LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 9 of total 9

Search options

  1. Article ; Online: Comparison of the efficacy of febuxostat vs. benzbromarone in the treatment of gout: a meta-analysis in Chinese gout patients.

    Yan, C-Q / Liang, C / Lan, Z-R / Su, C / Xiong, S-Y / Yang, Y-X / Chen, J-M / Tang, S-L / Huang, J-S / Zhang, Z-H / Luo, M-J / Xiao, Z-H

    European review for medical and pharmacological sciences

    2024  Volume 27, Issue 24, Page(s) 11988–12003

    Abstract: Objective: Febuxostat and benzbromarone are two common drugs for the treatment of gout, but the clinical efficacy of these two drugs is controversial. This meta-analysis aimed to compare the efficacy of febuxostat and benzbromarone in the treatment of ... ...

    Abstract Objective: Febuxostat and benzbromarone are two common drugs for the treatment of gout, but the clinical efficacy of these two drugs is controversial. This meta-analysis aimed to compare the efficacy of febuxostat and benzbromarone in the treatment of gout.
    Materials and methods: PubMed, Embase, and the Cochrane Library were searched for articles related to febuxostat and benzbromarone in the treatment of gout from inception to January 7, 2023. Titles and abstracts were reviewed in accordance with predesigned inclusion and exclusion criteria, and data were extracted independently. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of the studies, and the continuous variables were expressed as the standard mean square error (SMD) by STATA 16 (Stata Corp., College Station, TX, USA). The sensitivity analysis was conducted by randomly removing a study, and the heterogeneity was analyzed by funnel plots and Egger's test.
    Results: According to the search strategy, a total of 1,043 publications were retrieved from the three aforementioned databases, of which 45 publications were excluded due to duplication. Fourteen studies remained after screening titles and abstracts, and a total of 7 studies met the inclusion criteria after a comprehensive evaluation of the 14 studies. Meta-analysis showed that the uric acid (UA)-reducing effect of febuxostat is better than that of benzbromarone, while febuxostat showed a better ability to improve the estimated glomerular filtration rate (eGFR) and reduce Cr and blood urea nitrogen (BUN). In terms of hepatotoxicity, benzbromarone was not as potent as febuxostat in increasing alanine transaminase (ALT) and aspartate transaminase (AST), suggesting that benzbromarone has less hepatotoxicity. Moreover, there was no significant difference in the effect on blood lipid levels between the two drugs.
    Conclusions: The beneficial effect of febuxostat on renal function-related indexes such as the eGFR, Cr and BUN is significant, while benzbromarone is more effective in reducing UA and has relatively less hepatotoxicity. The specific efficacy of the two drugs needs to be confirmed by further research.
    MeSH term(s) Humans ; Allopurinol/therapeutic use ; Benzbromarone/therapeutic use ; Chemical and Drug Induced Liver Injury/drug therapy ; China ; Febuxostat/therapeutic use ; Gout/drug therapy ; Gout Suppressants/therapeutic use ; Hyperuricemia ; Treatment Outcome ; Uric Acid ; Uricosuric Agents/therapeutic use
    Chemical Substances Allopurinol (63CZ7GJN5I) ; Benzbromarone (4POG0RL69O) ; Febuxostat (101V0R1N2E) ; Gout Suppressants ; Uric Acid (268B43MJ25) ; Uricosuric Agents
    Language English
    Publishing date 2024-01-02
    Publishing country Italy
    Document type Comparative Study ; Journal Article ; Meta-Analysis
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202312_34797
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: MiR-497 inhibits cell proliferation and invasion ability by targeting HMGA2 in pancreatic ductal adenocarcinoma.

    Zhou, Z-G / Xu, C / Dong, Z / Wang, Y-P / Duan, J-Y / Yan, C-Q

    European review for medical and pharmacological sciences

    2020  Volume 24, Issue 1, Page(s) 122–129

    Abstract: Objective: MicroRNAs have been implicated to play a crucial regulating role in human cancers. The study aims to explore the role and clinical significance of miR-497 in pancreatic ductal adenocarcinoma (PDAC).: Patients and methods: The relative ... ...

