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Article: Effect of Sb and Zn Addition on the Microstructures and Tensile Properties of Sn-Bi-Based Alloys.

Yamauchi, Akira / Kurose, Masashi

2022 Volume 15, Issue 3

Abstract: The tensile behavior of Sn-Bi-Cu and Sn-Bi-Ni alloys has been widely investigated. Reportedly, the addition of small amounts of a third element can refine the microstructures of the eutectic Sn-58mass% Bi solder and improve its ductility. However, the ... ...

Abstract	The tensile behavior of Sn-Bi-Cu and Sn-Bi-Ni alloys has been widely investigated. Reportedly, the addition of small amounts of a third element can refine the microstructures of the eutectic Sn-58mass% Bi solder and improve its ductility. However, the superplasticity mechanism of Sn-based alloys has not been clearly established. Therefore, in this study, the effects of Sb and Zn addition on the microstructures and tensile properties of Sn-Bi-based alloys were investigated. The alloys were subjected to tensile tests under various strain rates and temperatures. We found that Zn- and Sb-added Sn-Bi-based alloys demonstrated superplastic deformation at high temperatures and low strain rates. Sb addition significantly affected the elongation of the Sn-Bi-Sb alloys because the metal dissolves in both the primary Sn phase and the eutectic Sn-Bi matrix. The segregation of Zn and formation of needle-like Zn particles at the eutectic Sn-Bi phase boundary affected the superplastic deformation of the alloys. The deformation of the Sn-40Bi-based alloys at high temperatures and low strain rates led to dynamic recovery, dynamic recrystallization, and/or grain boundary slip because of the accumulation of voids.
Language	English
Publishing date	2022-01-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15030884
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Growth Performance of Photoperiod-Sensitive Rice (Oryza sativa L.) Varieties in Different Soil Types under Rainfed Condition in Cambodia

Uch, Chanthol / Roeurn, Siranet / Ro, Sophoanrith / Kano-Nakata, Mana / Yamauchi, Akira / Ehara, Hiroshi

Agriculture. 2023 Aug. 13, v. 13, no. 8

2023

Abstract: In Cambodia, rice is predominantly produced in areas with rainfed lowland conditions where photoperiod-sensitive varieties are cultivated. A number of varieties have been released for rainfed lowland areas, and the rice grain yield has reportedly ... ...

Abstract	In Cambodia, rice is predominantly produced in areas with rainfed lowland conditions where photoperiod-sensitive varieties are cultivated. A number of varieties have been released for rainfed lowland areas, and the rice grain yield has reportedly increased by approximately 12% over the past ten years. Moreover, great fluctuations in yield performance have been observed across different soil types of the rainfed ecosystems of Cambodia. Therefore, the present study aimed to analyze the grain yield and stability among ten popular varieties that were released for rainfed lowland ecosystems across the four different soil types in Cambodia in two years. The grain yield varied 566 g m⁻² as the highest in clay soil and about 220 g m⁻² as the lowest in sandy soil. A combined ANOVA revealed significant differences for the main effect of genotype, environment, and genotype-by-environment interaction (GEI) for all yield-related traits and grain yield per square meter. The principal component test results showed that the heterogeneity of grain yield was mainly attributable to the effect of environment, followed by the effect of genotype. In fertile conditions, a higher percentage of filled grains was supported by higher leaf N until the late stage with a wider flag leaf. In conditions of moderate fertility, larger numbers of panicles were supported by a higher percentage of productive culms with higher leaf N until the late stage. In conditions of poor fertility, a higher percentage of filled grains was supported by higher leaf N until the late stage, which is considered to be important for higher grain yield. The variety Phka Rumduol showed these preferable traits and produced higher yields in fertile to poor natural soil fertility conditions with moderate variation. This variety is considered to be more desirable and ideal due to its stability and higher grain yield. The other varieties, namely, Phka Mealdei, Phka Rumdeng, and CAR4, were identified as above-average yielders. Therefore, those varieties potentially may be recommended for cultivation in rainfed lowland rice ecosystems in Cambodia due to their high yields. CAR4 showed moderate variation at the same level as Phka Rumduol. From the point of stability, Phka Rumduol and CAR4 can be expected to excel.
Keywords	Oryza sativa ; agriculture ; clay soils ; culms ; genotype ; genotype-environment interaction ; grain yield ; growth performance ; leaves ; rice ; sandy soils ; soil fertility ; Cambodia
Language	English
Dates of publication	2023-0813
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2651678-0
ISSN	2077-0472
ISSN	2077-0472
DOI	10.3390/agriculture13081602
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Article ; Online: Anti-fatigue activity of methyl dihydrojasmonate and linalool in a rat model evaluated by a novel index for neuro-immune and oxidative stress interactions.

