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Article ; Online: Shallow Low‐Velocity Layer in the Hyuga‐Nada Accretionary Prism and Its Hydrological Implications: Insights From a Passive Seismic Array

Akuhara, Takeshi / Yamashita, Yusuke / Ohyanagi, Shukei / Sawaki, Yasunori / Yamada, Tomoaki / Shinohara, Masanao

Journal of Geophysical Research: Solid Earth. 2023 Apr., v. 128, no. 4 p.e2022JB026298-

2023

Abstract: Shear wave velocity (Vs) estimations of accretionary prisms can pose unique constraints to the physical properties of rocks, which are hard to obtain from compressional velocities (Vp) alone. Thus, it would help better understand the fluid processes of ... ...

Abstract	Shear wave velocity (Vs) estimations of accretionary prisms can pose unique constraints to the physical properties of rocks, which are hard to obtain from compressional velocities (Vp) alone. Thus, it would help better understand the fluid processes of the accretion system. This study investigates the Vs structure of the Hyuga‐nada accretionary prism using an array of ocean‐bottom seismometers (OBSs) with a 2 km radius. Teleseismic Green's functions and a surface wave dispersion curve are inverted to one‐dimensional Vs structures using transdimensional inversion. The results indicate the presence of a low‐velocity zone 3–4 km below the seafloor. The reduced Vs corresponds to a reduced Vp feature obtained in a previous seismic refraction survey, and the high Vp/Vs ratio suggests the presence of high pore fluid pressure. In addition, the resolved lithological boundary exhibits a sharp offset that extends laterally across the OBS array. We attribute this offset to a blind fault below while acknowledging other possibilities, such as due to mud diapirism or intense fracturing. The predicted fault is located at the Kyushu–Palau Ridge flank, oriented roughly parallel to the ridge axis, and thus likely caused by ridge subduction. This fault may act as a fluid conduit, contributing to the formation of a fluid reservoir beneath the compacted sediment layers.
Keywords	geophysics ; hydrology ; research ; sediments ; subduction ; surveys
Language	English
Dates of publication	2023-04
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ISSN	2169-9313
DOI	10.1029/2022JB026298
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Article: Histological Characteristics of Conjunctiva-Associated Lymphoid Tissue in Young and Adult Holstein Cattle.

Kosenda, Keigo / Ichii, Osamu / Yamashita, Yusuke / Ohtsuka, Hiromichi / Fukuda, Shigeo / Kon, Yasuhiro

Animals : an open access journal from MDPI

2023 Volume 13, Issue 22

Abstract: The conjunctiva-associated lymphoid tissue (CALT) has been used as a target site for mucosal vaccinations in several animals. In this study, we compared the morphological features of CALT in the eyelid and third eyelid between Holstein calves and adult ... ...

Abstract	The conjunctiva-associated lymphoid tissue (CALT) has been used as a target site for mucosal vaccinations in several animals. In this study, we compared the morphological features of CALT in the eyelid and third eyelid between Holstein calves and adult cows. In the eyelids, CALTs in the form of diffused lymphoid tissue (DLT) and lymphatic follicles (LF) were observed, where DLTs were dominant and LFs were scarce. The CALTs of cows comprised T-, B-cells, macrophages, and antigen-presenting cells (APCs). In particular, B-cells were dominant except in the eyelids of the calves. The epithelial layer covering the CALT is often discontinuous and lacks goblet cells. Cytokeratin18 is strongly expressed in the epithelial layer covering the CALT, except in the third eyelids of adult cows. IgA-positive cells were diffusely distributed in the lamina propria of the conjunctiva of the eyelids and third eyelids. The eyelid CALT area in calves was lower than that in adult cows. Furthermore, the CALT of calves had a lower cellularity of B-cells and a higher cellularity of macrophages than that of adult cows. These histological characteristics indicate that CALT plays a role in the mucosal immune-inductive and effector sites. Furthermore, lower cellularity of B-cells in the CALT of calves indicates that the function of CALT as a mucosal immune induction site is less developed in calves than in adult cows.
Language	English
Publishing date	2023-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13223481
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Article ; Online: Autoclaving-Triggered Hydrogelation of Chitosan-Gluconic acid Conjugate Aqueous Solution for Wound Healing.