    Abstract Objective: MicroRNAs have been implicated to play a crucial regulating role in human cancers. The study aims to explore the role and clinical significance of miR-497 in pancreatic ductal adenocarcinoma (PDAC).
    Patients and methods: The relative expression of miR-497 in human PDAC tissue samples and adjacent normal tissues was measured using the quantitative Real Time-Polymerase Chain Reaction (qRT-PCR). Cell Counting Kit (CCK-8) assay, cell migration, and invasion assays were performed to detect cell proliferation and invasion ability. Downstream target gene was confirmed by using luciferase activity assays. QRT-PCR and Western blotting assays also were performed.
    Results: We found that miR-497 expression was significantly downregulated in PDAC tissues and cells. Lower miR-497 expression associated with lymph node metastasis and predicts a poor prognosis in PDAC patients. In in vitro assay, we demonstrated that miR-497 overexpression inhibited cell proliferation, migration, and invasion of PDAC. Furthermore, we demonstrated that HMGA2 was a direct target of miR-497 in PDAC cells. MiR-497 inhibited cell proliferation and invasion by regulating HMGA2 expression.
    Conclusions: Our results indicated that miR-497 may serve as a predictor for PDAC and could be a novel target of PDAC treatment.
    MeSH term(s) Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/metabolism ; Carcinoma, Pancreatic Ductal/pathology ; Cell Proliferation ; Female ; HMGA2 Protein/genetics ; HMGA2 Protein/metabolism ; Humans ; Male ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Middle Aged ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/pathology ; Tumor Cells, Cultured
    Chemical Substances HMGA2 Protein ; HMGA2 protein, human ; MIRN497 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2020-01-20
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202001_19901
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: MiR-519d inhibits prostate cancer cell proliferation, cycle and invasion via targeting NRBP1.

    Yan, C-Q / Lu, Y-H / Tang, S-M / Fan, W-X

    European review for medical and pharmacological sciences

    2018  Volume 22, Issue 10, Page(s) 2985–2990

    Abstract: Objective: To investigate the effects of miR-519d on the proliferation, cycle and invasion of human prostate cancer PC3 cells and its possible molecular mechanism.: Materials and methods: The proliferation, cycle, and invasion of human prostate ... ...

    Abstract Objective: To investigate the effects of miR-519d on the proliferation, cycle and invasion of human prostate cancer PC3 cells and its possible molecular mechanism.
    Materials and methods: The proliferation, cycle, and invasion of human prostate cancer PC3 cells were detected via cell counting kit-8 (CCK-8) and transwell assay. The expression of NRBP1 mRNA was detected via reverse transcription-polymerase chain reaction (RT-PCR). Western blotting was used to detect the expression of NRBP1, cyclin D1, and epithelial-mesenchymal transition (EMT) markers.
    Results: The expression of miR-519d in prostate cancer was decreased, which was correlated with tumor size, metastasis, and staging. Proliferation, cycle, and invasion of PC3 cells were significantly decreased after overexpression of miR-519d. Bioinformatics analysis and Western blotting showed that there was a potential miR-519d binding site in NRBP1 3'-UTR, and overexpression of miR-519d significantly inhibited the expression of NRBP1. The expression of E-cadherin in PC3 cells overexpressing miR-519d was up-regulated, and the expressions of N-cadherin, cyclin D1, vimentin, fibronectin, and Snail were down-regulated.
    Conclusions: MiR-519d can repress the proliferation, cycle, and invasion of prostate cancer PC3 cells by inhibiting NRBP1.
    MeSH term(s) Antigens, CD/genetics ; Cadherins/genetics ; Cell Culture Techniques ; Cell Cycle/genetics ; Cell Proliferation/genetics ; Down-Regulation ; Epithelial-Mesenchymal Transition/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; MicroRNAs/genetics ; Middle Aged ; Neoplasm Invasiveness ; PC-3 Cells ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Receptors, Cytoplasmic and Nuclear/genetics ; Up-Regulation ; Vesicular Transport Proteins/genetics
    Chemical Substances Antigens, CD ; CDH1 protein, human ; Cadherins ; MIRN519 microRNA, human ; MicroRNAs ; NRBP1 protein, human ; Receptors, Cytoplasmic and Nuclear ; Vesicular Transport Proteins
    Language English
    Publishing date 2018-06-03
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_201805_15054
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article: [Application of pancreaticojejunostomy with pancreatic duct binding external drainage in laparoscopic pancreatoduodenectomy].

