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  1. Article: Finite element analysis of 3 internal fixations for distal type C3 femur fractures with medial wall bone defects.

    Chen, Ding / Yu, Jiaona / Yu, Yang / Yan, Mingming

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2024  Volume 48, Issue 11, Page(s) 1711–1720

    Abstract: Objectives: Managing 33-C3 femur fractures with medial wall bone defects poses a significant challenge for orthopedic surgeons. The gold standard treatment for arbeitsgemeinschaftfür osteosynthesefragen (AO)/orthopedic trauma association (OTA) 33-C3 ... ...

    Title translation 有限元分析3种内固定方式治疗伴有内侧骨缺损的C3型股骨远端骨折.
    Abstract Objectives: Managing 33-C3 femur fractures with medial wall bone defects poses a significant challenge for orthopedic surgeons. The gold standard treatment for arbeitsgemeinschaftfür osteosynthesefragen (AO)/orthopedic trauma association (OTA) 33-C3 distal femur fractures with medial wall bone defects remains elusive. This study employs finite element analysis to compare the stability and mechanical behavior of 3 internal fixation patterns (single lateral distal locking plate, retrograde intramedullary nail, and dual plates) for 33-C3 femur fractures with medial wall bone defects. The aim is to provide a theoretical basis for the selection of internal fixation modalities in clinical practice.
    Methods: Enrollment included a 43-year-old male volunteer weighing 60 kg, without a history of femur fracture. Bilateral femur normality was verified through X-ray and CT scan assessments. A finite element simulation model of AO/OTA 33-C3 distal femur fracture with medial wall bone defect was established. Three fixation methods, named single lateral locking plate (single-plate group), retrograde intramedullary nail (retrograde intramedullary nail group), and dual plates (dual-plate group), were evaluated using finite element analysis under an axial load of 300 N. The assessment included an examination of von Mises stress distribution, shear stress, and displacement patterns at the internal fixation and femur fracture sites.
    Results: The finite element analysis revealed that dual-plate fixation effectively reduced the concentration of von Mises stress at the plate on the fracture site. Under full weight-bearing conditions, the maximum von Mises stress in the implants occurred at the distal femur defect level, with values of 149.30, 59.281, and 58.03 MPa for single-plate fixation, retrograde intramedullary nail, and dual-plate fixation methods, respectively. Similarly, the maximum shear stress in the implants was 77.867, 30.136, and 33.505 MPa for single-plate fixation, retrograde intramedullary nail, and dual-plate fixation methods, respectively, all presenting at the distal femur defect level. The maximum relative displacements of implants during compressive loading were 1.34, 1.25, and 0.83 mm for the single-plate , retrograde intramedullary nail, and dual-plate groups, respectively. Consistently, the maximum loading-point displacements of fracture sites were 1.529, 1.264, and 0.880 mm for the single-plate fixation group, retrograde intramedullary nail group, and dual-plate fixation group, respectively. Furthermore, at the distal femur defect level, the maximum von Mises stress was 72.682, 112.430, and 40.716 MPa for the single-plate, retrograde intramedullary nail, and dual-plate fixation groups, respectively.
    Conclusions: Dual-plate fixation demonstrates superior biomechanical outcomes and exhibites the lowest maximum von Mises stress and shear stress, along with minimal relative movements between fracture fragments. This configuration offers optimal mechanical stability for managing AO/OTA 33-C3 distal femur fractures with medial wall bone defects. Consequently, dual-plate fixation emerges as a better treatment strategy for patients presenting with comminuted intra-articular distal femur fractures accompanied by medial wall bone defects.
    MeSH term(s) Male ; Humans ; Adult ; Finite Element Analysis ; Femoral Fractures, Distal ; Fracture Fixation, Internal ; Fractures, Bone ; Femur/surgery
    Language Chinese
    Publishing date 2024-03-01
    Publishing country China
    Document type Case Reports ; Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.11817/j.issn.1672-7347.2023.230221
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  2. Article ; Online: Early endovascular approaches for treating acute mesenteric arterial occlusive disease in hemodialysis patients.

    Qu, Siyuan / Wen, Rui / Yan, Mingming / Qin, Jiao / Li, Jiali

    Hemodialysis international. International Symposium on Home Hemodialysis

    2024  Volume 28, Issue 2, Page(s) 241–246

    Abstract: Background: Among hemodialysis patients, acute superior mesenteric artery (SMA) thrombosis a condition with a high mortality rate. Very few larger case series have been reported.: Method: We reviewed eight hemodialysis patients with diabetes mellitus ...

