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  1. Article ; Online: EDITORIAL COMMENT.

    Awasthi, Shivanshu / Yamoah, Kosj

    Urology

    2022  Volume 163, Page(s) 89

    Language English
    Publishing date 2022-05-28
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 192062-5
    ISSN 1527-9995 ; 0090-4295
    ISSN (online) 1527-9995
    ISSN 0090-4295
    DOI 10.1016/j.urology.2021.08.058
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    Zs.A 1142: Show issues Location:
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    Zs.MO 275: Show issues

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  2. Article ; Online: The right to be screened: Identifying and addressing inequities in genetic screening.

    Swami, Nishwant / Yamoah, Kosj / Mahal, Brandon A / Dee, Edward Christopher

    Lancet regional health. Americas

    2022  Volume 11, Page(s) 100251

    Language English
    Publishing date 2022-04-04
    Publishing country England
    Document type Journal Article
    ISSN 2667-193X
    ISSN (online) 2667-193X
    DOI 10.1016/j.lana.2022.100251
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Mathematical modeling of radiotherapy: impact of model selection on estimating minimum radiation dose for tumor control.

    Kutuva, Achyudhan R / Caudell, Jimmy J / Yamoah, Kosj / Enderling, Heiko / Zahid, Mohammad U

    Frontiers in oncology

    2023  Volume 13, Page(s) 1130966

    Abstract: Introduction: Radiation therapy (RT) is one of the most common anticancer therapies. Yet, current radiation oncology practice does not adapt RT dose for individual patients, despite wide interpatient variability in radiosensitivity and accompanying ... ...

    Abstract Introduction: Radiation therapy (RT) is one of the most common anticancer therapies. Yet, current radiation oncology practice does not adapt RT dose for individual patients, despite wide interpatient variability in radiosensitivity and accompanying treatment response. We have previously shown that mechanistic mathematical modeling of tumor volume dynamics can simulate volumetric response to RT for individual patients and estimation personalized RT dose for optimal tumor volume reduction. However, understanding the implications of the choice of the underlying RT response model is critical when calculating personalized RT dose.
    Methods: In this study, we evaluate the mathematical implications and biological effects of 2 models of RT response on dose personalization: (1) cytotoxicity to cancer cells that lead to direct tumor volume reduction (DVR) and (2) radiation responses to the tumor microenvironment that lead to tumor carrying capacity reduction (CCR) and subsequent tumor shrinkage. Tumor growth was simulated as logistic growth with pre-treatment dynamics being described in the proliferation saturation index (PSI). The effect of RT was simulated according to each respective model for a standard schedule of fractionated RT with 2 Gy weekday fractions. Parameter sweeps were evaluated for the intrinsic tumor growth rate and the radiosensitivity parameter for both models to observe the qualitative impact of each model parameter. We then calculated the minimum RT dose required for locoregional tumor control (LRC) across all combinations of the full range of radiosensitvity and proliferation saturation values.
    Results: Both models estimate that patients with higher radiosensitivity will require a lower RT dose to achieve LRC. However, the two models make opposite estimates on the impact of PSI on the minimum RT dose for LRC: the DVR model estimates that tumors with higher PSI values will require a higher RT dose to achieve LRC, while the CCR model estimates that higher PSI values will require a lower RT dose to achieve LRC.
    Discussion: Ultimately, these results show the importance of understanding which model best describes tumor growth and treatment response in a particular setting, before using any such model to make estimates for personalized treatment recommendations.
    Language English
    Publishing date 2023-10-09
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1130966
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  4. Article ; Online: Radiation Therapy Summary of the AUA/ASTRO Guideline on Clinically Localized Prostate Cancer.

    Deville, Curtiland / Kamran, Sophia C / Morgan, Scott C / Yamoah, Kosj / Vapiwala, Neha

    Practical radiation oncology

    2023  Volume 14, Issue 1, Page(s) 47–56

    Abstract: Purpose: Our purpose was to develop a summary of recommendations regarding the management of patients with clinically localized prostate cancer based on the American Urologic Association/ ASTRO Guideline on Clinically Localized Prostate Cancer.: ... ...

