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Article ; Online: Electrochemical micromachining on nickel and nickel-based superalloys with two-tone sinusoidal signal

Xin Wang / Yan Peng

Electrochemistry Communications, Vol 158, Iss , Pp 107642- (2024)

1481

Abstract: Electrochemical micromachining is an emerging technology in the machining field. This method offers several advantages such as exceptional surface quality, minimal cathode depletion, and a high elimination rate. Often, an ultrashort pulse power supply is ...

Abstract	Electrochemical micromachining is an emerging technology in the machining field. This method offers several advantages such as exceptional surface quality, minimal cathode depletion, and a high elimination rate. Often, an ultrashort pulse power supply is employed in electrochemical micromachining to address over-machining in non-processing areas. While reducing the pulse duration can enhance processing accuracy, its high cost and impracticality for regular production limit its development. This paper presents the use of a Two-tone sinusoidal signal as an alternative to ultrashort pulse in electrochemical micromachining. We investigated the mechanism behind the reduced machining gap with this signal. By drilling micro-holes in the nickel sheet to optimize parameters such as voltage, fundamental frequency, and harmonic order. Using the Taguchi optimization method, we studied the impact of these control variables on the micromachining process during micro-hole drilling. The study also focused on fabricating micro-structures using the best processing parameters. Our results showed that using the optimized parameters greatly enhanced processing accuracy. Moreover, we found that high machining accuracy could be achieved when working on hard-to-cut super alloy plates.
Keywords	Electrochemistry ; Micromachining ; Micro-hole ; Optimization ; Micro-structure ; Nanoaccuracy machining ; Industrial electrochemistry ; TP250-261 ; Chemistry ; QD1-999
Subject code	670
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Система академічних бібліотек Китаю

Yan Peng

Український журнал з бібліотекознавства та інформаційних наук, Vol 0, Iss 4, Pp 56-

організація та функціонування

2019 Volume 65

Abstract: Стратегія модернізації системи освіти в Україні зумовлює важливість дослідження питань створення ефективної інфраструктури, здатної активно сприяти діяльності закладів вищої освіти. У цьому контексті дослідження системи академічних бібліотек економічно ... ...

Abstract	Стратегія модернізації системи освіти в Україні зумовлює важливість дослідження питань створення ефективної інфраструктури, здатної активно сприяти діяльності закладів вищої освіти. У цьому контексті дослідження системи академічних бібліотек економічно розвинених країн, однією з яких є Китай, сприяє розвитку і взаємозбагаченню практики функціонування книгозбірень в освітньому просторі. Стаття присвячена висвітленню особливостей формування системи бібліотек закладів вищої освіти Китайської Народної Республіки та дослідженню напрямів їхнього функціонування в цифровому просторі. Проаналізовано основні етапи модернізації університетів Китаю та створення їхньої інформаційної інфраструктури. Акцентовано на діяльності кращих академічних бібліотек відповідно до «Проекту 211» та «Проекту 985». Доведено, що система академічних бібліотек Китаю перебуває на етапі потужної модернізації техніко-технологічних та сервісних напрямів діяльності. Визначено критерії її ефективності. Розглянуто завдання та напрями модернізації діяльності бібліотек закладів вищої освіти. Представлено порівняльну характеристику співвідношення фінансових показників витрат на друковані та електронні ресурси провідними академічними бібліотеками Китайської Народної Республіки. Обґрунтовано визначальний вплив держави на формування та підтримку розвитку цифрового інформаційно-освітнього простору Китаю. Окреслено напрями інноваційного розвитку системи академічних бібліотек КНР, серед яких: формування комфортного інформаційного середовища; активне проектування та розбудова нових приміщень, оснащених новітньою технікою та спеціалізованим програмним забезпеченням; налагодження комунікацій; формування системи освітніх ресурсіву напрямі створення цифрових активів освітнього і наукового контенту; розбудова ефективного інформаційного сервісу та інформаційного забезпечення науково-дослідної діяльності.
Keywords	інформаційно-освітній простір ; бібліотеки закладів вищої освіти ; китайська народна республіка ; модернізація бібліотек ; інформаційні ресурси ; Bibliography. Library science. Information resources ; Z
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	KNUKiM Publishing Centre
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Searching for sliding surfaces in multi-level loess slopes based on the brachistochrone.

Yang, Kui-Bin / Zhu, Yan-Peng

Scientific reports

2023 Volume 13, Issue 1, Page(s) 6496

Abstract: As a key problem in slope-stability analysis, searching for potential sliding surfaces has attracted the attention of experts and scholars for a long time. However, the commonly used sliding surface curves are only considered in terms of shape ... ...