    Abstract Background: Among hemodialysis patients, acute superior mesenteric artery (SMA) thrombosis a condition with a high mortality rate. Very few larger case series have been reported.
    Method: We reviewed eight hemodialysis patients with diabetes mellitus and SMA thrombosis managed with endovascular therapy in our institution. Demographic, clinical, and radiological data were described. The patency of the SMA was assessed by computed tomography angiography (CTA) at one month after the endovascular procedure. At the last visit, clinical symptoms and check of mortality were recorded.
    Results: Multidetector CTA scan revealed severe stenosis of SMA in 6 patients and SMA occlusion in the other two patients. The severe stenosis of SMA were verified by angiography. Balloon angioplasty without stenting was performed to obtain satisfactory patency of SMA. Seven of eight patients achieved resolution of abdominal pain after the endovascular procedure. One patient died of suspected intestinal necrosis after 6 days of balloon angioplasty. All seven surviving patients did not experience a recurrence of symptoms with a median follow-up of 2 years. No significant residual stenotic or occlusive lesions were noted in follow-up CTA at one month after the endovascular procedure.
    Conclusion: SMA thrombosis should be systematically suspected in hemodialysis patients experiencing abdominal pain. Prompt diagnosis of SMA thrombosis as soon as possible and early endovascular therapy are required to obtain a favorable prognosis in the hemodialysis patient with SMA thrombosis.
    MeSH term(s) Humans ; Constriction, Pathologic ; Renal Dialysis ; Mesenteric Vascular Occlusion/diagnosis ; Mesenteric Vascular Occlusion/therapy ; Endovascular Procedures ; Thrombosis ; Abdominal Pain ; Stents ; Treatment Outcome ; Retrospective Studies
    Language English
    Publishing date 2024-02-22
    Publishing country Canada
    Document type Review ; Case Reports
    ZDB-ID 2192458-2
    ISSN 1542-4758 ; 1492-7535
    ISSN (online) 1542-4758
    ISSN 1492-7535
    DOI 10.1111/hdi.13139
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  3. Article ; Online: Sequential treatment of rituximab and belimumab in thrombotic thrombocytopenia purpura associated with systemic lupus erythematous: A respective case series and literature review.

    Liu, Jun / Yan, Mingming / Wen, Rui / Li, Jiali

    International journal of rheumatic diseases

    2023  Volume 26, Issue 5, Page(s) 960–964

    Abstract: Introduction: Thrombotic thrombocytopenia purpura (TTP) associated with systemic lupus erythematous (SLE), features the appearance of inhibitory autoantibodies against ADAMTS13. Rituximab and belimumab (BEL), as both targeting B cells, seem to be an ... ...

    Abstract Introduction: Thrombotic thrombocytopenia purpura (TTP) associated with systemic lupus erythematous (SLE), features the appearance of inhibitory autoantibodies against ADAMTS13. Rituximab and belimumab (BEL), as both targeting B cells, seem to be an optimal therapy to induce clinical remission, prevent relapse of disease and contribute to glucocorticoid induction. However, the clinical outcome of SLE-TTP treated with sequential therapy between rituximab and BEL remain elusive.
    Case series: We reported the clinical outcomes of 4 patients diagnosed with SLE-TTP who were administrated a combination of corticosteroids, plasma exchange, and rituximab at stage of induction. BEL was utilized to rapidly reduce the reliance on these agents and prevent relapse of TTP at maintenance stage. Ultimately, 4 patients fully recovered with a SLE Disease Activity Index score of 0 and reached the goal at dose of prednisolone <7.5 mg/d without relapse.
    Conclusion: Sequential treatment of rituximab and BEL could be an encouraging approach in treatment of SLE-TTP and rapid glucocorticoid reduction.
    MeSH term(s) Humans ; Rituximab/therapeutic use ; Glucocorticoids/therapeutic use ; Lupus Erythematosus, Systemic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/complications ; Purpura, Thrombotic Thrombocytopenic/diagnosis ; Purpura, Thrombotic Thrombocytopenic/therapy ; Recurrence
    Chemical Substances Rituximab (4F4X42SYQ6) ; belimumab (73B0K5S26A) ; Glucocorticoids
    Language English
    Publishing date 2023-01-02
    Publishing country England
    Document type Review ; Case Reports
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14556
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  4. Article ; Online: A hydrogel optical fibre sensor for rapid on-site ethanol determination.

