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Article ; Online: Diversity-Oriented Synthesis of Glycosylphosphatidylinositol Probes Based on an Orthogonally Protected Pentasaccharide.

Yan, Xin / Guo, Zhongwu

Organic letters

2023 Volume 25, Issue 12, Page(s) 2088–2092

Abstract: Two glycosylphosphatidylinositol (GPI) derivatives having an alkynyl group at different positions were derived from the same orthogonally protected pentasaccharide that in turn was assembled by a convergent [3+2] glycosylation strategy. The resultant ... ...

Abstract	Two glycosylphosphatidylinositol (GPI) derivatives having an alkynyl group at different positions were derived from the same orthogonally protected pentasaccharide that in turn was assembled by a convergent [3+2] glycosylation strategy. The resultant alkynylated GPIs are useful biological probes and are suitable for further modification by click reaction to obtain other GPI probes. The pentasaccharide is a versatile platform for the synthesis of various uniquely functionalized GPI probes.
MeSH term(s)	Glycosylphosphatidylinositols ; Oligosaccharides
Chemical Substances	Glycosylphosphatidylinositols ; Oligosaccharides
Language	English
Publishing date	2023-03-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.3c00448
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Preparation of metal organic frameworks modified chitosan composite with high capacity for Hg(II) adsorption.

Yan, Xin / Ge, Huacai

International journal of biological macromolecules

2023 Volume 232, Page(s) 123329

Abstract: In this study, a novel modified chitosan composite adsorbent (UNCS) was prepared by crosslinking between chitosan and metal organic frameworks (MOFs) material UiO-66- ... ...

Abstract	In this study, a novel modified chitosan composite adsorbent (UNCS) was prepared by crosslinking between chitosan and metal organic frameworks (MOFs) material UiO-66-NH
MeSH term(s)	Chitosan/chemistry ; Metal-Organic Frameworks ; Adsorption ; Kinetics ; Spectroscopy, Fourier Transform Infrared ; Water Pollutants, Chemical/chemistry ; Mercury/chemistry ; Hydrogen-Ion Concentration
Chemical Substances	Chitosan (9012-76-4) ; Metal-Organic Frameworks ; Water Pollutants, Chemical ; Mercury (FXS1BY2PGL)
Language	English
Publishing date	2023-01-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.123329
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Article ; Online: Esophageal Foreign Body Missed Diagnosis; an Analysis of 12 Cases.

Yan, Xin / Dai, Guoping

Archives of academic emergency medicine

2023 Volume 11, Issue 1, Page(s) e65

Abstract: Missed diagnosis of foreign bodies in esophagus occasionally results in adverse consequences for patients. This study aimed to analyze the clinical characteristics of esophageal foreign body missed diagnosis in 12 cases. Among the 12 patients, 7 didn't ... ...

Abstract	Missed diagnosis of foreign bodies in esophagus occasionally results in adverse consequences for patients. This study aimed to analyze the clinical characteristics of esophageal foreign body missed diagnosis in 12 cases. Among the 12 patients, 7 didn't undergo esophagus-related examination due to mild pain; One case didn't report a clear history of swallowing foreign bodies. For one case, computed tomography (CT) examination had not reached the esophageal foreign body level. Two cases were missed diagnosis because the foreign bodies were too tiny to develop clearly on CT. One case showed foreign body in esophagus during initial CT examination, but after subsequent gastroscopy, no foreign body was found. Among the 12 patients, 7 had esophageal perforation, 1 of which developed a neck abscess, and 1 had peri-esophageal abscess. It seems that, if foreign bodies in the pharynx or esophagus are suspected and no foreign bodies are found in the laryngoscope, chest CT scan is necessary. It is best to perform examination of full-length esophagus and pharynx, because foreign bodies may exist in the post-cricoid region or the deep part of the pyriform sinus, especially in older cases with longer retention times.
Language	English
Publishing date	2023-09-22
Publishing country	Iran
Document type	Case Reports
ISSN	2645-4904
ISSN (online)	2645-4904
DOI	10.22037/aaem.v11i1.2102
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Article: Nanoparticle-Mediated Strategies for Enhanced Drug Penetration and Retention in the Airway Mucosa.

