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Article ; Online: Evaluation Method of Public Physical Training Quality Based on Global Topology Optimization Deep Learning Model.

Yan, JingMing

Journal of environmental and public health

2022 Volume 2022, Page(s) 4043876

Abstract: In the quality evaluation of public sports training, the selected indicators are not comprehensive, resulting in some errors in the results of quality evaluation. Therefore, this paper designs a public sports training quality evaluation method based on ... ...

Abstract	In the quality evaluation of public sports training, the selected indicators are not comprehensive, resulting in some errors in the results of quality evaluation. Therefore, this paper designs a public sports training quality evaluation method based on the deep learning model of global topology optimization. Determine the basic principles of public sports training quality evaluation, determine the human coordinate points of public sports training by determining the basic section and basic axis of human training, and extract the data of public sports training quality evaluation. On this basis, quantify the public sports training quality evaluation index, construct the evaluation matrix, calculate the weight of the evaluation index, and determine the importance of the public sports training quality evaluation index. Preprocess the public sports training quality evaluation index set, search the optimal fitness value in the global topology optimization depth learning model, introduce the global topology optimization depth learning model, input the evaluation index and output the evaluation quality results, and realize the quality evaluation of public sports training. The experimental results show that the evaluation method in this paper can improve the accuracy of the evaluation results and is feasible.
MeSH term(s)	Deep Learning ; Exercise ; Humans ; Sports
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/4043876
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The Disruption of NMDAR/TRPM4 Death Signaling with TwinF Interface Inhibitors: A New Pharmacological Principle for Neuroprotection.

Yan, Jing / Bading, Hilmar

Pharmaceuticals (Basel, Switzerland)

2023 Volume 16, Issue 8

Abstract: With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors (NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4, it has become possible to develop a new pharmacological principle for ... ...

Abstract	With the discovery that the acquisition of toxic features by extrasynaptic NMDA receptors (NMDARs) involves their physical interaction with the non-selective cation channel, TRPM4, it has become possible to develop a new pharmacological principle for neuroprotection, namely the disruption of the NMDAR/TRPM4 death signaling complex. This can be accomplished through the expression of the TwinF domain, a 57-amino-acid-long stretch of TRPM4 that mediates its interaction with NMDARs, but also using small molecule TwinF interface (TI) inhibitors, also known as NMDAR/TRPM4 interaction interface inhibitors. Both TwinF and small molecule TI inhibitors detoxify extrasynaptic NMDARs without interfering with synaptic NMDARs, which serve important physiological functions in the brain. As the toxic signaling of extrasynaptic NMDARs contributes to a wide range of neurodegenerative conditions, TI inhibitors may offer therapeutic options for currently untreatable human neurodegenerative diseases including Amyotrophic Lateral Sclerosis, Alzheimer's disease, and Huntington's disease.
Language	English
Publishing date	2023-07-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph16081085
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Bone marrow immune cells stop weight regain.

Yan, Jing / Hu, Cheng

Cell metabolism

2023 Volume 35, Issue 11, Page(s) 1845–1846

Abstract: Weight regain is a major challenge in the long-term management of obesity; however, the underlying mechanisms remain unclear. Zhou et al. found that bone-marrow-derived ... ...

Abstract	Weight regain is a major challenge in the long-term management of obesity; however, the underlying mechanisms remain unclear. Zhou et al. found that bone-marrow-derived CD7
MeSH term(s)	Humans ; Bone Marrow ; Obesity ; Adipose Tissue, Beige ; Bone Marrow Cells ; Thermogenesis ; Weight Gain
Language	English
Publishing date	2023-11-06
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	2176834-1
ISSN	1932-7420 ; 1550-4131
ISSN (online)	1932-7420
ISSN	1550-4131
DOI	10.1016/j.cmet.2023.10.004
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Article ; Online: Secure State Estimation of Nonlinear Cyber-Physical Systems Against DoS Attacks: A Multiobserver Approach.

