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  1. Article ; Online: The role of cortical midline structure in diagnoses and neuromodulation for major depressive disorder.

    Yan, Xinyuan

    Psychoradiology

    2024  Volume 4, Page(s) kkae001

    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ISSN 2634-4416
    ISSN (online) 2634-4416
    DOI 10.1093/psyrad/kkae001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: CSK may be a potential prognostic biomarker reflecting the immune status of gastric cancer.

    Yan, X / Huan, J

    European review for medical and pharmacological sciences

    2024  Volume 28, Issue 1, Page(s) 221–230

    Abstract: Objective: C-terminal Src kinase (CSK), a sarcoma (Src) homologous family kinase, is one of the most important negative regulators. It acts as a tumor suppressor by inhibiting the activity of Src family tyrosine kinases. Paradoxically, CSK is highly ... ...

    Abstract Objective: C-terminal Src kinase (CSK), a sarcoma (Src) homologous family kinase, is one of the most important negative regulators. It acts as a tumor suppressor by inhibiting the activity of Src family tyrosine kinases. Paradoxically, CSK is highly expressed in a variety of common tumors. Therefore, we report the expression profile of CSK in pan-cancer patients, focusing on the prognostic value, immune infiltration pattern, and biological function of CSK in gastric cancer.
    Materials and methods: We used the TCGA database to analyze CSK expression, clinical relevance, prognostic significance, assessment of the tumor immune microenvironment, and GO and Kegg enrichment analysis based on co-expressed genes using a bioinformatics approach.
    Results: CSK is a protective factor in gastric cancer, and its expression correlates with the level of immune cell infiltration and immune checkpoint molecules.
    Conclusions: Our findings suggest that CSK is an independent prognostic factor in gastric cancer and may predict molecular targeting and immunotherapy and provide ideas for its therapeutic strategy.
    MeSH term(s) Humans ; src-Family Kinases/metabolism ; Phosphorylation ; CSK Tyrosine-Protein Kinase/metabolism ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics ; Prognosis ; Biomarkers/metabolism ; Tumor Microenvironment
    Chemical Substances src-Family Kinases (EC 2.7.10.2) ; CSK Tyrosine-Protein Kinase (EC 2.7.10.2) ; Biomarkers
    Language English
    Publishing date 2024-01-18
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 605550-3
    ISSN 2284-0729 ; 1128-3602 ; 0392-291X
    ISSN (online) 2284-0729
    ISSN 1128-3602 ; 0392-291X
    DOI 10.26355/eurrev_202401_34907
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1887: Show issues Location:
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  3. Book ; Online: Sustainability with Changing Climate and Extremes

    Yan, Xiaodong / Yang, Jia / Jin, Shaofei

    2022  

    Keywords Research & information: general ; Environmental economics ; trade conflict ; carbon emissions ; import and export trade ; cooperative emission reduction ; meteorological hazards ; risk assessment ; spatial pattern ; population exposure ; Qinghai-Tibet Plateau ; climate change ; slope geohazards ; new geohazard clusters ; extreme cooling events ; Arctic Oscillation ; winter in China ; atmospheric circulation ; GPP ; CMIP6 ; ESM ; STA ; China ; warm days ; cold days ; warm nights ; cold nights ; hot days ; frost days ; compound drought and heatwave events ; complex network ; event synchronization ; atmospheric circulation patterns ; urban agglomeration ; drought ; heat wave ; flood ; GM (1, 1) ; Arctic ; universal thermal climate index (UTCI) ; spatial-temporal changes ; 1979-2019 ; ecosystem services trade-offs ; land-use change ; soil conservation ; carbon storage ; water yield ; precipitation gradient ; Loess Plateau ; climate hazards ; geospatial analysis ; urban adaptation ; risk management ; snow disaster ; risk zoning ; Heilongjiang Province ; precipitation ; model resolutions ; cold region of China ; spatiotemporal distribution ; spatiotemporal variation ; 1961-2019 ; high-resolution and high-quality precipitation data ; independent and non-independent test ; the 0.01° multi-source fusion precipitation product ; extreme precipitation event ; forest types ; NDVI ; AVHRR GIMMS ; temperature range ; precipitation range ; snow cover ; black carbon concentration ; radiative forcing ; northeast China ; high temperature ; mobile phone data ; impact factor ; Zhuhai City ; WRF model ; projection ; short-lived heatwave event ; long-lived heatwave event ; Yangtze River Basin ; central and western Pacific ; thermocline ; yellowfin tuna ; CPUE ; El Niño ; La Niña ; GAM model ; spring soil moisture ; impact mechanism ; Songnen Plain ; Sanjiang Plain ; maize ; diurnal temperature range ; fresh air index ; natural microclimate comfort index ; fresh air-natural microclimate comfort index ; scenic spots ; Fujian province ; extreme climate indices ; temporal and spatial dynamics ; linear trend ; climate abrupt change ; central China ; peanut drought ; Shandong Province ; natural disaster risk assessment principles ; dry-hot wind disaster ; Shandong province ; natural disaster risk assessment principle ; summer maize ; inter- and mixed cropping ; flowering period ; yield ; potato climatic productivity potential ; Inner Mongolia ; effect ; human mobility ; rainfall ; taxi GPS data ; community ; Zhuhai central areas ; citrus ; quality ; future projection ; state-owned forest farms ; human resource allocation ; industrial structure ; coordination and adaptation ; personal structure ; contiguous poverty-stricken areas ; rainstorms and droughts ; direct economic losses ; disaster-affected population ; drought and flood ; vulnerability ; risk prediction ; agroecosystem ; heatwaves ; population exposure change ; global warming ; 1.5 °C warming scenario ; 2.0 °C warming scenario ; n/a
    Language English
    Size 1 electronic resource (588 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel
    Document type Book ; Online
    Note English
    HBZ-ID HT030380330
    ISBN 9783036558509 ; 3036558500
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Distinguishing atomic vibrations near point defects.

