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Article ; Online: Anti-inflammatory effect and pharmacokinetics of dehydroandrographolide, an active component of Andrographis paniculata, on Poly(I:C)-induced acute lung injury.

Liu, Yong-Guang / Zhang, Shan-Shan / Jin, Su-Wei / Xia, Tian-Ji / Liao, Yong-Hong / Pan, Rui-Le / Yan, Ming-Zhu / Chang, Qi

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 174, Page(s) 116456

Abstract: Acute lung injury (ALI) is a common and critical respiratory disorder caused by various factors, with viral infection being the leading contributor. Dehydroandrographolide (DAP), a constituent of the Chinese herbal plant Andrographis paniculata, exhibits ...

Abstract	Acute lung injury (ALI) is a common and critical respiratory disorder caused by various factors, with viral infection being the leading contributor. Dehydroandrographolide (DAP), a constituent of the Chinese herbal plant Andrographis paniculata, exhibits a range of activities including anti-inflammatory, in vitro antiviral and immune-enhancing effects. This study evaluated the anti-inflammatory effects and pharmacokinetics (PK) profile of DAP in ALI mice induced by intratracheal instillation of Poly(I:C) (PIC). The results showed that oral administration of DAP (10-40 mg/kg) effectively suppressed the increase in lung wet-dry weight ratio, total cells, total protein content, accumulation of immune cells, inflammatory cytokines and neutrophil elastase levels in bronchoalveolar lavage fluid of PIC-treated mice. DAP concentrations, determined by an LC-MS/MS method, in plasma after receiving DAP (20 mg/kg) were unchanged compared to those in normal mice. However, DAP concentrations and relative PK parameters in the lungs were significantly altered in PIC-treated mice, exhibiting a relatively higher maximum concentration, larger AUC, and longer elimination half-life than those in the lungs of normal mice. These results demonstrated that DAP could improve lung edema and inflammation in ALI mice, and suggested that lung injury might influence the PK properties of DAP, leading to increased lung distribution and residence. Our study provides evidence that DAP displays significant anti-inflammatory activity against viral lung injury and is more likely to distribute to damaged lung tissue.
MeSH term(s)	Animals ; Acute Lung Injury/drug therapy ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/pharmacology ; Diterpenes/pharmacokinetics ; Diterpenes/pharmacology ; Male ; Mice ; Poly I-C ; Bronchoalveolar Lavage Fluid ; Andrographis/chemistry ; Cytokines/metabolism ; Lung/drug effects ; Lung/metabolism ; Lung/pathology ; Leukocyte Elastase/metabolism
Chemical Substances	Anti-Inflammatory Agents ; Diterpenes ; dehydroandrographolide (TKB45D7LVX) ; Poly I-C (O84C90HH2L) ; Cytokines ; Leukocyte Elastase (EC 3.4.21.37)
Language	English
Publishing date	2024-03-28
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116456
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Interferon lambda in respiratory viral infection: immunomodulatory functions and antiviral effects in epithelium.

Liu, Yong-Guang / Jin, Su-Wei / Zhang, Shan-Shan / Xia, Tian-Ji / Liao, Yong-Hong / Pan, Rui-Le / Yan, Ming-Zhu / Chang, Qi

Frontiers in immunology

2024 Volume 15, Page(s) 1338096

Abstract: Type III interferon (IFN-λ), a new member of the IFN family, was initially considered to possess antiviral functions similar to those of type I interferon, both of which are induced via the JAK/STAT pathway. Nevertheless, recent findings demonstrated ... ...

Abstract	Type III interferon (IFN-λ), a new member of the IFN family, was initially considered to possess antiviral functions similar to those of type I interferon, both of which are induced via the JAK/STAT pathway. Nevertheless, recent findings demonstrated that IFN-λ exerts a nonredundant antiviral function at the mucosal surface, preferentially produced in epithelial cells in contrast to type I interferon, and its function cannot be replaced by type I interferon. This review summarizes recent studies showing that IFN-λ inhibits the spread of viruses from the cell surface to the body. Further studies have found that the role of IFN-λ is not only limited to the abovementioned functions, but it can also can exert direct and/or indirect effects on immune cells in virus-induced inflammation. This review focuses on the antiviral activity of IFN-λ in the mucosal epithelial cells and its action on immune cells and summarizes the pathways by which IFN-λ exerts its action and differentiates it from other interferons in terms of mechanism. Finally, we conclude that IFN-λ is a potent epidermal antiviral factor that enhances the respiratory mucosal immune response and has excellent therapeutic potential in combating respiratory viral infections.
MeSH term(s)	Humans ; Interferon Lambda ; Janus Kinases/metabolism ; Signal Transduction ; STAT Transcription Factors/metabolism ; Interferon Type I/metabolism ; Epithelium/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Virus Diseases
Chemical Substances	Interferon Lambda ; Janus Kinases (EC 2.7.10.2) ; STAT Transcription Factors ; Interferon Type I ; Antiviral Agents
Language	English
Publishing date	2024-03-01
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1338096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Impact of tectonic deformation on coal methane adsorption capacity