Yamashita, Yusuke / Ohzuno, Yoshihiro / Saito, Yoichi / Fujiwara, Yukio / Yoshida, Masahiro / Takei, Takayuki

Gels (Basel, Switzerland)

2023 Volume 9, Issue 4

Abstract: Moist wound healing is known to heal wounds faster than dry wound healing. Hydrogel wound dressings are suitable for moist wound healing because of their hyperhydrous structure. Chitosan, a natural polymer, promotes wound healing by stimulating ... ...

Abstract	Moist wound healing is known to heal wounds faster than dry wound healing. Hydrogel wound dressings are suitable for moist wound healing because of their hyperhydrous structure. Chitosan, a natural polymer, promotes wound healing by stimulating inflammatory cells and releasing bioactive compounds. Therefore, chitosan hydrogel has great potential as a wound dressing. In our previous study, physically crosslinked chitosan hydrogels were successfully prepared solely by freeze-thawing of chitosan-gluconic acid conjugate (CG) aqueous solution without using any toxic additives. Furthermore, the CG hydrogels could be sterilized by autoclaving (steam sterilization). In this study, we showed that autoclaving (121 °C, 20 min) of a CG aqueous solution simultaneously achieved gelation of the solution and sterilization of the hydrogel. Hydrogelation of CG aqueous solution by autoclaving is also physically crosslinking without any toxic additives. Further, we showed that the CG hydrogels retained favorable biological properties of the CG hydrogels prepared by freeze-thawing and subsequent autoclaving. These results indicated that CG hydrogels prepared by autoclaving were promising as wound dressings.
Language	English
Publishing date	2023-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2813982-3
ISSN	2310-2861 ; 2310-2861
ISSN (online)	2310-2861
ISSN	2310-2861
DOI	10.3390/gels9040280
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Article ; Online: Aortitis after switching short-acting granulocyte colony-stimulating factors in a lymphoma patient with HLA-B52.

Tane, Misato / Kosako, Hideki / Hosoi, Hiroki / Furuya, Yoshiaki / Hori, Yoshikazu / Yamashita, Yusuke / Murata, Shogo / Mushino, Toshiki / Sonoki, Takashi

International journal of hematology

2024 Volume 119, Issue 5, Page(s) 608–612

Abstract: Aortitis is a rare adverse event of granulocyte colony-stimulating factor (G-CSF) treatment. Several previous studies have described recurrent aortitis caused by re-administration of the same G-CSF. However, no previous studies have examined the safety ... ...

Abstract	Aortitis is a rare adverse event of granulocyte colony-stimulating factor (G-CSF) treatment. Several previous studies have described recurrent aortitis caused by re-administration of the same G-CSF. However, no previous studies have examined the safety of switching between short-acting G-CSFs in patients who develop aortitis. We report the case of a 55-year-old man with refractory diffuse large B-cell lymphoma, who developed G-CSF-associated aortitis. The aortitis was triggered by filgrastim and recurred after treatment with lenograstim. The patient possessed human leukocyte antigen B52, which has been implicated in Takayasu arteritis. In addition, a drug-induced lymphocyte stimulation test for lenograstim performed upon detection of recurrent G-CSF-associated aortitis produced a positive result. Our case suggests that switching from one short-acting G-CSF to another does not prevent recurrence of G-CSF-associated aortitis. Although the etiology of G-CSF-associated aortitis has not been fully elucidated, our case also suggests that some patients may be genetically predisposed to aortitis.
MeSH term(s)	Humans ; Male ; Granulocyte Colony-Stimulating Factor/adverse effects ; Granulocyte Colony-Stimulating Factor/administration & dosage ; Middle Aged ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Aortitis/chemically induced ; Aortitis/etiology ; HLA-B52 Antigen/adverse effects ; Filgrastim/adverse effects ; Filgrastim/administration & dosage ; Lenograstim ; Drug Substitution ; Recombinant Proteins/adverse effects ; Recombinant Proteins/administration & dosage ; Recombinant Proteins/therapeutic use
Chemical Substances	Granulocyte Colony-Stimulating Factor (143011-72-7) ; HLA-B52 Antigen ; Filgrastim (PVI5M0M1GW) ; Lenograstim (6WS4C399GB) ; Recombinant Proteins
Language	English
Publishing date	2024-03-23
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-024-03744-w
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Article: Impact of Surface Changes and Microbial Adhesion on Mucosal Surface Finishing of Resin Denture Bases by Shot Blast Polishing Using Viscoelastic Media.

