Article ; Online: Physiological functions of poorly absorbed polyphenols via the glucagon-like peptide-1.
Bioscience, biotechnology, and biochemistry
2024 Volume 88, Issue 5, Page(s) 493–498
Abstract: Polyphenols are compounds of plant origin with several documented bioactivities related to health promotion. Some polyphenols are hard to be absorbed into the body due to their structural characteristics. This review focuses on the health beneficial ... ...
Abstract | Polyphenols are compounds of plant origin with several documented bioactivities related to health promotion. Some polyphenols are hard to be absorbed into the body due to their structural characteristics. This review focuses on the health beneficial effects of polyphenols mediated by intestinal hormones, particularly related to the systemic functions through the secretion of glucagon-like peptide-1 (GLP-1), an enteric hormone that stimulates postprandial insulin secretion. GLP-1 is secreted from L cells in the distal small intestine. Therefore, some poorly absorbed polyphenols are known to have the ability to act on the intestines and promote GLP-1 secretion. It has been reported that it not only reduces hyperglycemia but also prevents obesity by reduction of overeating and improves blood vessel function. This review discusses examples of health effects of polyphenols mediated by GLP-1 secretion. |
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MeSH term(s) | Glucagon-Like Peptide 1/metabolism ; Polyphenols/metabolism ; Polyphenols/pharmacology ; Humans ; Animals ; Intestinal Absorption/drug effects ; Obesity/metabolism ; Obesity/drug therapy ; Insulin/metabolism |
Chemical Substances | Glucagon-Like Peptide 1 (89750-14-1) ; Polyphenols ; Insulin |
Language | English |
Publishing date | 2024-02-19 |
Publishing country | England |
Document type | Review ; Journal Article |
ZDB-ID | 1106450-x |
ISSN | 1347-6947 ; 0916-8451 |
ISSN (online) | 1347-6947 |
ISSN | 0916-8451 |
DOI | 10.1093/bbb/zbae021 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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