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Article: [Current status and challenges of long-term safety evaluation of using tests of cosmetics on human body].

Yan, Y C / Li, H / Tian, Y

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine

2024 Volume 57, Issue 12, Page(s) 2220–2223

Abstract: The use of cosmetics in the crowd has the long-term characteristics. The adverse reactions of cosmetics reported in other country in the world suggest that human patch tests and short-term human using test may not be sufficient to evaluate the safety of ... ...

Abstract	The use of cosmetics in the crowd has the long-term characteristics. The adverse reactions of cosmetics reported in other country in the world suggest that human patch tests and short-term human using test may not be sufficient to evaluate the safety of high-risk new cosmetic raw ingredients, and long-term human using test should be conducted for evaluation. Therefore, this article reviews the key factors that affect long-term human trial trials, such as site of use, single-use amount, frequency of use, duration of use, and subject conditions, providing supportive evidence for standardized safety evaluation standards for long-term human using test of cosmetics.
MeSH term(s)	Humans ; Cosmetics ; Human Experimentation
Chemical Substances	Cosmetics
Language	Chinese
Publishing date	2024-01-08
Publishing country	China
Document type	Review ; English Abstract ; Journal Article
ZDB-ID	604575-3
ISSN	0253-9624
ISSN	0253-9624
DOI	10.3760/cma.j.cn112150-20230509-00358
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Article ; Online: Immunobiology of Sperm Membrane Protiens.

Wang, L F / Yan, Y C / Koide, S S

Development, growth & differentiation

2023 Volume 28 Suppl s1, Page(s) 31–32

Language	English
Publishing date	2023-06-06
Publishing country	Japan
Document type	Journal Article
ZDB-ID	280433-5
ISSN	1440-169X ; 0012-1592
ISSN (online)	1440-169X
ISSN	0012-1592
DOI	10.1111/j.1440-169X.1986.28s1_31.x
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Article: [Chronic non-bacterial osteomyelitis with autoimmune hepatitis: a case report and literature review].

Jin, M / Zhong, X M / Yan, Y C / Yao, K Y / Lai, J M

Zhonghua er ke za zhi = Chinese journal of pediatrics

2023 Volume 61, Issue 7, Page(s) 637–641

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Female ; Humans ; Child ; Glucocorticoids ; Retrospective Studies ; Hepatitis, Autoimmune/complications ; Hepatitis, Autoimmune/diagnosis ; Hepatitis, Autoimmune/drug therapy ; Alanine Transaminase ; Osteomyelitis/diagnosis ; Osteomyelitis/drug therapy
Chemical Substances	Glucocorticoids ; Alanine Transaminase (EC 2.6.1.2)
Language	Chinese
Publishing date	2023-06-29
Publishing country	China
Document type	Review ; Case Reports ; English Abstract ; Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
DOI	10.3760/cma.j.cn112140-20230112-00028
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Article: TERF1 Regulates Nuclear Gene Expression Through Chloroplast Retrograde Signals

Wu, W / Liu, L. L / Yan, Y. C

Russian journal of plant physiology. 2019 Jan., v. 66, no. 1

2019

Abstract: Ethylene is an important phytohormone that regulates many important biological processes in plant. ERF (ethylene response factor) proteins are key transcription factors that activate the ethylene signaling pathway. However, our knowledge about the ... ...

Abstract	Ethylene is an important phytohormone that regulates many important biological processes in plant. ERF (ethylene response factor) proteins are key transcription factors that activate the ethylene signaling pathway. However, our knowledge about the mechanism of the ERF transcription factors in regulating nuclear genes expression is limited. Retrograde signaling pathway in chloroplast is a novel kind of mechanism that regulates nuclear gene expression by different signals in plastid. Based on our former research we analyzed the components related with retrograde signaling from plastid in the transgenic tobacco overexpressing TERF1, a member of ERF family transcription factors, to elucidate the interaction between ethylene signaling pathway and different retrograde signaling pathway in plastid under normal growth condition. Results show that TERF1 regulates different retrograde signals in plastid and thus regulates different nuclear genes expression under normal growth condition. We propose a new mechanism that links ethylene signaling pathway and retrograde signaling pathway as well as new potential of TERF1 in regulating nuclear genes expression at post-transcriptional level.
Keywords	chloroplasts ; ethylene ; gene overexpression ; genes ; tobacco ; transcription factors ; transgenic plants
Language	English
Dates of publication	2019-01
Size	p. 22-28.
Publishing place	Pleiades Publishing
Document type	Article
ZDB-ID	1166808-8
ISSN	1608-3407 ; 1070-3292 ; 1021-4437
ISSN (online)	1608-3407
ISSN	1070-3292 ; 1021-4437
DOI	10.1134/S1021443719010205
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Article: [Clinical analysis of six cases of mucormycosis in children with acute leukemia].