    Hong, Simin / Yan, Mingming / Feng, Yuan / Chen, Huifang / Xu, Ben / Zhao, Chunliu / Kang, Juan

    Analytical methods : advancing methods and applications

    2024  Volume 16, Issue 5, Page(s) 780–785

    Abstract: Ethanol plays a critical role in the modern chemical industry, food production, and medical research. Given its wide applications, the detection of ethanol concentration is very necessary. In this paper, a fibre device for rapid ethanol detection is ... ...

    Abstract Ethanol plays a critical role in the modern chemical industry, food production, and medical research. Given its wide applications, the detection of ethanol concentration is very necessary. In this paper, a fibre device for rapid ethanol detection is proposed. The sensing head was fabricated with multimode fibre. The hydrogel was photo-cured on the fibre tip from polyethylene glycol diacrylate (PEGDA). In the hydrogel, rhodamine 6G (R6G) was immobilized as the fluorescent indicator. The sensor was designed based on the swelling behaviour of the hydrogel in liquid. The transparency of the hydrogel was modulated by the component of the water-ethanol mixture, thus, the fluorescence intensity of R6G was monitored for the determination of ethanol. Within the range of 0-62.2 vol%, the detection limit (LOD) was 0.4 vol%. A detailed comparison with other detection methods showed that the proposed sensor has the advantages of being single-ended, low LOD, cost-effective, and easy to prepare. It has great potential for on-site ethanol detection applications.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d3ay02092d
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  5. Article ; Online: Experimental study and finite element analysis of heavy-duty escalator truss under full load conditions.

    Li, Ning / Cao, Zhongxi / Bao, Wei / Lin, Suixian / Zou, Tao / Yan, Mingming

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 4825

    Abstract: The performance of the heavy-duty escalator truss greatly affects the stability and service life of the whole escalator system, and the manufacturing cost of truss structure accounts for more than 1/5. Thus, how to design the truss structure reasonably ... ...

    Abstract The performance of the heavy-duty escalator truss greatly affects the stability and service life of the whole escalator system, and the manufacturing cost of truss structure accounts for more than 1/5. Thus, how to design the truss structure reasonably is a pivotal issue drawing the attention of numerous engineers and researchers. In this work, the experimental research of heavy-duty escalators under full load conditions were performed in terms of the end restraints, the docking port clearances, and the deflection. Based on the experimental results, the three-dimensional simulation model of truss structure was created, and the influences of various factors such as the internal chamfer of truss member, the lower deviation of truss member, the dead weight of escalator, and the pretension force of each bolt at the docking port were analyzed and quantified. Finally, the finite element model which can almost completely characterize the actual structure was obtained with slight difference. The conclusions drawn in this work provide the basis for the efficient design, correct simulation, low cost production and rapid installation of the heavy-duty escalator truss.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-55175-6
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  6. Article ; Online: Rapid determination of ethanol content based on an optical fiber-device and R6G-indicator.

    Yan, Mingming / Li, Minglu / Wang, Dongning / Chen, Huifang

    Analytical methods : advancing methods and applications

    2022  Volume 14, Issue 41, Page(s) 4122–4126

    Abstract: A rapid method for the determination of ethanol content is proposed and tested. A fluorescence detecting system, with a multimode fiber (MMF) sensing head, is employed. Rhodamine 6G (R6G) is applied as the fluorescent indicator. In the R6G aqueous ... ...

    Abstract A rapid method for the determination of ethanol content is proposed and tested. A fluorescence detecting system, with a multimode fiber (MMF) sensing head, is employed. Rhodamine 6G (R6G) is applied as the fluorescent indicator. In the R6G aqueous solution, the molecules aggregate at high concentration, causing fluorescence quenching. Nevertheless, aggregation and quenching rarely occur in ethanol. Taking an ethanol and water mixture as the solvent, the photoluminescence (PL) intensity reflects the aggregation degree and the ethanol content. Based on this phenomenon, the contents of the ethanol-water mixture were measured through PL intensity detection. A limit of detection (LOD) at ∼0.1 vol% level was obtained in the range of 0-100%. Commercial Chinese baijiu and rubbing alcohol were tested and the results obtained were consistent with the label values. The detecting system is compact and of low-cost, and the detecting method is rapid, accurate and repeatable. There is good prospect of applications for the determination of ethanol content on-site.
    MeSH term(s) Optical Fibers ; Rhodamines ; Water ; Ethanol
    Chemical Substances rhodamine 6G (037VRW83CF) ; Rhodamines ; Water (059QF0KO0R) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2022-10-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2515210-5
    ISSN 1759-9679 ; 1759-9660
    ISSN (online) 1759-9679
    ISSN 1759-9660
    DOI 10.1039/d2ay01319c
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  7. Article: Studies on the Antiliver Injury of Effective Parts from

    Wang, Chaonan / Cheng, Dongyan / Yan, Mingming / Wang, Lishu

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 7821724

    Abstract: The aim of this study was to evaluate the pharmacodynamics of the effective parts ... ...