Abstract	As a key problem in slope-stability analysis, searching for potential sliding surfaces has attracted the attention of experts and scholars for a long time. However, the commonly used sliding surface curves are only considered in terms of shape approximation and lack physical significance. The search process involved in stability analysis of multi-level slopes is complex and a large amount of calculation is required. In order to solve this problem, this paper proposes a new sliding surface form based on physical interpretation of the brachistochrone, and establishes a search model for the brachistochrone sliding surface of a multi-level loess slope. At the same time, in order to further expand the search range and find a more ideal potential sliding surface curve shape and position with a lower safety factor, we recommend continuing the sliding-surface search after the brachistochrone is improved. We compared the calculation results for the position of the potential sliding surface and the stability safety factor with the corresponding results for an arc sliding surface (in combination with a calculation example) to verify its rationality. The approach offered here not only provides a new choice of sliding surface curve form for slope-stability analysis, but also significantly improves search efficiency for potential sliding surfaces of multi-level loess slopes.
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-33559-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Design and Analysis of a Hybrid Displacement Amplifier Supporting a High-Performance Piezo Jet Dispenser.

Zhou, Shuai / Yan, Peng

Micromachines

2023 Volume 14, Issue 2

Abstract: In this study, a compliant amplifier powered by a piezoelectric stack is designed to meet high-performance dispensing operation requirements. By studying the issue of low frequency bandwidth on the traditional bridge-type amplifier mechanism, we propose ... ...

Abstract	In this study, a compliant amplifier powered by a piezoelectric stack is designed to meet high-performance dispensing operation requirements. By studying the issue of low frequency bandwidth on the traditional bridge-type amplifier mechanism, we propose a displacement amplifier mechanism, hybrid bridge-lever-bridge (HBLB), that enhances its dynamic performance by combining the traditional bridge-type and lever mechanism. A guiding beam is added to further improve its output stiffness with a guaranteed large amplification ratio. An analytical model has been developed to describe the full elastic deformation behavior of the HBLB mechanism that considers the lateral displacement loss of the input end, followed by a verification through a finite element analysis (FEA). Results revealed that the working principle of the HBLB optimizes the structural parameters using the finite element method. Finally, a prototype of the displacement amplifier was fabricated for performance tests. Static and dynamic test results revealed that the proposed mechanism can reach a travel range of 223.2 μm, and the frequency bandwidth is 1.184 kHz, which meets the requirements of a high-performance piezo jet dispenser.
Language	English
Publishing date	2023-01-27
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2620864-7
ISSN	2072-666X
ISSN	2072-666X
DOI	10.3390/mi14020322
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Identification of the dominant loop of a dual-loop macro-reentry left atrial flutter without prior intervention using high-density mapping technology: A case report.

Yu, Shan-Dong / Chu, Yan-Peng

World journal of clinical cases

2023 Volume 11, Issue 26, Page(s) 6165–6169

Abstract: Background: Left atrial flutter without prior cardiac interventions is uncommon, especially dual-loop macro-reentry atrial flutter. The critical step to ablate dual-loop macro-reentry atrial flutter is to identify the dominant loop and key isthmus. ... ...

Abstract	Background: Left atrial flutter without prior cardiac interventions is uncommon, especially dual-loop macro-reentry atrial flutter. The critical step to ablate dual-loop macro-reentry atrial flutter is to identify the dominant loop and key isthmus. Although entrainment mapping could help identify the dominant loop and key isthmus, it may alter or terminate tachycardia. High-density mapping allows the generation of electroanatomic maps without altering or terminating tachycardia. Case summary: Here, we report a case of symptomatic left atrial flutter without prior intervention. In this case, high-density mapping revealed a dual-loop macro-reentry around the mitral annulus and central scar of the anterior wall. The propagation result showed that the dominant loop was around the mitral annulus, and the key isthmus was between the central scar and mitral annulus. The atrial flutter terminated successfully after ablation was performed. Conclusion: In this case, we demonstrate that high-density mapping technology may help identify the dominant loop of dual-loop atrial flutter without entrainment, which makes ablation easier.
Language	English
Publishing date	2023-09-05
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i26.6165
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Robust composite repetitive control with disturbance observer for high-precision tracking of piezo-actuated nano-stages with measurement delays.

Zhang, Zhiming / Yan, Peng

The Review of scientific instruments

2023 Volume 94, Issue 6

Abstract: In this paper, a robust composite control strategy in the framework of unified infinite-dimensional H∞ optimal control is developed to support nano-scale periodic tracking with improved non-harmonic disturbance attenuation of piezo-actuated nano-stages ... ...

