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  1. Article ; Online: The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk

    Qin Li / Luo Qiang / Hu Yinlan / Yan Shuangshuang / Yang Xiaoqian / Zhang Yiwen / Xiong Feng / Wang Han

    Open Medicine, Vol 18, Iss 1, Pp 183-

    2023  Volume 90

    Abstract: Framingham risk score (FRS), systematic coronary risk evaluation (SCORE), the 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD), and their modified risk scores are the most common cardiovascular risk scores. The aim of this case– ... ...

    Abstract Framingham risk score (FRS), systematic coronary risk evaluation (SCORE), the 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD), and their modified risk scores are the most common cardiovascular risk scores. The aim of this case–control study was to evaluate the performance of cardiovascular risk scores in detecting carotid subclinical atherosclerosis (SCA) in patients with idiopathic inflammatory myopathies (IIMs). A total of 123 IIMs patients (71.5% female, mean age 50 ± 14 years) and 123 age- and gender-matched healthy controls were included in this study. Carotid SCA was more prevalent in IIMs patients compared with controls (77.2 vs 50.4%, P < 0.001). Moreover, patients with carotid SCA+ had older age, and all risk scores were significantly higher in IIMs patients with SCA+ compared to subjects with SCA− (all P < 0.001). According to FRS, SCORE, and ASCVD risk scores, 77.9, 96.8, and 66.7% patients with SCA+ were classified as low risk category, respectively. The modified scores also demonstrated a modest improvement in sensitivity. Notably, by adopting the optimal cutoff values, these risk scores had good discrimination on patients with SCA+, with area under curves of 0.802–0.893. In conclusion, all cardiovascular risk scores had a poor performance in identifying IIMs patients at high cardiovascular risk.
    Keywords autoimmune diseases ; cardiovascular risk score ; subclinical atherosclerosis ; Medicine ; R
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher De Gruyter
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Changes in the Soil Phosphorus Supply with Rice Straw Return in Cold Region

    Yan, Shuangshuang / Liu, Chunxue / Li, Jianan / Li, Jinwang / Cui, Can / Fan, Jinsheng / Gong, Zhenping / Zhang, Zhongxue / Yan, Chao

    Agronomy. 2023 Aug. 24, v. 13, no. 9

    2023  

    Abstract: Most phosphorus (P) in soil exists in nonlabile forms, leading to poor soil P supply capacity and limiting crop growth. This study evaluated the effect of 10 years of rice straw return on rice yield, soil P budget, P fractions, and phosphatase activity ... ...

    Abstract Most phosphorus (P) in soil exists in nonlabile forms, leading to poor soil P supply capacity and limiting crop growth. This study evaluated the effect of 10 years of rice straw return on rice yield, soil P budget, P fractions, and phosphatase activity to establish the relationship between soil P fractions and related microbial communities. Four treatments, i.e., no rice straw return (S0), low amount of rice straw return (S1), high amount of rice straw return (S2), and abandoned farmland (AL), were used in the evaluation. The results showed that rice straw return had no effect on the rice yield and P uptake, and the P budget was positive in the S2 treatment. Rice straw return increased the phosphatase activity and content of soil Olsen-P, total P, NaHCO₃-, and NaOH-extractable P, and the phosphatase activity and P fractions were both increased with the amount of straw returned. There was a positive correlation between most soil P fractions and active organic carbon fractions. Rice straw return changed the composition and abundance of soil phosphate-solubilizing bacteria (PSB). The findings showed that straw return decreased the proportion of soil nonlabile P, enhancing the soil P supply capacity, and they further showed that the abundance of PSB was not consistent with soil P content.
    Keywords abandoned land ; agronomy ; cold ; organic carbon ; phosphorus ; rice ; rice straw ; soil
    Language English
    Dates of publication 2023-0824
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2607043-1
    ISSN 2073-4395
    ISSN 2073-4395
    DOI 10.3390/agronomy13092214
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Systematic analysis of the UDP-glucosyltransferase family: discovery of a member involved in rutin biosynthesis in

    Gan, Yuwei / Yu, Bingwei / Liu, Renjian / Shu, Bingbing / Liang, Yonggui / Zhao, Yafei / Qiu, Zhengkun / Yan, Shuangshuang / Cao, Bihao

    Frontiers in plant science

    2023  Volume 14, Page(s) 1310080

    Abstract: Eggplant ( ...

    Abstract Eggplant (
    Language English
    Publishing date 2023-12-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2023.1310080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The poor performance of cardiovascular risk scores in identifying patients with idiopathic inflammatory myopathies at high cardiovascular risk.