Yan, Jing-Jing / Yang, Guang-Hong

IEEE transactions on cybernetics

2023 Volume 53, Issue 3, Page(s) 1447–1459

Abstract: This article focuses on the problem of secure state estimation for cyber-physical systems (CPSs), whose physical plants are modeled as nonlinear strict-feedback systems. The measured output is sent to the designed observer over a wireless communication ... ...

Abstract	This article focuses on the problem of secure state estimation for cyber-physical systems (CPSs), whose physical plants are modeled as nonlinear strict-feedback systems. The measured output is sent to the designed observer over a wireless communication network subject to denial-of-service (DoS) attacks. Due to the energy constraints of the attackers, the attack duration is upper bounded. Under DoS attacks, the transmission is prevented, which worsens the estimation accuracy of the existing nonlinear observers significantly. To maintain the estimation performance, a novel multiobserver scheme and a switched algorithm are proposed by introducing the hold-input mechanism and the cascade observer technique. In comparison to the existing results, where the estimation error systems may be unstable during the attack time interval, the estimation error of the designed observer converges exponentially, such that the estimation performance is improved effectively. Finally, the theoretical findings are illustrated by simulation results.
Language	English
Publishing date	2023-02-15
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2021.3100303
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Article: Dietary inflammatory index is associated with metabolic dysfunction-associated fatty liver disease among United States adults.

Yan, Jing / Zhou, Jun / Ding, Yuanyuan / Tu, Chuantao

Frontiers in nutrition

2024 Volume 11, Page(s) 1340453

Abstract: Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is presently the most prevalent chronic liver disorder globally that is closely linked to obesity, dyslipidemia metabolic syndrome, and type 2 diabetes mellitus (T2DM). Its ... ...

Abstract	Background: Metabolic dysfunction-associated fatty liver disease (MAFLD) is presently the most prevalent chronic liver disorder globally that is closely linked to obesity, dyslipidemia metabolic syndrome, and type 2 diabetes mellitus (T2DM). Its pathogenesis is strongly associated with inflammation, and diet is a major factor in reducing inflammation. However, current research has focused primarily on exploring the relationship between diet and NAFLD, with less research on its link to MAFLD. Methods: In this research, using dietary inflammatory index (DII) as a measure to assess dietary quality, we analyzed the relationship between diet and MAFLD. Data from the National Health and Nutrition Examination Survey (NHANES) 2017-2018, including 3,633 adults with complete DII and MAFLD, were used to develop cross-sectional analyses. Logistic regression analysis was adapted for investigating the relationship between DII and MAFLD development. Additionally, subgroup analysis and threshold effect analysis were carried out. Results: A positive link between DII and MAFLD was found in the fully adjusted model (OR = 1.05; 95%CI, 1.00-1.11, Conclusion: As a result, our research indicates that pro-inflammatory diet may increase the chance of MAFLD development, thus improved dietary patterns as a lifestyle intervention is an important strategy to decrease the incidence of MAFLD.
Language	English
Publishing date	2024-03-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2776676-7
ISSN	2296-861X
ISSN	2296-861X
DOI	10.3389/fnut.2024.1340453
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Article: [Effect of Concept and Practice of Palliative Care on the Death Status of Patients in Peking Union Medical College Hospital].

Ning, Xiao-Hong / Yan, Jing / Wang, You-Pei

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae

2024 Volume 45, Issue 6, Page(s) 949–954

Abstract: Objective To analyze the changes of death status of the inpatients in Peking Union Medical College Hospital before and after the development of palliative care.Methods All the death cases of Peking Union Medical College Hospital in 2013 (384 cases) and ... ...