    Yan, Xingxu

    Nature materials

    2023  Volume 22, Issue 5, Page(s) 540–541

    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-023-01538-9
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  5. Article ; Online: Anthraquinone-fused enediynes: discovery, biosynthesis and development.

    Yan, Xiaohui

    Natural product reports

    2022  Volume 39, Issue 3, Page(s) 703–728

    Abstract: Covering: up to the end of July, 2021Anthraquinone-fused enediynes (AFEs) are a subfamily of enediyne natural products. Dynemicin A (DYN A), the first member of the AFE family, was discovered more than thirty years ago. Subsequently, extensive studies ... ...

    Abstract Covering: up to the end of July, 2021Anthraquinone-fused enediynes (AFEs) are a subfamily of enediyne natural products. Dynemicin A (DYN A), the first member of the AFE family, was discovered more than thirty years ago. Subsequently, extensive studies have been reported on the mode of action and the interactions of AFEs with DNA using DYN A as a model. However, progress in the discovery, biosynthesis and clinical development of AFEs has been limited for a long time. In the past five years, four new AFEs have been discovered and significant progress has been made in the biosynthesis of AFEs, especially on the biogenesis of the anthraquinone moiety and their tailoring steps. Moreover, the streamlined total synthesis of AFEs and their analogues boosts the preparation of AFE-based linker-drugs, thus enabling the development of AFE-based antibody-drug conjugates (ADCs). This review summarizes the discovery, mechanism of action, biosynthesis, total synthesis and preclinical studies of AFEs.
    MeSH term(s) Anthraquinones/pharmacology ; Biological Products/pharmacology ; Enediynes/pharmacology
    Chemical Substances Anthraquinones ; Biological Products ; Enediynes
    Language English
    Publishing date 2022-03-23
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2002546-4
    ISSN 1460-4752 ; 0265-0568
    ISSN (online) 1460-4752
    ISSN 0265-0568
    DOI 10.1039/d1np00054c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Being targeted: How counter-arguing and message relevance mediate the effects of cultural value appeals on disease prevention attitudes and behaviors.

    Yan, Xiaodi

    Frontiers in psychology

    2022  Volume 13, Page(s) 1018402

    Abstract: This study investigated the effects of cultural value appeals in health persuasion. Situated in the COVID-19 pandemic, this study examined if and how individualistic and collectivistic appeals can improve attitudes and behaviors related to the use of ... ...