Wu Li / Bo Jiang / Yan-Ming Zhu

Adsorption Science & Technology, Vol

2019 Volume 37

Abstract: Tectonic deformation can cause significant changes in the physical and chemical structures of coal by damaging the macrostructure and macromolecular composition. For thorough research on the coal tectonic deformation impacts on gas adsorption capacity, ... ...

Abstract	Tectonic deformation can cause significant changes in the physical and chemical structures of coal by damaging the macrostructure and macromolecular composition. For thorough research on the coal tectonic deformation impacts on gas adsorption capacity, this paper collected and summarized the parameters of experimental adsorption isotherms and coal macerals, conducted proximate and ultimate analyses, and systematically discussed the adsorption properties of different structures of coals and the influence of temperature and pressure on coal adsorption. Furthermore, the semi-quantitative relationships between the structural parameters of coal and its methane adsorption capacity are explored. The results show that (1) due to different tectonic stresses, the molecular and porous structures of different types of tectonic coal exhibit significant differences (e.g. sample N25, which is in a fault zone, has the highest methane adsorption capacity), and (2) coal methane adsorption capacity decreases along with increasing temperature. At a pressure of 12 MPa, primary coal (N32) showed Langmuir volume (V L ) values of 15.38, 9.58, and 7.86 cm 3 /g and Langmuir pressure (P L ) values of 3.82, 2.07, and 1.81 MPa at temperatures of 30°C, 50°C, and 70°C, respectively. (3) The Langmuir volume appears to have a linear relationship with parameters I D1 /I G , Al/OX, and A-factor, as well as a parabolic curve relationship with f a , thereby illustrating that increases of apparent aromaticity can raise CH 4 adsorption on coal.
Keywords	Physical and theoretical chemistry ; QD450-801
Subject code	541
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	Hindawi - SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.

Xia, Tian-Ji / Jin, Su-Wei / Liu, Yong-Guang / Zhang, Shan-Shan / Wang, Zhi / Liu, Xin-Min / Pan, Rui-Le / Jiang, Ning / Liao, Yong-Hong / Yan, Ming-Zhu / Chang, Qi

Journal of ethnopharmacology

2024 Volume 326, Page(s) 117992

Abstract: Ethnopharmacological relevance: Sleep plays a critical role in several physiologic processes, and sleep disorders increase the risk of depression, dementia, stroke, cancer, and other diseases. Stress is one of the main causes of sleep disorders. Ginseng ...