Nishimura, Yasumitsu / Nomiyama, Kenta / Okamoto, Shuichiro / Igarashi, Mika / Sato, Yukino / Okamoto, Hikaru / Kamezaki, Ayasa / Itadani, Masumi / Kuribayashi, Futoshi / Yamauchi, Akira

Scientific reports

2024 Volume 14, Issue 1, Page(s) 10650

Abstract: Avoiding fatigue is a long-standing challenge in both healthy and diseased individuals. Establishing objective standard markers of fatigue is essential to evaluate conditions in spatiotemporally different locations and individuals and identify agents to ... ...

Abstract	Avoiding fatigue is a long-standing challenge in both healthy and diseased individuals. Establishing objective standard markers of fatigue is essential to evaluate conditions in spatiotemporally different locations and individuals and identify agents to fight against fatigue. Herein, we introduced a novel method for evaluating fatigue using nervous system markers (including dopamine, adrenaline, and noradrenaline), various cytokine levels (such as interleukin [IL]-1β, tumor necrosis factor [TNF]-α, IL-10, IL-2, IL-5 and IL-17A), and oxidative stress markers (such as diacron-reactive oxygen metabolites [d-ROMs] and biological antioxidant potential [BAP]) in a rat fatigue model. Using this method, the anti-fatigue effects of methyl dihydrojasmonate (MDJ) and linalool, the fragrance/flavor compounds used in various products, were assessed. Our method evaluated the anti-fatigue effects of the aforementioned compounds based on the changes in levels of the nerves system markers, cytokines, and oxidative stress markers. MDJ exerted more potent anti-fatigue effects than linalool. In conclusion, the reported method could serve as a useful tool for fatigue studies and these compounds may act as effective therapeutic agents for abrogating fatigue symptoms.
MeSH term(s)	Animals ; Oxidative Stress/drug effects ; Acyclic Monoterpenes/pharmacology ; Rats ; Fatigue/drug therapy ; Fatigue/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Male ; Cyclopentanes/pharmacology ; Antioxidants/pharmacology ; Biomarkers ; Monoterpenes/pharmacology ; Oxylipins/pharmacology ; Rats, Sprague-Dawley
Chemical Substances	linalool (D81QY6I88E) ; Acyclic Monoterpenes ; Cytokines ; Cyclopentanes ; Antioxidants ; Biomarkers ; Monoterpenes ; Oxylipins
Language	English
Publishing date	2024-05-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-60266-5
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Article ; Online: Redoxisome Update: TRX and TXNIP/TBP2-Dependent Regulation of NLRP-1/NLRP-3 Inflammasome.

Yoshihara, Eiji / Matsuo, Yoshiyuki / Masaki, So / Chen, Zhe / Tian, Hai / Masutani, Hiroshi / Yamauchi, Akira / Hirota, Kiichi / Yodoi, Junji

Antioxidants & redox signaling

2024 Volume 40, Issue 10-12, Page(s) 595–597

Abstract: Recent studies have provided evidence for the direct binding of thioredoxin-1 (TRX1) to a component of inflammasome complex NLR family pyrin domain containing 1 (NLRP-1). This interaction suggests a potential role for TRX1 in the regulation of the NLRP-1 ...

Abstract	Recent studies have provided evidence for the direct binding of thioredoxin-1 (TRX1) to a component of inflammasome complex NLR family pyrin domain containing 1 (NLRP-1). This interaction suggests a potential role for TRX1 in the regulation of the NLRP-1 inflammasome. Furthermore, the NLRP-3 inflammasome is known to bind TRX1 and its inhibitor, TRX-binding protein-2/TRX-interacting protein/vitamin D3 upregulated protein-1 (TBP2/TXNIP/VDUP-1). This binding forms a redox-sensitive complex, termed the "Redoxisome," as described previously. However, the specific functions of NLRP-1 within the redoxisome complex remain undefined.
MeSH term(s)	Inflammasomes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Oxidation-Reduction ; Thioredoxins/metabolism
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Thioredoxins (52500-60-4)
Language	English
Publishing date	2024-02-22
Publishing country	United States
Document type	Editorial
ZDB-ID	1483836-9
ISSN	1557-7716 ; 1523-0864
ISSN (online)	1557-7716
ISSN	1523-0864
DOI	10.1089/ars.2024.0549
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Zs.A 5488: Show issues

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Article ; Online: Characterization of missense mutations in the NADPH oxidase partner p22

Kawai, Chikage / Kajikawa, Mizuho / Yamauchi, Akira / Okamoto, Shuichiro / Kuribayashi, Futoshi / Miyano, Kei

Microbiology and immunology

2023 Volume 67, Issue 4, Page(s) 194–200

Abstract: Defective superoxide production by NADPH oxidase 2 (Nox2) in phagocyte cells results in the development of chronic granulomatous disease (CGD), a hereditary disease characterized by recurrent and life-threatening infections. The partner protein ... ...