Yan, Xin / Sha, Xianyi

Pharmaceutics

2023 Volume 15, Issue 10

Abstract: Airway mucus is a complex viscoelastic gel composed mainly of water, glycoproteins, lipids, enzymes, minerals, etc. Among them, glycoproteins are the main factors determining mucus's gel-like rheology. Airway mucus forms a protective barrier by secreting ...

Abstract	Airway mucus is a complex viscoelastic gel composed mainly of water, glycoproteins, lipids, enzymes, minerals, etc. Among them, glycoproteins are the main factors determining mucus's gel-like rheology. Airway mucus forms a protective barrier by secreting mucin, which represents a barrier for absorption, especially for more lipophilic drugs. It rapidly removes drugs from the airway through the physiological mucus clearance mechanism so drugs cannot remain in the lungs or reach the airway epithelial tissue for a long time. Significant progress has been made in enhancing drug lung deposition recently, but strategies are still needed to help drugs break through the lung mucosal barrier. Based on the physiopathological mechanisms of airway mucus, this paper reviews and summarizes strategies to enhance drug penetration and retention in the airway mucosa mediated by nano-delivery systems, including mucosal permeation systems, mucosal adhesion systems, and enzyme-modified delivery systems. On this basis, the potential and challenges of nano-delivery systems for improving airway mucus clearance are revealed. New ideas and approaches are provided for designing novel nano-delivery systems that effectively improve drug retention and penetration in the airway mucus layer.
Language	English
Publishing date	2023-10-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15102457
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Innovative Cyanine-Based Fluorescent Dye for Targeted Mitochondrial Imaging and Its Utility in Whole-Brain Visualization.

Yan, Xin / Chen, Xinqian / Shan, Zhiying / Bi, Lanrong

ACS omega

2024 Volume 9, Issue 2, Page(s) 2585–2596

Abstract: Conducting in vivo brain imaging can be a challenging task due to the complexity of brain tissue and the strict requirements for safe and effective imaging agents. However, a new fluorescent dye called Cy5-PEG2 has been developed that selectively ... ...

Abstract	Conducting in vivo brain imaging can be a challenging task due to the complexity of brain tissue and the strict requirements for safe and effective imaging agents. However, a new fluorescent dye called Cy5-PEG2 has been developed that selectively accumulates in mitochondria, enabling the visualization of these essential organelles in various cell lines. This dye is versatile and can be used for the real-time monitoring of mitochondrial dynamics in living cells. Moreover, it can cross the blood-brain barrier, making it a promising tool for noninvasive in vivo brain imaging. Based on the assessment of glial cell responses in the hippocampus and neocortex regions using GFAP and Iba1 biomarkers, Cy5-PEG2 seems to have minimal adverse effects on brain immune response or neuronal health. Therefore, this mitochondria-targeting fluorescent dye has the potential to advance our understanding of mitochondrial dynamics and function within the broader context of whole-brain physiology and disease progression. However, further research is needed to evaluate the safety and efficacy of Cy5-PEG2.
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c07374
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Article ; Online: Cervical Dystonia Caused by Variant of ATP13A2 Responsive to Subthalamic Deep Brain Stimulation.

Zhao, Mingming / Yan, Xin / Wang, Lin / Yin, Feng

Movement disorders : official journal of the Movement Disorder Society

2024

Language	English
Publishing date	2024-04-08
Publishing country	United States
Document type	Letter
ZDB-ID	607633-6
ISSN	1531-8257 ; 0885-3185
ISSN (online)	1531-8257
ISSN	0885-3185
DOI	10.1002/mds.29759
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Article ; Online: The interactive force between fat, oil, and grease (FOG) deposits and the effect of food waste disposers on kitchen drainage systems.

Yan, Xin / Guan, Yuxi / Fang, Zheng

Waste management (New York, N.Y.)

2024 Volume 180, Page(s) 85–95

Abstract: Food waste disposers (FWDs) streamline kitchen waste management and facilitate waste classification, whether they would increase the potential of blockage in kitchen drainage system is still unknown. This study conducted a theoretical analysis of the ... ...