Yamashita, Yusuke / Nishi, Yasuhiro / Murakami, Mamoru / Harada, Kae / Nishimura, Masahiro

Materials (Basel, Switzerland)

2022 Volume 15, Issue 6

Abstract: Surface changes and microbiological effects following shot blast polishing with viscoelastic media of the mucosal surface of resin denture bases were examined. Average surface roughness (Ra) and the depth of surface removal of specimens were measured ... ...

Abstract	Surface changes and microbiological effects following shot blast polishing with viscoelastic media of the mucosal surface of resin denture bases were examined. Average surface roughness (Ra) and the depth of surface removal of specimens were measured over time, and the clinical number of microbial adhesions on the mucosal surface of dentures was clinically assessed. The results obtained showed no changes in Ra after 20 s of polishing, Ra of <0.2 µm, and a depth of surface removal < 20 µm. This method of finishing did not affect the fit of the mucosal surface of the dentures. Furthermore, the adhesion of microorganisms to the mucosal surface of dentures was significantly suppressed. Shot blast polishing with viscoelastic media is useful for finishing the mucosal surface of resin denture bases.
Language	English
Publishing date	2022-03-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15062275
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Article ; Online: Copy number variations in BOLA-DQA2, BOLA-DQB, and BOLA-DQA5 show the genomic architecture and haplotype frequency of major histocompatibility complex class II genes in Holstein cows.

Fukunaga, Koya / Yamashita, Yusuke / Yagisawa, Takuya

HLA

2020 Volume 96, Issue 5, Page(s) 601–609

Abstract: Bovine major histocompatibility complex (MHC) class II region contains many genes. The bovine leukocyte antigen (BoLA)-DRB3 was reportedly associated with susceptibility of various phenotypes of infections including bovine leukemia virus-induced lymphoma. ...

Abstract	Bovine major histocompatibility complex (MHC) class II region contains many genes. The bovine leukocyte antigen (BoLA)-DRB3 was reportedly associated with susceptibility of various phenotypes of infections including bovine leukemia virus-induced lymphoma. However, the association of the remaining genes with various phenotypes has not been clarified due to the complicated genomic structure of the MHC class II region. Thus, in this study, we elucidated the MHC class II genomic structure, including the novel alleles and copy number variations (CNVs). We determined the copy numbers of BOLA-DQA2 (DQA2), BOLA-DQB (DQB2), BOLA-DQA5 (DQA5), BLA-DQB (DQB1), LOC100848815 (DQA1), and BOLA-DRB3 (DRB3) in 127 unrelated Holstein cows by TaqMan copy number assay. The genomes were sequenced using target next-generation sequencing (NGS) based on multiplex polymerase chain reaction. Combining the results of the copy numbers and alleles, we identified the BoLA alleles directly without haplotype estimation. Pairwise linkage disequilibrium (LD) analysis between alleles and genes were performed. The CNVs of DQA2, DQB2, and DQA5 in Holstein cows were detected. The frequency of the whole gene deletion in DQA2, DQB2, and DQA5 was 35.4%, 93.7%, and 93.7%, respectively. After target NGS, we identified 37 alleles in the six genes. Fifteen novel alleles (40.5%) were not registered in the IPD-MHC Database. LD analysis showed strong LD among the DQB2deletion, DQA5deletion, and DRB3*27:03 alleles. Our findings will provide important insights into the identification of the BoLA genes associated with various infection-related phenotypes.
MeSH term(s)	Alleles ; Animals ; Cattle ; DNA Copy Number Variations ; Female ; Genes, MHC Class II ; Genomics ; Haplotypes ; Histocompatibility Antigens Class II/genetics
Chemical Substances	Histocompatibility Antigens Class II
Language	English
Publishing date	2020-10-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.14086
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Article ; Online: Effects of Free Linoleic Acid and Oleic Acid in Sesame Meal Extract as Pancreatic Lipase Inhibitors on Postprandial Triglyceridemia: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Volunteers.