Zhang, L / Zhong, D X / Yue, M / Xuan, L T / Zhang, Z X / Li, J J / Li, J H / Zou, J Z / Yan, Y C / Liu, R

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi

2023 Volume 44, Issue 7, Page(s) 594–597

MeSH term(s)	Humans ; Child ; Mucormycosis/complications ; Mucormycosis/drug therapy ; Leukemia, Myeloid, Acute/complications ; Leukemia, Myeloid, Acute/drug therapy ; Acute Disease ; Antifungal Agents/therapeutic use
Chemical Substances	Antifungal Agents
Language	Chinese
Publishing date	2023-09-24
Publishing country	China
Document type	Journal Article
ZDB-ID	2997162-7
ISSN	0253-2727 ; 0253-2727
ISSN (online)	0253-2727
ISSN	0253-2727
DOI	10.3760/cma.j.issn.0253-2727.2023.07.014
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Article: [Factors affecting BK polyomavirus infection after kidney transplantation in post-school children and a predictive infection model].

Yan, Y C / Wang, Z G / Qi, Y B / Feng, Y / Feng, Y H / Jia, Y L / Cheng, F M / Feng, G W / Jiang, W / Shang, W W

Zhonghua yi xue za zhi

2023 Volume 103, Issue 20, Page(s) 1538–1545

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Male ; Female ; Humans ; Child, Preschool ; Child ; Adolescent ; Infant ; Kidney Transplantation/adverse effects ; Retrospective Studies ; Tacrolimus ; Viremia/etiology ; Kidney Diseases ; Polyomavirus Infections/epidemiology ; BK Virus ; Tumor Virus Infections/epidemiology
Chemical Substances	Tacrolimus (WM0HAQ4WNM)
Language	Chinese
Publishing date	2023-05-22
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20230105-00021
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Article ; Online: WWOX regulates the Elf5/Snail1 pathway to affect epithelial-mesenchymal transition of ovarian carcinoma cells in vitro.

Xu, Y / Yan, Y-C / Hu, Y-K / Fang, L-S / Li, Q / Xu, J / Yan, H-C

European review for medical and pharmacological sciences

2020 Volume 24, Issue 3, Page(s) 1041–1053

Abstract: Objective: Ovarian cancer is a highly invasive type of cancer. A previous study demonstrated that E-cadherin expression was upregulated in a human ovarian cancer cell line with a high expression of WW domain-containing oxidoreductase (WWOX), which is a ... ...

Abstract	Objective: Ovarian cancer is a highly invasive type of cancer. A previous study demonstrated that E-cadherin expression was upregulated in a human ovarian cancer cell line with a high expression of WW domain-containing oxidoreductase (WWOX), which is a tumor suppressor. Also, the migration and invasion ability of these cells was reduced. Snail family members are involved in the epithelial-to-mesenchymal transition (EMT) of ovarian cancer cells, and the expression of Snail family members is regulated by the transcription factor Elf5. The aim of the present research was to elucidate the role of WWOX in EMT of ovarian carcinoma cells through the Elf5/Snail pathway by gain and loss of function approaches in in vitro experiments. Materials and methods: First, a WWOX gene expressing plasmid was transfected into CD133+CD117+ HO8910 ovarian carcinoma cells, and an Elf5 shRNA plasmid was transfected into these cells to assess the changes in EMT-related factors, including Snail1, and the invasive ability of tumor cells ability. Second, the human ovarian carcinoma cell lines HO8910 and SKOV3 were divided into six groups to detect the same indicators. Results: The results demonstrated that the high expression of WWOX resulted in an increased E-cadherin expression, decreased Snail1 activity, and decreased invasion ability in CD133+CD117+ HO8910 cells. Elf5 shRNA transfection did not affect the WWOX expression; however, it decreased the expression of E-cadherin and Elf5 activity, while increasing Snail1 activity and invasion ability in CD133+CD117+ HO8910 cells. It was also observed that WWOX overexpression in HO8910 and SKOV3 cells inhibited the expression of EMT-related proteins and inhibited cell migration and invasion. Conclusions: Taken together, the results of the present report suggest that WWOX can decrease Snail1 activity by enhancing the activity of Elf5, thus upregulating E-cadherin expression and eventually inhibiting EMT of ovarian carcinoma.
MeSH term(s)	Carcinoma, Ovarian Epithelial/genetics ; Carcinoma, Ovarian Epithelial/metabolism ; Cell Line, Tumor ; DNA-Binding Proteins/biosynthesis ; DNA-Binding Proteins/genetics ; Epithelial-Mesenchymal Transition/physiology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Ovarian Neoplasms/genetics ; Ovarian Neoplasms/metabolism ; Signal Transduction/physiology ; Snail Family Transcription Factors/antagonists & inhibitors ; Snail Family Transcription Factors/biosynthesis ; Transcription Factors/biosynthesis ; Transcription Factors/genetics ; Tumor Suppressor Proteins/biosynthesis ; Tumor Suppressor Proteins/genetics ; WW Domain-Containing Oxidoreductase/biosynthesis ; WW Domain-Containing Oxidoreductase/genetics
Chemical Substances	DNA-Binding Proteins ; ELF5 protein, human ; SNAI1 protein, human ; Snail Family Transcription Factors ; Transcription Factors ; Tumor Suppressor Proteins ; WW Domain-Containing Oxidoreductase (EC 1.1.1.-) ; WWOX protein, human (EC 1.1.1.-)
Language	English
Publishing date	2020-02-24
Publishing country	Italy
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202002_20154
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Article: [ZEB2 variation in a patient with Mowat-Wilson syndrome].