    Chen, S X / Zhao, W H / Zhou, Z G / Duan, J Y / Xu, C / Yan, C Q

    Zhonghua wai ke za zhi [Chinese journal of surgery

    2020  Volume 58, Issue 7, Page(s) 516–519

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Aged ; Drainage/methods ; Female ; Humans ; Laparoscopy ; Male ; Middle Aged ; Pancreatic Ducts/surgery ; Pancreatic Fistula/prevention & control ; Pancreaticoduodenectomy/adverse effects ; Pancreaticoduodenectomy/methods ; Pancreaticojejunostomy/adverse effects ; Pancreaticojejunostomy/methods ; Retrospective Studies
    Language Chinese
    Publishing date 2020-07-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 604573-x
    ISSN 0529-5815
    ISSN 0529-5815
    DOI 10.3760/cma.j.cn112139-20191230-00644
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  5. Article: [Application of ARIMA model in predicting the incidence of tuberculosis in China from 2018 to 2019].

    Yan, C Q / Wang, R B / Liu, H C / Jiang, Y / Li, M C / Yin, S P / Xiao, T Y / Wan, K L / Rang, W Q

    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

    2019  Volume 40, Issue 6, Page(s) 633–637

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) China/epidemiology ; Forecasting ; Humans ; Incidence ; Models, Statistical ; Software ; Tuberculosis/diagnosis ; Tuberculosis/epidemiology
    Language Chinese
    Publishing date 2019-06-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 645026-x
    ISSN 0254-6450
    ISSN 0254-6450
    DOI 10.3760/cma.j.issn.0254-6450.2019.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Overexpression of the PDCD2-like gene results in inhibited TNF-alpha production in activated Daudi cells.

    Chen, Q / Yan, C-Q / Liu, F-J / Tong, J / Miao, S-L / Chen, J-P

    Human immunology

    2008  Volume 69, Issue 4-5, Page(s) 259–265

    Abstract: Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to ... ...

    Abstract Both PDCD2 and PDCD2-like proteins have PDCD2_C terminal domains, but their functions are still unclear. After analysis of their expression in Gene Expression Omnibus, we hypothesized that they played a role in inflammation. In Daudi cells exposed to lipopolysaccharides, PDCD2-like RNA was upregulated, whereas PDCD2 was downregulated. Overexpression of PDCD2-like gene effectively attenuated tumor necrosis factor (TNF)-alpha release but elevated interleukin (IL)-6 and PDCD2 expression induced by lipopolysaccharide (LPS). It is possible that both proteins have anti-inflammatory effects like IL-6. The results have implications for understanding the function of PDCD2/PDCD2-like proteins and may help in the development of novel anti-inflammatory drugs.
    MeSH term(s) Annexin A5/analysis ; Apoptosis ; Apoptosis Regulatory Proteins/genetics ; Cell Line, Tumor ; Electroporation ; Gene Expression Regulation ; Humans ; Interleukin-6/metabolism ; Lipopolysaccharides/immunology ; Lipopolysaccharides/pharmacology ; RNA, Messenger/analysis ; Transcription Factors/metabolism ; Transfection ; Tumor Necrosis Factor-alpha/antagonists & inhibitors ; Tumor Necrosis Factor-alpha/biosynthesis ; Up-Regulation
    Chemical Substances Annexin A5 ; Apoptosis Regulatory Proteins ; IL6 protein, human ; Interleukin-6 ; Lipopolysaccharides ; PDCD2 protein, human ; RNA, Messenger ; Transcription Factors ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2008-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 801524-7
    ISSN 1879-1166 ; 0198-8859
    ISSN (online) 1879-1166
    ISSN 0198-8859
    DOI 10.1016/j.humimm.2008.01.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Audio / Video: Pathogenesis-related proteins in somatic hybrid rice induced by bacterial blight