Li, Xuan / Yamada, Hiroaki / Morita, Sayo / Yamashita, Yusuke / Kim, Youngil / Kometani, Takashi / Narang, Nikesh / Furuta, Toma / Kim, Mujo

Nutrients

2023 Volume 15, Issue 7

Abstract: A great number of chemically diverse pancreatic lipase (PL) inhibitors have been identified to tackle obesity; however, very few of them have entered clinical studies. The ethanolic extract of sesame meal is a potent PL inhibitor, and its activity hinges ...

Abstract	A great number of chemically diverse pancreatic lipase (PL) inhibitors have been identified to tackle obesity; however, very few of them have entered clinical studies. The ethanolic extract of sesame meal is a potent PL inhibitor, and its activity hinges exclusively on two free fatty acids: linoleic acid and oleic acid, which were proven to reduce postprandial triglyceride excursion in rats. Herein, to investigate the clinical efficacy of the sesame meal extract, in a crossover trial, 30 healthy volunteers were randomized to receive the sesame meal extract containing experimental food or placebo along with a high-fat meal. Treatment with the sesame meal extract significantly lowered the incremental postprandial serum triglyceride concentration and reduced the incremental area under the curve (iAUC) by 16.8% (
MeSH term(s)	Animals ; Rats ; Humans ; Cross-Over Studies ; Oleic Acid/pharmacology ; Sesamum ; Linoleic Acid/pharmacology ; Lipase ; Healthy Volunteers ; Triglycerides ; Cholesterol ; Obesity ; Postprandial Period ; Dietary Fats
Chemical Substances	Oleic Acid (2UMI9U37CP) ; Linoleic Acid (9KJL21T0QJ) ; Lipase (EC 3.1.1.3) ; Triglycerides ; Cholesterol (97C5T2UQ7J) ; Dietary Fats
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15071748
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Article ; Online: Oral Ingestion of AP Collagen Peptide Leads to Systemic Absorption of Gly-Pro-Hyp, Alleviating H

Chae, Minjung / Moon, Chang Yong / Lim, Sung-Hwan / Yamashita, Yusuke / Yamada, Hiroaki / Ide, Masahiro / Park, Chan Woong / Roh, Jonghwa / Kim, Wangi

Journal of medicinal food

2023 Volume 26, Issue 5, Page(s) 299–306

Abstract: Collagen-derived dipeptides and tripeptides have various physiological activities. In this study, we compared the plasma kinetics of free Hyp, peptide-derived Hyp, Pro-Hyp, cyclo(Pro-Hyp), Hyp-Gly, Gly-Pro-Hyp, and Gly-Pro-Ala after ingestion of four ... ...