Abstract	Ethnopharmacological relevance: Sleep plays a critical role in several physiologic processes, and sleep disorders increase the risk of depression, dementia, stroke, cancer, and other diseases. Stress is one of the main causes of sleep disorders. Ginseng Radix et Rhizoma and Polygalae Radix have been reported to have effects of calming the mind and intensifying intelligence in Chinese Pharmacopoeia. Traditional Chinese medicine prescriptions composed of Ginseng Radix et Rhizoma and Polygalae Radix (Shen Yuan, SY) are commonly used to treat insomnia, depression, and other psychiatric disorders in clinical practice. Unfortunately, the underlying mechanisms of the SY extract's effect on sleep are still unknown. Aim of the study: This study aimed to investigate the hypnotic effect of the SY extract in normal mice and mice with chronic restraint stress (CRS)-induced sleep disorders and elucidate the underlying mechanisms. Materials and methods: The SY extract (0.5 and 1.0 g/kg) was intragastrically administered to normal mice for 1, 14, and 28 days and to CRS-treated mice for 28 days. The open field test (OFT) and pentobarbital sodium-induced sleep test (PST) were used to evaluate the hypnotic effect of the SY extract. Liquid chromatography-tandem mass spectrometry and enzyme-linked immunosorbent assay were utilized to detect the levels of neurotransmitters and hormones. Molecular changes at the mRNA and protein levels were determined using real-time quantitative polymerase chain reaction and Western blot analysis to identify the mechanisms by which SY improves sleep disorders. Results: The SY extract decreased sleep latency and increased sleep duration in normal mice. Similarly, the sleep duration of mice subjected to CRS was increased by administering SY. The SY extract increased the levels of tryptophan (Trp) and 5-hydroxytryptamine (5-HT) and the expression of tryptophan hydroxylase 2 (TPH2) in the cortex of normal mice. The SY extract increased the Trp level, transcription and expression of estrogen receptor beta and TPH2 in the cortex in mice with sleep disorders by decreasing the serum corticosterone level, which promoted the synthesis of 5-HT. Additionally, the SY extract enhanced the expression of arylalkylamine N-acetyltransferase, which increased the melatonin level and upregulated the expressions of melatonin receptor-2 (MT2) and Cryptochrome 1 (Cry1) in the hypothalamus of mice with sleep disorders. Conclusions: The SY extract exerted a hypnotic effect via the Trp/5-HT/melatonin pathway, which augmented the synthesis of 5-HT and melatonin and further increased the expressions of MT2 and Cry1.
MeSH term(s)	Humans ; Mice ; Animals ; Hypnotics and Sedatives/pharmacology ; Hypnotics and Sedatives/therapeutic use ; Tryptophan ; Serotonin/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Melatonin/pharmacology ; Sleep Initiation and Maintenance Disorders/drug therapy
Chemical Substances	Hypnotics and Sedatives ; Tryptophan (8DUH1N11BX) ; Serotonin (333DO1RDJY) ; Drugs, Chinese Herbal ; Melatonin (JL5DK93RCL)
Language	English
Publishing date	2024-02-28
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2024.117992
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Hydrocarbon Generation and Chemical Structure Evolution from Confined Pyrolysis of Bituminous Coal

Wu Li / Yan-Ming Zhu / Chang-Qing Hu / Sheng-Bo Han / Jin-Shui Wu

ACS Omega, Vol 5, Iss 31, Pp 19682-

2020 Volume 19694

Keywords	Chemistry ; QD1-999
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Chronic restraint stress induced changes in colonic homeostasis-related indexes and tryptophan-kynurenine metabolism in rats

Li, Chen-Chen / Gan, Long / Tan, Yue / Yan, Ming-Zhu / Liu, Xin-Min / Chang, Qi / Pan, Rui-Le

Journal of proteomics. 2021 May 30, v. 240

2021

Abstract: Chronic stressors represented risk factors for the etiology or exacerbation of several gastrointestinal diseases. The goal of the present study was to examine whether chronic restraint stress (CRS) could initiate and aggravate colonic inflammation, ... ...

Abstract	Chronic stressors represented risk factors for the etiology or exacerbation of several gastrointestinal diseases. The goal of the present study was to examine whether chronic restraint stress (CRS) could initiate and aggravate colonic inflammation, integrity damage and metabolic disturbance of rats. Firstly, increased inflammatory cytokines (interferon-γ (IFN-γ), tumor necrosis factor-α(TNF-α) and interleukin-10(IL-10)) and decreased tight junction (TJ) proteins (occludin and zonula occludins-1 (ZO-1)) in rat colon were observed. Secondly, untargeted metabolomics based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass (UPLC-Q-TOF/MS) revealed that TRP metabolism was the most prominently affected. Thirdly, quantification of TRP and its metabolites via prominence ultrafast liquid chromatography coupled with a QTRAP 5500 mass (UFLC-QTRAP-5500/MS) showed that TRP, kynurenine (KYN), kynurenic acid (KA) and 3-hydroxykynurenine (3−HK) were significantly increased. At the same time, 5-hydroxytryptamine (5-HT) was unchanged and 5-hydroxyindolacetic acid (5-HIAA) was significantly decreased in the colon of CRS rats. Besides, TRP metabolic enzyme changes were with the same trends as the corresponding metabolites. Thus, our data showed that CRS could initiate colonic inflammation, integrity damage and colonic metabolism disturbance, especially TRP-KYN metabolism pathway of rats, which may provide an experimental background for future research on stress-related gastrointestinal dysfunction.Chronic exposure to psychological stress could induce metabolic imbalance of the body, and stressful life events were intimately correlated with frequent relapses in patients with intestinal disorders. The present study showed that chronic restraint stress (CRS) could initiate and aggravate colonic inflammation, integrity damage and metabolic disturbance, especially tryptophan-kynurenine metabolism of rats. Tryptophan-kynurenine pathway may be involved in the initiation and development of diseases induced by chronic stress. This research may shed light on future research on stress-related gastrointestinal dysfunction.
Keywords	colon ; enzymes ; etiology ; inflammation ; interleukin-10 ; kynurenine ; metabolism ; metabolites ; metabolomics ; necrosis ; neoplasms ; occludins ; proteomics ; psychological stress ; rats ; serotonin ; tight junctions ; ultra-performance liquid chromatography ; ultrafast liquid chromatography
Language	English
Dates of publication	2021-0530
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2400835-7
ISSN	1876-7737 ; 1874-3919
ISSN (online)	1876-7737
ISSN	1874-3919
DOI	10.1016/j.jprot.2021.104190
Database	NAL-Catalogue (AGRICOLA)