    Abstract Purpose: Our purpose was to develop a summary of recommendations regarding the management of patients with clinically localized prostate cancer based on the American Urologic Association/ ASTRO Guideline on Clinically Localized Prostate Cancer.
    Methods: The American Urologic Association and ASTRO convened a multidisciplinary, expert panel to develop recommendations based on a systematic literature review using an a priori defined consensus-building methodology. The topics covered were risk assessment, staging, risk-based management, principles of management including active surveillance, surgery, radiation, and follow-up after treatment. Presented are recommendations from the guideline most pertinent to radiation oncologists with an additional statement on health equity, diversity, and inclusion related to guideline panel composition and the topic of clinically localized prostate cancer.
    Summary: Staging, risk assessment, and management options in prostate cancer have advanced over the last decade and significantly affect shared decision-making for treatment management. Current advancements and controversies discussed to guide staging, risk assessment, and treatment recommendations include the use of advanced imaging and tumor genomic profiling. An essential active surveillance strategy includes prostate-specific antigen monitoring and periodic digital rectal examination with changes triggering magnetic resonance imaging and possible biopsy thereafter and histologic progression or greater tumor volume prompting consideration of definitive local treatment. The panel recommends against routine use of adjuvant radiation therapy (RT) for patients with prostate cancer after prostatectomy with negative nodes and an undetectable prostate-specific antigen, while acknowledging that patients at highest risk of recurrence were relatively poorly represented in the 3 largest randomized trials comparing adjuvant RT to early salvage and that a role may exist for adjuvant RT in selected patients at highest risk. RT for clinically localized prostate cancer has evolved rapidly, with new trial results, therapeutic combinations, and technological advances. The recommendation of moderately hypofractionated RT has not changed, and the updated guideline incorporates a conditional recommendation for the use of ultrahypofractionated treatment. Health disparities and inequities exist in the management of clinically localized prostate cancer across the continuum of care that can influence guideline concordance.
    MeSH term(s) Male ; Humans ; Prostate-Specific Antigen ; Prostatic Neoplasms/radiotherapy ; Biopsy ; Consensus ; Genomics
    Chemical Substances Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-12-03
    Publishing country United States
    Document type Systematic Review ; Practice Guideline
    ZDB-ID 2655748-4
    ISSN 1879-8519 ; 1879-8500
    ISSN (online) 1879-8519
    ISSN 1879-8500
    DOI 10.1016/j.prro.2023.09.007
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  5. Article ; Online: Immunologic disparities in prostate cancer between American men of African and European descent.

    Abraham-Miranda, Julieta / Awasthi, Shivanshu / Yamoah, Kosj

    Critical reviews in oncology/hematology

    2021  Volume 164, Page(s) 103426

    Abstract: Health disparities between American men of African and European descent (AA and EA, respectively) can be attributed to multiple factors, including disparities in socioeconomic status, access to healthcare, lifestyle, ancestry, and molecular aberrations. ... ...

    Abstract Health disparities between American men of African and European descent (AA and EA, respectively) can be attributed to multiple factors, including disparities in socioeconomic status, access to healthcare, lifestyle, ancestry, and molecular aberrations. Numerous clinical trials and research studies are being performed to identify new and better therapeutic approaches to detect and treat prostate cancer. Of potential concern is the fact that the majority of the patients enrolled on these trials are EA. This disproportionate enrollment of EA could have implications when disease management recommendations are proposed without regard to the existing disparities in prostate cancer between races. With increasing advancements in immunotherapies, the immunological disparities between men of diverse ethnicities will need to be fully explored to develop novel and effective therapeutic approaches for prostate cancer patients globally. To help address this need, this review fully describes inequalities in prostate cancer at the immunological level between AA and EA.
    MeSH term(s) African Americans ; Humans ; Male ; Prostatic Neoplasms/epidemiology ; Prostatic Neoplasms/therapy ; United States/epidemiology
    Language English
    Publishing date 2021-07-14
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 605680-5
    ISSN 1879-0461 ; 0737-9587 ; 1040-8428
    ISSN (online) 1879-0461
    ISSN 0737-9587 ; 1040-8428
    DOI 10.1016/j.critrevonc.2021.103426
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    Zs.A 1931: Show issues Location:
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  6. Article ; Online: Management of early-stage metastatic prostate cancer: appraisal of locoregional treatments and radiation therapy, with or without immunomodulation.