    Abstract This study investigated the effects of cultural value appeals in health persuasion. Situated in the COVID-19 pandemic, this study examined if and how individualistic and collectivistic appeals can improve attitudes and behaviors related to the use of face masks among European Americans and Asian Americans. Results showed that for European Americans, collectivistic vs. individualistic appeals were more effective to improve attitudes and behavioral intention. Perceived message relevance and counter-arguing were significant mediators explaining the effects. For Asian Americans, both individualistic and collectivistic appeals predicted significant changes in attitudinal and behavioral outcomes. These findings have important theoretical and practical implications.
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.1018402
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Development and Optimization of Network Music Course Resources Based on Data Mining Technology under the Personalized Online Education Environment.

    Yan, Xiuli

    publication RETRACTED

    Journal of environmental and public health

    2022  Volume 2022, Page(s) 2876063

    Abstract: The ever-evolving Internet technology has brought more information resources for music teaching than ever before. For music educators, figuring out how to create and use these tools more effectively has become a pressing concern. China will usher in a ... ...

    Abstract The ever-evolving Internet technology has brought more information resources for music teaching than ever before. For music educators, figuring out how to create and use these tools more effectively has become a pressing concern. China will usher in a new age of innovation and integration between the Internet and different traditional businesses with the idea of "Internet Plus." MOOCs present significant challenges to traditional teachers and teaching methods as a typical practice of the transformation of education informatization to innovation, and they also drive global education toward a new process of informatization development. This paper adopts Internet thinking as the guiding ideology for the development of future music education concepts and, concurrently, conducts specific transformation research based on Internet technology from four aspects: music teaching content, music teaching methods, music education concepts, and the passing down of traditional music culture. The improved association rule algorithm is used to organise the students' access data, decide which high-frequency websites are accessible to the students, and realize the intuitive positioning of high-frequency access and learning issues. Assist the school's decision-making and educational levels in identifying the issues that students have with their learning, and then, improve the network teaching platform's material to complete the task of personalized network education.
    MeSH term(s) Data Mining ; Education, Distance ; Humans ; Learning ; Music ; Technology
    Language English
    Publishing date 2022-09-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Retracted Publication
    ZDB-ID 2526611-1
    ISSN 1687-9813 ; 1687-9813
    ISSN (online) 1687-9813
    ISSN 1687-9813
    DOI 10.1155/2022/2876063
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Shedding light on gene therapy of Parkinson's disease in non-human primates.

    Yan, Xunyi / Jin, Xin

    Innovation (Cambridge (Mass.))

    2024  Volume 5, Issue 2, Page(s) 100581

    Language English
    Publishing date 2024-01-24
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2666-6758
    ISSN (online) 2666-6758
    DOI 10.1016/j.xinn.2024.100581
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The "Hand as Foot" figural teaching method in anatomy of the anterior-chamber angle.

    Zhou, Qianzi / Yan, Xiaoteng

    Asian journal of surgery

    2024  Volume 47, Issue 4, Page(s) 1911–1912

    MeSH term(s) Humans ; Hand ; Upper Extremity ; Foot ; Lower Extremity
    Language English
    Publishing date 2024-01-05
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2831: Show issues Location:
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  10. Article ; Online: Learning Output Relevant Features by Joint Autoencoder.

    Yan, Shifu / Yan, Xuefeng

    IEEE transactions on cybernetics

    2024  Volume 54, Issue 2, Page(s) 1075–1083

    Abstract: Classical regression is a supervised task that uses target output to guide the modeling. Generally, the original input contains both output relevant and irrelevant information, whereas the latter may decrease the predictive performance to a certain ... ...

    Abstract Classical regression is a supervised task that uses target output to guide the modeling. Generally, the original input contains both output relevant and irrelevant information, whereas the latter may decrease the predictive performance to a certain extent. Without prior information about what information contributes to the prediction, the predictive performance of regression models can be improved based on such output relevant information as input. Thus, a joint autoencoder (JAE) combining the supervised and unsupervised mechanisms is proposed to learn output relevant features from the original input. In this way, both predictive and reconstructive performance are considered to learn the essential characteristics and avoid poor generalized performance on untrained instances. Meanwhile, hierarchy representations can be learned by successive JAEs with a local parameter embedding strategy, which is presented to preserve the predictive performance in this structure. In the experiments, the predictive performance and robustness of the proposal are verified on nine datasets with different sample sizes.
    Language English
    Publishing date 2024-01-17
    Publishing country United States
    Document type Journal Article
    ISSN 2168-2275
    ISSN (online) 2168-2275
    DOI 10.1109/TCYB.2022.3185588
    Database MEDical Literature Analysis and Retrieval System OnLINE

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