Abstract	Objective To analyze the changes of death status of the inpatients in Peking Union Medical College Hospital before and after the development of palliative care.Methods All the death cases of Peking Union Medical College Hospital in 2013 (384 cases) and 2019 (244 cases) were included in this study,and the general information of the patients and the details of diagnosis and treatment before death were collected.Results The departments of intensive care,emergency,and respiratory diseases and the international medical services had highest number of deaths in both 2013 and 2019,with the cumulative constituent ratios of 67.7% and 62.7%,respectively.The number of clinical departments that involved or implemented palliative care increased from 7 in 2013 to 14 in 2019.The number of patients who died in 2019 and exposed to palliative care increased (
MeSH term(s)	Humans ; Palliative Care ; Hospitals ; Retrospective Studies
Language	Chinese
Publishing date	2024-01-03
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	604853-5
ISSN	1000-503X
ISSN	1000-503X
DOI	10.3881/j.issn.1000-503X.15707
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Article ; Online: DFT Insight into a Strain-Release Mechanism in Bicyclo[1.1.0]butanes via Concerted Activation of Central and Lateral C-C Bonds with Rh(III) Catalysis.

Yan, Jing / Dong, Lihua / Yang, Yiying / Zhang, Dongju

Inorganic chemistry

2024

Abstract: Transition-metal-catalyzed, strain-release-driven transformations of "spring-loaded" bicyclo[1.1.0]butanes (BCBs) are considered potent tools in synthetic organic chemistry. Previously proposed strain-release mechanisms involve either the insertion of ... ...

Abstract	Transition-metal-catalyzed, strain-release-driven transformations of "spring-loaded" bicyclo[1.1.0]butanes (BCBs) are considered potent tools in synthetic organic chemistry. Previously proposed strain-release mechanisms involve either the insertion of the central C-C bond of BCBs into a metal-carbon bond, followed by β-C elimination, or the oxidative addition of the central or lateral C-C bond on the transition metal center, followed by reductive elimination. This study, employing DFT calculations on a Rh(III)-catalyzed model system in a three-component protocol involving oxime ether, BCB ester, and ethyl glyoxylate for constructing diastereoselective quaternary carbon centers, introduces an unusual strain-release mechanism for BCBs. In this mechanism, the catalytic reaction is initiated by the simultaneous cleavage of two C-C bonds (the central and lateral C-C bonds), resulting in the formation of a Rh-carbene intermediate. The new mechanism exhibits a barrier of 21.0 kcal/mol, making it energetically more favorable by 11.1 kcal/mol compared to the previously suggested most favorable pathway. This unusual reaction mode rationalizes experimental observation of the construction of quaternary carbon centers, including the excellent
Language	English
Publishing date	2024-04-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.4c00800
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Article ; Online: Secure State Estimation With Switched Compensation Mechanism Against DoS Attacks.

Yan, Jing-Jing / Yang, Guang-Hong

IEEE transactions on cybernetics

2022 Volume 52, Issue 9, Page(s) 9609–9620

Abstract: This article is concerned with the secure state estimation problem for cyber-physical systems under intermittent denial-of-service (DoS) attacks. Based on a switching scheme and the cascade observer technique, a novel resilient state observer with a ... ...

Abstract	This article is concerned with the secure state estimation problem for cyber-physical systems under intermittent denial-of-service (DoS) attacks. Based on a switching scheme and the cascade observer technique, a novel resilient state observer with a switched compensation mechanism is designed. Moreover, a quantitative relationship between the resilience against DoS attacks and the design parameters is revealed. Compared with the existing results, where only the boundedness of the estimation error is guaranteed under DoS attacks, the exponential convergence of the estimation error is achieved by employing the proposed observer scheme, such that the estimation performance is improved. More specifically, in the disturbance-free case, it is proven that the state estimation error converges exponentially to 0 despite the existence of DoS attacks. Finally, simulation results are provided to illustrate the effectiveness and merits of the proposed methods.
MeSH term(s)	Computer Simulation
Language	English
Publishing date	2022-08-18
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2021.3060743
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Thesis ; Online: Fraud investigation in the extravirgin olive oil supply chain

Yan, Jing

Identification of vulnerable points and development of novel fraud detection methods

2020

Abstract: With the globalisation of the food supply system, food fraud can have international impacts, sometimes with far-reaching and lethal consequences. Extra virgin olive oil (EVOO) is considered one of the most frequently reported commodities, suffering from ... ...