Wang, H / Yan, Y C / Li, Q / Zhang, Z / Xiao, P / Li, L / Yuan, X Y / Jiang, Q

Zhonghua er ke za zhi = Chinese journal of pediatrics

2019 Volume 57, Issue 2, Page(s) 150–152

Language	Chinese
Publishing date	2019-01-29
Publishing country	China
Document type	Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
DOI	10.3760/cma.j.issn.0578-1310.2019.02.018
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Article: First Report of Rhizopus oryzae Causing Postharvest Fruit Rot on Pear in China

Khokhar, I / Jia, Y / Mukhtar, I / Wang, J. H / Ruth, N / Eltoukhy, A / Fan, S. H / Li, X. J / Wang, J. Y / Yan, Y. C

Plant disease. 2019 June, v. 103, no. 6

2019

Abstract: China is a leader in pear production and is responsible for 65.7% of the world’s pear production and 72.3% of the cultivated acreage. In autumn 2018, a postharvest Rhizopus soft rot was observed at an incidence of 1 to 2% on pear (Bartlett) fruits at the ...

Abstract	China is a leader in pear production and is responsible for 65.7% of the world’s pear production and 72.3% of the cultivated acreage. In autumn 2018, a postharvest Rhizopus soft rot was observed at an incidence of 1 to 2% on pear (Bartlett) fruits at the local markets in Beijing (39°57′55.984′′ N, 116°20′8.124′′ E), China. Initial lesions appeared as water-soaked spots that rapidly expanded and covered the whole fruit, which was soft and necrotic. White hyphae appeared on affected spots of pears and fruit was slowly covered with clumped hair-like gray mycelium, sporangiophores, and sporangia. Small pieces (3 mm3) were taken from the margin of the infected tissues of 10 fruits, sterilized for 20 s with 75% ethanol and 3 min with 0.5% NaOCl, rinsed three times with sterile distilled water, and placed on potato dextrose agar (PDA). Purified fungal isolates on PDA were white to black with colorless to buff reverse. Daily radial mycelial growth was 45 mm/day and 15 mm/day at 25°C and 40°C, respectively. The mycelium produced stolons hyaline to brown, aseptate, and 11.2 to 42 μm in length. Brown rhizoids developed as well, which were highly branched, thick walled, aseptate, and 5.6 to 19.6 μm in length. Sporangiophores arose from stolons, opposite to rhizoids, single or in groups of two to five, unbranched, erect, hyaline to brown, smooth to punctuate, thick walled, stout, measuring 380 to 3,422 × 7.2 to 28 μm, often over 2 mm long. Sporangia were globose, 22.1 to 278.5 μm in diameter, dark brown to black, apophysate, and columellate. Sporangial wall was encrusted and quickly deliquescing upon maturity. The columella globose to subglobose, ovoid, or cylindrical, hyaline to brown, smooth, and 11.2 to 154 × 11.2 to 144 μm. A collar was not distinct but present in some cases. Sporangiospores of various shapes (ovoid, subglobose, angular) and sizes, gray in color and darker in mass, thick-walled with prominent ridges, 4.6 to 14.1 × 4.4 to 12.1 μm in size, but mostly 9 to 10 μm in diameter. On the basis of morphological features, fungus was identified as Rhizopus oryzae (Lunn 1977). To verify the identity, the fungal isolates were grown on PDA at 25°C for 4 days, mycelia were collected, ground with liquid nitrogen, and finally DNA of each isolate was extracted, partial ITS regions and elongation factor-alpha1 (EFl-a1) gene of the isolates were amplified using ITS1/ITS4 and EFl-983F/EFl-2218R primers and sequenced. ITS and EFl-a1 sequences of isolates were found 99% similar with of R. oryzae sequences. Sequences (ITS: MK156713; EFl: MK510718) of a representative isolate YC-IK5 were submitted in GenBank. For pathogenicity test, nine healthy pears were artificially inoculated with YC-IK5 isolate. A conidial suspension (0.1 ml; 106 conidia/ml) was inoculated using a sterile syringe to a depth of approximately 5 mm into the fruit cortical parenchyma, while sterile distilled water was used on three fruits for control and all fruits were placed into a chamber with 80% relative humidity at 30°C. Symptoms were developed after 48 h and were similar on infected fruit collected from a market. Reisolated fungus from the lesions on inoculated pears was identified as R. oryzae. Previously, R. oryzae has been reported from apples in Korea (Kwon et al. 2011). Rhizopus rot on pear fruit in China can severely damage both fruits and the price elasticities of demand tend to be high.
Keywords	DNA ; DNA primers ; Rhizopus oryzae ; acreage ; apples ; autumn ; color ; conidia ; crop production ; demand elasticities ; ethanol ; fruits ; fungi ; genes ; hyphae ; markets ; mycelium ; nitrogen ; pathogenicity ; pears ; plant rots ; relative humidity ; sporangia ; stolons ; tissues ; China ; Korean Peninsula
Language	English
Dates of publication	2019-06
Size	p. 1423.
Publishing place	Plant Disease
Document type	Article
ZDB-ID	754182-x
ISSN	0191-2917
ISSN	0191-2917
DOI	10.1094/PDIS-11-18-1993-PDN
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Article: [The value of brain magnetic resonance imaging in the early diagnosis of neuropsychiatric systemic lupus erythematosus].