Abstract	Defective superoxide production by NADPH oxidase 2 (Nox2) in phagocyte cells results in the development of chronic granulomatous disease (CGD), a hereditary disease characterized by recurrent and life-threatening infections. The partner protein p22
MeSH term(s)	Cricetulus ; Animals ; Cell Line ; Humans ; NADPH Oxidases/chemistry ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Mutation, Missense ; NADPH Oxidase 2/metabolism
Chemical Substances	CYBA protein, human (EC 1.6.3.1) ; NADPH Oxidases (EC 1.6.3.-) ; CYBB protein, human (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-)
Language	English
Publishing date	2023-01-22
Publishing country	Australia
Document type	Journal Article
ZDB-ID	224792-6
ISSN	1348-0421 ; 0385-5600
ISSN (online)	1348-0421
ISSN	0385-5600
DOI	10.1111/1348-0421.13051
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Article ; Online: DKK3 expression is correlated with poorer prognosis in head and neck squamous cell carcinoma: A bioinformatics study based on the TCGA database.

Katase, Naoki / Nishimatsu, Shin-Ichiro / Yamauchi, Akira / Okano, Shinji / Fujita, Shuichi

Journal of oral biosciences

2023 Volume 65, Issue 4, Page(s) 334–346

Abstract: Objective: We previously reported that dickkopf WNT signaling pathway inhibitor 3 (DKK3) expression is correlated with poorer prognosis in head and neck squamous cell carcinoma (HNSCC). Here we investigated DKK3 expression by using The Cancer Genome ... ...

Abstract	Objective: We previously reported that dickkopf WNT signaling pathway inhibitor 3 (DKK3) expression is correlated with poorer prognosis in head and neck squamous cell carcinoma (HNSCC). Here we investigated DKK3 expression by using The Cancer Genome Atlas (TCGA) public database and bioinformatic analyses. Methods: We used the RNA sequence data and divided the tumor samples into "DKK3-high" and "DKK3-low" groups according to median DKK3 expression. The correlations between DKK3 expression and the clinical data were investigated. Differentially expressed genes (DEGs) were detected using DESEq2 and analyzed by ShinyGO 0.77. A gene set enrichment analysis (GSEA) was also performed using GSEA software. The DEGs were also analyzed with TargetMine to establish the protein-protein interaction (PPI) network. Results: DKK3 expression was significantly increased in cancer samples, and a high DKK3 expression was significantly associated with shorter overall survival. We identified 854 DEGs, including 284 up-regulated and 570 down-regulated. Functional enrichment analyses revealed several Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with extracellular matrix remodeling. The PPI network identified COL8A1, AGTR1, FN1, P4HA3, PDGFRB, and CEP126 as the key genes. Conclusions: These results suggested the cancer-promoting ability of DKK3, the expression of which is a promising prognostic marker and therapeutic target for HNSCC.
MeSH term(s)	Humans ; Squamous Cell Carcinoma of Head and Neck/genetics ; Head and Neck Neoplasms/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Prognosis ; Computational Biology/methods ; Databases, Genetic ; Procollagen-Proline Dioxygenase/genetics ; Adaptor Proteins, Signal Transducing/genetics
Chemical Substances	P4HA3 protein, human (EC 1.14.11.2) ; Procollagen-Proline Dioxygenase (EC 1.14.11.2) ; DKK3 protein, human ; Adaptor Proteins, Signal Transducing
Language	English
Publishing date	2023-09-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218267-6
ISSN	1880-3865 ; 1349-0079
ISSN (online)	1880-3865
ISSN	1349-0079
DOI	10.1016/j.job.2023.09.002
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Article: [Galectin-9 as a possible suppressor for metastasis of breast cancer].