    Qin, Li / Luo, Qiang / Hu, Yinlan / Yan, Shuangshuang / Yang, Xiaoqian / Zhang, Yiwen / Xiong, Feng / Wang, Han

    Open medicine (Warsaw, Poland)

    2023  Volume 18, Issue 1, Page(s) 20230703

    Abstract: Framingham risk score (FRS), systematic coronary risk evaluation (SCORE), the 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD), and their modified risk scores are the most common cardiovascular risk scores. The aim of this case- ... ...

    Abstract Framingham risk score (FRS), systematic coronary risk evaluation (SCORE), the 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD), and their modified risk scores are the most common cardiovascular risk scores. The aim of this case-control study was to evaluate the performance of cardiovascular risk scores in detecting carotid subclinical atherosclerosis (SCA) in patients with idiopathic inflammatory myopathies (IIMs). A total of 123 IIMs patients (71.5% female, mean age 50 ± 14 years) and 123 age- and gender-matched healthy controls were included in this study. Carotid SCA was more prevalent in IIMs patients compared with controls (77.2 vs 50.4%,
    Language English
    Publishing date 2023-05-17
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2829380-0
    ISSN 2391-5463
    ISSN 2391-5463
    DOI 10.1515/med-2023-0703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: A putative E3 ubiquitin ligase substrate receptor degrades transcription factor SmNAC to enhance bacterial wilt resistance in eggplant.

    Yan, Shuangshuang / Wang, Yixi / Yu, Bingwei / Gan, Yuwei / Lei, Jianjun / Chen, Changming / Zhu, Zhangsheng / Qiu, Zhengkun / Cao, Bihao

    Horticulture research

    2023  Volume 11, Issue 1, Page(s) uhad246

    Abstract: Bacterial wilt caused ... ...

    Abstract Bacterial wilt caused by
    Language English
    Publishing date 2023-11-27
    Publishing country England
    Document type Journal Article
    ISSN 2662-6810
    ISSN 2662-6810
    DOI 10.1093/hr/uhad246
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Transcriptome analysis reveals key genes involved in the eggplant response to high-temperature stress

    Liu, Renjian / Shu, Bingbing / Wang, Yuyuan / Yu, Bingwei / Wang, Yixi / Gan, Yuwei / Liang, Yonggui / Qiu, Zhengkun / Yang, Jianguo / Yan, Shuangshuang / Cao, Bihao

    Environmental and Experimental Botany. 2023 July, v. 211 p.105369-

    2023  

    Abstract: High-temperature stress (HTS) affects the quality and yield of vegetable crops. Eggplant seedlings, flower organs and fruits are affected by HTS. However, the molecular mechanism underlying heat resistance in eggplant remains unclear. A thermotolerant ... ...

    Abstract High-temperature stress (HTS) affects the quality and yield of vegetable crops. Eggplant seedlings, flower organs and fruits are affected by HTS. However, the molecular mechanism underlying heat resistance in eggplant remains unclear. A thermotolerant eggplant line, E390, and a thermosensitive eggplant line, HM, were identified in this study. The differences in the physiological indices, chlorophyll fluorescence, and photosynthetic system parameters of the E390 and HM eggplant lines were analysed under HTS. To better study gene expression under HTS, a transcriptome analysis of eggplant leaves subjected to 42 ℃ high-temperature treatment (HTT) for 0, 1, 6, and 12 h was performed. Gene Ontology (GO) enrichment, Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment, and expression trend analysis of the differentially expressed genes (DEGs) identified were performed. The expression patterns of the genes related to transcription factors (TFs), hormones, and heat stress were further analysed. Twenty-three candidate genes responding to HTS were identified. Moreover, their expression patterns were verified by quantitative real-time RTPCR (qRTPCR). Yeast experiment results revealed that HSP70, MYB44, AFP2, HSFA8, EGY3, HSFA3, and TIFY6B might enhance the heat resistance of eggplant. This study provides a reference for further research on the molecular mechanism of eggplant in response to HTS.
    Keywords chlorophyll ; eggplants ; flowers ; gene expression ; gene expression regulation ; gene ontology ; genome ; heat stress ; heat tolerance ; photosynthesis ; thermosensitivity ; transcriptomics ; yeasts ; HTS ; HTT ; GO ; KEGG ; DEG ; TF ; qRTPCR ; FAO ; Hsf-Hsp ; ER ; HSF ; HSR ; UPR ; ABA ; SA ; ET ; CK ; GA ; ROS ; RNA-seq ; MDA ; TBA ; Pro ; NBT ; DAB ; SOD ; POD ; AsA ; GSH ; mRNA ; rRNA ; PCA ; FDR ; STEM ; WGCNA ; SD/-Ura ; RT ; NPQ ; rETR ; FPKM ; MAPK ; JA ; Eggplant ; Transcriptome analysis ; Heat resistance
    Language English
    Dates of publication 2023-07
    Publishing place Elsevier B.V.
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 195968-2
    ISSN 0098-8472
    ISSN 0098-8472
    DOI 10.1016/j.envexpbot.2023.105369
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: CsIVP Modulates Low Nitrogen and High-Temperature Resistance in Cucumber.