Lai, J M / Wu, F Q / Zhou, Z X / Yan, Y C / Su, G X / Li, S N / Zhu, J / Kang, M

Zhonghua er ke za zhi = Chinese journal of pediatrics

2016 Volume 54, Issue 6, Page(s) 446–450

Abstract: Objective: To investigate the value of brain magnetic resonance imaging (MRI) in evaluating the intracranial injuries in patients with juvenile onset systemic lupus erythematosus (SLE).: Method: Data of brain MRI, CT, electroencephalogram (EEG), ... ...

Abstract	Objective: To investigate the value of brain magnetic resonance imaging (MRI) in evaluating the intracranial injuries in patients with juvenile onset systemic lupus erythematosus (SLE). Method: Data of brain MRI, CT, electroencephalogram (EEG), cerebrospinal fluids analysis and clinical features of the central nervous system of 44 patients from March 2007 to March 2015 with juvenile onset SLE who were not treated with glucocorticoids (Gcs) and immunosuppressive agents (Is) were retrospectively analyzed and compared. Result: Twenty-seven out of 44 patients demonstrated abnormal signs on brain MRI, including encephalatrophy, cerebral infarction, demyelination, encephalorrhagia, vertebral arteriostenosis and abnormal signals on the brain diffusion-weighted imaging (DWI). Sixteen patients had clinical features of the central nervous system involvement, fifteen had continuous headache, nine had continuous dizziness, seven had convulsions, three had hemiplegia, one had blurred vision. Physical examination of the nervous system: ten patients had abnormal signs, all had cervical rigidity, five showed pyramidal sign, three showed loss of muscle tone, two with cranial neuropathies and one had paresthesia. EEG: Ten patients showed abnormal waves on EEG, all showed diffused slow-waves, and five showed sharp waves and spikes. Cerebrospinal fluids analysis: six patients had abnormal results, five of them had cell count elevation and one had cell count and protein elevation, while there was glucose and chloride degression. Brain CT: Eight patients received CT scan, two showed cerebral infarction. χ(2) test was used to compare the differences among head MRI, EEG, cerebrospinal fluid analysis, physical examination of the nervous system, clinical features of the nervous system, the difference was significant(χ(2)=12.055, P=0.001; χ(2)=19.627, P=0.001; χ(2)=3.859, P=0.049; χ(2)=12.055, P=0.001). Conclusion: Brain MRI may be a better method in early diagnosis of intracranial injuries than CT, EEG, cerebrospinal fluid analysis and physical examination of the nervous system. Patients with juvenile onset SLE should receive brain MRI after diagnosis in order to investigate the intracranial injuries. Abnormal signals on the DWI are the signs of active disease.
MeSH term(s)	Brain/diagnostic imaging ; Cerebral Infarction ; Cranial Nerve Diseases ; Diffusion Magnetic Resonance Imaging ; Early Diagnosis ; Electroencephalography ; Headache ; Humans ; Lupus Vasculitis, Central Nervous System/diagnostic imaging ; Retrospective Studies ; Seizures
Language	Chinese
Publishing date	2016-06-02
Publishing country	China
Document type	Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
DOI	10.3760/cma.j.issn.0578-1310.2016.06.012
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