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Article: Melatonin-related dysfunction in chronic restraint stress triggers sleep disorders in mice.

Xia, Tian-Ji / Wang, Zhi / Jin, Su-Wei / Liu, Xin-Min / Liu, Yong-Guang / Zhang, Shan-Shan / Pan, Rui-Le / Jiang, Ning / Liao, Yong-Hong / Yan, Ming-Zhu / Du, Li-Da / Chang, Qi

Frontiers in pharmacology

2023 Volume 14, Page(s) 1210393

Abstract: Stress may trigger sleep disorders and are also risk factors for depression. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture, ... ...

Abstract	Stress may trigger sleep disorders and are also risk factors for depression. The study explored the melatonin-related mechanisms of stress-associated sleep disorders on a mouse model of chronic stress by exploring the alteration in sleep architecture, melatonin, and related small molecule levels, transcription and expression of melatonin-related genes as well as proteins. Mice undergoing chronic restraint stress modeling for 28 days showed body weight loss and reduced locomotor activity. Sleep fragmentation, circadian rhythm disorders, and insomnia exhibited in CRS-treated mice formed sleep disorders. Tryptophan and 5-hydroxytryptamine levels were increased in the hypothalamus, while melatonin level was decreased. The transcription and expression of melatonin receptors were reduced, and circadian rhythm related genes were altered. Expression of downstream effectors to melatonin receptors was also affected. These results identified sleep disorders in a mice model of chronic stress. The alteration of melatonin-related pathways was shown to trigger sleep disorders.
Language	English
Publishing date	2023-06-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1210393
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chronic restraint stress induced changes in colonic homeostasis-related indexes and tryptophan-kynurenine metabolism in rats.

Li, Chen-Chen / Gan, Long / Tan, Yue / Yan, Ming-Zhu / Liu, Xin-Min / Chang, Qi / Pan, Rui-Le

Journal of proteomics

2021 Volume 240, Page(s) 104190

Abstract	Chronic stressors represented risk factors for the etiology or exacerbation of several gastrointestinal diseases. The goal of the present study was to examine whether chronic restraint stress (CRS) could initiate and aggravate colonic inflammation, integrity damage and metabolic disturbance of rats. Firstly, increased inflammatory cytokines (interferon-γ (IFN-γ), tumor necrosis factor-α(TNF-α) and interleukin-10(IL-10)) and decreased tight junction (TJ) proteins (occludin and zonula occludins-1 (ZO-1)) in rat colon were observed. Secondly, untargeted metabolomics based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass (UPLC-Q-TOF/MS) revealed that TRP metabolism was the most prominently affected. Thirdly, quantification of TRP and its metabolites via prominence ultrafast liquid chromatography coupled with a QTRAP 5500 mass (UFLC-QTRAP-5500/MS) showed that TRP, kynurenine (KYN), kynurenic acid (KA) and 3-hydroxykynurenine (3-HK) were significantly increased. At the same time, 5-hydroxytryptamine (5-HT) was unchanged and 5-hydroxyindolacetic acid (5-HIAA) was significantly decreased in the colon of CRS rats. Besides, TRP metabolic enzyme changes were with the same trends as the corresponding metabolites. Thus, our data showed that CRS could initiate colonic inflammation, integrity damage and colonic metabolism disturbance, especially TRP-KYN metabolism pathway of rats, which may provide an experimental background for future research on stress-related gastrointestinal dysfunction. SIGNIFICANCE: Chronic exposure to psychological stress could induce metabolic imbalance of the body, and stressful life events were intimately correlated with frequent relapses in patients with intestinal disorders. The present study showed that chronic restraint stress (CRS) could initiate and aggravate colonic inflammation, integrity damage and metabolic disturbance, especially tryptophan-kynurenine metabolism of rats. Tryptophan-kynurenine pathway may be involved in the initiation and development of diseases induced by chronic stress. This research may shed light on future research on stress-related gastrointestinal dysfunction.
MeSH term(s)	Animals ; Colon ; Homeostasis ; Humans ; Kynurenic Acid ; Kynurenine ; Rats ; Tryptophan
Chemical Substances	Kynurenine (343-65-7) ; Tryptophan (8DUH1N11BX) ; Kynurenic Acid (H030S2S85J)
Language	English
Publishing date	2021-03-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2400835-7
ISSN	1876-7737 ; 1874-3919
ISSN (online)	1876-7737
ISSN	1874-3919
DOI	10.1016/j.jprot.2021.104190
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Image-guided, surgical robot-assisted percutaneous puncture of the foramen ovale and foramina stylomastoideum