Abstract	Food waste disposers (FWDs) streamline kitchen waste management and facilitate waste classification, whether they would increase the potential of blockage in kitchen drainage system is still unknown. This study conducted a theoretical analysis of the interactive forces between fat, oil, and grease (FOG) deposits and their aggregation on pipe walls. The study involved grading food waste particles processed by FWDs using sieving and weighing techniques to determine the mean weight diameter (MWD) of various aggregations. A full-scale experimental system, implemented in a 60-m high test tower, simulated blockages in horizontal pipes of high-rise buildings. The effect of pipeline materials and particle sizes on blockage were examined by measuring the adhesion of deposits on horizontal pipes. Energy dispersive spectrometer (EDS) analysis suggested that liquid bridge force is a primary factor in aggregate formation. Hand-cut particles formed aggregates with the highest MWD value. Particle size analysis revealed that sizes ranging from 2.36 to 4.75 mm, 1.18-2.36 mm, and 0.60-1.18 mm constituted over 80 % of particles ground by FWDs, with an average size of 2.16 mm. Results of full-scale experiment indicate particle diameters, friction coefficients and lipophilic coefficient significantly affected the propensity of these aggregates to adhere to pipes. Notably, particles processed by FWDs tended to cause blockages more frequently than hand-cut particles. These findings elucidate the deposition mechanism of FOG deposits and offer strategies to reduce blockages in kitchen drainage systems, such as reducing current grinding particle size by 18 % to 1.77 mm or selecting pipes like cast iron and high-density polyethylene.
MeSH term(s)	Fats ; Food Loss and Waste ; Sewage ; Food ; Refuse Disposal ; Hydrocarbons
Chemical Substances	Fats ; Food Loss and Waste ; Sewage ; Hydrocarbons
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2001471-5
ISSN	1879-2456 ; 0956-053X
ISSN (online)	1879-2456
ISSN	0956-053X
DOI	10.1016/j.wasman.2024.03.020
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Article ; Online: Lipid Isobaric Mass Tagging for Enhanced Relative Quantification of Unsaturated

Yang, Tingyuan / Tang, Shuli / Feng, Jiaxin / Yan, Xin

ACS measurement science au

2024 Volume 4, Issue 2, Page(s) 213–222

Abstract: Changes in the levels of ... ...

Abstract	Changes in the levels of lipid
Language	English
Publishing date	2024-01-11
Publishing country	United States
Document type	Journal Article
ISSN	2694-250X
ISSN (online)	2694-250X
DOI	10.1021/acsmeasuresciau.3c00062
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Article ; Online: Computational Comparative Study of the Binding of Americium with N-Donor Ligands.

Yan, Xin / Jiang, Hui / Liu, Ziyi / Wang, Dongqi

Inorganic chemistry

2024 Volume 63, Issue 18, Page(s) 8206–8214

Abstract: The accessibility of multiple valence states of americium (Am) inspired redox-based protocols aimed at efficient separation of trivalent Am ( ... ...

Abstract	The accessibility of multiple valence states of americium (Am) inspired redox-based protocols aimed at efficient separation of trivalent Am (Am
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.4c00448
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Article ; Online: Knowledge Reuse in Product-Service Systems

Yan Xin / Ville Ojanen

Sustainability, Vol 14, Iss 14504, p

2022 Volume 14504

Abstract: The current study examines knowledge reuse (focused on the recipient) from a product life-cycle perspective in the context of product-service systems through 27 semi-structured interviews in 11 firms. This study focused on the phases of the beginning-of- ... ...

Abstract	The current study examines knowledge reuse (focused on the recipient) from a product life-cycle perspective in the context of product-service systems through 27 semi-structured interviews in 11 firms. This study focused on the phases of the beginning-of-life (represented by R&D, purchasing, and production) and the middle-of-life (represented by logistics, customer service/quality, and sales). Similarities and differences were found between and within the two phases and the six sub-phases. Our research suggests that to remain competitive, a consistent understanding of the knowledge requirements for both sender and recipient should be identified, a match between the knowledge sourced and the mechanism employed should be made, and organizational culture/mechanisms to retain higher-caliber employees should be prioritized.
Keywords	knowledge reuse ; product life cycle ; product-service systems ; sustainability ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	670
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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