    Sandoval, Maria L / Dohm, Ammoren / Yamoah, Kosj

    Endocrine-related cancer

    2021  Volume 28, Issue 8, Page(s) T109–T120

    Abstract: The current standard for the management of locally advanced and early stage metastatic prostate cancer relies on a backbone of androgen deprivation therapy (ADT) combined with radiotherapy (RT), a regimen that at a glance appears relatively ... ...

    Abstract The current standard for the management of locally advanced and early stage metastatic prostate cancer relies on a backbone of androgen deprivation therapy (ADT) combined with radiotherapy (RT), a regimen that at a glance appears relatively straightforward. The emergence of newer diagnostic, genomic and imaging modalities have allowed for better disease risk-stratification and opened avenues for the development of more patient-centered treatment strategies. This review aims to highlight the central role of RT as part of a multi-modal approach and discuss established and emerging data for the management of locally advanced disease, biochemical recurrence, and oligometastatic disease, as well as the use of immunotherapies and radio-isotopes. This review will also briefly discuss ongoing clinical trials that provide new insights into the paradigm shift in the management of locally advanced prostate cancer.
    MeSH term(s) Androgen Antagonists/therapeutic use ; Combined Modality Therapy ; Humans ; Immunomodulation ; Male ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/radiotherapy
    Chemical Substances Androgen Antagonists
    Language English
    Publishing date 2021-07-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1218450-0
    ISSN 1479-6821 ; 1351-0088
    ISSN (online) 1479-6821
    ISSN 1351-0088
    DOI 10.1530/ERC-21-0073
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    Zs.A 4192: Show issues Location:
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  7. Article ; Online: The imperative for clinical trial diversity: Perspectives in the context of prostate-specific membrane antigen-targeted imaging.

    Cho, Hae Lin / Perni, Subha / D'Amico, Anthony V / Yamoah, Kosj / Dee, Edward Christopher

    Prostate cancer and prostatic diseases

    2023  Volume 26, Issue 3, Page(s) 511–515

    MeSH term(s) Male ; Humans ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/therapy ; Prostate ; Antigens, Surface ; Prostate-Specific Antigen ; Positron Emission Tomography Computed Tomography
    Chemical Substances Antigens, Surface ; Prostate-Specific Antigen (EC 3.4.21.77)
    Language English
    Publishing date 2023-03-06
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural
    ZDB-ID 1419277-9
    ISSN 1476-5608 ; 1365-7852
    ISSN (online) 1476-5608
    ISSN 1365-7852
    DOI 10.1038/s41391-023-00657-3
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    Zs.A 5277: Show issues Location:
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  8. Article ; Online: The distinct impacts of race and genetic ancestry on health.

    Rebbeck, Timothy R / Mahal, Brandon / Maxwell, Kara N / Garraway, Isla P / Yamoah, Kosj

    Nature medicine

    2022  Volume 28, Issue 5, Page(s) 890–893

    MeSH term(s) Ethnicity ; Humans ; Whites/genetics
    Language English
    Publishing date 2022-05-09
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01796-1
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    Zs.MG 39: Show issues

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  9. Article ; Online: In Reply to "Pathogenic/Likely Pathogenic Somatic CDK12 Mutations in Black Men With Prostate Cancer".

    Valle, Luca F / Nickols, Nicholas G / Yamoah, Kosj / Garraway, Isla P / Maxwell, Kara N / Lynch, Julie A

    The oncologist

    2023  Volume 28, Issue 11, Page(s) e1129–e1130

    MeSH term(s) Male ; Humans ; Veterans ; Mutation ; Prostatic Neoplasms/pathology ; Genomics ; Cyclin-Dependent Kinases/genetics
    Chemical Substances CDK12 protein, human (EC 2.7.11.22) ; Cyclin-Dependent Kinases (EC 2.7.11.22)
    Language English
    Publishing date 2023-09-12
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyad264
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    Zs.MO 494: Show issues

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  10. Article ; Online: Biology vs Access to Care-Relative Contribution to Racial Disparities in Prostate Cancer.

    Gerke, Travis / Awasthi, Shivanshu / Yamoah, Kosj

    JAMA oncology

    2019  Volume 5, Issue 12, Page(s) 1809–1810

    MeSH term(s) African Americans ; Biology ; Health Services Accessibility ; Healthcare Disparities ; Humans ; Male ; Prostatic Neoplasms/therapy
    Language English
    Publishing date 2019-10-19
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2019.4497
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