Abstract	In this paper, a robust composite control strategy in the framework of unified infinite-dimensional H∞ optimal control is developed to support nano-scale periodic tracking with improved non-harmonic disturbance attenuation of piezo-actuated nano-stages with sensor-induced measurement delays. In particular, we analyze the electromechanical coupled dynamics and derive a multi-perturbation model, where an extended Youla-Kucera parameterization-based repetitive controller with a disturbance observer is constructed to optimize control performances on high-precision tracking and perturbation rejection. The controller parameters are solved by using a unified infinite-dimensional H∞ optimization method. Comprehensive experiments on a piezo-actuated stage are conducted, where comparative results with representative methods, such as the conventional repetitive control and proportional-integral-derivative control, demonstrate significant performance improvements in hysteresis compensation, trajectory tracking, and disturbance suppression of the proposed method.
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0145677
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Numerical Simulation of Fluid Flow, Solidification, and Solute Distribution in Billets under Combined Mold and Final Electromagnetic Stirring.

Feng, Zhenhua / Zhang, Guifang / Li, Pengchao / Yan, Peng

Materials (Basel, Switzerland)

2024 Volume 17, Issue 2

Abstract: In this study, a three-dimensional segmented coupled model for continuous casting billets under combined mold and final electromagnetic stirring (M-EMS, F-EMS) was developed. The model was verified by comparing carbon segregation in billets with and ... ...

Abstract	In this study, a three-dimensional segmented coupled model for continuous casting billets under combined mold and final electromagnetic stirring (M-EMS, F-EMS) was developed. The model was verified by comparing carbon segregation in billets with and without EMS through plant experiments. The findings revealed that both M-EMS and F-EMS induce tangential flow in molten steel, impacting solidification and solute distribution processes within the billet. For M-EMS, with operating parameters of 250A-2Hz, the maximum tangential velocity (velocity projected onto the cross-section) was observed at the liquid phase's edge. For F-EMS, with operating parameters of 250A-6Hz, the maximum tangential velocity occurred at fl=0.7. Furthermore, F-EMS accelerated heat transfer in the liquid phase, reducing the central liquid fraction from 0.93 to 0.85. M-EMS intensified the washing effect of molten steel on the solidification front, resulting in the formation of negative segregation within the mold. F-EMS significantly improved the centerline segregation issue, reducing carbon segregation from 1.15 to 1.02. Experimental and simulation results, with and without EMS, were in good agreement, indicating that M+F-EMS leads to a more uniform solute distribution within the billet, with a pronounced improvement in centerline segregation.
Language	English
Publishing date	2024-01-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma17020530
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Bioinformatics reveals the pathophysiological relationship between diabetic nephropathy and periodontitis in the context of aging.

Yan, Peng / Ke, Ben / Fang, Xiangdong

Heliyon

2024 Volume 10, Issue 2, Page(s) e24872

Abstract: Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Periodontitis (PD) is a microbially-induced chronic inflammatory disease that is thought to have a bidirectional relationship with diabetes mellitus. DN ...

Abstract	Diabetic nephropathy (DN) is one of the most common microvascular complications of diabetes mellitus. Periodontitis (PD) is a microbially-induced chronic inflammatory disease that is thought to have a bidirectional relationship with diabetes mellitus. DN and PD are recognized as models associated with accelerated aging. This study is divided into two parts, the first of which explores the bidirectional causal relationship through Mendelian randomization (MR). The second part aims to investigate the relationship between PD and DN in terms of potential crosstalk genes, aging-related genes, biological pathways, and processes using bioinformatic methods. MR analysis showed no evidence to support a causal relationship between DN and PD (
Language	English
Publishing date	2024-01-18
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24872
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Article ; Online: Identification of molecular mediators of renal sarcopenia risk: a mendelian randomization analysis.

Yan, Peng / Ke, Ben / Fang, Xiangdong

The journal of nutrition, health & aging

2024 Volume 28, Issue 1, Page(s) 100019

Abstract: Background: Observational studies have shown an association between reduced renal function and the risk of sarcopenia. However, the causal relationship and the underlying biological mechanisms remain uncertain. Using a Mendelian randomization (MR) ... ...