    Yu, C.L / Yan, S.P / Wang, C.C / Hu, H.T / Sun, W.N / Yan, C.Q / Chen, J.P / Yang, L

    Phytochemistry. 2008 July, v. 69, issue 10

    2008  

    Abstract: Rice bacterial blight, caused by Xanthomonas oryzae pv. Oryzae (Xoo), is one of the most serious rice diseases worldwide. The bacterial blight resistance trait from Oryza meyeriana, a wild rice species, was introduced into an elite japonica rice cultivar ...

    Abstract Rice bacterial blight, caused by Xanthomonas oryzae pv. Oryzae (Xoo), is one of the most serious rice diseases worldwide. The bacterial blight resistance trait from Oryza meyeriana, a wild rice species, was introduced into an elite japonica rice cultivar using asymmetric somatic hybridization. This study was carried out with the intention of understanding the molecular mechanism of incompatible interaction between Xoo and the stable somatic hybrids by using proteomic analyses. Proteins were extracted from leaves at 24, 48, and 72 h after Xoo inoculation and separated by 2-DE. A total of 77 protein spots changed their intensities significantly (p < 0.05) by more than 1.5-fold at least at one time point. Sixty-four protein spots were successfully identified by MS analysis. Among them, 51 were known to be involved in photosynthesis. Up-regulation of Rubisco large subunit (RcbL) small fragments and down-regulation of RcbL big fragments indicated that intact RcbL and RcbL big fragments degraded following Xoo attack, which was further confirmed by Western blot analysis. The differential expression of proteins related to signal transduction, antioxidant defense, photosynthesis, metabolism, and protein turnover during the Xoo infection, suggests the existence of a complex regulatory network in the somatic hybrid rice that increases resistance toward Xoo infection and damage.
    Keywords Oryza sativa ; rice ; somatic hybridization ; hybrids ; pathogenesis-related proteins ; plant proteins ; proteomics ; disease resistance ; resistance mechanisms ; blight ; bacterial diseases of plants ; Xanthomonas oryzae pv. oryzae ; plant pathogenic bacteria ; two-dimensional gel electrophoresis
    Language English
    Dates of publication 2008-07
    Size p. 1989-1996.
    Document type Article ; Audio / Video
    ZDB-ID 208884-8
    ISSN 1873-3700 ; 0031-9422
    ISSN (online) 1873-3700
    ISSN 0031-9422
    DOI 10.1016/j.phytochem.2008.04.006
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  8. Article: Use of asymmetric somatic hybridization for transfer of the bacterial blight resistance trait from Oryza meyeriana L. to O. sativa L. ssp. japonica

    Yan, C.Q / Qian, K.X / Yan, Q.S / Zhang, X.Q / Xue, G.P / Huangfu, W.G / Wu, Y.F / Zhao, Y.Z / Xue, Z.Y / Huang, J

    Plant cell reports. 2004 Mar., v. 22, no. 8

    2004  

    Abstract: Bacterial blight is one of the major diseases affecting rice productivity. To improve the resistance of cultivated rice to bacterial blight, we introduced a bacterial blight resistance trait from Oryza meyeriana, a wild rice species, into an elite ... ...