    Abstract The aim of this study was to evaluate the pharmacodynamics of the effective parts from
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/7821724
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  8. Article: Sodium-glucose co-transporter-2 inhibitor (SGLT2i) treatment and risk of osteomyelitis: A pharmacovigilance study of the FAERS database.

    Zhao, Hui / Li, Zi-Ran / Zhang, Qian / Zhong, Ming-Kang / Yan, Ming-Ming / Qiu, Xiao-Yan

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1110575

    Abstract: Background and purpose: ...

    Abstract Background and purpose:
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1110575
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  9. Article ; Online: Ethnic, Botanic, Phytochemistry and Pharmacology of the

    Zhao, Yu / Li, Jia / Cao, Guoshi / Zhao, Daqing / Li, Guangzhe / Zhang, Hongyin / Yan, Mingming

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 20

    Abstract: ... The ... ...

    Abstract The genus
    MeSH term(s) Acorus ; Alzheimer Disease/drug therapy ; Anisoles/pharmacology ; Water ; Phytochemicals/pharmacology ; Phytochemicals/therapeutic use ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Ethnopharmacology
    Chemical Substances Anisoles ; Water (059QF0KO0R) ; Phytochemicals ; Plant Extracts
    Language English
    Publishing date 2023-10-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28207117
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  10. Article ; Online: Yuhong ointment ameliorates inflammatory responses and wound healing in scalded mice.

    Yu, Qian / Shen, Yingxin / Xiao, Fengqin / Zhao, Yu / Piao, Songlan / Li, Guangzhe / Yan, Mingming

    Journal of ethnopharmacology

    2023  Volume 306, Page(s) 116118

    Abstract: Ethnopharmacological relevance: Yuhong ointment (YHO) is famous for its efficacy in clearing away heat and dampness, reducing swelling and relieving pain, and it has been used for more than 600 years. Scalding damages the skin's defense function, ... ...

    Abstract Ethnopharmacological relevance: Yuhong ointment (YHO) is famous for its efficacy in clearing away heat and dampness, reducing swelling and relieving pain, and it has been used for more than 600 years. Scalding damages the skin's defense function, resulting in a large number of necrotic tissues and cells on the wound surface, which favors bacterial growth and inflammation. If the inflammation reaction is not controlled on time, it may lead to reduced immunity and cause complications such as infection. Yuhong ointment can promote wound healing in scalded mice, but its potential pharmacological mechanism is still unclear.
    Aim of the study: This study focused on identifying the active ingredients of YHO and on investigating the performance of YHO in terms of anti-inflammatory activity and scald wound healing activity.
    Materials and methods: High-performance liquid chromatography (HPLC) and high-performance liquid chromatography-mass spectrometry (HPLC-MS) were performed to identify the active ingredients of YHO. The performance of transdermal delivery of YHO was studied via HPLC for analyzing the ingredients of the exposed skin liquid of mice. Enzyme-linked immunosorbent assay (ELISA) analysis, immunohistochemistry, and real-time fluorescence quantitative PCR (qRT-PCR) were used to investigate the anti-inflammatory and scald wound healing activity of YHO.
    Results: A total of 41 components of YHO were identified via HPLC and HPLC-MS for the first time. In the transdermal delivery experiment, the cumulative amounts of chlorogenic acid, sesamol, ferulic acid, and L-shikonin were calculated to be 342.28, 567.89, 384.54, and 528.67 μg/cm
    Conclusions: In this work, the active ingredients of YHO were identified via HPLC and HPLC-MS analysis. Importantly, YHO showed great advantages in transdermal delivery and scald wound healing, which can be attributed to the both anti-inflammatory and tissue regeneration mechanisms. Therefore, this work not only identified the active ingredients of YHO but also revealed the potential pharmacological mechanism of YHO for the healing of scald.
    MeSH term(s) Mice ; Animals ; Vascular Endothelial Growth Factor A/metabolism ; Interleukin-10 ; Ointments ; Interleukin-6 ; Wound Healing ; Anti-Inflammatory Agents/pharmacology ; Inflammation/drug therapy ; Burns/drug therapy
    Chemical Substances Vascular Endothelial Growth Factor A ; Interleukin-10 (130068-27-8) ; Ointments ; Interleukin-6 ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-01-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2022.116118
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