    Yan, Shuangshuang / Yu, Bingwei / Ming, Fangyan / Liang, Yonggui / Zhong, Yanting / Wang, Zhongyi / Zhang, Xiaolan / Li, Xuexian / Qiu, Zhengkun / Cao, Bihao

    Plant & cell physiology

    2022  Volume 63, Issue 5, Page(s) 605–617

    Abstract: Crop plants experience various abiotic stresses that reduce yield and quality. Although several adaptative physiological and defense responses to single stress have been identified, the behavior and mechanisms of plant response to multiple stresses ... ...

    Abstract Crop plants experience various abiotic stresses that reduce yield and quality. Although several adaptative physiological and defense responses to single stress have been identified, the behavior and mechanisms of plant response to multiple stresses remain underexamined. Herein, we determined that the leaf and vascular changes in Cucumis sativus Irregular Vasculature Patterning (CsIVP)-RNAi cucumber plants can enhance resistance to nitrogen deficiency and high-temperature stress. CsIVP negatively regulated high nitrate affinity transporters (NRT2.1, NRT2.5) and reallocation transporters (NRT1.7, NRT1.9, NRT1.12) under low nitrogen stress. Furthermore, CsIVP-RNAi plants have high survival rate with low heat injury level under high-temperature condition. Several key high-temperature regulators, including Hsfs, Hsps, DREB2C, MBF1b and WRKY33 have significant expression in CsIVP-RNAi plants. CsIVP negatively mediated high-temperature responses by physically interacting with CsDREB2C. Altogether, these results indicated that CsIVP integrates innate programming of plant development, nutrient transport and high-temperature resistance, providing a potentially valuable target for breeding nutrient-efficient and heat-resistant crops.
    MeSH term(s) Cucumis sativus/metabolism ; Gene Expression Regulation, Plant ; Hot Temperature ; Nitrogen/metabolism ; Plant Breeding ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Temperature
    Chemical Substances Plant Proteins ; Nitrogen (N762921K75)
    Language English
    Publishing date 2022-02-08
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 208907-5
    ISSN 1471-9053 ; 0032-0781
    ISSN (online) 1471-9053
    ISSN 0032-0781
    DOI 10.1093/pcp/pcac020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Integrated proteomics and metabolomics analysis of rice leaves in response to rice straw return.

    Yan, Shuangshuang / Gong, Shengdan / Sun, Kexin / Li, Jinwang / Zhang, Hongming / Fan, Jinsheng / Gong, Zhenping / Zhang, Zhongxue / Yan, Chao

    Frontiers in plant science

    2022  Volume 13, Page(s) 997557

    Abstract: Straw return is crucial for the sustainable development of rice planting, but no consistent results were observed for the effect of straw return on rice growth. To investigate the response of rice leaves to rice straw return in Northeast China, two ... ...

    Abstract Straw return is crucial for the sustainable development of rice planting, but no consistent results were observed for the effect of straw return on rice growth. To investigate the response of rice leaves to rice straw return in Northeast China, two treatments were set, no straw return (S0) and rice straw return (SR). We analyzed the physiological index of rice leaves and measured differentially expressed proteins (DEPs) and differentially expressed metabolites (DEMs) levels in rice leaves by the use of proteomics and metabolomics approaches. The results showed that, compared with the S0 treatment, the SR treatment significantly decreased the dry weight of rice plants and non-structural carbohydrate contents and destroyed the chloroplast ultrastructure. In rice leaves of SR treatment, 329 DEPs were upregulated, 303 DEPs were downregulated, 44 DEMs were upregulated, and 71 DEMs were downregulated. These DEPs were mainly involved in photosynthesis and oxidative phosphorylation, and DEMs were mainly involved in alpha-linolenic acid metabolism, galactose metabolism, glycerophospholipid metabolism, pentose and gluconic acid metabolism, and other metabolic pathways. Rice straw return promoted the accumulation of scavenging substances of active oxygen and osmotic adjustment substances, such as glutathione, organic acids, amino acids, and other substances. The SR treatment reduced the photosynthetic capacity and energy production of carbon metabolism, inhibiting the growth of rice plants, while the increase of metabolites involved in defense against abiotic stress enhanced the adaptability of rice plants to straw return stress.
    Language English
    Publishing date 2022-09-13
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2613694-6
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2022.997557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Association between organophosphorus pesticide exposure and depression risk in adults: A cross-sectional study with NHANES data.