Fan-Hao Meng / Yu Song / Bo Qiao / Neng-Hao Jin / Yan-Ming Zhu / Bo-Fu Liang / Deng-Fa Gao / Hai-Zhong Zhang / Ning-Ning Wang

Chinese Medical Journal, Vol 134, Iss 19, Pp 2362-

a cadaveric study

2021 Volume 2364

Keywords	Medicine ; R
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Identification of in vivo components in rats after oral administration of lotus leaf flavonoids using ultra fast liquid chromatography with tandem mass spectrometry

Ye, Lin-Hu / He, Xiao-Xi / Yan, Ming-Zhu / Chang, Qi

Analytical methods. 2014 July 10, v. 6, no. 15

2014

Abstract: The herb of lotus (Nelumbo nucifera) leaves is the traditional Chinese medicine He Ye, which is commonly used to treat sunstroke, assuage thirst, and cure both diarrhea and fever in China. Lotus leaves are rich in flavonoids, which exhibit various ... ...

Abstract	The herb of lotus (Nelumbo nucifera) leaves is the traditional Chinese medicine He Ye, which is commonly used to treat sunstroke, assuage thirst, and cure both diarrhea and fever in China. Lotus leaves are rich in flavonoids, which exhibit various biological activities. However, the in vivo components, including parent compounds and their metabolites after consumption of the leaves have not been investigated extensively. In the present study, a method based on ultra fast liquid chromatography with tandem mass spectrometry (UFLC-MS/MS) was established to identify the in vivo components in rats after oral administration of a lotus leaf flavonoid extract. Plasma and urine samples were collected before and after dosing and treated by liquid–liquid extraction with ethyl acetate, and followed by UFLC-MS/MS assay. Q1 (first quadrupole) full scan combined with multiple reaction monitoring (MRM) survey scan were used for the detection of parent flavonoids and their metabolites. MRM-information dependent acquisition (IDA) of enhanced product ions (MRM-IDA-EPI) was used for the structural identification of detected components. A total of thirty-seven components were identified, including quercetin-3-O-glucuronide, quercetin-3-O-glucoside, quercetin-3-O-galacoside, quercetin and kaempferol, as well as their methylation, glucuronidation, and sulfonation metabolites. The result may help better understand the pharmacological activities of the traditional Chinese medicine He Ye.
Keywords	Lotus ; Nelumbo nucifera ; Oriental traditional medicine ; diarrhea ; ethyl acetate ; fever ; heat stroke ; ions ; kaempferol ; leaves ; liquid-liquid extraction ; medicinal properties ; metabolites ; methylation ; monitoring ; oral administration ; quercetin ; rats ; surveys ; tandem mass spectrometry ; thirst ; ultrafast liquid chromatography ; urine ; China
Language	English
Dates of publication	2014-0710
Size	p. 6088-6094.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2515210-5
ISSN	1759-9679 ; 1759-9660
ISSN (online)	1759-9679
ISSN	1759-9660
DOI	10.1039/c4ay00652f
Database	NAL-Catalogue (AGRICOLA)

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