Abstract	With the globalisation of the food supply system, food fraud can have international impacts, sometimes with far-reaching and lethal consequences. Extra virgin olive oil (EVOO) is considered one of the most frequently reported commodities, suffering from fraud. Knowledge about risk factors and precise laboratory and broad on-site screening methods will help to combat fraud in the EVOO supply chain network. The main objectives of this thesis are to develop strategies to combat fraud in the EVOO supply chains through knowledge about weak spots and underlying risk factors and the development of novel detection methods.To achieve these goals, firstly, the EVOO supply chain was assessed for their vulnerability using the SSAFE food fraud vulnerability assessment tool. These assessments indicate that the EVOO supply chain is fairly vulnerable. B2B companies and retailers in the EVOO supply chain are more vulnerable to fraud than olive oil producers and food manufacturers due to the additional vulnerability related to opportunities in time and place and a lack of control measures. Fraud vulnerability across the EVOO supply chain was not only determined by the place of the actor in the chain (node), but also by the scale and location of the companies.Four novel methods were developed in this thesis for EVOO authentication. Monochloropropanediol (MCPD) esters and glycidyl esters (GEs) analysis by gas chromatography-tandem mass spectrometry (GC-MS/MS) was applied to defect EVOO adulteration with lower grade oils. The limit of fraud detection of lower grade olive oils in EVOO was 2% when using 3-MCPD esters, 5% for 2-MCPD esters and 13–14% for GEs. These results imply that the method is fairly useful for confirmatory analysis. However, 3-MCPD analysis by GC-MS/MS is currently a tedious and time-consuming method, it is not recommended to use this method to analyse a large number of suspect samples when a quick response is required. In addition, three rapid and non-destructive techniques were developed. The volatile organic ...
Keywords	Life Science
Subject code	540
Language	English
Publisher	Wageningen University
Publishing country	nl
Document type	Thesis ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: TwinF interface inhibitor FP802 stops loss of motor neurons and mitigates disease progression in a mouse model of ALS.

Yan, Jing / Wang, Yu Meng / Hellwig, Andrea / Bading, Hilmar

Cell reports. Medicine

2024 Volume 5, Issue 2, Page(s) 101413

Abstract: Toxic signaling by extrasynaptic NMDA receptors (eNMDARs) is considered an important promoter of amyotrophic lateral sclerosis (ALS) disease progression. To exploit this therapeutically, we take advantage of TwinF interface (TI) inhibition, a ... ...

Abstract	Toxic signaling by extrasynaptic NMDA receptors (eNMDARs) is considered an important promoter of amyotrophic lateral sclerosis (ALS) disease progression. To exploit this therapeutically, we take advantage of TwinF interface (TI) inhibition, a pharmacological principle that, contrary to classical NMDAR pharmacology, allows selective elimination of eNMDAR-mediated toxicity via disruption of the NMDAR/TRPM4 death signaling complex while sparing the vital physiological functions of synaptic NMDARs. Post-disease onset treatment of the SOD1
MeSH term(s)	Mice ; Animals ; Humans ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/pathology ; Superoxide Dismutase/metabolism ; Superoxide Dismutase/pharmacology ; Superoxide Dismutase/therapeutic use ; Mice, Transgenic ; Motor Neurons/metabolism ; Motor Neurons/pathology ; Disease Models, Animal ; Disease Progression ; TRPM Cation Channels
Chemical Substances	Superoxide Dismutase (EC 1.15.1.1) ; TRPM4 protein, mouse ; TRPM Cation Channels
Language	English
Publishing date	2024-02-06
Publishing country	United States
Document type	Journal Article
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2024.101413
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