    Wu, Yudong / Song, Jian / Zhang, Qin / Yan, Shuangshuang / Sun, Xiaoni / Yi, Weizhuo / Pan, Rubing / Cheng, Jian / Xu, Zhiwei / Su, Hong

    Environmental pollution (Barking, Essex : 1987)

    2022  Volume 316, Issue Pt 1, Page(s) 120445

    Abstract: Organophosphorus pesticides (OPPs) are widely used pesticides, and previous studies showed that OPPs can increase the risk of central nervous system disorders (e.g., Parkinson's and Alzheimer's disease). However, few studies have comprehensively explored ...

    Abstract Organophosphorus pesticides (OPPs) are widely used pesticides, and previous studies showed that OPPs can increase the risk of central nervous system disorders (e.g., Parkinson's and Alzheimer's disease). However, few studies have comprehensively explored their association with depression in general adults. We analyzed data from 5206 participants aged 20 years or more based on four National Health and Nutrition Examination Survey (NHANES) cycles. OPPs exposure was estimated using measures of urinary concentrations for six OPPs metabolites. Survey-weighted generalized linear regression model (SWGLM) was used to explore the association of OPPs metabolites with depression. Subgroup analyses were performed by age (≦60 years and >60 years) and gender. The weighted quantile sum (WQS) regression model was used to explore the overall association of six OPPs metabolites with depression. In addition, The Bayesian kernel machine regression (BKMR) model was applied to investigate the interaction and joint effects of multiple OPPs metabolites with depression. The SWGLM showed that dimethyl phosphate (DMP) and dimethyl thiophosphate (DMTP), whether taken as continuous or quartile variables, had a positive correlation with depression. Diethyl phosphate (DEP) and dimethyl dithiophosphate (DMDTP) in the highest quartile were positively associated with depression compared to the lowest quartile. In subgroup analysis, we found that the effects of the above chemicals on depression existed in the male and young middle-aged population, while DMP was present in the female. There was a significant combined overall effect of six OPPs metabolites with depression [OR = 1.232, 95%CI: (1.011, 1.504)] in WQS. Furthermore, the BKMR model also showed a positive trend in the overall effect of six OPPs metabolites with depression. In conclusion, our results suggest that exposure to OPPs may increase the risk of depression in US adults. Men and young and middle-aged populations are more vulnerable to OPPs and the mixture of OPPs metabolites may induce depression.
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2022.120445
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Heat Stress Resistance Mechanisms of Two Cucumber Varieties from Different Regions.

    Yu, Bingwei / Ming, Fangyan / Liang, Yonggui / Wang, Yixi / Gan, Yuwei / Qiu, Zhengkun / Yan, Shuangshuang / Cao, Bihao

    International journal of molecular sciences

    2022  Volume 23, Issue 3

    Abstract: High temperatures affect the yield and quality of vegetable crops. Unlike thermosensitive plants, thermotolerant plants have excellent systems for withstanding heat stress. This study evaluated various heat resistance indexes of the thermotolerant ... ...

    Abstract High temperatures affect the yield and quality of vegetable crops. Unlike thermosensitive plants, thermotolerant plants have excellent systems for withstanding heat stress. This study evaluated various heat resistance indexes of the thermotolerant cucumber (TT) and thermosensitive cucumber (TS) plants at the seedling stage. The similarities and differences between the regulatory genes were assessed through transcriptome analysis to understand the mechanisms for heat stress resistance in cucumber. The TT plants exhibited enhanced leaf status, photosystem, root viability, and ROS scavenging under high temperature compared to the TS plants. Additionally, transcriptome analysis showed that the genes involved in photosynthesis, the chlorophyll metabolism, and defense responses were upregulated in TT plants but downregulated in TS plants. Zeatin riboside (ZR), brassinosteroid (BR), and jasmonic acid (JA) levels were higher in TT plants than in TS. The heat stress increased gibberellic acid (GA) and indoleacetic acid (IAA) levels in both plant lines; however, the level of GA was higher in TT. Correlation and interaction analyses revealed that heat cucumber heat resistance is regulated by a few transcription factor family genes and metabolic pathways. Our study revealed different phenotypic and physiological mechanisms of the heat response by the thermotolerant and thermosensitive cucumber plants. The plants were also shown to exhibit different expression profiles and metabolic pathways. The heat resistant pathways and genes of two cucumber varieties were also identified. These results enhance our understanding of the molecular mechanisms of cucumber response to high-temperature stress.
    MeSH term(s) Cucumis sativus/genetics ; Cucumis sativus/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Plant ; Heat-Shock Response/genetics ; Plant Proteins/genetics ; Plant Proteins/metabolism ; Seedlings/genetics ; Seedlings/metabolism ; Transcriptome
    Chemical Substances Plant Proteins
    Language English
    Publishing date 2022-02-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23031817
    Database MEDical Literature Analysis and Retrieval System OnLINE

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