Abstract	Collagen-derived dipeptides and tripeptides have various physiological activities. In this study, we compared the plasma kinetics of free Hyp, peptide-derived Hyp, Pro-Hyp, cyclo(Pro-Hyp), Hyp-Gly, Gly-Pro-Hyp, and Gly-Pro-Ala after ingestion of four different collagen samples: AP collagen peptide (APCP), general collagen peptide, collagen, and APCP and
MeSH term(s)	Absorption, Physiological ; Collagen/administration & dosage ; Collagen/chemistry ; Eating ; Fibroblasts/metabolism ; Hydrogen Peroxide ; Peptides
Chemical Substances	Collagen (9007-34-5) ; glycyl-prolyl-hydroxyproline ; Hydrogen Peroxide (BBX060AN9V) ; Peptides
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	1427365-2
ISSN	1557-7600 ; 1096-620X
ISSN (online)	1557-7600
ISSN	1096-620X
DOI	10.1089/jmf.2022.K.0149
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Article ; Online: Relationships between the expression of adipose genes and profiles of hospitalized dogs

Sugiyama, Yukina / Shimokawa, Fumie / Sugiyama, Kazutoshi / Kobayashi, Takashi / Yamashita, Yusuke / Kazama, Kei / Onda, Ken / Funaba, Masayuki / Murakami, Masaru

Vet Res Commun. 2022 Dec., v. 46, no. 4 p.1239-1244

2022

Abstract: Obesity is one of the risk factors for the onset of various metabolic diseases in dogs. Energy expenditure in brown/beige adipocytes, which is partially regulated by the bone morphogenetic protein (BMP) pathway, is a key factor determining systemic ... ...

Abstract	Obesity is one of the risk factors for the onset of various metabolic diseases in dogs. Energy expenditure in brown/beige adipocytes, which is partially regulated by the bone morphogenetic protein (BMP) pathway, is a key factor determining systemic energy balance. Here, we examined gene expression in the fat depots of 129 hospitalized dogs, and the relationship between the relative levels of gene expression and profiles of dogs. We evaluated the expression levels of 23 genes such as regulatory genes of adipocyte differentiation and function, adipokines, genes related to brown adipogenesis and uncoupling protein (Ucp), and genes involved in BMP signaling. A reliable equation of multiple regression was not obtained to explain the body condition score (BCS), which is an index of adiposity. Positive relationships were detected between the expression levels of many genes, except for Ucp1 or Ucp3. BCS was found to increase with age. BCS was negatively correlated to the expression levels of Pparγ and Fasn, and positively correlated to Leptin and Opn3 expression. Aging decreased the expression levels of genes related to adipocyte differentiation and function (Pparγ, Fabp4, Fasn, Hsl, and Insr) and Adipoq. In addition, age was negatively correlated with the expression of genes involved in brown adipogenesis and BMP signaling components (Prdm16, Bmp4, Alk3, Actr2a, and Actr2b). In contrast, the expression levels of Leptin and Ucp2 were found to increase with age. The present study clarifies BCS- and age-related gene expressions in the adipose tissue, which potentially contribute to elucidating the etiology of canine obesity.
Keywords	adipocytes ; adipogenesis ; adipose tissue ; adiposity ; body condition ; bone morphogenetic proteins ; dogs ; energy expenditure ; equations ; etiology ; gene expression ; genes ; leptin ; obesity ; regression analysis ; risk
Language	English
Dates of publication	2022-12
Size	p. 1239-1244.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	406735-6
ISSN	1573-7446 ; 0165-7380
ISSN (online)	1573-7446
ISSN	0165-7380
DOI	10.1007/s11259-022-09989-2
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Article: IGLL5

Hosoi, Hiroki / Tabata, Shotaro / Kosako, Hideki / Hori, Yoshikazu / Okamura, Tadashi / Yamashita, Yusuke / Fujimoto, Kota / Kajioka, Daiki / Suzuki, Kentaro / Osato, Motomi / Yamada, Gen / Sonoki, Takashi

Leukemia research reports

2024 Volume 21, Page(s) 100451

Abstract: ... ...

Abstract	IGLL5
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2706248-X
ISSN	2213-0489
ISSN	2213-0489
DOI	10.1016/j.lrr.2024.100451
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