Abstract	Background: Observational studies have shown an association between reduced renal function and the risk of sarcopenia. However, the causal relationship and the underlying biological mechanisms remain uncertain. Using a Mendelian randomization (MR) framework, we investigated the causal role of 27 hypothetical risk mediators, including metabolites, hormones, inflammation, and stress traits, on the risk of sarcopenia. Methods: Instrumental variables (IVs) to proxy renal function were identified by selecting single nucleotide polymorphisms (SNPs) reliably associated with creatinine and cystatin C-based glomerular filtration rate (GFR) in CKDGen summary data. IVs for putative risk traits and sarcopenia traits were constructed from relevant genome-wide association studies (GWAS). MR estimated effects were obtained using an inverse-variance weighted effects model, and various sensitivity analyses were performed. The mediating role of hypothetical risk factors in the relationship between GFR and sarcopenia was assessed through multivariate MR. Results: Genetically predicted reduced GFRcrea was associated with higher odds of appendicular lean mass (ALM) (odds ratio (OR): 0.64, 95% confidence interval (CI) 0.37 to 0.68) and grip strength (OR: 0.67; 95% CI 0.58 to 0.78). Likewise, GFRcys highlighted a causal relationship with ALM (OR: 0.52; 95% CI 0.42 to 0.65) and grip strength (OR: 0.66; 95% CI 0.59 to 0.74). Both estimated GFR (eGFR) were negatively associated with IGF-1, IL-16, 25(OH)D, triglycerides (range of effect size per standard deviation: -0.81 to -0.30), and positively correlated with HDL cholesterol (0.62, 0.31). There was a positive correlation between IGF-1, fasting insulin and ALM as well as grip strength (OR range: 1.04-1.67) and a negative correlation between serum CRP and ALM (OR: 0.95) as well as grip strength (OR: 0.98). Additionally, genetically predicted IL-1β (OR: 0.95) and total cholesterol (OR: 0.96) were negatively associated with ALM. We found evidence that IGF-1 mediates the relationship between eGFR and risk for muscle mass and strength. Conclusions: This MR study provides insight into the potential causal mechanisms between renal function and the risk of sarcopenia and proposes IGF-1 as a potential target for the prevention of renal sarcopenia.
MeSH term(s)	Humans ; Mendelian Randomization Analysis ; Insulin-Like Growth Factor I/genetics ; Genome-Wide Association Study ; Sarcopenia/genetics ; Kidney
Chemical Substances	Insulin-Like Growth Factor I (67763-96-6)
Language	English
Publishing date	2024-01-01
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2081921-3
ISSN	1760-4788 ; 1279-7707
ISSN (online)	1760-4788
ISSN	1279-7707
DOI	10.1016/j.jnha.2023.100019
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Article ; Online: Optimized rituximab regimen versus recommended regimen for idiopathic membranous nephropathy: A single-center retrospective cohort study.

Yan, Peng / Fang, Xiangdong / Ke, Ben

International immunopharmacology

2024 Volume 130, Page(s) 111718

Abstract: Background: Rituximab (RTX) has become the first-line treatment for idiopathic membranous nephropathy (IMN). Compared with conventional therapy, rituximab therapy has a more favorable safety profile. However, the recommended RTX dose as a flux may have ... ...

Abstract	Background: Rituximab (RTX) has become the first-line treatment for idiopathic membranous nephropathy (IMN). Compared with conventional therapy, rituximab therapy has a more favorable safety profile. However, the recommended RTX dose as a flux may have its limitations. The aim of this study was to investigate the clinical efficacy and safety of three regimens, including a cyclic corticosteroid-cyclophosphamide regimen and two different doses of RTX regimens, for the treatment of IMN. Methods: We recruited 58 patients with IMN confirmed by renal biopsy. 20 patients were treated with a cycle regimen, 22 patients were received RTX with 500 mg per week, totaling a dose of 2000 mg (optimized RTX group), and 16 patients received RTX with 1000 mg at day 1 and day 15 (recommended RTX group). Treatment responses, including complete remission (CR) and partial remission (PR), and outcome adverse events such as steroid diabetes, infections and a drop in white blood cell count, were compared among the three groups after 9 months of follow-up. Results: At 9-month follow-up, the composite remission rates (CR + PR) were 90 %, 72.7 %, and 75 % for the cycle regimen group, optimized RTX group, and recommended RTX group, respectively, with CR of 35 %, 22.7 %, and 25 %, respectively. There was no statistical difference between the three groups on CR and composite remission. Kaplan-Meier survival analyses showed no significant differences in cumulative CR rates and cumulative composite remission rates among the three groups (P = 0.632, P = 0.258). The cycle regimen group had a higher risk of steroid diabetes (35 %). Compared with the recommended RTX regimen, the optimized regimen reduced the incidence of adverse events of infection (9.1 % vs. 37.5 %, P = 0.049), especially in patients older than 60 years of age (P = 0.026). A lower anti-PLA2R at baseline may be associated with a higher risk of infection (P = 0.043). Conclusions: The efficiency of low-dose and long-course of RTX regiment is not inferior to the recommended treatment regimen, and this regimen can effectively reduce the incidence of infection in patients with IMN. Moreover, we recommend a low-dose, long course of RTX treatment for the elderly.
MeSH term(s)	Humans ; Aged ; Rituximab/adverse effects ; Glomerulonephritis, Membranous/drug therapy ; Retrospective Studies ; Treatment Outcome ; Steroids/therapeutic use ; Diabetes Mellitus/drug therapy ; Immunosuppressive Agents/therapeutic use
Chemical Substances	Rituximab (4F4X42SYQ6) ; Steroids ; Immunosuppressive Agents
Language	English
Publishing date	2024-02-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2043785-7
ISSN	1878-1705 ; 1567-5769
ISSN (online)	1878-1705
ISSN	1567-5769
DOI	10.1016/j.intimp.2024.111718
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