Yamauchi, Akira

Nihon rinsho. Japanese journal of clinical medicine

2012 Volume 70 Suppl 7, Page(s) 448–453

MeSH term(s)	Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Female ; Galectins/analysis ; Galectins/physiology ; Humans ; Neoplasm Metastasis/diagnosis
Chemical Substances	Galectins ; LGALS9 protein, human
Language	Japanese
Publishing date	2012-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
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Article: Fine definition of the epitopes on the human gp91phox/NOX2 for the monoclonal antibodies CL-5 and 48

Kawai, Chikage / Miyano, Kei / Okamoto, Shuichiro / Yamauchi, Akira / Kuribayashi, Futoshi

Journal of immunological methods. 2022 Feb., v. 501

2022

Abstract: Superoxide-producing NADPH oxidase, gp91ᵖʰᵒˣ/NOX2, in phagocytes plays a critical role in the host defenses against pathogens. Moreover, gp91ᵖʰᵒˣ/NOX2 contributes to the oxidative stress in endothelial cells. Therefore, investigating the level of ... ...

Abstract	Superoxide-producing NADPH oxidase, gp91ᵖʰᵒˣ/NOX2, in phagocytes plays a critical role in the host defenses against pathogens. Moreover, gp91ᵖʰᵒˣ/NOX2 contributes to the oxidative stress in endothelial cells. Therefore, investigating the level of gp91ᵖʰᵒˣ/NOX2 with immunoblotting is important for estimating the amount of superoxide produced. Here, we showed that the epitopes in human gp91ᵖʰᵒˣ/NOX2 recognized by monoclonal antibodies (mAbs) CL-5 and 48 were in amino acids 132–147 and 136–144, respectively. Although the epitopes were close to the N-glycosylation sites, N-glycan maturation did not affect mAbs recognition. When Pro-136 was substituted with Arg, the corresponding mouse residue, human gp91ᵖʰᵒˣ/NOX2 was not recognized by mAbs CL-5 and 48; however, the substitution did not affect gp91ᵖʰᵒˣ/NOX2-based oxidase activity. This finding explains why these mAbs specifically recognize the human but not mouse gp91ᵖʰᵒˣ/NOX2. Hence, these mAbs are useful for investigating the level of gp91ᵖʰᵒˣ/NOX2 without amino acid substitutions in the epitopes.
Keywords	NAD(P)H oxidase (H2O2-forming) ; amino acids ; epitopes ; glycosylation ; humans ; immunoblotting ; mice ; oxidative stress
Language	English
Dates of publication	2022-02
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2021.113213
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Fine definition of the epitopes on the human gp91

Kawai, Chikage / Miyano, Kei / Okamoto, Shuichiro / Yamauchi, Akira / Kuribayashi, Futoshi

Journal of immunological methods

2021 Volume 501, Page(s) 113213

Abstract: Superoxide-producing NADPH oxidase, ... ...

Abstract	Superoxide-producing NADPH oxidase, gp91
MeSH term(s)	Animals ; Antibodies, Monoclonal/immunology ; Antibody Specificity ; CHO Cells ; COS Cells ; Chlorocebus aethiops ; Cricetulus ; Epitope Mapping ; Epitopes ; Glycosylation ; HL-60 Cells ; Humans ; Mice ; NADPH Oxidase 2/genetics ; NADPH Oxidase 2/immunology ; NADPH Oxidase 2/metabolism ; Protein Processing, Post-Translational ; RAW 264.7 Cells ; Receptors, Immunologic/genetics ; Receptors, Immunologic/immunology ; Receptors, Immunologic/metabolism ; Superoxides/metabolism
Chemical Substances	Antibodies, Monoclonal ; Epitopes ; Pirb protein, mouse ; Receptors, Immunologic ; Superoxides (11062-77-4) ; CYBB protein, human (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-)
Language	English
Publishing date	2021-12-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2021.113213
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Article ; Online: Regulation of Derlin-1-mediated degradation of NADPH oxidase partner p22

Miyano, Kei / Okamoto, Shuichiro / Kajikawa, Mizuho / Kiyohara, Takuya / Kawai, Chikage / Yamauchi, Akira / Kuribayashi, Futoshi

Redox biology

2022 Volume 56, Page(s) 102479

Abstract: The transmembrane protein ... ...

Abstract	The transmembrane protein p22
MeSH term(s)	Granulomatous Disease, Chronic ; Humans ; Membrane Proteins/metabolism ; Mutant Proteins ; NADPH Oxidases/genetics ; NADPH Oxidases/metabolism ; Reactive Oxygen Species/metabolism ; Serine ; Sulfhydryl Compounds
Chemical Substances	DERL1 protein, human ; Membrane Proteins ; Mutant Proteins ; Reactive Oxygen Species ; Sulfhydryl Compounds ; Serine (452VLY9402) ; NADPH Oxidases (EC 1.6.3.-) ; CYBA protein, human (EC 1.6.3.1)
Language	English
Publishing date	2022-09-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2022.102479
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