuka, Shigenari / Kodar, Kristel / Yamasaki, Sho / Timmer, Mattie S M / Stocker, Bridget L

    Journal of medicinal chemistry

    2024  Volume 67, Issue 7, Page(s) 5373–5390

    Abstract: There is a need for improved vaccine adjuvants to augment vaccine efficacy. One way to address this is by targeting multiple immune cell pathogen recognition receptors (PRRs) using chimeric pathogen-associated molecular patterns (PAMPs). Conjugation of ... ...

    Abstract There is a need for improved vaccine adjuvants to augment vaccine efficacy. One way to address this is by targeting multiple immune cell pathogen recognition receptors (PRRs) using chimeric pathogen-associated molecular patterns (PAMPs). Conjugation of the PAMPs will ensure codelivery of the immunostimulatory molecules to the same cell, enhancing adjuvant activity. The macrophage inducible C-type lectin (Mincle) is a promising PRR for adjuvant development; however, no effective chimeric Mincle adjuvants have been prepared. We addressed this by synthesizing Mincle adjuvant conjugates, MDP-C18Brar and MDP-C18Brar-dilipid, which contain PAMPs recognized by Mincle and the nucleotide-binding oligomerization domain 2 (NOD2). The two PAMPs are joined by a pH-sensitive oxyamine linker which, upon acidification at lysosomal pH, hydrolyzed to release the NOD2 ligands. The conjugates elicited the production of Th1 and Th17 promoting cytokines
    MeSH term(s) Adjuvants, Vaccine ; Pathogen-Associated Molecular Pattern Molecules ; Adjuvants, Immunologic/pharmacology ; Adjuvants, Immunologic/chemistry ; Immunity, Cellular ; Cytokines ; Antigens ; Receptors, Immunologic ; Lectins, C-Type
    Chemical Substances Adjuvants, Vaccine ; Pathogen-Associated Molecular Pattern Molecules ; Adjuvants, Immunologic ; Cytokines ; Antigens ; Receptors, Immunologic ; Lectins, C-Type
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01840
    Database MEDical Literature Analysis and Retrieval System OnLINE

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