    Abstract Bacterial blight is one of the major diseases affecting rice productivity. To improve the resistance of cultivated rice to bacterial blight, we introduced a bacterial blight resistance trait from Oryza meyeriana, a wild rice species, into an elite japonica rice cultivar (Dalixiang) using asymmetric somatic hybridization. One hundred and thirty-two independent lines were regenerated. The hybrid plants possessed several morphological features of the donor species, O. meyeriana. Random amplified polymorphic DNA analysis revealed that hybrid plants exhibited banding patterns derived from their parental genotypes. For the majority of the hybrids, resistance to bacterial blight pathogens was intermediate to that observed for O. meyeriana and O. sativa (cv. Dalixiang). Four of the hybrid lines exhibited a high bacterial blight resistance, but it was less than that observed for O. meyeriana. These results demonstrate that O. meyeriana can be used as a good genetic source for improving bacterial blight resistance in commercial rice cultivars through asymmetric somatic hybridization.
    Keywords Oryza ; Oryza sativa ; rice ; grain crops ; cultivars ; blight ; bacterial diseases of plants ; Xanthomonas oryzae pv. oryzae ; plant pathogenic bacteria ; disease resistance ; somatic hybridization ; callus culture ; micropropagation ; in vitro regeneration ; somatic embryos ; protoplast fusion ; plant morphology ; random amplified polymorphic DNA technique
    Language English
    Dates of publication 2004-03
    Size p. 569-575.
    Document type Article
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-085X ; 0721-7714
    ISSN (online) 1432-203X
    ISSN 0721-085X ; 0721-7714
    Database NAL-Catalogue (AGRICOLA)

    More links

    Kategorien

  9. Article: Use of asymmetric somatic hybridization for transfer of the bacterial blight resistance trait from Oryza meyeriana L. to O. sativa L. ssp. japonica.

    Yan, C-Q / Qian, K-X / Yan, Q-S / Zhang, X-Q / Xue, G-P / Huangfu, W-G / Wu, Y-F / Zhao, Y-Z / Xue, Z-Y / Huang, J / Xu, G-Z / Wu, P

    Plant cell reports

    2003  Volume 22, Issue 8, Page(s) 569–575

    Abstract: Bacterial blight is one of the major diseases affecting rice productivity. To improve the resistance of cultivated rice to bacterial blight, we introduced a bacterial blight resistance trait from Oryza meyeriana, a wild rice species, into an elite ... ...

    Abstract Bacterial blight is one of the major diseases affecting rice productivity. To improve the resistance of cultivated rice to bacterial blight, we introduced a bacterial blight resistance trait from Oryza meyeriana, a wild rice species, into an elite japonica rice cultivar (Dalixiang) using asymmetric somatic hybridization. One hundred and thirty-two independent lines were regenerated. The hybrid plants possessed several morphological features of the donor species, O. meyeriana. Random amplified polymorphic DNA analysis revealed that hybrid plants exhibited banding patterns derived from their parental genotypes. For the majority of the hybrids, resistance to bacterial blight pathogens was intermediate to that observed for O. meyeriana and O. sativa (cv. Dalixiang). Four of the hybrid lines exhibited a high bacterial blight resistance, but it was less than that observed for O. meyeriana. These results demonstrate that O. meyeriana can be used as a good genetic source for improving bacterial blight resistance in commercial rice cultivars through asymmetric somatic hybridization.
    MeSH term(s) Crosses, Genetic ; Hybridization, Genetic ; Immunity, Innate ; Oryza/genetics ; Plant Diseases/genetics ; Plants, Genetically Modified/genetics ; Protoplasts/physiology ; Regeneration
    Language English
    Publishing date 2003-11-01
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 8397-5
    ISSN 1432-203X ; 0721-7714 ; 0721-085X
    ISSN (online) 1432-203X
    ISSN 0721-7714 ; 0721-085X
    DOI 10.1007/s00299-003-0732-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top